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CompositionAmicline Plus Tablet is primarily used to manage amoebiasis, a parasitic infection of the intestines. This combination medicine belongs to a group of medications known as antiprotozoal and antibacterial drugs.
Aside from its primary use, Amicline Plus Tablet also manages giardiasis and trichomoniasis, which are other forms of protozoal infections. Additionally, it's effective in managing anaerobic bacterial infections, which are caused by bacteria that can survive without oxygen.
Amicline Plus Tablet is used for the following:
Managing intestinal and hepatic amoebiasis: This is a type of infection caused by a parasite called Entamoeba histolytica that primarily affects the intestines and liver.
Controlling giardiasis: This is an infection in your small intestine caused by a microscopic parasite called Giardia.
Handling trichomoniasis: A sexually transmitted infection caused by a parasite.
Management of anaerobic bacterial infections: These are infections caused by bacteria that do not need oxygen to grow and multiply. They can cause conditions like intra-abdominal sepsis, gynecologic infections, skin and soft tissue infections, and periodontal disease.
Here's how you should take Amicline Plus Tablet:
Swallow the tablet whole with a glass of water after your meals. Don't crush or chew it.
Complete the full course of this medicine as prescribed by your doctor.
If you're unsure about anything, it's always best to consult your doctor.
Amicline Plus Tablet is taken orally.
While taking Amicline Plus Tablet, you may experience some side effects. These include:
Nausea
Vomiting
Metallic taste: You might experience an unusual taste in your mouth.
Abdominal pain
Headache
Dizziness
Fatigue: This medicine could make you feel tired or weak.
Rash
Itching
These side effects are usually temporary and subside once you stop taking the medication. However, if they persist or worsen, please consult your doctor.
Most side effects are temporary and generally harmless, which resolve upon discontinuing the use of Amicline Plus Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.
Here are two tips to manage common side effects:
Nausea: Try taking Amicline Plus Tablet with food to lessen this effect.
Abdominal pain: If you experience stomach discomfort after taking this medicine, consider having it after meals.
Amicline Plus Tablet contains two active ingredients:
Diloxanide Furoate (375 mg): Primarily acting in the bowel lumen, diloxanide furoate inhibits the trophozoites of Entamoeba histolytica, which causes amoebiasis. This action helps limit the spread of the infection.
Ornidazole (250 mg): This component belongs to a class called nitroimidazole derivatives with antiprotozoal and antibacterial properties. After entering microorganisms, it is converted into reactive intermediates that interrupt DNA and inhibit nucleic acid synthesis, causing cell death. Ornidazole is effective against protozoa like Trichomonas and Giardia, as well as anaerobic bacteria such as Bacteroides and Clostridium.
Together, these components help manage amoebiasis, giardiasis, trichomoniasis, and anaerobic bacterial infections effectively.
Amicline Plus Tablet should not be taken during the first trimester of pregnancy. If you are pregnant or planning to conceive, discuss this with your doctor before starting this medicine.
This medicine is contraindicated for breastfeeding/lactating women. Consult your doctor to understand the potential risks and benefits.
Avoid consuming alcohol during and for 3 days after treatment with Amicline Plus Tablet. Alcohol may react with this medicine, causing unwanted effects.
Caution is advised while taking Amicline Plus Tablet if you have liver problems. Discuss your liver health with your doctor before starting this medicine, as it may affect liver function.
If you have a history of kidney issues, it's wise to consult your doctor before taking Amicline Plus Tablet. Proper advice from your doctor can help ensure its safe use.
As this medicine may cause drowsiness or dizziness, caution is advised when driving or operating machinery. Consult your doctor about how best to use it safely in such situations.
Do not take Amicline Plus Tablet if you have a known allergy to diloxanide, ornidazole, or any other component of the formulation. Discuss any allergies with your doctor before starting the medication.
Amicline Plus Tablet is contraindicated for children under 3 years of age. For older children, always consult your doctor before giving them the medicine.
Older patients should take Amicline Plus Tablet under medical supervision as they may be more susceptible to its side effects. Your doctor will provide guidance based on your health status.
Amicline Plus Tablet interacts with the following medicines:
Alcohol: With ornidazole, a component of Amicline Plus Tablet, alcohol can lead to a disulfiram-like reaction.
Anticoagulants: Medicines like warfarin and heparin can have their effects enhanced by ornidazole.
Anti-seizure Medicines: Drugs like phenytoin and phenobarbital could potentially speed up the metabolism of ornidazole.
Acid Reducers: Cimetidine might slow down the metabolism of ornidazole.
Mood Stabilisers: Ornidazole might increase the risk of lithium toxicity.
No specific food interactions have been reported with Amicline Plus Tablet. However, it is recommended to take it after meals for optimal absorption and to reduce gastrointestinal discomfort.
Amicline Plus Tablet interacts with the following diseases:
Neurological Disorders: If you have active neurological disorders, you should avoid this medicine as it may worsen your condition.
Liver Disease: If you have liver problems, be cautious as this medicine can further affect your liver function. Your doctor may need to adjust your dose accordingly.
The Amicline Plus Tablet should be taken as recommended by your doctor. The dosage can vary depending on individual factors such as the severity of your condition and how you respond to the medicine. Following the prescribed dosage is crucial, and exceeding it without consulting your doctor is not advised.
Symptoms of an overdose may include feeling nauseous, being unsteady on your feet, and experiencing seizures. If you have taken more than the prescribed dose, inform your doctor.
If you forget to take Amicline Plus Tablet at the scheduled time, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue with your regular schedule. Do not increase your dosage without speaking to your doctor.
Store your Amicline Plus Tablet below 30°C, in a cool and dry place.
Protect it from light and moisture to maintain its effectiveness.
Keep it out of reach of children for their safety.
Make sure to use your medication before the expiry date mentioned on the pack.
As Amicline Plus Tablet is used to manage amoebiasis, giardiasis, trichomoniasis, and anaerobic bacterial infections, maintaining good personal hygiene is crucial. This includes regular handwashing, especially before meals.
If you're diagnosed with any of these conditions, try to consume well-cooked food and boiled or purified water to reduce the risk of further infection.
| Drug Category | Amebicide, Antiprotozoal |
| Therapeutic Category | Antiprotozoal, Antibacterial |
| Available Dosage Types | Tablet |
| Habit Forming | No |
| Ailment | Amoebiasis, Giardiasis, Trichomoniasis |
It's used to manage conditions like amoebiasis, giardiasis, trichomoniasis, and certain anaerobic bacterial infections.
Amicline Plus Tablet works by inhibiting harmful microorganisms in your body and disrupting their DNA, which causes cell death.
No, you should avoid alcohol during and for three days after the course. It may cause an unpleasant reaction.
This medicine may cause drowsiness or dizziness. Be cautious while driving or operating machinery.
In case of an overdose, symptoms like nausea or seizures might occur. Seek immediate medical attention.
No, if you're hypersensitive to diloxanide, ornidazole or any other component of this medicine, avoid it.
Common side effects include nausea, headache, and fatigue. Rare but serious side effects can include seizures or liver problems.
Check out Editorial Policy
Centers for Disease Control and Prevention. (2020). FDA Briefing Document: NDA 210132 Tindamax (Tinidazole) Tablets. https://www.fda.gov/media/164399/download
Pai, P. N., Rao, G. K., Srinivas, B., & Puranik, S. (2008). RPLC Determination of Tinidazole and Diloxanide Furoate in Tablets. Indian journal of pharmaceutical sciences, 70(5), 670–672. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038301/
U.S. Food and Drug Administration. (2004). Medical Review(s). Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/nda/2004/21-618_Tindamax_Medr_P3.pdf
Bush, N., Sharma, V., Chandrahasan, K., & Patil, A. N. (2020). Ofloxacin-ornidazole fixed-dose combination medication-induced pancreatitis with positive rechallenge. Journal of family medicine and primary care, 9(6), 3157–3159. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491762/
We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.
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