Sildoo M 25 Tablet 10

Dr. Reddys Laboratories Ltd

Strip of 10 Units

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MRP ~~₹322.77~~

₹258.22

₹32.28/Units

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Prescription required for this medicine

Store Below 30° C

Composition

Mirabegron (25 Mg) + Silodosin (8 Mg)

Sildoo M 25 Tablet 10 is used to manage symptoms of benign prostatic hyperplasia (BPH), a non-cancerous enlargement of the prostate gland that affects many men as they age. It is a combination medicine that belongs to the class of medications known as a beta-3 adrenergic agonist and an alpha-1A adrenergic blocker.

BPH can cause troublesome lower urinary tract symptoms that significantly impact quality of life. These symptoms include difficulty starting urination, weak urine stream, frequent urination (especially at night), urgent need to urinate, feeling of incomplete bladder emptying, and straining during urination.

This medicine should be taken orally as directed by your doctor. It is important to inform your doctor about any pre-existing conditions, such as liver or kidney disease, low blood pressure, heart conditions, or eye problems, before starting this medicine. If you notice any side effects while taking this medicine, notify your doctor promptly. Continue taking the medicine for the full duration prescribed by your doctor to achieve optimal results.

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Sildoo M 25 Tablet 10 is used for the following:

Management of benign prostatic hyperplasia (BPH)
Improvement of lower urinary tract symptoms (LUTS), including:
- Difficulty starting urination
- Weak or interrupted urine stream
- Frequent or urgent urination (especially at night)
- Feeling of incomplete bladder emptying
- Straining during urination

Follow these instructions while taking Sildoo M 25 Tablet 10:

Swallow the tablet whole with a full glass of water.
Do not crush, chew, or break the tablet as it is an extended-release formulation.
Take this medicine at the same time each day for the best results.
You may take it with or without food.
If you miss a dose, take it as soon as you remember, unless it's nearly time for your next dose.
Never take two doses to make up for a missed one.
Consult your doctor if you are unsure about how to take this medicine.

Sildoo M 25 Tablet 10 is taken orally.

Sildoo M 25 Tablet 10 may have the following common side effects:

Retrograde ejaculation: Semen enters the bladder instead of exiting through the urethra during ejaculation. This is harmless but may affect fertility
Dizziness
Headache
Diarrhoea
Nasal congestion
Orthostatic hypotension: This refers to a sudden drop in blood pressure when you stand up quickly, which can make you feel lightheaded.
Nausea
Fatigue

Management Of Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Sildoo M 25 Tablet 10. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Dizziness: Take Sildoo M 25 Tablet 10 at bedtime rather than in the morning to reduce the impact of dizziness on your daily activities.
Nausea: Consider taking this medicine with food to help reduce stomach discomfort.

Sildoo M 25 Tablet 10 contains two active ingredients:

Mirabegron (25 mg): This component is a beta-3 adrenergic receptor agonist that works on the bladder muscle (detrusor). It helps relax the bladder during the filling phase, increasing bladder capacity and reducing the frequency and urgency of urination.
Silodosin (8 mg): This is a selective alpha-1A adrenergic receptor antagonist that specifically targets receptors in the prostate gland and bladder neck. By blocking these receptors, it relaxes smooth muscle tissue in these areas, reducing resistance to urine flow and making urination easier.

Pregnancy

Sildoo M 25 Tablet 10 is contraindicated during pregnancy. This medicine is designed for male patients with prostate conditions and should not be used by women. If you are pregnant, you should avoid handling crushed or broken tablets as the medicine could potentially be absorbed through the skin.

Breastfeeding

Sildoo M 25 Tablet 10 is contraindicated for breastfeeding women. This medicine is specifically formulated for men with benign prostatic hyperplasia (an enlarged prostate gland) and is not suitable for women who are breastfeeding or lactating.

Alcohol

Limit alcohol consumption while taking Sildoo M 25 Tablet 10. Alcohol may increase your chance of experiencing dizziness or drowsiness when combined with this medicine.

Liver

Doctor consultation is advised while taking Sildoo M 25 Tablet 10 if you have mild to moderate liver impairment. This medicine is not recommended for those with severe liver disease. Your doctor may need to monitor your liver function while you are using this medicine.

Kidney

Doctor consultation is advised before using Sildoo M 25 Tablet 10 if you have kidney problems. Your doctor might need to adjust your dosage if you have moderate to severe kidney disease, as this medicine is processed by your kidneys.

Use In Driving And Operating Machinery

Exercise caution when driving or operating machinery while taking Sildoo M 25 Tablet 10. This medicine may cause dizziness, particularly when standing up quickly. Wait to understand how this medicine affects you before engaging in activities requiring alertness.

Allergy

Avoid taking Sildoo M 25 Tablet 10 if you have a known hypersensitivity (allergy) to mirabegron or silodosin, the active ingredients. Consult your doctor about any past allergic reactions to medicines, especially those used for prostate or bladder conditions.

Children

Sildoo M 25 Tablet 10 is contraindicated for children under 18 years of age. This medicine is specifically designed to manage benign prostatic hyperplasia, a condition that affects adult men. It is not suitable for use in children.

Older Patients

Older patients should take Sildoo M 25 Tablet 10 under medical supervision, as they may be more sensitive to side effects, particularly low blood pressure when standing up. Your doctor will monitor your response to the medicine and may adjust the dosage if needed.

Drug-Drug Interactions

Sildoo M 25 Tablet 10 interacts with the following medicines:

Alpha-blockers: Other alpha-blockers such as doxazosin or terazosin may cause excessive blood pressure lowering when taken with Sildoo M 25 Tablet 10.
PDE-5 inhibitors: Medicines such as sildenafil or tadalafil increase the risk of low blood pressure (hypotension) when combined with Sildoo M 25 Tablet 10.
Blood pressure medicines: Anti-hypertensive medicines such as amlodipine or lisinopril may enhance the blood pressure-lowering effect of Sildoo M 25 Tablet 10.

Drug-Food Interactions

Grapefruit Juice: Avoid excessive grapefruit juice, as it may interfere with the metabolism of this medication.

Drug-Disease Interactions

Sildoo M 25 Tablet 10 interacts with the following diseases:

Low blood pressure: Sildoo M 25 Tablet 10 can further lower blood pressure, potentially causing dizziness or fainting in affected patients.
Cataracts/glaucoma: If you have these eye conditions, inform your eye surgeon about using Sildoo M 25 Tablet 10 before undergoing surgery.

Daily Dose

The daily dose of Sildoo M 25 Tablet 10 should be taken as prescribed by your doctor. The dosage may vary based on your specific condition and how your body responds to the medicine. Always follow your doctor's instructions and never change the dose yourself.

Over Dose

Taking too many Sildoo M 25 Tablet 10s may cause dizziness, severe headache, or a dangerous drop in blood pressure (low blood pressure). You might feel extremely lightheaded when standing up. Contact your doctor if you suspect an overdose.

Missed Dose

If you forget to take Sildoo M 25 Tablet 10, take it as soon as you remember. If it's almost time for your next dose, skip the missed one and continue with your regular schedule. Never take a double dose to make up for a missed one.

Store Sildoo M 25 Tablet 10 below 30°C in a cool, dry place.
Keep away from direct sunlight and moisture.
Protect it in its original packaging.
Store safely out of reach of children and pets.
Do not use after the expiry date printed on the package.

Limit evening fluid intake, especially caffeine and alcohol, to reduce nighttime urination (nocturia) associated with benign prostatic hyperplasia (enlarged prostate).
Practise "double voiding" (urinating, waiting a moment, then trying again) to help empty your bladder more completely and reduce feelings of incomplete emptying.

Fact Box

Dosage Forms Available	Tablet Er
Habit Forming	No
Ailment	Enlarged prostate, Urinary symptoms
Drug Category	Alpha-blocker + Beta-3 agonist
Therapeutic Category	BPH medication

What is Sildoo M 25 Tablet 10 used for?

Sildoo M 25 Tablet 10 is used to manage symptoms of benign prostatic hyperplasia (BPH), a non-cancerous enlarged prostate that affects older men and causes urinary problems.

How does Sildoo M 25 Tablet 10 work in the body?

It works through two mechanisms: silodosin relaxes the prostate and bladder neck muscles, while mirabegron relaxes the bladder muscle. Together, they improve urine flow and reduce urgency.

What are the common side effects of Sildoo M 25 Tablet 10?

Common side effects include retrograde ejaculation (semen flowing into the bladder instead of out), dizziness, headache, diarrhoea, and nasal congestion or runny nose.

Can I drive after taking Sildoo M 25 Tablet 10?

You should be cautious when driving until you know how this medicine affects you, as it may cause dizziness. If you feel dizzy, avoid driving or operating machinery until you feel better.

Should I take Sildoo M 25 Tablet 10 with food?

You can take this medicine with or without food. The important thing is to take it at the same time each day to maintain consistent levels in your body.

What should I do if I miss a dose?

Take it as soon as you remember, unless it's nearly time for your next dose. Never take a double dose to make up for a missed one.

Will Sildoo M 25 Tablet 10 reduce the size of my prostate?

This medicine provides symptom relief but does not reduce prostate size. It helps improve urinary flow and reduces symptoms without shrinking the enlarged prostate.

Last Updated On 12 Sep. 2025 | 9:07AM (IST)

Certified Content

Written by

Ashmita Borgohain

Medical Content Writer | 13 years

MSc (Applied Genetics)

Reviewed by

Dr. Chhavi Rosha

Medical Content Writer | 10 years

BAMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

Bigshare Services Pvt. Ltd. 306, Right Wing, 3rd Floor Amrutha Ville, Opp.Yash Hyderabad - 500082 Telangana

Country of origin: INDIA

Expiry on or after: August 2026

In case of any issues, contact us:

support@truemeds.in|09240250346

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

Astellas Pharma US, Inc. (2012). HIGHLIGHTS OF PRESCRIBING INFORMATION [Press release]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/202611s000lbl.pdf
Mirabegron: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB08893
Watson Pharmaceuticals, Inc. (2013). RAPAFLO prescribing information [Prescribing information]. In RAPAFLO Prescribing Information (pp. 1–22). https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/022206s012lbl.pdf
Silodosin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB06207

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Disclaimer

We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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