Gibtulio Met 12.5mg/500mg Tablet 10

Lupin Ltd

Strip of 10 Units

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MRP ~~₹117.15~~

₹99.58

₹11.71/Units

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Composition

Empagliflozin (12.5 Mg) + Metformin (500 Mg)

Gibtulio Met 12.5mg/500mg Tablet is primarily used for managing type 2 diabetes mellitus in adults. This combination medicine is part of the sodium-glucose co-transporter-2 (SGLT2) inhibitors and biguanide antidiabetic classes of medicines.

In addition to this key use, this medicine also helps control high blood sugar levels, preventing complications related to diabetes. It further aids in reducing the risk of cardiovascular events such as heart attack and stroke in patients with established cardiovascular disease and type 2 diabetes.

You should take this medicine as directed by your doctor. Before starting, it's important to inform your doctor about any pre-existing conditions or ongoing medications. If you notice any side effects while on this medication, notify your doctor immediately. For optimal results, continue taking the medicine for the duration prescribed by your doctor.

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Gibtulio Met 12.5mg/500mg Tablet is used for the following:

Management of type 2 diabetes mellitus in adults
Assisting diet and exercise in controlling high blood sugar levels
Reduction of the risk of cardiovascular events such as heart attack and stroke in patients with type 2 diabetes and established cardiovascular disease
Use in patients already being treated with empagliflozin and metformin as separate tablets

Here's how to take Gibtulio Met 12.5mg/500mg Tablet:

Swallow the tablet whole with a glass of water.
Do not crush, cut or chew the tablet.
If you forget a dose, take it as soon as you remember unless it's nearly time for your next dose, in which case skip the missed dose and continue your regular schedule.

Gibtulio Met 12.5mg/500mg Tablet is taken orally.

Gibtulio Met 12.5mg/500mg Tablet may have the following common side effects:

Upper respiratory tract infections
Urinary tract infections
Genital mycotic infections: These are yeast or fungal infections that can occur in the genital area.
Nausea
Vomiting
Diarrhoea
Increased urination

Managing the Side Effects:

Most side effects are temporary and generally harmless, and they resolve when you discontinue using Gibtulio Met 12.5mg/500mg Tablet. However, if you experience any serious side effects or worsening of any symptoms, please consult your doctor.

Here are some guidelines for managing common side effects:

Diarrhoea: Try taking Gibtulio Met 12.5mg/500mg Tablet with food to lessen this effect.
Increased urination: If this is disturbing your sleep, consider taking your tablet in the morning rather than at night.

Gibtulio Met 12.5mg/500mg Tablet contains two active components:

Empagliflozin (12.5 mg): This component works by inhibiting a substance in your kidneys known as SGLT2. By doing so, it reduces the reabsorption of glucose and increases its excretion through urine, helping to lower your blood sugar levels.
Metformin (500 mg): As a biguanide antidiabetic agent, metformin works by decreasing glucose production in your liver. It also reduces the intestinal absorption of glucose and increases its utilisation in your body by improving insulin sensitivity.

Pregnancy

Gibtulio Met 12.5mg/500mg Tablet is not recommended during pregnancy. If you are pregnant or planning to conceive, discuss this with your doctor before starting this medicine.

Breastfeeding

This medicine is contraindicated for breastfeeding women. Consult your doctor to understand the potential risks and benefits.

Alcohol

Caution is advised while consuming alcohol during the course of Gibtulio Met 12.5mg/500mg Tablet. Consult with your doctor for specific advice.

Liver

This medicine is often prescribed for adults, who may be more susceptible to liver health issues. Discuss liver-related concerns with your doctor before starting treatment with Gibtulio Met 12.5mg/500mg Tablet.

Kidney

Gibtulio Met 12.5mg/500mg Tablet should not be used in patients with severe kidney disease or issues. Consult your doctor if you have a history of kidney problems.

Using Machines & Driving

There's no known effect of this medicine on your ability to drive or operate machinery. However, if you experience any side effects that might affect your ability, consult your doctor.

Allergy

Gibtulio Met 12.5mg/500mg Tablet is contraindicated in patients with hypersensitivity to its active ingredients, empagliflozin and metformin. If you're allergic to these, it's best to avoid this medication.

Children

This medicine is not recommended for use in children under 18 years of age unless specifically prescribed by a doctor.

Older Patients

Older patients should take Gibtulio Met 12.5mg/500mg Tablet under medical supervision as they may be more susceptible to its side effects. Older patients might also have liver and kidney issues and might be on other medication. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Gibtulio Met 12.5mg/500mg Tablet interacts with the following medicines:

NSAIDs: Medicines like ibuprofen and naproxen can impair renal function, which may increase the risk of lactic acidosis when you take them with this medicine.
Cationic Medicines: Medications such as amiloride, digoxin, morphine, and ranitidine that are eliminated by renal tubular secretion can interact with metformin and increase the risk of lactic acidosis.
Diuretics: Loop diuretics like furosemide and torsemide may decrease renal function and increase the risk of lactic acidosis.
Insulin or Insulin Secretagogues: Taking medications like insulin and glipizide with Gibtulio Met 12.5mg/500mg Tablet can increase your risk of hypoglycaemia.

Drug-Food Interactions

Certain foods can interact with Gibtulio Met 12.5mg/500mg Tablet.

Drug-Disease Interactions

Gibtulio Met 12.5mg/500mg Tablet interacts with the following diseases:

Renal Disease: If you have severe renal impairment or end-stage renal disease, taking this medicine could exacerbate your condition.
Liver Disease: If you have liver problems, extra caution is needed since liver disease might affect how the medicine works in your body.
Heart Failure: This medication should be used carefully if you have heart failure as it can impact the effectiveness of the medicine.
Genital Mycotic Infections: If you have a history of genital mycotic infections or urinary tract infections, taking this medicine could cause these conditions to flare up.

Daily Dose

The daily dose of Gibtulio Met 12.5mg/500mg Tablet should be taken as advised by your doctor. The exact dosage may vary based on individual factors like the severity of your diabetes and how well you respond to the medication. Always stick to the prescribed dosage and avoid exceeding it without first consulting your doctor.

Over Dose

If you accidentally take more than your prescribed dose of Gibtulio Met 12.5mg/500mg Tablet, you might feel nauseous or have diarrhoea. Don't panic, but do let your doctor know about this.

Missed Dose

If you forget to take a dose of Gibtulio Met 12.5mg/500mg Tablet, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed one and continue with your usual dosing schedule. Never double up on doses without discussing it with your doctor.

Securely store Gibtulio Met 12.5mg/500mg Tablet in a dry, cool place, ideally at room temperature below 30°C.
Keep it away from direct sunlight and extreme heat or cold.
Ensure the Tablet container is tightly closed when not in use to prevent exposure to air and moisture.
Always keep this medication out of reach of children.
Do remember to use Gibtulio Met 12.5mg/500mg Tablet before its expiry date.

Since Gibtulio Met 12.5mg/500mg Tablet is taken to manage type 2 diabetes, you should limit your intake of foods high in sugar and processed carbs. Opt for whole grains, fruits, vegetables, and lean proteins instead.
Regular physical activity is key in managing type 2 diabetes. Try to incorporate at least 30 minutes of moderate exercise, like walking or cycling, into your daily routine.

Fact Box

Available Dosage Types	Tablet
Habit Forming	No
Ailment	Type 2 Diabetes Mellitus, Cardiovascular Disease
Drug Category	SGLT2 Inhibitor, Biguanide
Therapeutic Category	Antidiabetic

What is Gibtulio Met 12.5mg/500mg Tablet used for?

This medicine is used to manage type 2 diabetes in adults, especially when diabetes isn't adequately controlled by metformin alone or with other antidiabetic medicines.

How does Gibtulio Met 12.5mg/500mg Tablet work?

It contains two ingredients, empagliflozin and metformin, that work together to lower blood sugar levels by reducing glucose production and increasing glucose excretion.

How should I take this medicine?

You must take the medicine as directed by your doctor.

What should I do if I miss a dose?

If you miss a dose, take it as soon as you remember unless it's almost time for the next dose. In this case, skip the missed dose.

Who shouldn't take Gibtulio Met 12.5mg/500mg Tablet?

It shouldn't be taken by people with severe kidney problems, metabolic acidosis, or those allergic to empagliflozin, metformin, or any components of the tablet.

Are there any precautions I should take while using this medicine?

Stay hydrated and limit alcohol intake to reduce lactic acidosis risk. Consult your doctor if you experience symptoms like malaise, myalgias, or abdominal pain.

Can Gibtulio Met 12.5mg/500mg Tablet interact with other medicines?

Yes, it may interact with certain medications like NSAIDs or diuretics. Always inform your doctor about all medicines you're taking before starting this medication.

Last Updated On 13 May. 2025 | 10:30AM (IST)

Certified Content

Written by

Dr Nikita Lobo

Medical Content Reviewer | 8 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Medical Content Writer | 9 years

BAMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

Kalpataru Inspire, 3rd Floor, Off. Western Express Highway, Santacruz (East), Mumbai

Country of origin: GERMANY

Expiry on or after: March 2026

In case of any issues, contact us:

support@truemeds.in|09240250346

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

Clinics Cardive Publishing (Pty) Ltd. (2022, October 1). FDA approves empagliflozin for heart failure regardless of ejection fraction. PubMed Central (PMC). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887434/
Empagliflozin: MedlinePlus Drug Information. (n.d.). https://medlineplus.gov/druginfo/meds/a614043.html
Empagliflozin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB09038
Metformin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00331
Metformin: MedlinePlus drug information. (n.d.). https://medlineplus.gov/druginfo/meds/a696005.html

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We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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