Topaz 25 Tablet 10

Intas Pharmaceuticals Ltd

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Store Below 30° C

Composition

Topiramate (25 Mg)

Strength:

25 MG 100 MG 200 MG

Topaz-25 Tablet is used to prevent migraine and manage epilepsy. It is a single-ingredient anticonvulsant medicine containing topiramate.

It helps reduce seizure frequency and control abnormal electrical activity in the brain, and is also used for Lennox-Gastaut syndrome, a severe form of epilepsy. Take it in the dose, frequency and duration prescribed by your doctor. Do not stop it suddenly, as this can trigger seizures.

Stay well hydrated, especially in hot weather or during exercise, to help reduce the risk of kidney stones linked to this medicine. Keep a regular sleep routine and avoid alcohol.

Before starting, tell your doctor if you have kidney stones, kidney problems or any pre-existing conditions, and about all other medicines, supplements or herbal products you take. Tell your doctor if you are pregnant or planning a pregnancy. Follow the prescribed dose, frequency and duration, report persistent or serious side effects, and do not stop the medicine unless your doctor advises you to do so.

Topaz-25 Tablet is used in adults and children to manage epilepsy, including Lennox-Gastaut syndrome, and to help prevent migraine.

Uses of Topaz-25 Tablet are:

Epilepsy: Helps control abnormal electrical activity in the brain and prevent seizures.
Lennox-Gastaut Syndrome: Used in this severe form of epilepsy that often does not respond well to other treatments.
Migraine Prevention: Helps reduce the frequency of migraine headaches.

Here's how you should take Topaz-25 Tablet:

Swallow the tablet whole with water. Avoid crushing, chewing, or breaking it.
You can take it with or without food.
Try to take your dose at the same time every day.
Continue taking this medicine until your doctor advises you to stop.

Topaz-25 Tablet is taken orally.

Topaz-25 Tablet may cause some side effects that are usually mild and go away as your body adjusts to the medicine.

A few common side effects of Topaz-25 Tablet:

Nervous system: Numbness and tingling, fatigue, sleepiness and dizziness.
Digestive: Loose motions (diarrhoea), stomach pain, nausea and taste changes.

If any side effect does not improve or becomes serious, speak to your doctor. Do not stop taking the medicine unless your doctor advises you to do so.

Management Of Side Effects:

Most side effects are temporary and generally harmless, which resolve upon discontinuing the use of Topaz-25 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are a few tips for managing common side effects:

Diarrhoea and abdominal pain: Try taking this tablet with food to lessen this effect.
Nausea and taste changes: If you experience nausea or changes in taste, consider taking this medicine after meals.

Topaz-25 Tablet contains topiramate (25 mg), which acts on the body through the following mechanisms:

Enhancing GABA: Topiramate enhances the activity of GABA, a neurotransmitter that calms the brain.
Blocking glutamate: It also inhibits glutamate, a neurotransmitter that excites the brain.
Inhibiting channels: It prevents the functioning of voltage-gated sodium and calcium channels in nerve cells.
Modulating calcium channels: Topiramate modulates high-voltage activated calcium channels, which help in nerve signalling.

Pregnancy

This medication should be used with caution during pregnancy. Consult your doctor before taking this medicine if you are pregnant or planning to.

Breastfeeding

Caution is advised while taking this medicine if you are breastfeeding. Consult your doctor for specific advice.

Alcohol

Consuming alcohol while taking Topaz-25 Tablet should be avoided, as it might increase the risk of dizziness, drowsiness, and impaired concentration.

Liver

If you have liver problems, exercise caution before starting this medicine. This medicine might affect liver function, so consult your doctor before starting this medication.

Kidney

Caution is advised before taking this medicine if you have kidney disease or kidney stones. Inform your doctor of any kidney problems before starting this medicine.

Use In Driving And Operating Machinery

Topaz-25 Tablet may cause drowsiness, dizziness, confusion, and vision changes that could affect your ability to drive or operate machinery. If you experience any of these symptoms, avoid these activities until you feel well enough.

Allergy

Don't take this medicine if you are allergic to topiramate or any other ingredients in the formula. If you experience an allergic reaction, stop using this medicine and seek medical attention immediately.

Children

Caution is advised while giving Topaz-25 Tablet to children under 18 years of age. Always consult your doctor before giving this medicine to a child.

Older Patients

Older patients should take this medicine under medical supervision as they may be more susceptible to its side effects. Caution is advised especially for patients over 70 years of age, since they might also have liver and kidney issues and could be on other medication.

Drug-Drug Interactions

Topaz-25 Tablet interacts with the following medicines:

Oral contraceptives: Topaz-25 Tablet may reduce the effectiveness of oral contraceptives like levonorgestrel and ethinylestradiol, increasing the risk of unplanned pregnancy.
Valproates: When combined with this medicine, valproates like sodium valproate and divalproex sodium could increase the risk of hypothermia and hyperammonaemia.
Carbonic anhydrase inhibitors: Concurrent use with medicines like acetazolamide or dichlorphenamide can increase your risk of kidney stones and metabolic acidosis.
Central Nervous System (CNS) depressants: Taking this medicine with CNS depressants such as opioids like clonidine and carbamazepine, muscle relaxants like cyclobenzaprine, or benzodiazepines like diazepam and alprazolam can intensify dizziness, drowsiness, and impaired concentration.

Drug-Food Interactions

The following foods interact with Topaz-25 Tablet:

High-fat meals: Consuming a high-fat meal before taking this tablet could increase the absorption rate of the medicine into your body and increase the risk of kidney stone formation.

Drug-Disease Interactions

Topaz-25 Tablet interacts with the following diseases:

Kidney disease: If you have kidney disease, kidney stones, or are on dialysis, this medication could exacerbate your condition.
Liver disease: People with liver issues should be cautious as this medicine may worsen their condition, leading to liver toxicity.
Lung or breathing disorders: If you have asthma or COPD (Chronic Obstructive Pulmonary Disease), this medicine might affect your breathing capacity.
Metabolic acidosis: Patients with this condition need to be careful as this medicine can even lower bicarbonate levels in the blood.

Daily Dose

Your doctor will prescribe the daily dosage of this medicine based on your specific condition and response to the medicine. Stick to this prescribed dosage and do not exceed it without consulting your doctor.

Over Dose

Overdosing on Topaz-25 Tablet might lead to symptoms like dizziness, confusion, or increased sleepiness. If you experience these symptoms, inform your doctor.

Missed Dose

If you've missed a dose of Topaz-25 Tablet, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and resume your normal schedule. Always consult your doctor before making any changes to your dosage.

Store this medicine at room temperature, ideally below 25° Celsius.
Keep it away from direct sunlight and moisture.
Do not keep the medicine within reach of children.
Check the expiration date on the pack before taking each dose. Never use the medicine past this date.

If you are taking Topaz-25 Tablet for migraines, try to identify and avoid foods that trigger your headaches. Common triggers include cheese, chocolate, and caffeine.
In case of epilepsy or seizures, maintaining a regular sleep pattern can help manage the condition. Lack of sleep may increase seizure frequency.

Fact Box

Dosage Forms Available	Tablet
Habit Forming	No
Ailment	Migraines, Epilepsy, Lennox-Gastaut Syndrome
Drug Category	Anticonvulsants
Therapeutic Category	Antiepileptics

What does Topaz-25 Tablet do?

Topaz-25 Tablet is an oral medicine that helps manage migraines, seizures, and Lennox-Gastaut syndrome by reducing abnormal electrical activity in the brain.

How do I take Topaz-25 Tablet?

You should take Topaz-25 Tablet orally as directed by your doctor. It's important not to crush, chew or break the tablet and to take it consistently at the same time each day.

What if I miss a dose of Topaz-25 Tablet?

If you miss a dose of Topaz-25 Tablet, take it as soon as you remember, unless it's nearly time for your next dose. Avoid taking two doses at once.

Can I suddenly stop taking Topaz-25 Tablet?

No, you should not suddenly stop taking Topaz-25 Tablet without consulting your doctor, as this may lead to an increase in seizures or other symptoms.

What should I avoid while taking Topaz-25 Tablet?

While taking Topaz-25 Tablet, avoid driving or operating machinery until you know its effects on you. Also, avoid consumption of alcohol.

Can I take Topaz-25 Tablet while pregnant or breastfeeding?

Topaz-25 Tablet could possibly affect your baby if you're pregnant or breastfeeding. Always consult your doctor before taking any medication.

How should I store Topaz-25 Tablet?

Keep your tablets at room temperature, away from light and moisture. Ensure they're kept out of reach of children and pets.

Last Updated On 06 Oct. 2026 | 11:29AM (IST)

Certified Content

Written by

Dr. Michelle Frank

Medical Content Writer | 10 years

Doctor of Medicine

Reviewed by

Dr. Chhavi Rosha

Medical Content Writer | 10 years

BAMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

Corporate House, Near Sola Bridge, S. G. Highway, Thaltej, Ahmedabad 380054, Gujarat, India

Country of origin: INDIA

Expiry on or after: February 2027

In case of any issues, contact us:

support@truemeds.in|09240250346

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

U.S. Food and Drug Administration. (2012, Oct). Topamax (topiramate) tablets label. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020844s041lbl.pdf
DrugBank Online. (2024, May 9). Topiramate. https://go.drugbank.com/drugs/DB00273
Fariba KA, Saadabadi A. (2023, Jan 31). Topiramate. In: StatPearls [Internet]. https://www.ncbi.nlm.nih.gov/books/NBK554530/
National Center for Biotechnology Information (2024). Topiramate. https://pubchem.ncbi.nlm.nih.gov/compound/Topiramate.
Lyseng-Williamson, K. A., & Yang, L. P. (2007). Topiramate: a review of its use in the treatment of epilepsy. https://doi.org/10.2165/00003495-200767150-00008
Perucca E. (1997). A pharmacological and clinical review on topiramate, a new antiepileptic drug. https://doi.org/10.1006/phrs.1997.0124
Langtry, H. D., Gillis, J. C., & Davis, R. (1997). Topiramate. A review of its pharmacodynamic and pharmacokinetic properties and clinical efficacy in the management of epilepsy. https://doi.org/10.2165/00003495-199754050-00009

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Disclaimer

We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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