Tazact 4.5 GM Injection is a high-strength antibiotic used to treat moderate to severe bacterial infections. It is effective for infections of the lungs (pneumonia), abdomen, urinary tract, and skin, as well as complex hospital-acquired infections. It contains a penicillin-class antibiotic combined with a beta-lactamase inhibitor, which provides a broad range of activity against many different types of bacteria.
The injection works by inhibiting the formation of the bacterial cell wall, which causes the bacteria to die and prevents the infection from spreading to other parts of the body. Tazobactam helps protect Piperacillin from bacterial enzymes (beta-lactamases) that would otherwise inactivate the antibiotic, allowing it to work against resistant bacteria. It is often used in emergency or critical care situations where a rapid and potent antibacterial effect is necessary.
This medication must be administered by a healthcare professional in a clinical setting. Inform your doctor immediately if you have a history of allergies to penicillin or cephalosporins. It is vital to complete the full prescribed course, even if you feel better, to ensure the infection is completely cleared and to prevent the development of antibiotic-resistant bacteria.
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Tazact 4.5gm Injection 1
Vial of 1 UNITS
MRP ₹426.66
₹341.33
₹426.66/UNITS
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CompositionAbout Tazact 4.5gm Injection 1
Uses of Tazact 4.5gm Injection 1
Tazact 4.5gm Injection is used to treat serious and life-threatening bacterial infections such as pneumonia, intra-abdominal infections, sepsis, and complicated urinary tract infections. It contains a combination of piperacillin and tazobactam, which work together to stop the growth of bacteria, including resistant strains. This injection is administered intravenously in hospital settings and is also used to manage kidney infections such as uncomplicated and complicated pyelonephritis, ensuring effective control of severe infections.
Directions for Use of Tazact 4.5gm Injection 1
Here's how to use Tazact 4.5 GM Injection:
It should be administered as an intravenous infusion, which means it's injected into your vein.
The injection should be given slowly over 30 minutes.
For certain conditions like nosocomial pneumonia, it can be infused over 4 hours to potentially improve outcomes.
Always follow your doctor's instructions on how often to receive this medicine.
Consult your doctor for specific advice on using this medicine correctly.
Route of Administration
Tazact 4.5 GM Injection is administered intravenously.
Side Effects of Tazact 4.5gm Injection 1
Tazact 4.5 gm Injection may cause side effects including diarrhoea, constipation, nausea, headache, insomnia, and skin rash. In rare cases, allergic reactions may appear as itchy, red, swollen, blistered, or peeling skin. If any of these symptoms persist or worsen, consult your healthcare provider.
Management Of Side Effects:
Most side effects are temporary and generally harmless, which are resolved by discontinuing the use of Tazact 4.5 GM Injection. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.
Here are a couple of tips to help manage some common side effects:
Diarrhoea: Try to ensure you stay hydrated by drinking plenty of fluids.
Nausea: Consider having this medication with or after your meals to help minimise this effect.
How Tazact 4.5gm Injection 1 Works?
Tazact 4.5 GM Injection contains two active ingredients that work together to manage bacterial infections:
Piperacillin (4000 mg): This broad-spectrum antibiotic works by inhibiting septum formation and cell wall synthesis in susceptible bacteria. By doing so, it stops the bacteria from growing and multiplying, thereby helping your body fight off the infection.
Tazobactam (500 mg): Tazobactam acts as a beta-lactamase inhibitor. Beta-lactamase enzymes in certain bacteria can inactivate piperacillin. Tazobactam prevents this by binding irreversibly to these enzymes, thus extending the antibiotic spectrum of piperacillin against beta-lactamase producing bacteria that would otherwise be resistant.
Safety Measures & Warnings
Pregnancy
Caution is advised while taking Tazact 4.5 GM Injection if you are pregnant. It is best to consult your doctor before taking this medicine.
Breastfeeding
If you are breastfeeding, it's recommended to consult your doctor before administering Tazact 4.5 GM Injection to understand potential risks and benefits.
Alcohol
Interaction of Tazact 4.5 GM Injection with alcohol is unknown. Therefore, it is advisable to discuss this with your doctor.
Liver
Tazact 4.5 GM Injection may affect liver function. If you have pre-existing liver issues, discuss them with your doctor before receiving this medicine.
Kidney
If you have a history of kidney problems, caution is advised before using Tazact 4.5 GM Injection. Your doctor can guide you based on your health status.
Use In Driving And Operating Machinery
There's no known interaction of Tazact 4.5 GM Injection that could affect your ability to drive or operate machinery. However, if you feel unwell or dizzy after receiving the injection, avoid these activities.
Allergy
Tazact 4.5 GM Injection is contraindicated in patients with a history of allergic reactions to penicillins or beta-lactamase inhibitors.
Children
Tazact 4.5 GM Injection is meant for adults and should not be given to children under 18 years of age without medical supervision.
Older Patients
Older patients should take Tazact 4.5 GM Injection under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age.
Interactions of Tazact 4.5gm Injection 1
Drug-Drug Interactions
Tazact 4.5 GM Injection interacts with the following medicines:
Probenecid: This medicine competes with piperacillin for renal tubular secretion, which can increase the plasma concentrations of piperacillin. Thus, it is not recommended to co-administer Tazact 4.5 GM Injection and probenecid.
Aminoglycosides: When used together with Tazact 4.5 GM Injection, medicines like gentamicin and amikacin might increase the risk of nephrotoxicity or kidney damage. If this combination is used, your kidney function should be closely monitored.
Heparin: High doses of heparin, when given along with Tazact 4.5 GM Injection, may increase the risk of bleeding due to heparin-induced thrombocytopenia.
Drug-Food Interactions
There are no known specific food interactions with Tazact 4.5 GM Injection.
Drug-Disease Interactions
Tazact 4.5 GM Injection interacts with the following diseases:
Renal Impairment: If you have a kidney disease or impaired kidney function, caution should be exercised while using this medication. The dosage of Tazact 4.5 GM Injection needs to be adjusted based on your kidney function.
Allergic Reactions: If you have a history of allergic reactions to penicillins, cephalosporins or beta-lactamase inhibitors, then Tazact 4.5 GM Injection should be avoided as it could trigger severe allergic reactions.
Dosage of Tazact 4.5gm Injection 1
Daily Dose
The daily dose of Tazact 4.5 GM Injection is determined by your doctor, who will consider factors such as the severity of your condition and your response to treatment. It's essential to follow your doctor's prescription without exceeding the recommended dosage. For more specific information, you can refer to the package insert.
Over Dose
Overdosing on Tazact 4.5 GM Injection could lead to symptoms such as diarrhoea, constipation, and nausea among others. If you suspect an overdose, it is advised to speak with your doctor who can provide the necessary guidance.
Missed Dose
If you miss a dose of Tazact 4.5 GM Injection, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue with your regular schedule. Do not increase the dosage without consulting your doctor.
Storage
Store Tazact 4.5 GM Injection vials at a temperature below 25°C.
Keep the product away from light exposure.
Ensure you keep this medicine out of reach and sight of children.
Special Dietary And Lifestyle Recommendation
Stay hydrated: Since Tazact 4.5 GM Injection is used to manage severe infections, it's crucial to maintain proper hydration. Drinking plenty of fluids can help your body flush out toxins.
Balanced diet: Consuming a balanced diet with fruits, vegetables, and lean proteins can help boost your immune system, aiding your body in fighting off infections.
Fact Box
| Dosage Forms Available | Injection |
| Habit Forming | No |
| Ailment | Nosocomial Pneumonia, Complicated Urinary Tract Infections, Complicated Intra-abdominal Infections |
| Drug Category | Beta-lactamase Inhibitor |
| Therapeutic Category | Antibiotic |
Frequently Asked Questions (FAQs)
What is Tazact 4.5 GM Injection used for?
Tazact 4.5 GM Injection is used to manage moderate to severe infections caused by specific bacteria in conditions like pneumonia, and skin and urinary tract infections.
How does Tazact 4.5 GM Injection work?
The injection combines two active ingredients: piperacillin, an antibiotic, and tazobactam, a beta-lactamase inhibitor. Together, they kill bacteria and prevent their growth.
Can I use this medicine if I'm allergic to penicillins?
No, if you have a history of allergic reactions to any penicillin's, cephalosporins or beta-lactamase inhibitors, you should avoid this medicine.
What are the possible side effects of Tazact 4.5 GM Injection?
Some common side effects include diarrhoea, nausea, headache, insomnia and rash. Rarely, serious reactions such as anaphylaxis can occur. Please consult your doctor if they persist.
Can Tazact 4.5 GM Injection interact with other medications?
Yes, for instance, probenecid may increase piperacillin levels in your blood. Also, combining it with aminoglycosides may increase the risk of kidney damage.
How should I store Tazact 4.5 GM Injection?
Store the vials below 25°C and protect them from light. After mixing it into a solution, use it within 24 hours at room temperature.
Is Tazact 4.5 GM Injection suitable for all adults?
Not all adults can take this medicine. It's not recommended for those with severe kidney impairment or allergies to any of its components.
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Manufacturer details
Country of origin: INDIA
References
Piperacillin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00319
Piperacillin and tazobactam injection: MedlinePlus drug information. (n.d.). https://medlineplus.gov/druginfo/meds/a694003.html
National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 43672, Piperacillin. Retrieved June 18, 2024 from https://pubchem.ncbi.nlm.nih.gov/compound/Piperacillin
Tazobactam: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB01606
National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 123630, Tazobactam. Retrieved June 18, 2024 from https://pubchem.ncbi.nlm.nih.gov/compound/Tazobactam.
Disclaimer
We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.
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