CompositionIstamet G Ir 50/500/2 Tablet 10 is used to manage blood sugar levels in adults with type 2 diabetes mellitus. It is a combination medicine that belongs to the classes of sulfonylureas, biguanides, and dipeptidyl peptidase-4 (DPP-4) inhibitors.
This medicine helps improve blood glucose control when diet, exercise, or single or dual therapy is not sufficient.Take this medicine exactly as prescribed by your doctor. Inform your doctor if you have kidney disease, liver disease, heart conditions, or a history of low blood sugar before taking this medicine. Continue taking the medicine for the duration advised by your doctor to maintain stable blood sugar levels.
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Istamet G Ir 50/500/2 Tablet 10
Strip of 10 Units
MRP ₹152.81
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About Istamet G Ir 50/500/2 Tablet 10
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Uses of Istamet G Ir 50/500/2 Tablet 10
Istamet G Ir 50/500/2 Tablet 10 is used to:
- Manage type 2 diabetes mellitus
- Improve blood sugar control in adults
- Support glycaemic control when combination therapy is required
Directions for Use of Istamet G Ir 50/500/2 Tablet 10
Follow these instructions while taking Istamet G Ir 50/500/2 Tablet 10:
- Take this medicine exactly as prescribed by your doctor.
- Swallow the tablet whole with water.
- Take it with meals to reduce stomach upset and help maintain stable blood sugar levels.
- Take it at the same time each day for consistent blood sugar control.
- Do not skip meals while taking this medicine.
Route of Administration
Istamet G Ir 50/500/2 Tablet 10 is taken orally.
Side Effects of Istamet G Ir 50/500/2 Tablet 10
Istamet G Ir 50/500/2 Tablet 10 may cause side effects such as:
- Nausea
- Diarrhoea
- Hypoglycaemia (low blood sugar)
- Headache
- Dizziness
- Abdominal discomfort
Management Of Side Effects:
Most side effects of Istamet G Ir 50/500/2 Tablet 10 are mild and improve over time. Consult your doctor if symptoms persist or worsen.
Some tips that may help include:
- Low blood sugar (hypoglycaemia): Carry a source of fast-acting sugar such as glucose tablets, candy, or fruit juice. Eat regular meals and avoid skipping food.
- Nausea or stomach discomfort: Take this medicine with meals and avoid heavy or oily foods.
- Diarrhoea: Stay hydrated and eat light, easily digestible foods until symptoms improve.
How Istamet G Ir 50/500/2 Tablet 10 Works?
Istamet G Ir 50/500/2 Tablet 10 contains the following components:
- Glimepiride (2 mg): This is a sulfonylurea that stimulates insulin secretion from pancreatic beta cells. It helps lower blood glucose levels by enhancing the body’s natural insulin response, particularly after meals.
- Metformin (500 mg): This is a biguanide that reduces hepatic glucose production and improves insulin sensitivity in peripheral tissues such as muscles. It also helps decrease intestinal glucose absorption, contributing to better overall glycaemic control.
- Sitagliptin (50 mg): This is a DPP-4 inhibitor that increases the levels of incretin hormones (GLP-1 and GIP). These hormones enhance glucose-dependent insulin release and reduce glucagon secretion, helping regulate blood sugar levels without significantly increasing the risk of hypoglycaemia.
Safety Measures & Warnings
Pregnancy
Istamet G Ir 50/500/2 Tablet 10 should be taken during pregnancy only if prescribed by a doctor. Insulin is often preferred during pregnancy for better glucose control.
Breastfeeding
Consult your doctor before taking Istamet G Ir 50/500/2 Tablet 10 while breastfeeding. Some components may pass into breast milk and could affect the baby’s blood sugar levels. Careful monitoring or an alternative treatment may be advised.
Alcohol
Avoid alcohol while taking this medicine. Alcohol may increase the risk of hypoglycaemia and can also raise the risk of lactic acidosis, especially due to metformin. It may also make blood sugar levels more difficult to control.
Liver
Use this medicine with caution if you have liver problems. Impaired liver function may increase the risk of hypoglycaemia and may increase the risk of hypoglycaemia. Regular monitoring may be required.
Kidney
Use with caution in patients with kidney impairment. Reduced kidney function may increase the risk of lactic acidosis and affect the clearance of metformin and sitagliptin. Dose adjustment and regular monitoring may be required.
Use In Driving And Operating Machinery
Istamet G Ir 50/500/2 Tablet 10 may cause hypoglycaemia, which can lead to dizziness, confusion, or reduced alertness. Avoid driving or operating machinery if you experience symptoms of low blood sugar.
Allergy
Do not take Istamet G Ir 50/500/2 Tablet 10 if you are allergic to any of its components. Seek immediate medical attention if you develop symptoms such as rash, swelling, or difficulty breathing.
Children
This medicine is not routinely recommended in children, as safety and effectiveness have not been fully established. Use only if clearly prescribed by a doctor.
Older Patients
Older adults may be more sensitive to the effects of this medicine, especially hypoglycaemia and kidney-related complications. Dose adjustment and regular monitoring may be required.
Interactions of Istamet G Ir 50/500/2 Tablet 10
Drug-Drug Interactions
Istamet G Ir 50/500/2 Tablet 10 may interact with other medicines, such as:
- Antihypertensive medicines (e.g., enalapril, atenolol): Some antihypertensive medicines (especially beta-blockers) may mask symptoms of hypoglycaemia or affect blood sugar levels. Close monitoring of blood glucose levels may be required, especially when starting or adjusting therapy.
- Antidiabetic medicines (e.g., insulin): Concomitant use with other blood sugar-lowering medicines may significantly increase the risk of hypoglycaemia. Dose adjustment and careful monitoring are important to avoid sudden drops in blood glucose levels.
- Antitubercular medicines (e.g., rifampicin): These medicines may reduce the effectiveness of sitagliptin and glimepiride by increasing their metabolism, leading to poor blood sugar control. Monitoring and dose adjustment may be required.
- Antiepileptic medicines (e.g., phenytoin): These medicines may alter blood sugar levels and reduce the effectiveness of this combination. Regular monitoring of glucose levels is recommended.
- Corticosteroids (e.g., prednisolone): May increase blood glucose levels and reduce the effectiveness of this medicine by promoting insulin resistance. Blood sugar monitoring and dose adjustment may be necessary.
- Diuretics (e.g., furosemide, hydrochlorothiazide): May impair blood glucose control and affect kidney function, which can influence the clearance of metformin and sitagliptin. Monitoring is advised.
- Cimetidine and other medicines affecting renal function: May reduce the clearance of metformin, increasing the risk of lactic acidosis. Caution and monitoring are required.
- Digoxin: Sitagliptin may slightly increase digoxin levels, which may increase the risk of toxicity in sensitive individuals. Monitoring may be required.
Drug-Disease Interactions
Use Istamet G Ir 50/500/2 Tablet 10 with caution if you have:
- Heart disease: Patients with heart conditions, especially heart failure, may have an increased risk of complications such as lactic acidosis. Careful monitoring is required during treatment.
- Hypoglycaemia risk conditions: Patients with irregular eating patterns, malnutrition, or severe illness may be more prone to low blood sugar due to glimepiride. Regular meals and monitoring are important.
- Pancreatitis: Sitagliptin has been associated with cases of pancreatitis. Patients with a history of pancreatitis should take this medicine with caution and report symptoms such as severe abdominal pain immediately.
- Vitamin B12 deficiency: Long-term use of metformin may reduce vitamin B12 levels, potentially leading to anaemia or neuropathy. Periodic monitoring may be recommended.
Dosage of Istamet G Ir 50/500/2 Tablet 10
Daily Dose
Take Istamet G Ir 50/500/2 Tablet 10 exactly as prescribed by your doctor. The dose is usually individualised based on your blood glucose levels, response to treatment, and tolerance. It is typically taken with food to improve glycaemic control and reduce the risk of gastrointestinal side effects. Your doctor may adjust the dose gradually to achieve optimal blood sugar levels while minimising the risk of hypoglycaemia.
Over Dose
Taking more than the prescribed dose may increase the risk of serious side effects such as severe hypoglycaemia or lactic acidosis. Symptoms of hypoglycaemia may include sweating, confusion, dizziness, or weakness, while lactic acidosis may present with rapid breathing, muscle pain, or unusual fatigue. Seek immediate medical attention if an overdose is suspected.
Missed Dose
If you miss a dose, take it as soon as you remember with food. If it is close to your next scheduled dose, skip the missed dose and continue your regular dosing schedule. Do not take two doses at the same time to make up for a missed dose, as this may increase the risk of hypoglycaemia.
Storage
- Store at room temperature (below 25°C).
- Keep away from moisture and direct sunlight.
- Keep out of reach of children.
- Do not use after the expiry date.
Special Dietary And Lifestyle Recommendation
- Follow a balanced, carbohydrate-controlled diet to help maintain stable blood sugar levels. Include whole grains, lean proteins, healthy fats, and fibre-rich foods in your daily meals.
- Maintain a regular meal schedule and avoid skipping meals, as irregular eating patterns may lead to fluctuations in blood sugar levels.
- Engage in regular physical activity such as walking, cycling, or light exercise, which can help improve insulin sensitivity and support overall metabolic health.
- Monitor your blood sugar levels regularly as advised by your doctor to track your response to treatment and make necessary adjustments.
- Maintain a healthy body weight, as weight management plays an important role in improving blood sugar control and reducing the risk of complications.
- Stay well hydrated and limit intake of sugary foods, processed snacks, and excessive alcohol, as these may affect blood sugar levels.
Fact Box
| Dosage Forms Available | Tablet |
| Habit Forming | No |
| Ailment | Type 2 diabetes mellitus |
| Drug Category | Sulfonylurea, Biguanide and DPP-4 inhibitor |
| Therapeutic Category | Antidiabetic combination |
Frequently Asked Questions (FAQs)
What is Istamet G Ir 50/500/2 Tablet 10 used for?
Istamet G Ir 50/500/2 Tablet 10 is used to manage blood sugar levels in adults with type 2 diabetes mellitus. It is usually prescribed when diet, exercise, or single medicines or dual therapy are not sufficient to achieve adequate glycaemic control.
How does Istamet G Ir 50/500/2 Tablet 10 work?
This medicine works through three different mechanisms. It increases insulin release from the pancreas, reduces glucose production in the liver, and improves the body’s response to insulin, helping maintain better blood sugar control throughout the day.
Can this medicine cause low blood sugar?
Yes, this medicine may cause hypoglycaemia, especially due to glimepiride. The risk is higher if you skip meals, exercise excessively, or take it with other antidiabetic medicines. Always carry a quick source of sugar and eat meals regularly.
Can I take this medicine with food?
Yes, this medicine should be taken with meals. Taking it with food helps reduce stomach-related side effects and lowers the risk of low blood sugar.
Can this medicine affect the kidneys?
Yes, metformin is eliminated through the kidneys, and reduced kidney function may increase the risk of lactic acidosis. Your doctor may monitor kidney function regularly during treatment.
Can this medicine cause stomach upset?
Yes, some people may experience nausea, diarrhoea, or abdominal discomfort, especially at the beginning of treatment. Taking the medicine with meals usually helps reduce these symptoms.
Can I stop taking this medicine once my sugar levels are normal?
No, do not stop taking this medicine without consulting your doctor. Even if your blood sugar levels improve, stopping treatment may lead to poor glycaemic control and increase the risk of complications.
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Manufacturer details
SUN HOUSE CTS No. 201, 201, Western Express Hwy, Ram Nagar, Goregaon, Mumbai, Maharashtra 400063
Country of origin: INDIA
Country of origin: INDIA
Expiry on or after: July 2026
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References
- National Library of Medicine. (n.d.). Glimepiride. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Glimepiride
- National Library of Medicine. (n.d.). Metformin. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Metformin
- National Library of Medicine. (n.d.). Sitagliptin. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Sitagliptin
- National Library of Medicine. (n.d.). Glimepiride. MedlinePlus Drug Information. https://medlineplus.gov/druginfo/meds/a696016.html
- National Library of Medicine. (n.d.). Metformin. MedlinePlus Drug Information.
https://medlineplus.gov/druginfo/meds/a696005.html - National Library of Medicine. (n.d.). Sitagliptin. MedlinePlus Drug Information.
https://medlineplus.gov/druginfo/meds/a606023.html - Wishart, D. S., Feunang, Y. D., Guo, A. C., Lo, E. J., Marcu, A., Grant, J. R., Sajed, T., Johnson, D., Li, C., Sayeeda, Z., Assempour, N., Iynkkaran, I., Liu, Y., Maciejewski, A., Gale, N., Wilson, A., Chin, L., Cummings, R., Le, D., & DrugBank. (n.d.). Glimepiride. DrugBank Online.
https://go.drugbank.com/drugs/DB00222 - Wishart, D. S., Feunang, Y. D., Guo, A. C., Lo, E. J., Marcu, A., Grant, J. R., Sajed, T., Johnson, D., Li, C., Sayeeda, Z., Assempour, N., Iynkkaran, I., Liu, Y., Maciejewski, A., Gale, N., Wilson, A., Chin, L., Cummings, R., Le, D., & DrugBank. (n.d.). Metformin. DrugBank Online.
https://go.drugbank.com/drugs/DB00331 - Wishart, D. S., Feunang, Y. D., Guo, A. C., Lo, E. J., Marcu, A., Grant, J. R., Sajed, T., Johnson, D., Li, C., Sayeeda, Z., Assempour, N., Iynkkaran, I., Liu, Y., Maciejewski, A., Gale, N., Wilson, A., Chin, L., Cummings, R., Le, D., & DrugBank. (n.d.). Sitagliptin. DrugBank Online.
https://go.drugbank.com/drugs/DB01261
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We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.
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