ISTAMET EMPA 25/100/1000 TABLET 10 is used for the treatment of adults with Type 2 Diabetes Mellitus that is inadequately controlled on metformin monotherapy or dual therapy. It belongs to the antidiabetic class of medicines.
This tablet, when used along with a balanced diet and regular physical activity, helps achieve and maintain better blood glucose control. Maintaining optimal glycaemic levels is important to reduce the risk of long-term complications such as heart disease, kidney damage, nerve damage, and vision impairment.
Before starting this medicine, consult your doctor for appropriate dose selection based on blood sugar levels, kidney function, liver function, and overall clinical condition. Inform your doctor about all existing medical conditions and ongoing treatments. Report any unusual symptoms or side effects promptly.
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Istamet Empa 25/100/1000 Tablet 10
Strip of 10 Units
MRP ₹215.53
₹172.42
₹21.55/Units
100% genuine medicines
Safe & secure payments
15 days Easy returns
Prescription required for this medicine
Store Below 30° C
CompositionAbout Istamet Empa 25/100/1000 Tablet 10
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Uses of Istamet Empa 25/100/1000 Tablet 10
ISTAMET EMPA 25/100/1000 TABLET 10 is used for:
- Improving glycaemic control in adults with Type 2 Diabetes Mellitus
Directions for Use of Istamet Empa 25/100/1000 Tablet 10
- Swallow the tablet whole with water
- Take it preferably at the same time each day
- It is usually taken with food to reduce stomach discomfort
- Do not crush, chew, or split the tablet
- Always follow your doctor’s instructions regarding dose and timing
Route of Administration
ISTAMET EMPA 25/100/1000 TABLET 10 is intended for oral use.
Side Effects of Istamet Empa 25/100/1000 Tablet 10
ISTAMET EMPA 25/100/1000 TABLET 10 may cause the following common side effects:
- Urinary tract infections
- Genital infections
- Diarrhoea
- Nausea
- Flatulence
- Abdominal discomfort
- Indigestion
- Increased urination
Management Of Side Effects:
Most side effects are mild and resolve with continued use or dose adjustment. Consult your doctor if symptoms persist or worsen.
- Urinary tract or genital infections: Maintain good personal hygiene, stay well hydrated, and seek medical advice if there is a burning sensation, discharge, or fever.
- Increased urination: Ensure adequate fluid intake to prevent dehydration.
How Istamet Empa 25/100/1000 Tablet 10 Works?
ISTAMET EMPA 25/100/1000 TABLET 10 contains the following active components:
- Empagliflozin (25 mg): Empagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor. It lowers blood glucose by reducing glucose reabsorption in the kidneys, leading to increased glucose excretion through urine.
- Metformin (1000 mg): Metformin is a biguanide that decreases glucose production in the liver and improves insulin sensitivity in peripheral tissues, enhancing glucose utilisation.
- Sitagliptin (100 mg): Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that increases levels of incretin hormones, thereby improving insulin release and reducing glucagon secretion in a glucose-dependent manner.
Safety Measures & Warnings
Pregnancy
Caution is advised while taking ISTAMET EMPA 25/100/1000 TABLET 10 if you are pregnant. It is best to consult your doctor before taking this medicine, as it should only be used during pregnancy if the potential benefit justifies the potential risk to the baby.
Breastfeeding
ISTAMET EMPA 25/100/1000 TABLET 10 is not recommended during breastfeeding as its safety has not been established. Always consult your doctor before use.
Alcohol
Alcohol may increase the risk of low blood sugar, dehydration, and lactic acidosis when taken with ISTAMET EMPA 25/100/1000 TABLET 10. Alcohol intake should be avoided or strictly limited.
Liver
ISTAMET EMPA 25/100/1000 TABLET 10 should be used cautiously in patients with liver impairment and is not recommended in severe liver disease. Inform your doctor about any liver-related conditions.
Kidney
ISTAMET EMPA 25/100/1000 TABLET 10 is contraindicated in severe kidney impairment. Patients with mild to moderate kidney disease require regular monitoring of kidney function, and dose adjustments may be necessary.
Use In Driving And Operating Machinery
Fluctuations in blood sugar levels may cause dizziness or drowsiness. Avoid driving or operating heavy machinery until you know how this medicine affects you.
Allergy
Do not use ISTAMET EMPA 25/100/1000 TABLET 10 if you are allergic to empagliflozin, metformin, sitagliptin, or any other component. Seek immediate medical help if rash, swelling, or breathing difficulty occurs.
Children
ISTAMET EMPA 25/100/1000 TABLET 10 is not recommended for individuals below 18 years of age.
Older Patients
Elderly patients may be at increased risk of dehydration, low blood pressure, and kidney impairment. Close monitoring is advised if ISTAMET EMPA 25/100/1000 TABLET 10 is prescribed.
Interactions of Istamet Empa 25/100/1000 Tablet 10
Drug-Drug Interactions
ISTAMET EMPA 25/100/1000 TABLET 10 interacts with the following medicines:
- Diuretics (e.g., furosemide and hydrochlorothiazide): The concomitant use may increase the risk of dehydration and low blood pressure
- Cationic medicines (e.g., cimetidine, ranolazine): The concomitant use may affect metformin elimination
- Carbonic anhydrase inhibitors (e.g., topiramate, acetazolamide): The concomitant use may increase the risk of lactic acidosis
Drug-Disease Interactions
ISTAMET EMPA 25/100/1000 TABLET 10 interacts with the following diseases:
- Urinary tract infections (UTIs): There may be a higher risk of UTIs while on this tablet.
- Vitamin B12 deficiency: The metformin in this tablet can reduce Vitamin B12 levels over time.
- Kidney impairment: This tablet should be used with caution; discontinue if kidney function worsens.
- Pancreatitis: Sitagliptin has been associated with reports of acute pancreatitis, requiring immediate discontinuation if suspected.
- Diabetic ketoacidosis: ISTAMET EMPA 25/100/1000 TABLET 10 may increase the risk of diabetic ketoacidosis, including cases with near-normal blood glucose levels; treatment should be discontinued immediately and medical evaluation is required if symptoms such as nausea, vomiting, abdominal pain, rapid breathing, or confusion occur.
Dosage of Istamet Empa 25/100/1000 Tablet 10
Daily Dose
The recommended dose of ISTAMET EMPA 25/100/1000 TABLET 10 is determined by your doctor based on individual blood sugar control, kidney function, and treatment response. Do not modify the dose without medical advice.
Over Dose
Overdose of ISTAMET EMPA 25/100/1000 TABLET 10 may lead to severe dehydration, excessive urination, dizziness, low blood sugar, or symptoms of lactic acidosis such as rapid breathing, muscle pain, or extreme weakness. Seek immediate medical attention if overdose is suspected.
Missed Dose
If a dose of ISTAMET EMPA 25/100/1000 TABLET 10 is missed, take it as soon as remembered unless it is close to the next scheduled dose. Skip the missed dose if necessary. Do not take a double dose.
Storage
- Store in a cool, dry place away from moisture and sunlight
- Keep out of reach of children
- Do not use after the expiry date printed on the pack
Special Dietary And Lifestyle Recommendation
- Follow a diet low in refined sugars and simple carbohydrates
- Maintain adequate hydration throughout the day
- Engage in regular physical activity as advised by your doctor
- Monitor blood glucose levels regularly
- Attend routine follow-up visits for kidney function and overall diabetes management
Fact Box
| Dosage Forms Available | Tablet Er |
| Habit Forming | No |
| Ailment | Type 2 diabetes mellitus |
| Drug Category | SGLT2 inhibitor, biguanide, DPP-4 inhibitor
|
| Therapeutic Category | Antidiabetics |
Frequently Asked Questions (FAQs)
What is ISTAMET EMPA 25/100/1000 TABLET 10 used for?
Can ISTAMET EMPA 25/100/1000 TABLET 10 cause low blood sugar?
Is long-term use of ISTAMET EMPA 25/100/1000 TABLET 10 safe?
Does ISTAMET EMPA 25/100/1000 TABLET 10 help prevent diabetes complications?
Can elderly patients take ISTAMET EMPA 25/100/1000 TABLET 10?
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Manufacturer details
Country of origin: INDIA
References
- Merck Sharp & Dohme Corp. (2007). HIGHLIGHTS OF PRESCRIBING INFORMATION. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/022044s042lbl.pdf
- Sitagliptin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB01261
- Metformin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00331
- Empagliflozin: MedlinePlus Drug Information. (n.d.). https://medlineplus.gov/druginfo/meds/a614043.html
- Empagliflozin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB09038
- Empagliflozin, Sitagliptin and Metformin Hydrochloride Tablet. (n.d.). Torrentpharma.Com. Retrieved January 19, 2026, from https://www.torrentpharma.com/assets/Empagliflozin_Sitagliptin_Metformin_PI_cd9fab6934.pdf
Disclaimer
We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.
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