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CompositionTolkem Tablet is primarily used for the symptomatic relief of painful muscle spasms and spasticity. This medicine is a centrally acting skeletal muscle relaxant containing Tolperisone, which works by reducing muscle rigidity and abnormal muscle tone. It is beneficial for managing conditions such as muscle stiffness due to spinal cord injuries, stroke, or multiple sclerosis, and is also used to address acute and chronic pain conditions like low back pain and neck pain.
Tolkem Tablet provides relief from muscle spasms and stiffness caused by spinal cord injuries, stroke, and multiple sclerosis. It also helps manage pain from conditions like low back pain, neck pain, and chronic pain syndromes such as myofascial pain. Additionally, it is useful for controlling spasticity disorders like cerebral palsy in children older than 3 months.
Here's how you should take Tolkem Tablet:
Swallow the tablet whole with a glass of water.
Avoid crushing or chewing the tablet as it may reduce its effectiveness.
Do not exceed the recommended dose without consulting your doctor. Exceeding the dose can lead to unwanted side effects.
It's crucial not to abruptly stop taking this medicine; always consult your doctor before making any changes to your dosage.
Tolkem Tablet is taken orally.
Tolkem Tablet may cause drowsiness, dizziness, fatigue, dry mouth, nausea, abdominal discomfort, and hypotension (low blood pressure).
Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Tolkem Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.
Here are some tips to manage common side effects:
Drowsiness: If Tolkem Tablet makes you feel sleepy during the day, consider taking it at night instead.
Nausea: Try taking Tolkem Tablet with food or milk to help reduce feelings of nausea.
Tolkem Tablet contains tolperisone (150 mg). Here's how it works:
Neuronal Membrane Stabilisation: Tolperisone acts by blocking voltage-gated sodium and calcium channels in neurons. This helps stabilise nerve membranes and reduces their excitability, leading to a decrease in muscle spasms.
Inhibition of Neurotransmitter Pathways: The medicine also inhibits descending noradrenergic and serotonergic pathways that facilitate muscle tone and spinal reflexes. This further assists in relieving muscle spasms without significantly affecting neuromuscular transmission.
By acting through these mechanisms, Tolkem Tablet helps manage painful muscle spasms and spasticity related to various neurological disorders and musculoskeletal conditions.
Tolkem Tablet is contraindicated during pregnancy. If you are pregnant or planning to conceive, ensure to discuss this with your doctor before starting this medicine.
Caution is advised when taking Tolkem Tablet if you are breastfeeding. It's best to consult your doctor before taking this medicine.
The interaction of Tolkem Tablet with alcohol may cause excessive drowsiness and calmness. Therefore, it's recommended to avoid alcohol consumption while on this medication.
If you have liver health issues, it's advisable to discuss them with your doctor before starting Tolkem Tablet. This medicine could affect liver function.
Caution is advised before using Tolkem Tablet if you have a history of kidney problems. Before taking this medicine, it's a good idea to consult your doctor.
Tolkem Tablet may cause drowsiness and dizziness. Therefore, if you are driving or operating machinery, use caution when taking this medication.
If you are allergic to tolperisone or any other ingredients in Tolkem Tablet, avoid using this medicine. Always inform your doctor about your allergies beforehand.
Tolkem Tablet should not be given to children without medical consultation. Always consult your doctor before giving any medicine to a child.
Older patients should take Tolkem Tablet under medical supervision as they may be more susceptible to its side effects. Your doctor will guide you based on your health status.
Tolkem Tablet interacts with the following medicines:
CNS depressants: Taking Tolkem Tablet alongside other medicines that depress the central nervous system, such as benzodiazepines (like diazepam), opioids (like morphine), and tricyclic antidepressants (like amitriptyline), can lead to increased sedation and potential respiratory depression.
CYP1A2 inhibitors: Strong inhibitors of the CYP1A2 isoenzyme, such as fluvoxamine and ciprofloxacin, can increase the levels of tolperisone in your body. This could potentially lead to more pronounced side effects.
Tolkem Tablet doesn't have any known significant interactions with specific foods or beverages.
Tolkem Tablet interacts with the following diseases:
Myasthenia gravis: If you have myasthenia gravis, a condition causing muscle weakness, taking Tolkem Tablet may worsen your symptoms.
Severe renal or hepatic impairment: People with severe kidney or liver conditions should take caution when using Tolkem Tablet as it could potentially exacerbate their conditions.
Arrhythmias or heart failure: If you have irregular heartbeats or heart failure, it's important to exercise caution when taking Tolkem Tablet. It may interact with other medications you're taking for these conditions.
The daily dose of Tolkem Tablet should be taken exactly as directed by your doctor. The dosage can vary depending on individual factors such as the severity of your condition and how well you respond to the medicine. Always stick to your prescribed dosage and never increase it without consulting your doctor.
If too much Tolkem Tablet is consumed, it may lead to symptoms such as drowsiness, confusion, and a drop in blood pressure. In case you experience these symptoms or any other unusual changes, please get in touch with your doctor.
If you forget to take your Tolkem Tablet, simply take it as soon as you remember. But if it's nearly time for your next dose, skip the missed one and continue with your regular schedule. It's important not to double up on doses without your doctor's advice.
Keep Tolkem Tablet in a dry place, safeguarded from light and moisture.
The ideal storage temperature is not exceeding 30°C.
Always store this medicine out of children's reach for safety reasons.
Make sure you use the medicine before its expiry date.
If you're taking Tolkem Tablet to manage muscle spasms or spasticity, incorporating physical activity into your routine could be beneficial. Regular exercise can help enhance mobility and decrease muscle rigidity.
Eating a well-balanced diet is also essential. Nutrients like calcium and vitamin D contribute to maintaining strong bones and muscles, helping to manage conditions like low back pain or myofascial pain syndrome.
| Available Dosage Types | Tablet |
| Habit Forming | No |
| Ailment | Spinal Cord Injury, Stroke, Multiple Sclerosis |
| Drug Category | Centrally Acting Muscle Relaxant |
| Therapeutic Category | Skeletal Muscle Relaxant |
Tolkem Tablet is mainly used to manage painful muscle spasms and stiffness related to neurological disorders and musculoskeletal conditions, improving mobility and comfort.
Tolkem Tablet works by blocking specific paths in the spinal cord and brainstem. This reduces nerve excitability and inhibits reflexes, resulting in muscle relaxation.
Some medicines may interact with Tolkem Tablet, particularly CNS depressants. Always consult your doctor before starting any new medication while taking Tolkem Tablet.
Common side effects include drowsiness, dry mouth, nausea, headache, low blood pressure, and rarely allergic reactions. Most are mild and temporary.
Drinking alcohol while taking Tolkem Tablet can increase the risk of side effects like drowsiness or respiratory depression. It's best to avoid alcohol during treatment.
Tolkem Tablet should be used cautiously in elderly patients, those with heart conditions or a history of drug dependence, and during pregnancy or lactation.
Overdosing on Tolkem Tablet can lead to drowsiness, confusion, low blood pressure, breathing difficulties or even coma. If you suspect an overdose, seek immediate medical attention.
Check out Editorial Policy
Tolperisone: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB06264
Tolperisone - referral | European Medicines Agency. (n.d.). https://www.ema.europa.eu/en/medicines/human/referrals/tolperisone
Quasthoff, S., Möckel, C., Zieglgänsberger, W., & Schreibmayer, W. (2008). Tolperisone: A Typical Representative of a Class of Centrally Acting Muscle Relaxants with Less Sedative Side Effects. CNS Neuroscience & Therapeutics, 14(2), 107–119. https://doi.org/10.1111/j.1527-3458.2008.00044.x
Tekes, K. (2014). Basic aspects of the pharmacodynamics of Tolperisone, a widely applicable centrally acting muscle relaxant. the Open Medicinal Chemistry Journal, 8(1), 17–22. https://doi.org/10.2174/1874104501408010017
Nalamachu, S., Pergolizzi, J., & Kaye, R. (2020). Tolperisone for the Treatment of Acute Muscle Spasm of the Back: Results from the Dose-Ranging Phase 2 STAR Study (NCT03802565) Journal of Pain Research, Volume 13, 3059–3069. https://doi.org/10.2147/jpr.s278857
We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.
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