Sacuvat 50 MG Tablet 14 is used in the treatment of chronic heart failure with a reduced ejection fraction in adults to lessen the risk of cardiovascular events and hospitalisation. This medicine works to improve the weakened heart's ability to pump blood, relax blood vessels, and manage fluid retention, making it a crucial therapy for patients who continue to experience symptoms despite optimal treatment with other standard heart failure medications.
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Sacuvat 50 MG Tablet 14
Pack of 14 Units
Old MRP ₹630
MRP ₹590.62
₹294.72
₹42.19/Units
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CompositionAbout Sacuvat 50 MG Tablet 14
Uses of Sacuvat 50 MG Tablet 14
Sacuvat 50 MG Tablet 14 is used to manage chronic heart failure, working as an ARNI (Angiotensin Receptor-Neprilysin Inhibitor) to relax and widen blood vessels, which makes it easier for the heart to pump blood, ultimately improving heart efficiency and reducing the risk of hospitalisation and heart-related complications.
Directions for Use of Sacuvat 50 MG Tablet 14
- Swallow the tablet whole with a glass of water. Avoid crushing or chewing it.
- You can take it with or without food, as per your comfort.
- Do not increase or decrease the dose without consulting your doctor.
Route of Administration
Sacuvat 50 MG Tablet 14 is taken orally.
Side Effects of Sacuvat 50 MG Tablet 14
Sacuvat 50 MG Tablet 14 may cause low blood pressure (hypotension), high potassium levels (hyperkalemia), kidney dysfunction, cough, dizziness, diarrhoea, headache, and fatigue. Speak to your healthcare provider if symptoms worsen.
Managing the Side Effects:
Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Sacuvat 50 MG Tablet 14. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.
Here are a couple of tips for managing common side effects:
- Dizziness: Try taking Sacuvat 50 MG Tablet 14 at night, this might help manage dizziness during your daily activities.
- Diarrhoea: Consider taking this medicine with food to lessen this effect.
How Sacuvat 50 MG Tablet 14 Works?
Sacuvat 50 MG Tablet 14 contains two active components that work together in complementary ways:
- Sacubitril (24 mg): This component inhibits an enzyme called neprilysin in your body. Neprilysin is responsible for breaking down certain beneficial peptides that promote blood vessel dilation. By blocking neprilysin, sacubitril increases the levels of these peptides, leading to vasodilation and improved kidney function.
- Valsartan (26 mg): Valsartan blocks a specific receptor in your body known as the angiotensin II receptor type-1 (AT1). By inhibiting this receptor, valsartan prevents the narrowing of blood vessels and the secretion of a hormone called aldosterone, reducing sodium and water retention in your body.
Safety Measures & Warnings
Pregnancy
Sacuvat 50 MG Tablet 14 is contraindicated during pregnancy. If you are pregnant or planning to conceive, make sure to discuss this with your doctor before starting this medicine.
Breastfeeding
Sacuvat 50 MG Tablet 14 is not recommended for breastfeeding women. Consult your doctor to understand the potential risks and benefits.
Alcohol
There's no known interaction between Sacuvat 50 MG Tablet 14 and alcohol, but it's always wise to consult your doctor before consuming alcohol while taking this medicine.
Liver
Caution is advised while taking Sacuvat 50 MG Tablet 14 in case of mild to moderate liver impairment. This medicine isn't recommended for severe liver diseases. If you have liver problems, discuss them with your doctor before starting Sacuvat 50 MG Tablet 14.
Kidney
Caution is advised before using Sacuvat 50 MG Tablet 14 if you have a history of any kidney problems. It's a good idea to consult your doctor before taking this medicine.
Using Machines & Driving
As Sacuvat 50 MG Tablet 14 may cause dizziness, it's advisable to avoid driving or operating heavy machinery until you know how the medicine affects you.
Allergy
If you're allergic to sacubitril or valsartan, do not take Sacuvat 50 MG Tablet 14. Consult your doctor if you've had an allergic reaction to similar medicines in the past.
Children
Sacuvat 50 MG Tablet 14 is not recommended for use in children under 18 years of age. Always consult your doctor before giving any medicine to a child.
Older Patients
Older patients should take Sacuvat 50 MG Tablet 14 under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age.
Interactions of Sacuvat 50 MG Tablet 14
Drug-Drug Interactions
Sacuvat 50 MG Tablet 14 interacts with the following medicines:
- ACE Inhibitors: Medicines such as enalapril or lisinopril may interact with Sacuvat 50 MG Tablet 14, potentially leading to increased risk of angioedema and low blood pressure.
- ARBs: Other angiotensin receptor blockers like losartan can interact with Sacuvat 50 MG Tablet 14, increasing the risk of hypotension.
- Potassium-Sparing Diuretics: Diuretics like spironolactone or amiloride, when taken with Sacuvat 50 MG Tablet 14, might increase the levels of potassium in your blood.
- NSAIDs: Non-Steroidal Anti-Inflammatory Drugs including ibuprofen or naproxen could decrease the blood pressure-lowering effect of Sacuvat 50 MG Tablet 14 and increase the risk of kidney problems.
Drug-Food Interactions
There are no clinically significant food interactions identified with Sacuvat 50 MG Tablet 14. It can be taken with or without food.
Drug-Disease Interactions
Sacuvat 50 MG Tablet 14 interacts with the following diseases:
- Liver Disease: Caution is advised for patients with moderate liver impairment as it may affect how Sacuvat 50 MG Tablet 14 works in your body.
- Renal Impairment: Patients with severe kidney disease should take care as Sacuvat 50 MG Tablet 14 could exacerbate their condition.
- Hypotension: Individuals suffering from low blood pressure might experience further decreases in blood pressure levels when taking Sacuvat 50 MG Tablet 14.
Dosage of Sacuvat 50 MG Tablet 14
Daily Dose
Take your daily recommended dose of Sacuvat 50 MG Tablet 14 as your doctor prescribes. The dosage can vary depending on factors such as your condition's severity and your treatment response. It's crucial to stick to the prescribed dosage and not exceed it without consulting your doctor.
Over Dose
If you accidentally take more than the prescribed dose of Sacuvat 50 MG Tablet 14, you might experience symptoms like low blood pressure, high potassium levels, and kidney dysfunction. If these symptoms persist or worsen, inform your doctor.
Missed Dose
If you forget to take your Sacuvat 50 MG Tablet 14 at the scheduled time, take it as soon as you remember. But if it's almost time for your next dose, skip the missed one and continue with your regular dosage schedule. Never alter your dosage without consulting your doctor.
Storage
- Keep your Sacuvat 50 MG Tablet 14 in its original packaging to protect it from moisture.
- Store it at room temperature below 30°C.
- Ensure it is kept out of the reach and sight of children.
- It's crucial to use this medicine before the expiry date printed on the pack.
Diet & Lifestyle
- Since Sacuvat 50 MG Tablet 14 is used to manage heart failure, it's important that you limit your salt intake. This can help reduce fluid build-up and pressure on your heart.
- Regular light exercise, such as walking or cycling, may also help improve your cardiovascular health. However, do ensure you consult with your doctor about the right level of physical activity for you.
Fact Box
| Available Dosage Types | Tablet |
| Habit Forming | No |
| Ailment | Heart Failure, Reduced Ejection Fraction |
| Drug Category | Neprilysin Inhibitor, Angiotensin Receptor Blocker |
| Therapeutic Category | Heart Failure Medication |
Frequently Asked Questions (FAQs)
What is Sacuvat 50 MG Tablet 14 used for?
Sacuvat 50 MG Tablet 14 is used to manage certain types of heart failure in adults, specifically those with reduced ejection fraction despite optimal treatment.
How does Sacuvat 50 MG Tablet 14 work in the body?
Sacuvat 50 MG Tablet 14 contains sacubitril and valsartan which relaxes blood vessels, reduces strain on the heart, and helps it pump blood more efficiently by reducing fluid retention and cardiac stress.
Can I take Sacuvat 50 MG Tablet 14 with food?
Yes, Sacuvat 50 MG Tablet 14 tablets can be taken with or without food. They should be swallowed whole with a glass of water.
What are the common side effects of Sacuvat 50 MG Tablet 14?
Common side effects may include low blood pressure, high potassium levels, kidney dysfunction, cough, dizziness, diarrhoea, headache, and fatigue.
Can I take Sacuvat 50 MG Tablet 14 if I am pregnant or breastfeeding?
Use in pregnancy or breastfeeding is not recommended. Please consult your doctor for advice.
Are there any medicines that interact with Sacuvat 50 MG Tablet 14?
Yes, certain medicines like ACE inhibitors, ARBs, aliskiren, potassium supplements or substitutes, NSAIDs and lithium may interact with Sacuvat 50 MG Tablet 14. Please inform your doctor about all medications you are currently taking.
How should I store my Sacuvat 50 MG Tablet 14?
Store your Sacuvat 50 MG Tablet 14 tablets at room temperature below 30°C. Protect them from moisture and keep them in their original package until use.
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References
- ENTRESTO® (sacubitril and valsartan) tablets. (N.d.). Fda.Gov. Retrieved August 28, 2024, from
- https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/207620s018lbl.pdf
- Entresto tablets.(N.d.). Europa.Eu. Retrieved August 28, 2024, from https://www.ema.europa.eu/en/documents/product-information/entresto-epar-product-information_en.pdf
- https://www.ema.europa.eu/en/documents/product-information/entresto-epar-product-information_en.pdf
- CARMADA. (n.d.). Sacubitril and Valsartan tablets [Report]. https://www.sanofi.in/dam/jcr:2e79c610-7644-4d4c-bf51-1651a1804410/Carmada%20PI-%20Valsartan+Secubitril-Annotated-Nov%202023.pdf
- Sacubitril: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB09292
- Valsartan: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00177
- Kido, K., Colvin, B. M., Szymanski, T. W., & Guglin, M. (2022). Sacubitril/Valsartan Off-Label uses for heart failure. Journal of Cardiac Failure, 28(7), 1185–1201. https://doi.org/10.1016/j.cardfail.2022.03.348
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We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.
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