Linero M 500 Tablet 10

Intas Pharmaceuticals Ltd

Strip of 10 Units

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MRP ~~₹82.5~~

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Composition

Linagliptin (2.5 Mg) + Metformin (500 Mg)

Linero M 500 Tablet is used to manage type 2 diabetes mellitus in adults who need better control of their blood sugar levels. It is a combination medicine that belongs to the class of oral anti-diabetic medications.

This medicine helps improve glycaemic control when diet and exercise alone aren't enough to maintain healthy blood sugar levels. It can be used as an initial therapy or in patients who aren't adequately controlled on either of the individual components alone.

You should take this medicine as directed by your doctor, who will determine the appropriate dosage based on your condition. Before starting this medicine, inform your doctor about any pre-existing conditions or medications you're currently taking. If you notice any unusual side effects while using this medicine, notify your doctor promptly. Continue taking the medicine for the entire duration prescribed by your doctor to achieve optimal results.

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Linero M 500 Tablet is used for the following:

Managing type 2 diabetes mellitus in adults
Improving blood sugar control with diet and exercise
Helping when single diabetes medicine isn't effective
Reducing glucose production by the liver
Increasing insulin sensitivity in body tissues
Enhancing insulin release in response to meals
Supporting weight management during diabetes treatment
Preventing complications related to uncontrolled diabetes

Follow these instructions while taking Linero M 500 Tablet:

Swallow the tablet whole with a full glass of water.
Do not crush, break or chew the tablet.
If you miss a dose, take it as soon as you remember.
Consult your doctor if you have questions about using this medicine.

Linero M 500 Tablet is taken orally.

Linero M 500 Tablet may have the following common side effects:

Diarrhoea
Nausea
Abdominal pain
Nasopharyngitis: This refers to inflammation of the nasal passages and the back of the throat, commonly known as a cold.
Upper respiratory tract infections
Arthralgia: This refers to joint pain, which can occur in any part of your body where two or more bones meet.
Hypoglycaemia: This is when your blood sugar drops too low, which may cause symptoms like sweating, shakiness, confusion, and hunger.

Managing the Side Effects:

Most side effects are temporary and generally harmless, and resolve on discontinuing the use of Linero M 500 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Diarrhoea: Try taking Linero M 500 Tablet with meals to reduce this side effect.
Nausea: Taking this medicine with food can help decrease feelings of nausea.

Linero M 500 Tablet contains two active ingredients:

Linagliptin (2.5 mg): As a dipeptidyl peptidase-4 (DPP-4) inhibitor, it increases the levels of incretin hormones like glucagon-like peptide-1 (GLP-1) in your body. These hormones help stimulate insulin release from the pancreas when blood sugar is high, while also reducing glucagon production.
Metformin (500 mg): This biguanide works by decreasing glucose production in the liver, reducing glucose absorption in the intestines, and improving insulin sensitivity. It helps your body's cells respond better to insulin, allowing them to take up glucose more effectively from the bloodstream.

Pregnancy

Linero M 500 Tablet is not recommended during pregnancy. If you are pregnant or planning to conceive, make sure to discuss this with your doctor before starting this medicine.

Breastfeeding

Linero M 500 Tablet is not recommended during breastfeeding. Consult your doctor to understand the potential risks and benefits and to discuss alternative treatments with more safety information.

Alcohol

Caution is advised while consuming alcohol when taking Linero M 500 Tablet. Alcohol may increase the risk of low blood sugar (hypoglycaemia) and a rare but serious condition called lactic acidosis, which affects how your body processes energy.

Liver

Caution is advised while taking Linero M 500 Tablet if you have liver problems. This medicine contains metformin, which may affect your liver function. If you have any liver conditions, discuss them with your doctor before starting this medicine.

Kidney

Linero M 500 Tablet is contraindicated if you have severe kidney problems. Your doctor will check your kidney function before prescribing this medicine and periodically during treatment. Regular monitoring is important to prevent rare but serious side effects.

Using Machines & Driving

You may drive and use machines while taking Linero M 500 Tablet. However, be aware that if you experience low blood sugar levels (hypoglycaemia), your ability to concentrate may be affected. Monitor your blood sugar regularly, especially when starting treatment.

Allergy

Caution is advised if you have a history of allergic reactions to any medicines. If you have previously experienced any allergic reaction to linagliptin, metformin or any other diabetes medicines, inform your doctor before taking Linero M 500 Tablet.

Children

Caution is advised while giving Linero M 500 Tablet to children under 18 years of age. The safety and effectiveness of this medicine have not been established for paediatric patients. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should take Linero M 500 Tablet under medical supervision as they may be more susceptible to its side effects. The risk of certain complications increases with age. Your doctor may monitor your kidney function more frequently and adjust the dosage accordingly.

Drug-Drug Interactions

Linero M 500 Tablet interacts with the following medicines:

Carbonic anhydrase inhibitors: Medicines like topiramate and acetazolamide may increase the risk of lactic acidosis when taken with Linero M 500 Tablet.
Cationic medicines: Medicines eliminated by renal tubular secretion such as cimetidine and ranitidine can increase metformin levels in your blood.
Contrast agents: Iodinated contrast materials used in imaging tests may lead to kidney problems and metformin accumulation.
Insulin secretagogues: Medicines like glimepiride or gliclazide may increase your risk of low blood sugar (hypoglycaemia) when combined with Linero M 500 Tablet.

Drug-Food Interactions

Linero M 500 Tablet should be taken with meals to reduce stomach discomfort.

High-fat meals: May slow the absorption of metformin, potentially affecting how quickly the medicine works.

Drug-Disease Interactions

Linero M 500 Tablet interacts with the following diseases:

Kidney disease: Not recommended for patients with severe kidney problems (eGFR below 30 mL/min) as it increases the risk of lactic acidosis.
Metabolic acidosis: This medicine is contraindicated in patients with acute or chronic metabolic acidosis, including diabetic ketoacidosis.
Pancreatitis: Linagliptin has been associated with pancreatitis; use with caution if you have a history of this condition.

Daily Dose

The daily dose of Linero M 500 Tablet should be taken as prescribed by your doctor. The dosage may change based on individual factors such as your blood glucose levels and response to treatment. Always follow the prescribed dosage without exceeding it.

Over Dose

An overdose of Linero M 500 Tablet may cause stomach problems like severe nausea, vomiting, diarrhoea, and abdominal pain. You might also experience low blood sugar, dizziness, and weakness. Contact your doctor if these symptoms occur.

Missed Dose

If you forget to take Linero M 500 Tablet, take it as soon as you remember. If it's nearly time for your next dose, skip the missed one and continue your regular schedule. Never double your dose to make up for a missed one.

Store Linero M 500 Tablet at 25°C. Temperature excursions are permitted in the 15°C to 30°C range.
Keep the medicine protected from light and moisture.
Store in the original packaging until ready for use.
Keep out of sight and reach of children.
Do not use this medicine after the expiry date printed on the package.
Safely dispose of any unused tablets.

Monitor your carbohydrate intake and choose foods with a low glycaemic index (foods that release glucose slowly) to help maintain steady blood glucose levels throughout the day.
Engage in regular physical activity, like brisk walking for at least 30 minutes daily. Exercise improves insulin sensitivity and helps your body use glucose more effectively.

Fact Box

Drug Category	DPP-4 inhibitor, Biguanide
Therapeutic Category	Anti-diabetic medication
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Type 2 diabetes

What is Linero M 500 Tablet?

Linero M 500 Tablet is a combination medicine for type 2 diabetes that contains linagliptin and metformin. It helps control blood sugar levels when diet and exercise are not enough.

How does Linero M 500 Tablet work?

It works in two ways: linagliptin increases insulin release after meals, while metformin reduces sugar production by your liver and helps your body use insulin better.

When should I take Linero M 500 Tablet?

You must take this medicine as prescribed by your doctor.

What are the common side effects of Linero M 500 Tablet?

Common side effects include stomach discomfort, diarrhoea, nausea, throat infections, and joint pain. Most side effects improve as your body adjusts to the medicine.

Can Linero M 500 Tablet cause vitamin deficiency?

Yes, long-term use may reduce vitamin B12 absorption. Your doctor might check your B12 levels periodically and recommend supplements if needed.

Is it safe to use Linero M 500 Tablet if I have kidney problems?

No, this medicine is not suitable if you have severe kidney problems. Your doctor should check your kidney function before and during treatment.

What should I do if I miss a dose?

Take the missed dose as soon as you remember. If it's nearly time for your next dose, skip the missed one. Never take a double dose to make up for a forgotten one.

Last Updated On 29 Apr. 2025 | 2:58PM (IST)

Certified Content

Written by

Dr Nikita Lobo

Medical Content Reviewer | 8 years

BDS, MDS

Reviewed by

Dr. Meenakshi Maruwada

Medical Content Writer | 8 years

BDS, PGCAD, GMHE (IIM-B)

Check out Editorial Policy

Manufacturer details

Corporate House, Near Sola Bridge, S. G. Highway, Thaltej, Ahmedabad 380054, Gujarat, India

Country of origin: INDIA

Expiry on or after: November 2025

In case of any issues, contact us:

support@truemeds.in|08069808861

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

MedlinePlus. (n.d.). Linagliptin and metformin. Retrieved April 1, 2025, from https://medlineplus.gov/druginfo/meds/a611036.html
MedlinePlus. (n.d.). Metformin. Retrieved April 1, 2025, from https://medlineplus.gov/druginfo/meds/a696005.html
U.S. Food and Drug Administration. (2023). JENTADUETO (linagliptin and metformin hydrochloride) tablets, for oral use: Prescribing information (201280s027lbl.pdf). Retrieved April 1, 2025, from https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/201280s027lbl.pdf
U.S. Food and Drug Administration. (2011). FDA drug safety communication: Updated information about the risk of lactic acidosis with use of metformin in certain patients with reduced kidney function. Retrieved April 1, 2025, from https://www.fda.gov/downloads/drugs/drugsafety/ucm280360.pdf

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Disclaimer

We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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Registered Office Address

Intellihealth Solutions Private Limited

Unit-301 & 304, Lightbridge Tunga Village, Saki Vihar Rd, Chandivali, Powai, Mumbai, Maharashtra, India, 400072.

CIN: U62099MH2019PTC320566

Telephone:09240250346

Grievance Officer

Name: Chandrasekhar Swaminathan

Email: grievance-officer@truemeds.in

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