Valprol Cr 200 Tablet 15

Intas Pharmaceuticals Ltd

Strip of 15 Units

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Old MRP ₹61.32

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Composition

Sodium Valproate / Valproic Acid (200 Mg)

Strength:

300 MG 400 MG 500 MG 200 MG

Valprol CR 200 Tablet is used to treat epilepsy, bipolar disorder, and prevent migraine attacks. It contains sodium valproate and valproic acid in a controlled-release form, which helps stabilise abnormal electrical activity in the brain. By regulating neurotransmitter levels, this medicine helps reduce the frequency of seizures, control mood swings, and prevent recurrent migraine episodes. Doctor may prescribe it as part of long-term treatment to maintain stable brain activity and improve overall quality of life.

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Valprol CR 200 Tablet is used to treat epilepsy, including tonic-clonic, absence, myoclonic, and partial seizures. It is also prescribed for manic episodes in bipolar disorder and may help prevent migraine headaches.

Use Valprol-CR-200 Tablet by following these steps:

Swallow the tablet whole with a glass of water.
Do not chew, crush, or break the tablet as it's designed for controlled release to maintain steady blood levels.
Consult your doctor if there's any need to adjust your dosage. It's important not to stop taking this medicine without discussing it with your doctor first.

Valprol-CR-200 Tablet is taken orally.

Valprol CR 200 Tablet may cause some common side effects, including nausea, vomiting, abdominal pain, diarrhoea, or constipation. You may also experience dizziness, headache, tremors—rhythmic, involuntary movements of the body—weight gain, increased appetite, hair loss, or irregular menstrual cycles. Persistent side effects should be reported to your doctor.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Valprol-CR-200 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Nausea, vomiting, and abdominal pain: Try taking Valprol-CR-200 Tablet with or after meals to lessen this effect.
Diarrhoea or constipation: Ensure you stay hydrated by drinking plenty of fluids throughout the day.

Valprol-CR-200 Tablet contains sodium valproate/valproic acid (200 mg), which works in the body as follows:

Enhances GABA Effects: Sodium valproate/valproic acid increases the levels of a neurotransmitter called gamma-aminobutyric acid (GABA) in your brain. GABA helps in reducing excessive neuronal activity, which can lead to seizures and mood instability.
Blocks Sodium and Calcium Channels: Valproic acid also inhibits the activity of voltage-gated sodium channels and T-type calcium channels in your brain, contributing further to its antiepileptic properties.
Inhibits the HDAC Enzyme: Additionally, it suppresses the enzyme histone deacetylase (HDAC), which may have a role in stabilising the mood. This mechanism could explain its effectiveness in managing bipolar disorder.

Pregnancy

Taking Valprol-CR-200 Tablet is contraindicated during pregnancy. If you're pregnant or planning to conceive, it's crucial to discuss this with your doctor before starting this medicine.

Breastfeeding

Valprol-CR-200 Tablet is not recommended for breastfeeding women. It's advisable to consult your doctor to understand the potential risks and benefits.

Alcohol

Drinking alcohol while taking Valprol-CR-200 Tablet isn't advised, as it could potentially increase side effects. Discuss your alcohol intake with your doctor for a more personalised recommendation.

Liver

Use of Valprol-CR-200 Tablet should be cautious if you have liver disease, as it may impair liver function further. It’s best to consult your doctor before starting this medicine.

Kidney

If you have a history of kidney problems, caution is advised before taking Valprol-CR-200 Tablet. Consulting your doctor is always a good idea before starting this medicine.

Using Machines & Driving

As Valprol-CR-200 Tablet may cause dizziness or tiredness, it's best to avoid driving or using heavy machinery until you know how the medicine affects you.

Allergy

If you are allergic to sodium valproate, valproic acid, or any other ingredients in Valprol-CR-200 Tablet, do not take this medicine. Consult your doctor about alternative management strategies.

Children

Valprol-CR-200 Tablet is not recommended for children under 18 years of age. Always consult your doctor before giving this medicine to a child.

Older Patients

Older patients should take Valprol-CR-200 Tablet under medical supervision due to potential susceptibility to its side effects. Especially if you are above 70 years of age and might have liver and kidney issues or might be on other medication, your doctor will guide you based on your health status.

Drug-Drug Interactions

Valprol-CR-200 Tablet interacts with the following medicines:

Antiepileptic medicines: When taken with medicines like carbamazepine and phenytoin, Valprol-CR-200 Tablet can alter their blood levels, potentially affecting their efficacy or causing side effects.
Salicylates: Medicines such as aspirin can increase the blood levels of Valprol-CR-200 Tablet, leading to increased toxicity.
Benzodiazepines: Diazepam and lorazepam can interact with Valprol-CR-200 Tablet, influencing their metabolism and excretion.
Antipsychotics: Quetiapine and olanzapine may have altered effects when taken with Valprol-CR-200 Tablet.
Antidepressants: Amitriptyline, nortriptyline, and fluoxetine may interact with Valprol-CR-200 Tablet, potentially altering their effectiveness.
Anticoagulants: Medicine like warfarin when co-administration with Valprol-CR-200 Tablet can affect the blood levels of warfarin, impacting its anticoagulant effect.

Drug-Disease Interactions

Valprol-CR-200 Tablet interacts with the following diseases:

Liver disease: If you have liver disease, taking Valprol-CR-200 Tablet might worsen your condition as it is extensively metabolised in the liver.
Urea cycle disorders: People suffering from disorders of the urea cycle should avoid taking this medication as it can increase ammonia levels in the blood.
Acute intermittent porphyria: Use of Valprol-CR-200 Tablet in patients with this condition could lead to an exacerbation of their symptoms.

Daily Dose

The daily dose of Valprol-CR-200 Tablet should be taken as instructed by your doctor. The prescribed dosage is based on individual factors such as the severity of your condition and how you respond to the medicine. It's important to follow your doctor's dosage instructions and avoid exceeding the prescribed dose without a consultation.

Over Dose

Taking more than the prescribed dose of Valprol-CR-200 Tablet can lead to excess levels in your body, potentially causing symptoms like dizziness, nausea, or tremors. If you suspect you've taken too much, it's crucial to inform your doctor about it.

Missed Dose

If you forget to take a dose of Valprol-CR-200 Tablet, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed one and continue with your regular schedule. Never take an extra dose without consulting your doctor.

Store Valprol-CR-200 Tablet at room temperature, between 15-30°C.
Keep it in a tightly closed, light-resistant container to protect it from bright light.
Avoid storing this medicine in damp areas like bathrooms or near kitchen sinks.
Always keep out of the reach of children.
Ensure that you use this medicine before its expiry date.

Since Valprol-CR-200 Tablet is used to manage epilepsy and bipolar disorder, adopting a balanced diet rich in fruits, vegetables and whole grains can promote overall brain health.
Regular physical activity is beneficial for mental well-being. However, individuals with epilepsy should engage in safe exercises and avoid high-risk activities that could trigger a seizure. Always consult your doctor for personalised advice.

Fact Box

Available Dosage Types	Tablet CR
Habit Forming	No
Ailment	Epilepsy, Bipolar Disorder, Migraine
Drug Category	GABA Enhancer
Therapeutic Category	Antiepileptic

What is Valprol-CR-200 Tablet used for?

This medicine is primarily used to manage various types of seizures, and manic episodes in bipolar disorder and to prevent migraine headaches.

How does Valprol-CR-200 Tablet work in the body?

It increases levels of a brain chemical called gamma-aminobutyric acid, which helps regulate nerve signals, thereby controlling seizures and mood swings.

Can I crush or chew Valprol-CR-200 Tablet?

No, you should swallow the tablet whole with water. Crushing or chewing can disrupt its controlled-release mechanism.

What are the common side effects of Valprol-CR-200 Tablet?

Common side effects include nausea, vomiting, abdominal pain, diarrhoea or constipation, dizziness, headache, tremor, increased appetite and weight gain among others.

Who should not take Valprol-CR-200 Tablet?

People with liver disease, known hypersensitivity to sodium valproate or valproic acid, urea cycle disorders, acute intermittent porphyria and pregnant women should avoid this medication.

Can I breastfeed while taking Valprol-CR-200 Tablet?

Breastfeeding is not recommended while on this medication as valproic acid is excreted in human milk which may harm nursing infants.

Does Valprol-CR-200 Tablet interact with other medicines?

Yes. It can interact with several medications like other antiepileptic medicines, aspirin and other salicylates, benzodiazepines and more. Always consult your doctor before starting new medicines.

Last Updated On 09 Dec. 2025 | 11:06AM (IST)

Certified Content

Written by

Dr Nikita Lobo

Medical Content Reviewer | 8 years

BDS, MDS

Reviewed by

Dr. Osama Ahmed

Medical Content Writer | 3 years

Bachelor of Dental Surgery

Check out Editorial Policy

Manufacturer details

Corporate House, Near Sola Bridge, S. G. Highway, Thaltej, Ahmedabad 380054, Gujarat, India

Country of origin: INDIA

Expiry on or after: April 2026

In case of any issues, contact us:

support@truemeds.in|09240250346

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

NHS UK. (n.d.). Valproic acid: a medicine to treat epilepsy and bipolar disorder. Retrieved 1 April 2024, from https://www.nhs.uk/medicines/valproic-acid/
Patel AR, Nagalli S. Valproate Toxicity. [Updated 2024 May 6]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK560898/
Cipriani, A., Reid, K., Young, A. H., Macritchie, K., & Geddes, J. (2013). Valproic acid, valproate and divalproex in the maintenance treatment of bipolar disorder. The Cochrane database of systematic reviews, 2013(10), CD003196. https://doi.org/10.1002/14651858.CD003196.pub2
Jochim, J., Rifkin-Zybutz, R. P., Geddes, J., & Cipriani, A. (2019). Valproate for acute mania. The Cochrane database of systematic reviews, 10(10), CD004052. https://doi.org/10.1002/14651858.CD004052.pub2
Wang, Y., Xia, J., Helfer, B., Li, C., & Leucht, S. (2016). Valproate for schizophrenia. The Cochrane database of systematic reviews, 11(11), CD004028. https://doi.org/10.1002/14651858.CD004028.pub4

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Disclaimer

We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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