Piosteris M 500 Tablet 10

Steris Healthcare

Strip of 10 Units

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MRP ~~₹118~~

₹58.88

₹11.8/Units

50.1% off

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Composition

Metformin (500 Mg) + Pioglitazone (15 Mg)

Piosteris M 500 Tablet 10 is primarily used in the management of type 2 diabetes mellitus in adults. This medication is a combination formulation that belongs to the class of antidiabetic medicines.

In addition to its primary purpose, it also helps improve insulin resistance and control high blood sugar levels. Its benefits are most effective when combined with a balanced diet and regular exercise.

Before starting this medicine, it’s crucial to consult your doctor to determine the correct dosage and schedule based on your needs. If you have any ongoing health issues or are taking other medications, be sure to inform your doctor before beginning this treatment. If you experience any noticeable side effects while taking this medicine, notify your doctor immediately. It is essential to complete the full course prescribed by your doctor for the best results.

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Piosteris M 500 Tablet 10 is used for the following:

Management of type 2 diabetes mellitus in adults
Reduction of high blood sugar levels
Improvement of insulin sensitivity
Decrease in hepatic glucose production
Control of intestinal glucose absorption

Here's how you should take Piosteris M 500 Tablet 10:

Swallow the tablet whole with a glass of water.
Avoid crushing or chewing the tablet.
Do not exceed the recommended dose unless advised by your doctor.

Piosteris M 500 Tablet 10 is taken orally.

Piosteris M 500 Tablet 10 may cause the following common side effects:

Diarrhoea
Nausea
Vomiting
Flatulence: This might cause excessive gas in your stomach or intestines.
Indigestion
Metallic taste: This medicine may cause a sharp or unpleasant taste in your mouth.
Weight gain

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Piosteris M 500 Tablet 10. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are a couple of tips to manage common side effects:

Diarrhoea: Try taking Piosteris M 500 Tablet 10 with food to minimise this effect.
Indigestion: It might be helpful to take this medicine after meals to lessen discomfort in your stomach.

Piosteris M 500 Tablet 10 consists of two active ingredients that work together to manage high blood sugar levels:

Pioglitazone (15 mg): Pioglitazone primarily targets PPAR-gamma receptors located in muscle and fat cells. By activating these receptors, it influences certain genes that enhance insulin sensitivity, promote better glucose utilisation in peripheral tissues like muscles, and reduce glucose production by the liver.
Metformin (500 mg): Metformin works on several fronts to control blood glucose levels. It decreases glucose production by the liver, enhances the uptake of glucose by muscles, and reduces the absorption of glucose from the gut. Notably, Metformin does not stimulate insulin production, thereby lowering the risk of hypoglycaemia (low blood sugar levels).

Pregnancy

Piosteris M 500 Tablet 10 is not recommended for use during pregnancy. If you are pregnant or planning to conceive, make sure to discuss this with your doctor before starting this medicine.

Breastfeeding

Caution is advised if you are breastfeeding while taking Piosteris M 500 Tablet 10. The ingredients pioglitazone and metformin may be present in breast milk. Consult your doctor to understand the potential risks and benefits.

Alcohol

Drinking alcohol while taking Piosteris M 500 Tablet 10 may increase the risk of low blood sugar levels (hypoglycemia) and lactic acidosis. It is advisable to limit alcohol intake during the course of this medication.

Liver

If you have liver problems, caution is advised when taking Piosteris M 500 Tablet 10, as this medicine may affect liver function. Discuss these concerns with your doctor before starting treatment.

Kidney

Piosteris M 500 Tablet 10 should not be used if you have severe kidney disease. If you have a history of kidney problems, it's best to consult your doctor before taking this medicine.

Using Machines & Driving

Piosteris M 500 Tablet 10 does not usually affect your ability to drive or operate machinery. However, if you experience side effects like dizziness or fatigue, avoid such activities until you feel better.

Allergy

Do not take Piosteris M 500 Tablet 10 if you are allergic to pioglitazone, metformin, or any other ingredients in this medicine. If you experience any signs of an allergic reaction, seek immediate medical attention.

Children

The safety and effectiveness of Piosteris M 500 Tablet 10 have not been established in patients below 18 years of age. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should take Piosteris M 500 Tablet 10 under medical supervision, as they may be more susceptible to its side effects. Your doctor will guide you based on your health status, particularly if you have liver or kidney issues or are taking other medications.

Drug-Drug Interactions

Piosteris M 500 Tablet 10 interacts with the following medicines:

Cationic medications: Medicines like amiloride, digoxin, and trimethoprim, which are eliminated by renal tubular secretion, may interact with Piosteris M 500 Tablet 10. This interaction can increase the risk of metformin accumulation and lactic acidosis.
CYP2C8 inhibitors: Medicines such as gemfibrozil can significantly increase pioglitazone concentrations when taken with Piosteris M 500 Tablet 10.
CYP2C8 inducers: Medicines like rifampin can significantly reduce pioglitazone concentrations when taken with this medicine.

Drug-Food Interactions

No specific interactions between Piosteris M 500 Tablet 10 and food have been established.

Drug-Disease Interactions

Piosteris M 500 Tablet 10 interacts with the following diseases:

Severe renal impairment: People with severe renal impairment should avoid taking Piosteris M 500 Tablet 10, as it could exacerbate their condition.
Metabolic acidosis: This medicine can potentially worsen metabolic acidosis, including diabetic ketoacidosis.
Heart failure: Patients suffering from heart failure (particularly NYHA Class III or IV) should avoid this medication due to potential adverse effects.

Daily Dose

Your doctor will prescribe the daily dosage of Piosteris M 500 Tablet 10, which should be strictly followed. This dosage may vary based on the severity of your condition and your response to treatment.

Over Dose

An overdose of Piosteris M 500 Tablet 10 could lead to symptoms such as nausea, vomiting, diarrhoea, and abdominal discomfort. If you suspect that you've taken more than the prescribed dose, inform your doctor without delay.

Missed Dose

If you forget to take your dose of Piosteris M 500 Tablet 10, take it as soon as you remember. However, if it's nearly time for the next dose, skip the missed one and continue with your regular schedule. Always consult your doctor before making any changes to your dosage.

Store Piosteris M 500 Tablet 10 in a cool, dry place, ideally at a temperature below 30°C.
Keep it out of reach of children

Balanced diet rich in fibre and low in sugar to support the management of type 2 diabetes. This can help control blood sugar levels, along with taking Piosteris M 500 Tablet 10.
Regular physical activity, such as walking or cycling, can improve your body's insulin sensitivity and help in managing diabetes more effectively. Remember to consult your doctor before starting any new exercise regimen.

Fact Box

Available Dosage Types	Tablet
Habit Forming	No
Ailment	Type 2 Diabetes Mellitus
Drug Category	Insulin Sensitiser, Biguanide
Therapeutic Category	Antidiabetic

Is Piosteris M 500 Tablet 10 suitable for early treatment of type 2 diabetes?

Yes, Piosteris M 500 Tablet 10 can be used as initial therapy when HbA1c is above 7.5% or if single medicines like metformin or pioglitazone don't control blood sugar levels.

How does sustained-release metformin in Piosteris M 500 Tablet 10 compare to normal metformin?

The sustained-release metformin in Piosteris M 500 Tablet 10 allows once-daily dosing, has better gut tolerance, and maintains more consistent blood levels than regular metformin.

Can Piosteris M 500 Tablet 10 cause low blood sugar?

The risk of low blood sugar with Piosteris M 500 Tablet 10 is low, but it increases when used with insulin or medicines that stimulate insulin production.

When will I see the effects of Piosteris M 500 Tablet 10 on my blood sugar levels?

The full effect of Piosteris M 500 Tablet 10 may take up to 4-6 weeks to show. Regularly monitor your blood glucose and HbA1c levels.

What should I do if I miss a dose of Piosteris M 500 Tablet 10?

If you miss a dose, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and continue with your regular schedule.

Can I take Piosteris M 500 Tablet 10 if I have kidney problems?

No, Piosteris M 500 Tablet 10 should not be used if you have severe kidney impairment, identified by an eGFR below 30 mL/min/1.73 m2.

What are some side effects of taking Piosteris M 500 Tablet 10?

Common side effects include gastrointestinal symptoms such as diarrhoea and nausea, weight gain, swelling in the limbs, and upper respiratory tract infections.

Last Updated On 13 May. 2025 | 11:20AM (IST)

Certified Content

Written by

Dr. Michelle Frank

Medical Content Writer | 9 years

Doctor of Medicine

Reviewed by

Dr. Chhavi Rosha

Medical Content Writer | 9 years

BAMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

Tanaji Chowk, Ambedkar Nagar, Kurla West, Kurla, Mumbai, Maharashtra 400070

Country of origin: INDIA

Expiry on or after: October 2025

In case of any issues, contact us:

support@truemeds.in|08069808861

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

Competact European Medicines Agency. (2022). Pioglitazone/metformin. European Medicines Agency. https://www.ema.europa.eu/en/medicines/human/EPAR/competact
Metformin: MedlinePlus drug information. (n.d.). MedlinePlus - Health Information from the National Library of Medicine. https://medlineplus.gov/druginfo/meds/a696005.html
Pioglitazone: MedlinePlus drug information. (n.d.). MedlinePlus - Health Information from the National Library of Medicine. https://medlineplus.gov/druginfo/meds/a699016.html
Pioglitazone is a medicine you can get on prescription. It's used to treat type 2 diabetes. (2022, March 15). nhs.uk. https://www.nhs.uk/medicines/pioglitazone/about-pioglitazone/
Pioglitazone (marketed as Actos, Actoplus met, Duetact, and Oseni) Inf. (2022, February 7). U.S. Food and Drug Administration. https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/pioglitazone-marketed-actos-actoplus-met-duetact-and-oseni-information

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We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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CIN: U85320MH2019PTC320566

Telephone:09240250346

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Email: grievance-officer@truemeds.in

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