Headset Tablet 2

Headset Tablet 2 may interact with the following medicines:

• Antihypertensive medicines (e.g., enalapril, losartan and metoprolol): Naproxen may reduce their blood pressure-lowering effects and increase the risk of kidney impairment with certain antihypertensive medicines.
• Diuretics (e.g., furosemide and hydrochlorothiazide): Naproxen may reduce their diuretic effects and increase the risk of kidney problems.
• Anticoagulants and antiplatelet medicines (e.g., warfarin, apixaban, aspirin and clopidogrel): Concurrent use may increase the risk of gastrointestinal and other bleeding.
• Other NSAIDs (e.g., ibuprofen and diclofenac): Taking these medicines together may increase the risk of stomach ulcers, bleeding and kidney damage.
• Antidepressants (e.g., fluoxetine, sertraline, venlafaxine and duloxetine): SSRIs and SNRIs may increase the risk of bleeding with naproxen and serotonin syndrome with sumatriptan.
• Monoamine oxidase-A inhibitors (e.g., moclobemide and phenelzine): These medicines may increase sumatriptan exposure and cause serious adverse effects. Concurrent use, or use within 2 weeks of stopping an MAO-A inhibitor, is contraindicated.
• Other triptans and ergot-containing medicines (e.g., rizatriptan, zolmitriptan and ergotamine): Using these medicines within 24 hours of Headset Tablet 2 may increase the risk of excessive blood vessel constriction.
• Lithium: Naproxen may increase lithium concentrations, raising the risk of lithium toxicity.
• Methotrexate: Naproxen may reduce methotrexate clearance and increase its toxicity.
• Digoxin: Naproxen may increase digoxin concentrations and the risk of adverse effects.
• Corticosteroids (e.g., prednisolone): Concurrent use may increase the risk of gastrointestinal ulceration and bleeding.

Headset Tablet 2 may interact with the following conditions:

• Coronary artery disease or previous heart attack: Sumatriptan may constrict coronary blood vessels, while naproxen may increase cardiovascular risk. This combination is contraindicated in patients with ischaemic heart disease.
• Uncontrolled hypertension: Sumatriptan may cause a significant increase in blood pressure, while naproxen may worsen blood pressure control.
• History of stroke or transient ischaemic attack: Sumatriptan can constrict blood vessels and is contraindicated in patients with these conditions.
• Peripheral vascular disease: Sumatriptan may further reduce blood flow through narrowed blood vessels.
• Stomach ulcers or gastrointestinal bleeding: Naproxen may worsen existing ulcers and increase the risk of gastrointestinal bleeding.
• Medication-overuse headache: Frequent use of medicines for acute migraine attacks may worsen headache frequency and severity.

Headset Tablet 2 should be taken only for an acute migraine attack, in the dose prescribed by your doctor. It is not intended for regular daily use or migraine prevention. Follow the approved package insert for the maximum number of tablets permitted within 24 hours and the minimum interval between doses.

Taking more than the prescribed dose may cause nausea, vomiting, abdominal pain, dizziness, drowsiness or an increase in blood pressure. Severe overdose may cause gastrointestinal bleeding, kidney problems or cardiovascular complications. Seek immediate medical attention if an overdose is suspected.

A missed dose is generally not applicable because Headset Tablet 2 is taken when a migraine attack occurs rather than on a fixed daily schedule. Do not take an additional tablet to make up for a missed dose. Follow your doctor's instructions if the headache persists or returns.