Pangraf 5.0 Capsule 10

Pangraf 5.0 Capsule 10 is used for the following:

• Prevention of organ rejection after transplantation

• Management of liver transplant complications

• Prevention of kidney and heart transplant rejection

• Management of atopic dermatitis

• Treatment of severe rheumatoid arthritis

• Suppression of excessive immune responses

• Management of autoimmune conditions

• Swallow the capsule whole with a glass of water.

• Take this medicine on an empty stomach, at least one hour before meals or two hours after meals.

• Do not crush, chew, or open the capsule.

• Take this medicine at the same time each day to maintain consistent levels in your blood.

• Store the medicine at room temperature, away from moisture and light.

• Consult your doctor if you have any questions about using this medicine.

Pangraf 5.0 Capsule 10 is taken orally.

This capsule contains tacrolimus (5 mg), which works on the body as follows:

• Inhibition of calcineurin: Tacrolimus forms a complex with a protein called FKBP in your body, which then blocks an enzyme called calcineurin that plays a key role in activating your immune system.

• T-cell suppression: By inhibiting calcineurin, tacrolimus prevents the activation of T-cells, which are white blood cells responsible for attacking foreign substances in your body.

• Reduced immune response: The suppression of T-cells leads to a decreased immune response, which helps prevent your body from rejecting transplanted organs.

• Prevention of cytokine production: Tacrolimus reduces the production of certain proteins called cytokines that normally help coordinate immune system attacks against foreign tissues.

• Store Pangraf 5.0 Capsule 10 at room temperature.

• Keep the medicine protected from light and moisture.

• Store in the original packaging until ready to use.

• Keep out of reach of children and pets.

• Check the expiry date before use and discard if expired.

• Avoid consuming sour fruits or juices while taking this capsule, as it can increase tacrolimus (the active ingredient) levels in your blood, potentially causing harmful side effects.

• Maintain consistent eating habits and timing of meals relative to when you take this medicine, as this helps achieve stable tacrolimus levels in your body.