Advagraf 1Mg Capsule 10

Advagraf 1Mg Capsule 10 is used to prevent organ rejection in adults after a kidney or liver transplant.

Uses of Advagraf 1Mg Capsule 10 are:

• Kidney Transplant: Helps prevent organ rejection after a kidney transplant in adults.
• Liver Transplant: Helps lower the risk of organ rejection after a liver transplant in adults.
• Resistant Rejection: Used to manage allograft rejection episodes that have not responded to other immunosuppressive medicines.

Here's how to take Advagraf 1 mg Capsule:

• Swallow this capsule whole with water. Do not crush or open it.

• It's best to take this medicine on an empty stomach, ideally one hour before or two to three hours after a meal.

Advagraf 1 mg Capsule is taken orally.

Advagraf 1 mg Capsule contains tacrolimus (1 mg), which works by:

• Binding to FKBP-12: Tacrolimus binds to a protein in your body known as FKBP-12. This binding forms a complex in your body, which plays a crucial role in the medicine's action.

• Inhibiting Calcineurin: The complex formed by tacrolimus and FKBP-12 blocks the activity of an enzyme called calcineurin phosphatase. This enzyme is key in triggering your body's immune response.

• Suppression of IL-2 transcription: By blocking calcineurin, tacrolimus effectively stops the creation of a compound called interleukin-2 (IL-2). This compound is responsible for activating T lymphocytes, a type of white blood cell that can cause your body to reject a transplanted organ.

• Preventing T-lymphocyte activation: The overall effect of tacrolimus is to prevent T-lymphocytes from becoming activated. In this way, it stops your body's immune response, which could lead to the rejection of the transplanted organ.

• Store your Advagraf 1 mg Capsule at room temperature, ideally around 25°C.

• Protect it from moisture and direct light.

• Keep the medicine out of reach and sight of children.

• Once opened, use this medicine within 1 year to ensure its effectiveness.

• Always check the expiry date before using the medicine.

• As Advagraf 1 mg Capsule may lead to hypertension, consider adopting a low-sodium diet to manage blood pressure levels better.

• Since this medicine can increase your skin's sensitivity to sunlight, always wear protective clothing and use a high-factor sunscreen when outdoors. This can help reduce the risk of developing skin cancers, a potential side effect of taking Advagraf 1 mg Capsule.