Accufine 20mg Capsule 10

Healing Pharma

Strip of 10 Units

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Old MRP ₹302

MRP ~~₹283.12~~

₹141.28

₹28.31/Units

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Composition

Isotretinoin (20 Mg)

Strength:

10 MG 20 MG 30 MG 40 MG 5 MG

Accufine 20mg Capsule 10 is used to treat severe, disfiguring nodular acne that doesn't respond to topical treatments. It works by reducing sebum production, preventing clogged pores, and inhibiting the formation of new acne lesions, resulting in clearer skin.

Before taking this, it is crucial to consult your doctor for the suitable dosage and frequency. Inform your doctor about any pre-existing conditions, ongoing medications you may be taking, and if you are pregnant or planning to get pregnant. Women who could get pregnant should use effective contraception while pregnant women should not take Accufine 20mg Capsule 10 at all. If you experience any side effects while using this medicine, notify your doctor immediately. For optimal results, continue taking the medication for the duration prescribed by your doctor.

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Accufine 20mg Capsule 10 is used to treat severe, stubborn, or cystic acne by reducing oil production, preventing clogged pores, and controlling bacterial growth. It helps achieve clearer skin and reduces the risk of long-term acne scars.

Swallow the capsule whole, without breaking or chewing it.
Always take the capsule with food, as it can boost the absorption of isotretinoin.
Do not exceed the dose recommended by your doctor.
Ensure you consult your doctor before adjusting your dosage or stopping the medication.

Accufine 20mg Capsule 10 is taken orally.

Common side effects of Accufine 20mg Capsule 10 are dry, peeling skin, itchy or red skin, dry and irritated eyes, joint and muscle aches, skin thinning, and nosebleeds. These symptoms may vary in severity.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Accufine 20mg Capsule 10. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Dry, peeling skin: If you have dry or peeling skin, consider applying a moisturiser after taking this medicine.
Nosebleeds: To manage nosebleeds, try taking medicine with a good amount of water.

Accufine 20mg Capsule 10 contains isotretinoin (20 mg), which acts on your body in the following ways:

Reduces Sebum Production: Isotretinoin works by decreasing the size and output of sebaceous glands—glands in your skin that produce an oily substance called sebum. Less sebum makes your pores less likely to get blocked and inflamed.
Alters Cell Growth: Isotretinoin, a derivative of vitamin A, alters DNA transcription. This process affects how skin cells grow and differentiate.
Prevents Pore Clogging: Isotretinoin makes your skin cells less "sticky", preventing them from clumping together and clogging pores.
Hinders Bacterial Growth: Isotretinoin also inhibits the growth of Propionibacterium acnes, a type of bacteria that causes acne.

Pregnancy

Is it safe to take the Accufine 20mg Capsule 10 during pregnancy?

Accufine 20mg Capsule 10 is contraindicated during pregnancy. If you are pregnant or planning to conceive, discuss it with your doctor before starting this medication.

Breastfeeding

Is it safe to take Accufine 20mg Capsule 10 during breastfeeding?

Accufine 20mg Capsule 10 is contraindicated for breastfeeding women. Discuss it with your doctor if you are breastfeeding before starting this medication.

Alcohol

Is it safe to drink alcohol while taking Accufine 20mg Capsule 10?

As this medicine may impact blood glucose levels, it's advisable to limit alcohol consumption while taking Accufine 20mg Capsule 10.

Liver

Is it advisable to take Accufine 20mg Capsule 10 when experiencing liver problems?

Caution is advised while taking Accufine 20mg Capsule 10 if you have liver problems. The medicine may affect liver function, so discuss your liver health with your doctor before starting this medication.

Kidney

Is it advisable to use Accufine 20mg Capsule 10 when experiencing kidney problems?

Caution is advised when using Accufine 20mg Capsule 10 if you have a history of kidney problems. Consult your doctor before taking this medicine.

Using Machines & Driving

Is it safe to operate heavy machinery or drive when using the Accufine 20mg Capsule 10?

As Accufine 20mg Capsule 10 may cause drowsiness, dizziness, and vision changes, caution is advised when driving or operating machines, especially at night.

Allergy

Are there any specific conditions that should be considered before taking Accufine 20mg Capsule 10?

Avoid using it if you're allergic to isotretinoin or any other ingredients in Accufine 20mg Capsule 10. Discuss any allergies with your doctor before starting this medicine.

Children

Is Accufine 20mg Capsule 10 suitable for infants or children?

Accufine 20mg Capsule 10 isn't recommended for use in children under the age of 18 years. Always consult your doctor for appropriate treatment options for children.

Older Patients

Is Accufine 20mg Capsule 10 suitable for older patients?

Older patients should take Accufine 20mg Capsule 10 under medical supervision as they may be more susceptible to its side effects. If you're above 70 years of age, consult your doctor who will guide you based on your health status.

Drug-Drug Interactions

Accufine 20mg Capsule 10 interacts with the following medicines:

Tetracycline Antibiotics: These antibiotics, like doxycycline and minocycline, interact with Accufine 20mg Capsule 10. Their combined use may increase the risk of a condition called pseudotumor cerebri, which results in high pressure in the fluid around the brain.
Vitamin A Supplements: Supplements containing vitamin A can interact with Accufine 20mg Capsule 10, leading to increased side effects such as dry skin, chapped lips, and vision problems due to vitamin A overdose.

Drug-Food Interactions

Accufine 20mg Capsule 10 interacts with the following foods:

High-fat meals: Consuming this medication along with a high-fat meal can enhance the absorption of isotretinoin, thereby increasing its effectiveness.

Drug-Disease Interactions

Accufine 20mg Capsule 10 interacts with the following diseases:

Liver Disease: Individuals with liver disease should use this medicine cautiously as it could potentially worsen their condition.
Mental health issues: There's a risk that isotretinoin can cause changes in mood and behaviour. If you've previously suffered from depression or other mental health issues, it is essential to discuss this with your doctor before starting Accufine 20mg Capsule 10.

Daily Dose

The daily dose of Accufine 20mg Capsule 10 should be taken as advised by your doctor. The dosage may vary depending on individual factors, such as the severity of your acne and your response to the medicine. Always adhere to the prescribed dose and refrain from exceeding it without consulting your doctor.

Over Dose

If you accidentally take more Accufine 20mg Capsule 10s than prescribed, you might experience symptoms like severe headache, nausea or vomiting, drowsiness, irritability and itching. If this happens, inform your doctor right away.

Missed Dose

If you forget to take an Accufine 20mg Capsule 10 at your usual time, take it as soon as you remember. But if it's nearly time for your next dose, skip the missed one and continue with your regular schedule. Never double up on doses without talking to your doctor.

Keep your Accufine 20mg Capsule 10 in the original packaging.
Store at room temperature, ideally between 15 and 30°C.
Avoid placing them in areas of high humidity, like the bathroom.
Keep the medicine out of sight and reach of children.

It is beneficial to maintain a balanced diet rich in fruits, vegetables, and whole grains to support overall skin health while using Accufine 20mg Capsule 10.
As this medicine can make your skin more sensitive to sunlight, it's essential to minimise sun exposure and consistently use sunscreen when outside.

Fact Box

Available Dosage Types	Capsule
Habit Forming	No
Ailment	Severe Cystic Acne, Nodular Acne
Drug Category	DNA Transcription Alterer
Therapeutic Category	Anti-acne

What is Accufine 20mg Capsule 10 used for?

Accufine 20mg Capsule 10 is primarily used to manage nodular or conglobate acne, or acne that is at risk of causing permanent scarring in adults and adolescents that hasn't responded well to other treatments like topical creams and oral antibiotics.

How do Accufine 20mg Capsule 10 work?

Accufine 20mg Capsule 10 reduces sebum production, makes your skin less hospitable for acne-causing bacteria, and helps clear up existing acne lesions and prevent new ones from forming.

How long does it take for Accufine 20mg Capsule 10 to start working?

You may notice your acne starts to improve within the first month, but significant clearing usually takes 2-3 months or more. In general, it depends on your health status and the severity of your condition.

Can I take Accufine 20mg Capsule 10 during pregnancy?

No, you must not take Accufine 20mg Capsule 10 during pregnancy as it can cause severe birth defects. Reliable contraception is required before, during and after treatment.

What if I miss an Accufine 20mg Capsule 10 dose?

If you miss a dose of Accufine 20mg Capsule 10, take it as soon as you remember unless it's almost time for your next dose. Do not double up doses.

Can I drink alcohol while taking Accufine 20mg Capsule 10?

As this medicine may impact blood glucose levels, it's advisable to limit alcohol consumption while taking Accufine 20mg Capsule 10.

How should I store my Accufine 20mg Capsule 10?

Keep your capsules in their original packaging at room temperature, away from heat, light and moisture. Keep out of sight and reach of children and pets.

What are the side effects of Accufine 20mg Capsule 10?

Common side effects of Accufine 20mg Capsule 10 include dryness of skin, lips, and nosebleeds, and skin thinning.

Last Updated On 07 Oct. 2025 | 6:06AM (IST)

Certified Content

Written by

Dr Nikita Lobo

Medical Content Reviewer | 8 years

BDS, MDS

Reviewed by

Dr. Mandeep Chadha

Lead Medical Content Reviewer | 11 years

MBBS, DNB (OBGY)

Check out Editorial Policy

Manufacturer details

Healing Pharma India Pvt Ltd ,411 4th Floor, B wing,Western Edge II,Behind Metro Mall, Western Express Hwy, Borivali East, Mumbai, Maharashtra 400066

Country of origin: INDIA

Expiry on or after: March 2026

In case of any issues, contact us:

support@truemeds.in|09240250346

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

Isotretinoin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00982
Isotretinoin: MedlinePlus drug information. (n.d.). https://medlineplus.gov/druginfo/meds/a681043.html
National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 5282379, Isotretinoin. Retrieved June 18, 2024 from https://pubchem.ncbi.nlm.nih.gov/compound/Isotretinoin
Pile, H. D., & Sadiq, N. M. (2023, May 1). Isotretinoin. StatPearls - NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK525949/
Layton, A. (2009). The use of isotretinoin in acne. Dermato-endocrinology, 1(3), 162–169. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835909/
Isotretinoin 20mg Soft Capsules - Summary of Product Characteristics (SmPC) - (emc). (n.d.). https://www.medicines.org.uk/emc/product/10527/smpc

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We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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