Prograf 0.5Mg Capsule 10

Astellas Pharma Inc

STRIP of 50 Units
STRIP of 10 Units

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MRP ~~₹216.93~~

₹180.05

₹21.69/Units

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Prescription required for this medicine

Store Between 15°C to 30°C

Composition

Tacrolimus (0.5 Mg)

Strength:

1 MG 0.5 MG

Prograf 0.5 mg Capsule 10 is used to manage liver transplant. It is a single-ingredient immunosuppressant medicine containing tacrolimus.
This medicine helps prevent rejection of a transplanted liver. It also helps prevent rejection of a transplanted kidney. It also helps manage the risk of rejection after a heart transplant.
Before starting, tell your doctor about your medical conditions and allergies. Tell the doctor about all other medicines, supplements or herbal products you take. Tell your doctor if you are pregnant, planning a pregnancy or breastfeeding. Attend any monitoring appointments advised by your doctor. Report persistent or serious side effects to your doctor. Do not stop taking or using the medicine unless your doctor advises you to do so."

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Prograf 0.5 mg Capsule 10 is used to manage liver transplant.

Uses of Prograf 0.5 mg Capsule 10 are:

Liver Transplant: Helps prevent rejection of a transplanted liver.
Kidney Transplant: Helps prevent rejection of a transplanted kidney.
Heart Transplant: Helps manage the risk of rejection after a heart transplant.

To ensure you are using Prograf 0.5mg Capsule 10 correctly, follow these steps:

Swallow the whole capsule with a glass of water.
Avoid chewing or breaking the capsule.
Always consult your doctor for specific advice on how to take this medicine.

Prograf 0.5mg Capsule 10 is taken orally.

Prograf 0.5 mg Capsule 10 may cause some side effects that are usually mild and go away as your body adjusts to the medicine.

A few common side effects of Prograf 0.5 mg Capsule 10:

Kidney and blood pressure: reduced kidney function and high blood pressure (High blood pressure).
Metabolic: raised blood sugar that can lead to diabetes, and raised potassium levels (Hyperkalaemia (high potassium levels)).
General: fever, headache, and feeling sick (nausea).
Digestive and blood: loose motions (diarrhoea), anaemia (a low red blood cell count that may cause tiredness), and a low white blood cell count (leucopenia).

If any side effect does not improve or becomes serious, speak to your doctor. Do not stop taking the medicine unless your doctor advises you to do so.

Management Of Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Fujigraf 0.5 Capsule. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Hypertension: Try taking this medicine at night if it causes high blood pressure during the day.
Diarrhoea: Consider taking Prograf 0.5mg Capsule 10 with food or milk to lessen this effect.

Prograf 0.5mg Capsule 10 contains tacrolimus (0.5 mg). Here is how it works:

Immune response suppression: Tacrolimus suppresses the immune response by inhibiting T-lymphocyte activation. T-lymphocytes are a type of white blood cell that play a key role in the immune system's reaction to foreign substances.
Calcineurin inhibition: Tacrolimus forms a complex with an intracellular protein called FKBP-12, and this complex inhibits an enzyme known as calcineurin phosphatase. This inhibition process suppresses the transcription of certain genes in T cells that are involved in triggering immune responses.

Pregnancy

Prograf 0.5mg Capsule 10 can potentially harm the foetus. It should be taken by pregnant women if the possible benefits outweigh the potential risks to the unborn baby. Consulting your doctor before taking this medicine is strongly advised.

Breastfeeding

As Prograf 0.5mg Capsule 10 is excreted in breast milk, breastfeeding should be avoided while taking this medication.

Alcohol

There's no specific information about the interaction of Prograf 0.5mg Capsule 10 with alcohol. It is a better to consult your doctor before consuming alcohol while taking this medicine.

Liver

If you have any liver conditions, be cautious when taking Prograf 0.5mg Capsule 10. Consult your doctor for advices tailored to your health status.

Kidney

Caution is advised when using this medicine if you have a history of kidney problems. Consult your doctor before starting this medicine.

Use In Driving And Operating Machinery

This medicine may cause side effects like dizziness or blurred vision, which could affect your ability to drive or operate machinery. Avoid such activities until you know how this medicine affects you.

Allergy

Do not take Prograf 0.5mg Capsule 10 if you are allergic to tacrolimus or any other ingredients in the formulation.

Children

This medicine is not recommended for use in children, as its safety and efficacy have not been established for paediatric patients.

Older Patients

Elderly patients should take Prograf 0.5mg Capsule 10 under direct medical supervision, as they might be more susceptible to its side effects. If you are over 70 years of age, your doctor will guide you based on your overall health status.

Drug-Drug Interactions

Prograf 0.5mg Capsule 10 interacts with the following medicines:

Antifungal medications: Medicines such as clotrimazole, fluconazole, and itraconazole can increase the levels of tacrolimus in the body.
Calcium channel blockers: Medicines like diltiazem, verapamil, and nifedipine can also increase tacrolimus levels.
Macrolide antibiotics: Medications like erythromycin can raise tacrolimus levels.
Anti-tuberculosis medicine: Rifampin can significantly decrease tacrolimus concentrations.
Non-steroidal anti-inflammatory drugs (NSAIDs): These medicines may increase the nephrotoxic effect of tacrolimus.

Drug-Food Interactions

Prograf 0.5mg Capsule 10 interacts with grape fruit juice, which can significantly increase the concentration of tacrolimus in your body.

Drug-Disease Interactions

Prograf 0.5mg Capsule 10 interacts with the following diseases:

Hypersensitivity: If you have hypersensitivity to tacrolimus or any other ingredients in this medicine, such as polyoxyl 60 hydrogenated castor oil, you should avoid taking it.
Diabetes: Tacrolimus may cause new-onset diabetes after a transplant. Regular monitoring of blood glucose levels is required.
Renal Problems: Patients with renal issues should be cautious because tacrolimus can cause nephrotoxicity.

Daily Dose

The daily dose of Prograf 0.5mg Capsule 10 should be taken according to your doctor’s instructions. This dosage may vary based on the severity of your condition and your response to the medication.

Over Dose

In the event of an overdose of Fujigraf 0.5 Capsule, you may experience symptoms such as tremors, changes in kidney function, high blood pressure, and altered mental status.

Missed Dose

If you miss a dose of Fujigraf 0.5 Capsule, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed one and continue with your normal dose. Never adjust your dosage without consulting your doctor.

Store Prograf 0.5mg Capsule 10 at a temperature not exceeding 30°C.
Keep it safe from sunlight.
Keep out of reach of children.

Since Prograf 0.5mg Capsule 10 is used for organ transplant patients, maintaining a balanced diet is important. Include plenty of fresh fruits, vegetables, whole grains, and lean proteins in your diet to support your overall health and immune function.
Try to avoid grape fruit and grape fruit juice while taking this medication, as they can interfere with the way the medicine works. Check with your doctor for more specific advice about your diet.

Fact Box

Dosage Forms Available	Capsule
Habit Forming	No
Ailment	Organ Rejection in Transplants
Drug Category	Calcineurin Inhibitor
Therapeutic Category	Immunosuppressant

What is Prograf 0.5mg Capsule 10 used for?

Prograf 0.5mg Capsule 10 is used to prevent the body from rejecting a transplanted organ such as the liver, kidney, or heart in adult patients.

Can I take Prograf 0.5mg Capsule 10 with other medications?

Inform your doctor about all the medicines you are currently taking, as tacrolimus can interact with many medicines, potentially altering their effects.

How long do I need to take Prograf 0.5mg Capsule 10 after my transplant?

You will typically need to take immunosuppressants like Prograf 0.5mg Capsule 10 for life to prevent organ rejection. Don't stop taking it unless advised by your doctor.

What are the possible signs of organ rejection I should be aware of?

Look out for symptoms like fever, tenderness or pain over the transplanted organ, flu-like symptoms, changes in urine output or colour, yellowing of skin or eyes (jaundice), and unusual tiredness.

How often should I get my tacrolimus blood levels checked?

Initially, frequent blood checks will determine the right dose for you. Once stabilised, levels will be checked periodically, usually monthly or as directed by your doctor.

Can Prograf 0.5mg Capsule 10 harm an unborn baby if taken during pregnancy?

Yes, tacrolimus can harm an unborn baby. It is crucial to discuss this with your doctor if you are pregnant or planning to get pregnant while on this medication.

Can I breastfeed while taking Fujigraf 0.5 Capsule?

Tacrolimus is excreted in human milk; therefore, breastfeeding is not recommended while taking this medicine due to potential harm to the nursing infant.

Last Updated On 17 Sep. 2026 | 7:48PM (IST)

Certified Content

Written by

Dr. Michelle Frank

Medical Content Writer | 10 years

Doctor of Medicine

Reviewed by

Dr. Saniya K Mulla

Medical Content Writer | 7 years

MBBS

Check out Editorial Policy

Manufacturer details

Sangam Complex, Andheri - Kurla Rd, Dr. Charatsingh Colony, S B Singh Colony, J B Nagar, Andheri East, Mumbai, Maharashtra 400059

Country of origin: IRELAND

Expiry on or after: February 2027

In case of any issues, contact us:

support@truemeds.in|09240250346

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

U.S. Food and Drug Administration. (n.d.). Tacrolimus Capsules. FDA Draft Guidance. Retrieved on 1 April 2024 from https://www.accessdata.fda.gov/drugsatfda_docs/psg/Tacrolimus_caps_16729_RC12-12.pdf
Araya, A. A., & Tasnif, Y. (2023). Tacrolimus. Treasure Island (FL): StatPearls Publishing. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK544318/
Tacrolimus: MedlinePlus drug information. (n.d.). MedlinePlus - Health Information from the National Library of Medicine. Retrieved from https://medlineplus.gov/druginfo/meds/a601117.html
Tacrolimus. (n.d.). DrugBank Online | Database for Drug and Drug Target Info. https://go.drugbank.com/drugs/DB00864
Tacrolimus Patient Information Leaflet: Non-Renal Transplant Indication (for renal patients only) Information about Tacrolimus, a drug used to suppress the immune system. (n.d.). NHS. https://www.uhsussex.nhs.uk/resources/tacrolimus-patient-information-leaflet-non-renal-transplant-indication-for-ward-patients-only/

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Disclaimer

We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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Telephone:09240250346

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