Olsertain H 40 Tablet 15

Dr. Reddys Laboratories Ltd

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STRIP of 15 Units

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MRP ~~₹300.6~~

₹255.51

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Store Below 30° C

Composition

Hydrochlorothiazide (12.5 Mg) + Olmesartan Medoxomil (40 Mg)

Olsertain H 40 Tablet is a combination medicine used to treat high blood pressure (hypertension) in adults when single-medication therapy is insufficient. Lowering blood pressure helps reduce the risk of heart attack, stroke, and kidney damage.

It contains olmesartan medoxomil and hydrochlorothiazide. Take it with or without food as prescribed by your doctor, swallowing the tablet whole with water. Continue taking it regularly as advised, even if you feel well, as high blood pressure typically shows no warning signs.

Lifestyle modifications play a crucial role in managing blood pressure. These include adhering to a low-salt diet, exercising regularly, keeping a healthy body weight, and avoiding smoking and excessive alcohol consumption.

Before taking this medicine, inform your doctor if you have kidney or liver issues, diabetes, gout, or electrolyte imbalances. This medicine must not be used during pregnancy or breastfeeding. Your doctor may check your kidney function and electrolyte levels regularly.

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Olsertain H 40 Tablet is used in adults for the effective long-term control of high blood pressure and organ protection.

Uses of Olsertain H 40 Tablet are:

Hypertension Control: Helps achieve target blood pressure in adults with high blood pressure.
Combination Therapy: Provides dual-action blood pressure control when a single medicine is not adequate.
Cardiovascular Risk Reduction: Helps lower the risk of stroke, heart attack, and progressive kidney damage.

Here's how you should take Olsertain H 40 Tablet 15:

Swallow the tablet whole with a sufficient amount of water.
You can take the medicine with or without food.
Do not crush or chew the tablet.
Consult your doctor if you miss a dose and remember not to double dose.
Always follow your doctor's advice about how and when to take this medicine.

Olsertain H 40 Tablet 15 is taken orally.

Olsertain H 40 Tablet may cause some side effects that are usually mild and go away as your body adjusts to the medicine.

A few common side effects of Olsertain H 40 Tablet:

Neurological: Dizziness and headache.
Digestive: Feeling sick (nausea), loose motions (diarrhoea), and loss of appetite.
Skin: Mild skin rash and itching.
Metabolic: Electrolyte imbalances or mild changes in blood uric acid levels.

If side effects do not improve or become serious, speak to your doctor right away.

Management Of Side Effects:

Most side effects are temporary and generally harmless, which resolves on discontinuing the use of Olsertain H 40 Tablet 15. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor. Here are two guidelines for managing common side effects:

Dizziness: If you feel dizzy after taking this medicine, avoid driving or operating heavy machinery until you feel better.
Nausea: If you experience nausea, consider taking this medicine with food or milk to lessen this effect.

Olsertain H 40 Tablet 15 consists of two active ingredients:

Olmesartan medoxomil (40 mg): This ingredient belongs to a class of medicines called angiotensin II receptor blockers (ARBs). It works by selectively binding to certain receptors in your body which are involved in tightening your blood vessels, leading to lower blood pressure.
Hydrochlorothiazide (12.5 mg): This component is a type of diuretic or water pill. It works by reducing the absorption of salt in your kidneys, which causes your body to get rid of excess water and salt through urine. This helps decrease the volume of blood that needs to be pumped through your body, thereby reducing your blood pressure.

Pregnancy

You should avoid taking Olsertain H 40 Tablet 15 during the second and third trimesters of pregnancy as it can harm the foetus. As soon as you know you're pregnant, it's important to stop using this medicine.

Breastfeeding

While breastfeeding, it's best to consult your doctor before taking the Olsertain H 40 Tablet 15.

Alcohol

Caution is advised while consuming alcohol when taking Olsertain H 40 Tablet 15. Your doctor can provide more specific guidance.

Liver

If you have liver health issues, particularly severe ones, it's crucial to discuss these with your doctor before starting the Olsertain H 40 Tablet 15. This medicine may impact liver function.

Kidney

For individuals with issues related to kidney health, caution is advised when taking Olsertain H 40 Tablet 15. Consult your doctor for advice tailored to your specific health condition.

Use In Driving And Operating Machinery

Olsertain H 40 Tablet 15 might cause dizziness; hence, caution is recommended while driving or operating heavy machinery.

Allergy

If you are allergic to any component of Olsertain H 40 Tablet 15 or other sulfonamide-derived medicines, avoid this medication.

Children

Children under 1 year of age should not be given Olsertain H 40 Tablet 15 due to potential risks. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should use Olsertain H 40 Tablet 15 under medical supervision as they may be more susceptible to its side effects. If you're over 70 years of age, your doctor will guide you based on your health status.

Drug-Drug Interactions

Olsertain H 40 Tablet 15 interacts with the following medicines:

Potassium-enhancing Medicines: Medicines such as potassium-sparing diuretics, salt substitutes containing potassium, and potassium supplements could elevate your potassium levels when taken with Olsertain H 40 Tablet 15.
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): NSAIDs like ibuprofen and aspirin can lessen Olsertain H 40 Tablet 15's blood pressure-lowering effects and increase the risk of kidney impairment and high potassium levels.
Antidiabetic Medicines: If you take insulin or oral hypoglycemic agents, you may need to adjust their dosage while on the Olsertain H 40 Tablet 15.

Drug-Food Interactions

There are no specific food items known to interact adversely with Olsertain H 40 Tablet 15.

Drug-Disease Interactions

Olsertain H 40 Tablet 15 interacts with the following diseases:

Kidney Disease: Individuals suffering from significant kidney impairment might experience alterations in renal function while on this medicine.
Liver Disease: If you have liver disease or progressive liver conditions, minor changes in fluid and electrolyte balance induced by Olsertain H 40 Tablet 15 could lead to hepatic coma.
Diabetes: The diuretic effect of Olsertain H 40 Tablet 15 may alter blood glucose levels, necessitating closer monitoring.
Cardiovascular Conditions: For those with severe congestive heart failure, this medication might cause decreased urinary output and increased nitrogen compounds in the blood.

Daily Dose

The daily dose of Olsertain H 40 Tablet 15 should be as prescribed by your doctor. The dosage may vary based on individual factors such as the condition's severity and the response to treatment. Always follow the prescribed dosage and don't exceed it without consulting your doctor.

Over Dose

Overdosing on Olsertain H 40 Tablet 15 could lead to common symptoms such as feeling dizzy, nauseous, or developing a rash. If any of these symptoms persist or worsen, it is important to inform your doctor.

Missed Dose

If you happen to miss a dose of Olsertain H 40 Tablet 15, take it as soon as you remember. However, if it's nearly time for the next dose, skip the missed one and continue with your regular dosage schedule. Never increase your dosage without consulting your doctor.

Keep your Olsertain H 40 Tablet 15 in a tight, light-resistant container.
Store at a cool room temperature between 20° to 25°C.
Ensure the location is free from moisture.
Always keep this medicine out of reach of children.

Since Olsertain H 40 Tablet 15 is used to manage hypertension, try to limit your salt intake. Too much salt can raise your blood pressure, making the condition harder to control.
Regular physical activity such as walking, cycling, or yoga can help lower high blood pressure. Try to be active for at least 30 minutes every day.

Fact Box

Dosage Forms Available	Tablet
Habit Forming	No
Ailment	Hypertension
Drug Category	Angiotensin II Blocker, Diuretic
Therapeutic Category	Antihypertensive

What is Olsertain H 40 Tablet 15 used for?

Olsertain H 40 Tablet 15 is used to manage hypertension (high blood pressure) in adults. It works by decreasing the blood pressure through a combination of mechanisms.

How does Olsertain H 40 Tablet 15 work?

Olsertain H 40 Tablet 15 contains olmesartan and hydrochlorothiazide, which work together to reduce blood pressure. Olmesartan blocks certain effects of a chemical in your body, leading to the relaxation of blood vessels. Hydrochlorothiazide helps your body get rid of extra salt and water.

How should I take Olsertain H 40 Tablet 15?

You can take Olsertain H 40 Tablet 15 with or without food. Swallow the tablet whole with a sufficient amount of water. If you miss a dose, skip it if it's nearly time for your next one.

Can I take an Olsertain H 40 Tablet 15 during pregnancy?

No, you should not take this medicine during pregnancy, especially in the second and third trimesters, as it can harm the developing foetus. Always consult your doctor.

Can I use Olsertain H 40 Tablet 15 while breastfeeding?

Considering the potential adverse effects on the nursing infant, consult your doctor before breastfeeding if you are taking this medicine.

What should I do if I forget to take my dose?

If you miss a dose, take it as soon as possible unless it's almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule.

Are there any side effects associated with Olsertain H 40 Tablet 15?

The most common side effects include nausea, high levels of uric acid in the blood (hyperuricemia), dizziness, upper respiratory tract infection, high potassium levels (hyperkalemia), vertigo, and rash.

Last Updated On 15 Sep. 2026 | 6:30PM (IST)

Certified Content

Written by

Dr Vatsalya D Ghanekar

Medical Content Writer | 7 years

MD Ayurveda

Reviewed by

Dr. Chhavi Rosha

Medical Content Writer | 10 years

BAMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

Bigshare Services Pvt. Ltd. 306, Right Wing, 3rd Floor Amrutha Ville, Opp.Yash Hyderabad - 500082 Telangana

Country of origin: INDIA

Expiry on or after: March 2027

In case of any issues, contact us:

support@truemeds.in|09240250346

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

Daiichi Sankyo, Inc. (2003). Highlights of prescribing information [Prescribing information]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021532s015lbl.pdf
Hydrochlorothiazide: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00999
Olmesartan: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00275
Greathouse, M. (2006). Olmesartan medoxomil combined with hydrochlorothiazide for the treatment of hypertension. Vascular Health and Risk Management, 2(4), 401–409. https://doi.org/10.2147/vhrm.2006.2.4.401

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Disclaimer

We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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