Combimist L Inhaler 200mdi

Zydus Healthcare Ltd

Bottle of 200 MDI

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MRP ~~₹399.3~~

₹319.44

₹2/MDI

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Composition

Ipratropium (0.02 Mg) + Levosalbutamol (0.05 Mg)

Combimist-L Inhaler is used to manage asthma and chronic obstructive pulmonary disease (COPD). It combines a bronchodilator to relax the airways and a adrenergic beta-agonists, making breathing easier.

In addition to its primary use, this medicine also helps in the treatment and prevention of asthma and bronchitis. It works by relaxing the muscles around the airways and widening the lung passages, making it easier for you to breathe. This can help reduce symptoms such as shortness of breath, coughing, and wheezing (a whistling sound while breathing).

You should take this medicine exactly as prescribed by your doctor. The usual dosage is 2 puffs four times a day, but your doctor will determine the right dosage for you. Inform your doctor about any pre-existing conditions or ongoing medications before beginning this medicine. If you notice any side effects while using this medicine, notify your doctor immediately. Continue using the inhaler for the duration prescribed by your doctor for optimal results.

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Combimist L Inhaler is used to relieve bronchospasm in conditions like asthma and chronic obstructive pulmonary disease (COPD). It helps open up the airways, improving breathing and reducing symptoms like wheezing and shortness of breath.

Follow these instructions while using Combimist-L Inhaler:

Shake the inhaler well before each use.
Remove the cap from the mouthpiece.
Breathe out fully before placing the inhaler in your mouth.
Place the mouthpiece between your lips and close your lips around it.
While breathing in deeply, press down on the top of the inhaler.
Hold your breath for a few seconds, then breathe out slowly.
Wait at least one minute before taking a second puff if needed.
Replace the cap after use to keep the mouthpiece clean.

Combimist-L Inhaler is administered via inhalation.

Combimist-L Inhaler may have the following common side effects:

Dry mouth
Headache
Tremors: These are involuntary, rhythmic muscle movements that can affect your hands or other parts of your body.
Palpitations: This refers to the sensation of your heart beating unusually fast or irregularly.
Muscle cramps
Nausea
Dizziness
Diarrhoea
Abdominal pain
Cough
Sore throat

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Combimist-L Inhaler. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Dry mouth: Try sipping water before using the inhaler to reduce this effect.
Nausea: Using this inhaler after meals might help reduce feelings of sickness.

Combimist-L Inhaler contains two active ingredients:

Levosalbutamol (0.05 mg): As a selective beta-2 adrenergic agonist, this medicine stimulates specific receptors called beta-2 receptors in your lungs. This stimulation causes the muscles around your airways to relax and widen, allowing more air to flow in and out of your lungs. This action helps to relieve breathing difficulties and reduce symptoms like wheezing.
Ipratropium (0.02 mg): This is an anticholinergic bronchodilator that works by blocking the action of acetylcholine, a chemical that causes the airways to constrict or narrow. By preventing this action, ipratropium helps to relax and open up the airways, making breathing easier.

Pregnancy

Caution is advised while taking Combimist-L Inhaler if you are pregnant. It is best to consult your doctor before taking this medicine.

Breastfeeding

Caution is advised while taking Combimist-L Inhaler if you are breastfeeding. It is best to consult your doctor before taking this medicine.

Alcohol

Caution is advised while taking Combimist-L Inhaler when consuming alcohol. It is best to consult your doctor about potential interactions between alcohol and this medicine.

Liver

Caution is advised while taking Combimist-L Inhaler if you have any liver problems. If you have a history of liver disease, discuss this with your doctor before starting this medicine.

Kidney

Caution is advised before using Combimist-L Inhaler if you have a history of any kidney problems. It is a good idea to consult your doctor before taking this medicine.

Using Machines & Driving

Exercise caution when driving or operating machinery while using Combimist-L Inhaler. Some side effects like dizziness or tremors may affect your ability to perform these tasks safely.

Allergy

Tell your doctor about any allergies you have before using Combimist-L Inhaler. If you notice symptoms like rash, itching, or breathing difficulties after using the inhaler, seek medical help immediately.

Children

Caution is advised while giving Combimist-L Inhaler to children under 18 years of age. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should take Combimist-L Inhaler under medical supervision as they may be more susceptible to side effects. Your doctor will guide you based on your health status, especially if you have other medical conditions or are taking other medicines.

Drug-Drug Interactions

Combimist-L Inhaler interacts with the following medicines:

Beta-blockers: Medicines like propranolol and atenolol may counteract the bronchodilator effects of levosalbutamol in Combimist-L Inhaler.
Other bronchodilators: Using medicines such as albuterol or salmeterol alongside Combimist-L Inhaler may increase the risk of side effects like tremors and palpitations.
Diuretics: Water pills such as furosemide and hydrochlorothiazide may enhance the potential for low potassium levels when used with levosalbutamol.
Monoamine oxidase inhibitors (MAOIs): Medicines like phenelzine and tranylcypromine can increase the risk of cardiovascular side effects when combined with Combimist-L Inhaler.
Tricyclic antidepressants: Medicines such as amitriptyline and imipramine may potentiate the effects of levosalbutamol, increasing the risk of irregular heartbeat.

Drug-Food Interactions

Drug-Disease Interactions

Combimist-L Inhaler interacts with the following diseases:

High blood pressure: The levosalbutamol component may temporarily increase blood pressure in some patients.
Diabetes: This inhaler may affect blood glucose control, requiring more frequent monitoring of sugar levels.
Glaucoma: Ipratropium in Combimist-L Inhaler may increase eye pressure in patients with narrow-angle glaucoma.
Enlarged prostate: The anticholinergic effects of ipratropium may worsen urinary retention in men with prostate problems.
Thyroid problems: Patients with thyroid disorders may experience enhanced sensitivity to the cardiovascular effects of levosalbutamol.

Daily Dose

The daily dose of Combimist-L Inhaler should be taken as prescribed by your doctor. The dosage may change based on individual factors such as the severity of your breathing condition and response to treatment. Always follow the prescribed dosage and never exceed it without consulting your doctor.

Over Dose

Using too much Combimist-L Inhaler may cause dry mouth, headache, tremors, palpitations (fast heartbeat), muscle cramps, dizziness and nausea. You might also experience increased heart rate and shakiness in your hands. Contact your doctor if these symptoms occur.

Missed Dose

If you forget to take your dose, use it as soon as you remember. If it's almost time for your next dose, skip the missed one and continue with your regular schedule. Never take a double dose to make up for the missed one.

Store Combimist-L Inhaler at room temperature below 25°C.
Keep the inhaler away from direct sunlight, heat, and moisture.
Replace the cap firmly after each use to protect the mouthpiece.
Keep this medicine out of sight and reach of children.
Do not use Combimist-L Inhaler after the expiry date printed on the packaging.

Avoid smoking and second-hand smoke exposure as these can worsen COPD and asthma symptoms, making your Combimist-L Inhaler less effective.
Stay hydrated by drinking 8-10 glasses of water daily to help keep mucus in your airways thin, making it easier to clear your lungs and breathe better.

Fact Box

Available Dosage Types	Inhaler
Habit Forming	No
Ailment	COPD, asthma, bronchitis
Drug Category	Bronchodilator combination
Therapeutic Category	Respiratory medicine

How does Combimist-L Inhaler work in the lungs?

It contains two medicines that work together to relax your airway muscles. Ipratropium blocks airway-narrowing chemicals while levosalbutamol opens airways, making breathing easier.

Can I use Combimist-L Inhaler with a spacer device?

Yes, you can use a spacer with this inhaler. Spacers help coordinate your breathing with the inhaler, especially if you find it difficult to use the inhaler correctly.

How quickly will I feel the effects after using the inhaler?

The medicine typically starts working within minutes after you use it. The effects can last for several hours, helping you breathe more easily.

What should I do if I miss a scheduled dose?

Take it as soon as you remember. If it's nearly time for your next dose, skip the missed one and continue with your regular schedule. Never take a double dose.

Can I stop using the inhaler once I feel better?

No, don't stop using the inhaler unless your doctor advises you to. Stopping suddenly may worsen your breathing problems and other symptoms.

What are the common side effects I might experience?

Common side effects may include dry mouth, headache, tremors (shaking), fast heartbeat, muscle cramps, dizziness, nausea, and sore throat. Most are mild and temporary.

Should I inform my doctor about my other medicines?

Yes, tell your doctor about all medicines you take. Combimist-L Inhaler may interact with other bronchodilators, beta-blockers, water pills, and certain antidepressants.

Last Updated On 18 Aug. 2025 | 6:12AM (IST)

Certified Content

Written by

Dr Nikita Lobo

Medical Content Reviewer | 8 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Medical Content Writer | 9 years

BAMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

Zydus Tower, Satellite Cross Roads, Sarkhej - Gandhinagar Highway, Ahmedabad Ahmedabad GJ 380015 IN

Country of origin: INDIA

Expiry on or after: January 2026

In case of any issues, contact us:

support@truemeds.in|09240250346

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

Unknown. (2000). IPRATROPIUM BROMIDE Nasal Solution 0.06% NASAL SPRAY 42 mcg/spray. https://docs.boehringer-ingelheim.com/Prescribing%20Information/PIs/Roxane/Ipratropium%20Bromide/Ipratropium%20Bromide%20Nasal%20Spray%2006.pdf
Boehringer Ingelheim Pharmaceuticals, Inc. (1996). COMBIVENT RESPIMAT. https://content.boehringer-ingelheim.com/DAM/736f603f-9560-470d-a627-af1e011edbcd/combivent%20respimat-us-pi.pdf
Nephron Pharmaceuticals Corporation. (n.d.). Prescribing information. https://nephronpharm.com/wp-content/uploads/2024/04/IC-23020Rev2004-07-1720Insert20Ipratropium20Bromide200.0225.pdf
Ipratropium: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00332
NCATS Inxight Drugs — LEVALBUTEROL HYDROCHLORIDE. (2017). Ncats.io. https://drugs.ncats.io/drug/WDQ1526QJM
Levosalbutamol: Uses, Interactions, Mechanism of Action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB13139

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Disclaimer

We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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CIN: U62099MH2019PTC320566

Telephone:09240250346

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