Zolineg 2 Injection 1

Sanofi India Ltd.

Vial of 1 UNITS

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MRP ~~₹1836.99~~

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Composition

Colistin (2 Miu)

Acostin Forte 2 MIU Injection is a potent medication primarily prescribed to treat some types of serious infections caused by certain bacteria. This medicine is part of a group known as antibiotics.

This injection is often recommended for managing infections that may not respond well to other antibiotics. Its targeted mechanism of action allows it to combat specific bacteria effectively, ensuring you receive optimal treatment.

Before taking this injection, consult your doctor who will determine the appropriate dosage and frequency. Make sure you inform your doctor about any pre-existing conditions or ongoing medication. If you notice any side effects while on this medicine, notify your doctor immediately. It's important to continue taking the medicine for the duration prescribed by your doctor for optimal results.

Acostin Forte 2 MIU Injection is used for the following:

Treats severe bacterial infections caused by multidrug-resistant Gram-negative bacteria.
Treats respiratory tract, urinary tract, bloodstream, or abdominal infections.

Administer Acostin Forte 2 MIU Injection as advised below:

This injection will be administered by a healthcare professional.
Be sure to stay well-hydrated before and after each dose.
Since this treatment is managed by a healthcare professional, you will receive detailed instructions during administration. Always consult your doctor for personalised guidance.

Acostin Forte 2 MIU Injection can be administered intravenously or intramuscularly.

Acostin Forte 2 MIU Injection may cause the following side effects:

Nausea and vomiting
Dizziness
Muscle weakness
increase in urine output
Fatigue

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve upon discontinuing the use of Acostin Forte 2 MIU Injection. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Nausea and Vomiting: Avoid spicy or greasy foods that can aggravate nausea.
Dizziness: Sit or lie down immediately if you feel dizzy to avoid falls. Avoid sudden movements, such as getting up quickly from a seated or lying position.
Increase in Urine Output: Limit caffeine or diuretics, which can further increase urine production.

Acostin Forte 2 MIU Injection contains Colistimethate sodium (2 MIU), which works in the following ways:

Targets Specific Bacteria: Colistin specifically targets gram-negative bacteria, which are responsible for certain types of infections.
Disrupts Bacterial Cell Membrane: Colistin interacts with the membrane of the bacterial cell, causing it to become leaky. This causes essential substances inside the bacterium to leak out, leading to its death.
Halts Bacterial Growth: By disrupting the bacterial cell membrane, colistin inhibits the growth and multiplication of the bacteria, helping to control and eliminate the infection.

Pregnancy

Acostin Forte 2 MIU Injection should be cautiously taken during pregnancy due to its potential to cause serious harm to the developing foetus. If you are pregnant or planning to conceive, inform your doctor immediately. Use effective contraception during treatment to avoid pregnancy.

Breastfeeding

This medication is also not recommended for breastfeeding mothers, as it may pass into breast milk and harm the infant. Consult your doctor to discuss alternatives or the need to discontinue breastfeeding during treatment.

Alcohol

Consuming alcohol while using Acostin Forte 2 MIU Injection can amplify its potential side effects, particularly those affecting the liver. It's crucial to discuss your alcohol consumption habits with your doctor before starting this treatment.

Liver

Patients with existing liver conditions should exercise caution while using Acostin Forte 2 MIU Injection, as it may exacerbate liver problems.

Kidney

Acostin Forte 2 MIU Injection may also affect kidney function, particularly in individuals with pre-existing kidney issues. Discuss your kidney health with your doctor, who may recommend dosage adjustments or additional monitoring during treatment.

Using Machines & Driving

This medicine can cause side effects such as dizziness, fatigue, or weakness, which may impair your ability to drive or operate machinery safely. Ensure you understand how medicine affects you before engaging in such activities.

Allergy

If you have a known allergy to Colistin or any other ingredient in Acostin Forte 2 MIU Injection, avoid using this medication. Notify your doctor immediately if you experience symptoms like rash, itching, swelling, or difficulty breathing.

Children

Acostin Forte 2 MIU Injection can be used in children. Your doctor will guide you to the appropriate dosage before administering.

Older Patients

Older adults, particularly those above 70 years of age, are more susceptible to the side effects of Acostin Forte 2 MIU Injection. Caution and close monitoring by a healthcare professional are recommended for this age group.

Drug-Drug Interactions

Acostin Forte 2 MIU Injection interacts with the following medicines:

Antibiotics: There is an enhanced risk of kidney damage with aminoglycosides (e.g., gentamicin).
Muscle Relaxants: There is an increased muscle weakness risk with neuromuscular blockers such as tubocurarine.

Drug-Disease Interactions

Acostin Forte 2 MIU Injection interacts with the following diseases:

Kidney Disease: Acostin Forte 2 MIU Injection can be nephrotoxic, potentially causing or worsening kidney damage. Patients with kidney issues may require dose adjustments and regular monitoring of kidney function.
Myasthenia gravis: This medicine can exacerbate muscle weakness, a hallmark of myasthenia gravis. The medicine's interaction with neuromuscular functions may cause breathing difficulties.
Porphyria: Porphyria is a rare genetic disorder, and some antibiotics, including colistin, may trigger attacks. Using Acostin Forte 2 MIU Injection could worsen symptoms like abdominal pain, neuropathy, or mental health disturbances.
Asthma: Colistin can cause breathing difficulties or trigger bronchospasms in sensitive individuals. Asthmatic patients may experience an increased risk of respiratory side effects.

Daily Dose

The daily dose of Acostin Forte 2 MIU Injection should be administered as recommended by your doctor. The dosage may vary based on individual factors, such as the severity of the condition and response to treatment. It's crucial to adhere to the prescribed dosage and not to exceed it without consulting your doctor.

Over Dose

Overdosing on Acostin Forte 2 MIU Injection might result in symptoms similar to its side effects, such as muscle weakness and breathlessness. If you suspect an overdose, you should inform your doctor about it.

Missed Dose

If you forget to administer your scheduled dose of Acostin Forte 2 MIU Injection, contact your healthcare provider. Do not increase the dosage without consulting your doctor.

Store Acostin Forte 2 MIU Injection in temperature 2–8°C.
Keep it away from direct sunlight and damp areas like the bathroom or kitchen.
Ensure it's stored out of the reach and sight of children.
Make sure to use this medicine before its expiry date

Incorporate yoghurt or other probiotic-rich foods to restore healthy gut bacteria, which can be affected by antibiotics.
Avoid processed and greasy foods that can strain digestion and weaken your recovery.
Avoid caffeinated and sugary beverages, which can dehydrate the body.

Fact Box

Available Dosage Types	Injection
Habit Forming	No
Ailment	Bacterial infections
Drug Category	Polymyxin antibiotic
Therapeutic Category	Antibiotic

What is Acostin Forte 2 MIU Injection used for?

Acostin Forte 2 MIU Injection is used to treat severe bacterial infections caused by multidrug-resistant Gram-negative bacteria. It is commonly prescribed for respiratory, urinary tract, abdominal, or bloodstream infections. This medication is often reserved for serious cases due to its potent nature.

How is Acostin Forte 2 MIU Injection administered?

It is administered intravenously (IV) under the supervision of a healthcare professional. The dosage depends on the type and severity of the infection as well as kidney function. Proper monitoring during administration is essential to prevent side effects.

Can I drink alcohol while using Acostin Forte 2 MIU Injection?

It is advisable to avoid alcohol while taking this medication. Alcohol can increase the risk of side effects like nausea and kidney stress. Consult your doctor for specific recommendations based on your condition.

Can I use this medicine during pregnancy or breastfeeding?

During pregnancy, it should only be used if absolutely necessary and prescribed by a doctor. While breastfeeding, caution is advised as the medicine may pass into breast milk. Discuss the risks and benefits with your healthcare provider.

What are the potential side effects of Acostin Forte 2 MIU Injection?

Common side effects include nausea, dizziness, and fatigue. Severe reactions may involve kidney or nerve damage, difficulty breathing, or allergic reactions. Report any unusual or severe symptoms to your doctor immediately.

Does this medicine interact with other medicines or food?

It may interact with aminoglycosides, diuretics, and neuromuscular blockers, increasing side effects. No significant food interactions are reported, but a kidney-friendly diet is recommended. Inform your doctor about all medications and supplements you are taking.

How should I store Acostin Forte 2 MIU Injection?

Store it in a refrigerator at 2–8°C and avoid freezing. Use immediately after preparation by a healthcare professional. Keep it out of reach of children and dispose of unused portions properly.

Last Updated On 15 Aug. 2025 | 5:33PM (IST)

Certified Content

Written by

Dr. Divya Mandial

Medical Content Writer | 9 years

PhD in Chemistry

Reviewed by

Dr. Betina Chandolia

Lead Medical Content Reviewer | 10 years

BDS, MDS, PGCCL, PGDMH

Check out Editorial Policy

Manufacturer details

CTS No.117-B L & T Business Park, Saki Vihar Rd, Powai, Mumbai, Maharashtra 400072

Country of origin: INDIA

Expiry on or after: January 2026

In case of any issues, contact us:

support@truemeds.in|08069808861

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

Colistimethate for Injection. (N.d.). Fda.Gov. Retrieved November 18, 2024, from https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/050108s033lbl.pdf
Colistin. (n.d.). RxList. Retrieved November 18, 2024, from https://www.rxlist.com/colistin/generic-drug.htm
Colistin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00803

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Disclaimer

We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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