Trinexovas 40 Tablet 15

Macleods Pharmaceuticals Pvt.ltd

Strip of 15 Units

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Old MRP ₹449.85

MRP ~~₹421.73~~

₹337.38

₹28.12/Units

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Prescription required for this medicine

Store Below 30^o C

Composition

Chlorthalidone (12.5 Mg) + Cilnidipine (10 Mg) + Olmesartan Medoxomil (40 Mg)

TriNexovas 40 Tablet is used in managing high blood pressure by combining three antihypertensive ingredients that work together to achieve stronger and more stable blood pressure control. It is particularly useful for patients who require multiple medications for effective management. Consult your doctor before starting this medicine and share details of any health conditions or medicines you take. Inform your doctor if side effects appear and continue the treatment for the prescribed duration.

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TriNexovas 40 Tablet is used to reduce high blood pressure in adults who need stronger management than single-medicine treatment can offer. It helps maintain long-term blood pressure stability and reduces strain on the heart. This combination therapy is commonly prescribed when lifestyle changes and monotherapy fail to achieve target levels.

Follow these instructions while taking TriNexovas 40 Tablet:

Swallow the tablet whole with a glass of water.
Avoid crushing or chewing the tablet as it may affect its absorption and efficacy.
Do not exceed the recommended dose without consulting your doctor.
If you miss a dose, take it as soon as you remember. But if it's close to your next dose time, skip the missed one. Never take two doses at once.
Remember not to stop taking this medicine without talking to your doctor first.

TriNexovas 40 Tablet is taken orally.

TriNexovas 40 Tablet may cause side effects including dizziness, lightheadedness, headache, tiredness, nausea, vomiting, diarrhoea, constipation, or increased urination. Consult your doctor if any side effects persist.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of TriNexovas 40 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are a couple of tips for managing common side effects:

Nausea or vomiting: Try taking TriNexovas 40 Tablet with food.
Increased urination: Consider taking this medicine at night to avoid frequent trips to the toilet during the day.

TriNexovas 40 Tablet combines the action of three active ingredients:

Cilnidipine (10 mg): Cilnidipine is a calcium channel blocker. It works by blocking the movement of calcium into the cells of your heart and blood vessels. This relaxation of blood vessels reduces the resistance to blood flow, thereby lowering your blood pressure.
Olmesartan Medoxomil (40 mg): This ingredient is an angiotensin II receptor blocker. It prevents a substance called angiotensin II from binding to receptors on blood vessels, which causes them to narrow. By blocking this effect, blood vessels relax and widen, reducing blood pressure.
Chlorthalidone (12.5 mg): This is a thiazide-like diuretic, a type of medicine that helps your kidneys get rid of excess water and salt from your body. By doing so, it reduces the volume of blood your heart has to pump, thus lowering your blood pressure.

Pregnancy

Caution is advised while taking TriNexovas 40 Tablet if you are pregnant. It is best to consult your doctor before taking this medicine.

Breastfeeding

TriNexovas 40 Tablet is not recommended during breastfeeding. Consult your doctor to understand the potential risks and benefits.

Alcohol

You should avoid consuming alcohol while taking TriNexovas 40 Tablet as it may intensify side effects like dizziness or lightheadedness. Always check with your doctor for specific advice.

Liver

Caution is advised while taking TriNexovas 40 Tablet if you have mild to moderate liver impairment. This medicine may affect liver function, hence it's not recommended for severe liver diseases.

Kidney

If you have a history of kidney problems, it's a good idea to consult your doctor before taking TriNexovas 40 Tablet.

Using Machines & Driving

TriNexovas 40 Tablet can sometimes cause dizziness, so caution is advised when driving or operating heavy machinery until you know how the medicine affects you.

Allergy

If you are allergic to any of the ingredients in TriNexovas 40 Tablet, avoid using this medicine and inform your doctor about the same.

Children

TriNexovas 40 Tablet is formulated for adult use. Caution is advised while giving this medicine to children under 18 years of age. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should take TriNexovas 40 Tablet under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age. Your doctor will guide you based on your health status.

Drug-Drug Interactions

TriNexovas 40 Tablet interacts with the following medicines:

Lithium: TriNexovas 40 Tablet can affect lithium levels in your body. High lithium levels can lead to harmful side effects.
NSAIDs: Medicines like ibuprofen and naproxen may reduce the blood pressure-lowering effect of this tablet.
Blood pressure-lowering medication: Medicines like cholestramine can decrease the absorption of chlorthalidone in the body, reducing its effectiveness.
Corticosteroids: They may increase the blood pressure, which can counteract the effect of TriNexovas 40 Tablet.
Alcohol, Barbiturates, or Narcotics: They may cause orthostatic hypotension (low blood pressure when standing up) when taken with this tablet.
Other Antihypertensive Medications: Taking other blood pressure-lowering medicines with TriNexovas 40 Tablet could further lower your blood pressure, potentially leading to hypotension.

Drug-Food Interactions

TriNexovas 40 Tablet's interaction with food:

Grapefruit Juice: Consuming grapefruit juice while taking this medication can increase cilnidipine levels in your blood, potentially causing side effects.

Drug-Disease Interactions

TriNexovas 40 Tablet interacts with the following diseases:

Kidney Disease: If you have kidney disease, this medicine might make your condition worse by affecting kidney function.
Liver Disease: It should be used with caution if you have liver disease as it may impact the metabolism and clearance of the medicine.
Diabetes: This medication may affect your blood sugar levels, requiring you to adjust your diabetes medication dosage.
Gout: As a diuretic, chlorthalidone may raise uric acid levels in your body, potentially triggering a gout attack.
Lupus: This medicine can worsen symptoms in individuals with lupus, an auto-immune condition.

Daily Dose

You should take the daily dose of TriNexovas 40 Tablet as prescribed by your doctor. The dosage may vary depending on factors such as the severity of your condition and how you respond to the medication. Always stick to the prescribed dosage and don't exceed it without consulting your doctor.

Over Dose

If you take more than the recommended dose of TriNexovas 40 Tablet, you may experience common symptoms like dizziness, headache, or upset stomach. If these symptoms persist or get worse, inform your doctor.

Missed Dose

If you forget to take a dose of TriNexovas 40 Tablet, take it as soon as you remember. If it's nearly time for your next dose, skip the missed one and continue with your regular schedule. Don't increase your dosage without consulting your doctor.

Store TriNexovas 40 Tablet at room temperature, ideally below 30°C.
Keep the medicine in a tightly sealed container.
Protect the tablet from light and moisture.
Always keep this medicine out of the reach of children.
Make sure to use the tablet before its expiry date.

Limit your salt intake: Eating too much salt can raise your blood pressure, and TriNexovas 40 Tablet is used to manage hypertension or high blood pressure. So, try to limit your daily salt intake.
Avoid grapefruit juice: It can interact with one component of TriNexovas 40 Tablet (cilnidipine) and increase its level in your blood. It's best to avoid consuming grapefruit or grapefruit juice while taking this medication.

Fact Box

Available Dosage Types	Tablet
Habit Forming	No
Ailment	Hypertension
Drug Category	Diuretic, Calcium Channel Blocker, Angiotensin II Receptor Blocker
Therapeutic Category	Antihypertensive

What is TriNexovas 40 Tablet used for?

This medicine is used to manage high blood pressure in adults, especially when one medication isn't effective enough.

How does TriNexovas 40 Tablet work?

It combines three active ingredients that lower blood pressure in different ways: reducing blood volume, relaxing blood vessels, and promoting vasodilation.

Can I chew or crush TriNexovas 40 Tablet?

No, the tablet should be swallowed whole with water. Chewing or crushing it might affect how your body absorbs it.

What happens if I miss a dose of this medicine?

If you remember soon after missing a dose, take it then. If it's nearly time for your next dose, skip the missed one.

Is it safe to use TriNexovas 40 Tablet during pregnancy or breastfeeding?

It is not recommended during pregnancy or breastfeeding unless your doctor believes the benefits outweigh potential risks.

How long does TriNexovas 40 Tablet take to start working?

The effect varies among individuals; some may see benefits in a few days, while others may need a few weeks for full effect.

Can I consume grapefruit juice while taking this medicine?

Avoid grapefruit juice as it can interact with one of the tablet's components, potentially increasing its levels in your blood.

Last Updated On 11 Dec. 2025 | 8:10AM (IST)

Certified Content

Written by

Dr Nikita Lobo

Medical Content Reviewer | 8 years

BDS, MDS

Reviewed by

Dr. Meenakshi Maruwada

Medical Content Writer | 9 years

BDS, PGCAD, GMHE (IIM-B)

Check out Editorial Policy

Manufacturer details

Atlanta Arcade, Marol Church Rd, Bori Colony, Vijay Nagar Colony West, Marol, Andheri East, Mumbai, Maharashtra 400059

Country of origin: INDIA

Expiry on or after: April 2026

In case of any issues, contact us:

support@truemeds.in|09240250346

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

DailyMed. (n.d.). Chlorthalidone- chlorthalidone tablet. Retrieved April 1, 2024, from https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=ef8023a3-b2be-436e-9085-576781950665
DailyMed. (n.d.). Chlordiazepoxide and clidinium bromide- chlordiazepoxide hydrochloride and clidinium bromide capsule. Retrieved April 1, 2024, from https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=a337a621-bf57-4aa4-8224-4356fa2cdbc4
U.S. Food and Drug Administration. (n.d.). Olmesartan Medoxomil Clinical Pharmacology Biopharmaceutics Review(s). Retrieved April 1, 2024, from https://www.accessdata.fda.gov/drugsatfda_docs/pediatric/021286_Olmesartan_Clinpharm_BPCA.pdf
U.S. Food and Drug Administration. (n.d.). Olmesartan Medoxomil PSG. Retrieved April 1, 2024, from https://www.accessdata.fda.gov/drugsatfda_docs/psg/PSG_012283.pdf
Zhang, J., Ding, E. L., & Song, Y. (2015). Adverse Effects of Bisphosphonates: Implications for Osteoporosis Management. Mayo Clinic Proceedings, 84(7), 632–638. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397623/

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Disclaimer

We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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