Ampoule of 1 ML
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CompositionProluton Depot 250mg Injection 1ml is a synthetic progestin used to lower the risk of preterm birth in pregnant women with a singleton pregnancy and a history of previous preterm delivery. The active ingredient, hydroxyprogesterone caproate, works by maintaining uterine quiescence (calmness) and supporting the pregnancy until delivery (typically used between 16 to 37 weeks).
Proluton Depot 250mg Injection 1ml is used in pregnant women to lower the risk of preterm birth in those with a history of spontaneous preterm delivery. Containing Progesterone, it helps maintain a state of rest in the uterus by preventing premature contractions. This injection is vital for supporting the healthy maintenance of the uterine lining throughout the pregnancy.
Administer Proluton Depot 250mg Injection 1ml as follows:
The injection is to be administered intramuscularly only by a trained healthcare professional.
It should not be self-administered at home.
Always follow your doctor's advice regarding the timing of your injections.
If you are due an injection but cannot reach your doctor's office, consult your doctor about rescheduling.
Do not attempt to catch up on missed doses without consulting your doctor.
Proluton Depot 250mg Injection 1ml is administered via an intramuscular route.
Proluton Depot 250mg Injection 1ml may cause side effects such as injection site pain, swelling, nausea, diarrhoea, headache, dizziness, fatigue or fever. If these side effects persist or seem concerning, consult your doctor promptly.
Most side effects are temporary and generally harmless, which resolve upon discontinuing Proluton Depot 250mg Injection 1ml. However, if you experience any serious side effects or worsening symptoms, please consult your doctor.
Here are some general guidelines for managing common side effects:
Nausea: If you feel nauseous after getting Proluton Depot 250mg Injection 1ml, try having a light meal beforehand.
Diarrhoea: Ensure you stay hydrated by drinking plenty of fluids if diarrhoea occurs after the injection.
Proluton Depot 250mg Injection 1ml contains hydroxyprogesterone (250 mg), which acts on the body in the following ways:
Promotes Uterine Quiescence: Hydroxyprogesterone helps maintain a state of rest in the uterus, known as uterine quiescence. This essentially suppresses uterine contractions, helping to prevent preterm birth.
Maintains the Uterine Lining: Hydroxyprogesterone also assists in maintaining the uterine lining, which is crucial for a healthy pregnancy. A healthy uterine lining is better equipped to support the development of the foetus, thus further reducing the risk of preterm birth.
Proluton Depot 250mg Injection 1ml is used during pregnancy to reduce the risk of preterm birth. However, it's not recommended for women with multiple pregnancies or other risk factors for preterm birth. Make sure to discuss this with your doctor before starting this medicine.
Small amounts of the medicine may pass into breast milk. It's best to consult your doctor before taking this medicine while breastfeeding.
There is no known interaction between Proluton Depot 250mg Injection 1ml and alcohol. However, it's always a good idea to avoid alcohol while on medication.
Proluton Depot 250mg Injection 1ml is contraindicated for those with liver tumours or active liver disease. If you have liver problems, discuss them with your doctor before starting this medicine.
Caution is advised if you have a history of any kidney problems. Consult your doctor before taking this medicine.
Proluton Depot 250mg Injection 1ml can cause dizziness as a side effect. If you feel dizzy after administration, avoid driving or operating heavy machinery.
This medicine is contraindicated for those allergic to hydroxyprogesterone or any other components of Proluton Depot 250mg Injection 1ml. Always inform your doctor about any past allergies before starting this medication.
This medicine isn't intended for children under 18 years of age. Always consult your doctor before giving any medicine to a child.
Older patients should take Proluton Depot 250mg Injection 1ml under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age. Your doctor will guide you based on your health status.
Proluton Depot 250mg Injection 1ml interacts with the following medicines:
Antibiotics: Medications like rifampin may decrease the effectiveness of Proluton Depot 250mg Injection 1ml due to increased metabolism of hydroxyprogesterone.
Medicines affecting glucose tolerance: Medications such as corticosteroids might impact the effectiveness of Proluton Depot 250mg Injection 1ml in women with impaired glucose tolerance or diabetes.
None
Proluton Depot 250mg Injection 1ml interacts with the following diseases:
Breast cancer or other hormone-sensitive cancers: Hydroxyprogesterone in Proluton Depot 250mg Injection 1ml could potentially stimulate growth in hormone-sensitive tumours.
Liver disease: Patients with liver ailments should be cautious as this medication might exacerbate their condition due to altered medicine metabolism and elimination processes.
Thrombosis or thromboembolic disorders: The risk of blood clot formation may increase when using this medication.
Uncontrolled hypertension: There's a potential risk of worsening blood pressure control when using Proluton Depot 250mg Injection 1ml.
Your doctor will prescribe the daily dosage of Proluton Depot 250mg Injection 1ml. This can vary depending on individual factors, such as your response to treatment and the severity of your condition. Following this prescribed dosage is crucial and never exceeding it without consulting your doctor.
An overdose is highly unlikely for this medication as it is administered by a skilled healthcare professional.
If you forget to have a dose of Proluton Depot 250mg Injection 1ml Injection as scheduled, consult with your doctor for advice.
Store Proluton Depot 250mg Injection 1ml in the refrigerator or (2°C - 8°C). Do Not Freeze.
Keep it away from direct light and moisture.
Make sure this medicine is kept out of reach and sight of children.
Always check the expiry date before use.
Maintain a balanced diet rich in proteins and vitamins to support healthy pregnancy. This includes lean meats, dairy products, fruits, and vegetables.
Avoid stress as much as possible. Prolonged stress can potentially trigger premature labour. Practice relaxation techniques such as prenatal yoga or meditation, but always consult your doctor before starting any new exercise regimen.
| Available Dosage Types | Injection |
| Habit Forming | No |
| Ailment | Birth Risk |
| Drug Category | Synthetic Progestin |
| Therapeutic Category | Preterm Birth Preventive |
Proluton Depot 250mg Injection 1ml is used to reduce the risk of preterm birth in women who have previously had a singleton spontaneous preterm birth.
It contains hydroxyprogesterone, a synthetic form of progesterone, which helps maintain the uterine lining and suppress uterine contractions, reducing the risk of preterm birth.
Women with hormone-sensitive cancers, unexplained vaginal bleeding, liver disease, uncontrolled hypertension or history of blood clotting disorders should avoid using this medicine.
If you have diabetes, you should use Proluton Depot 250mg Injection 1ml with caution, as it may affect glucose tolerance. Always consult your doctor before use.
Side effects include reactions at the injection site, nausea, diarrhoea, headache, dizziness, fatigue, fever and skin rash. Most are mild and temporary.
Some medications may interact with hydroxyprogesterone. Before using this medicine, inform your doctor about all other medicines or supplements you are taking.
Store it at room temperature, away from light and moisture. Use it within 28 days of its first use, and discard any unused product after this period.
Check out Editorial Policy
Ther-Rx Corporation. (1956). Highlights of prescribing information for Makena [Prescribing information]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021945s005lbl.pdf
McGUFF PHARMACEUTICALS, INC. (n.d.). Hydroxyprogesterone caproate injection USP [Report]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/200271lbl.pdf
DailyMed - HYDROXYPROGESTERONE CAPROATE injection. (n.d.). https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=5cea00ef-d8d6-426d-ae27-9171af00adc7
Hydroxyprogesterone caproate: Uses, Interactions, Mechanism of Action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB06789
We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.
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