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Spegra Tablet 30

Emcure Pharmaceuticals Ltd

BOTTLE of 30 Units
STRIP of 10 Units
BOTTLE of 90 Units

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MRP ~~₹4969~~

₹3975.2

₹165.63/Units

20% off

*MRP inclusive of all taxes

100% genuine medicines

Safe & secure payments

15 days Easy returns

Prescription required for this medicine

Store Below 30° C

Composition

Dolutegravir (50 Mg) + Emtricitabine (200 Mg) + Tenofovir Alfenamide (25 Mg)

Spegra Tablet is used to treat HIV-1 infection in adults and children as a complete daily regimen, reducing the amount of virus in the body and helping restore and protect the immune system.

It contains dolutegravir, emtricitabine and tenofovir alafenamide, three antiretroviral medicines that block HIV from multiplying at different stages.

Take it once a day as prescribed, and do not stop or miss doses without medical advice, as this can let the virus become resistant.

Tell your doctor if you also have hepatitis B before use, as stopping this medicine can cause a serious flare of hepatitis. Report unusual muscle pain or weakness, breathlessness, or abdominal pain. Regular blood tests monitor your treatment.

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Spegra Tablet is used to treat HIV-1 infection.

Uses of Spegra Tablet are:

HIV-1 Treatment: Treats HIV-1 infection as a complete regimen.
Viral Load Reduction: Reduces the amount of HIV in the blood.
Immune Support: Helps restore and protect the immune system.

Take this tablet with or without food.
Swallow the tablet whole with water; do not crush or chew it.
Always follow your doctor’s prescribed dosage instructions.

Spegra Tablet is taken orally.

Spegra Tablet may cause some side effects that are usually mild and go away as your body adjusts to the medicine.

A few common side effects of Spegra Tablet are:

Nervous System: Headache, difficulty sleeping and fatigue.
Digestive: Feeling sick (nausea), diarrhoea and abdominal pain in some people.

If side effects do not improve or become serious, speak to your doctor right away.

Management Of Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Spegra Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor. Here are some general guidelines for managing common side effects:

Headache: Stay hydrated and rest in case of headache.
Nausea: Take the tablet with food to prevent nausea.
Diarrhea: Stay hydrated by drinking fluids.

Spegra Tablet works by combining three components:

Dolutegravir (50 mg): It inhibits the action of integrase, an enzyme essential for the HIV virus to multiply and spread. By blocking this enzyme, it prevents the virus from integrating its genetic material into healthy human cells.
Emtricitabine (200 mg): A reverse transcriptase inhibitor, Emtricitabine blocks the enzyme that HIV uses to convert its RNA into DNA. This prevents the virus from creating new copies of itself.
Tenofovir Alafenamide (25 mg): It hinders the virus's ability to incorporate itself into healthy cells, effectively stopping the spread of HIV in the body.

Pregnancy

Spegra Tablet is not recommended during pregnancy unless deemed essential by a healthcare provider, as some components may harm the developing baby.

Breastfeeding

Avoid breastfeeding while taking Spegra Tablet due to the risk of passing this medication to the baby through breast milk.

Alcohol

Avoid alcohol while taking Spegra Tablet, as it may exacerbate side effects like nausea or dizziness.

Liver

Use Spegra Tablet cautiously if you have existing liver disease, including hepatitis B or C. Regular liver function tests may be required. Your doctor will guide you based on your health status.

Kidney

This tablet is not recommended for individuals with severe renal impairment. Inform your doctor before this tablet is prescribed to you.

Use In Driving And Operating Machinery

Spegra Tablet may cause dizziness or fatigue. Avoid driving or operating machinery until you know how it affects you.

Allergy

Do not use this medication if you are allergic to any of its components, including dolutegravir, emtricitabine, or tenofovir. Symptoms of an allergic reaction include rash, fever, or swelling.

Children

This tablet is not recommended for children weighing less than 40 kg. Your doctor will guide you on dosage depending on your child’s age and weight.

Older Patients

Elderly patients may be more susceptible to side effects. Dose adjustments may be required. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Spegra Tablet can interact with the following medications:

Antiarrhythmic such as Dofetilide: Spegra Tablet is contraindicated with dofetilide due to the risk of severe side effects, such as life-threatening arrhythmias.
Antibiotics such as Rifampin: This medicine can reduce the effectiveness of dolutegravir by lowering its concentration in the blood.
Anticonvulsants such as Carbamazepine and Phenobarbital: These medicines can also reduce the blood levels of the active ingredients in Spegra Tablet, potentially diminishing its effectiveness.

Drug-Food Interactions

There are no specific food restrictions for Spegra Tablet.

Drug-Disease Interactions

Spegra Tablet can interact with the following conditions:

Kidney or Liver Impairment: Use Spegra Tablet cautiously in patients with kidney or liver problems, as these conditions can affect how the medication is processed in the body. Regular monitoring of liver and kidney function is recommended.

Daily Dose

The daily dose of Spegra Tablet should be taken as advised by your doctor. The dosage may vary based on factors such as the severity of your condition and how you respond to the medicine. Always follow the dosage prescribed by your doctor and avoid exceeding it without consultation.

Over Dose

If more than the recommended dose is taken, seek medical attention immediately. Symptoms of overdose may include dizziness, nausea, or increased side effects.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is close to your next dose, skip the missed dose. Do not double the dose.

Store at room temperature (15°C-30°C) away from direct sunlight and moisture.
Keep out of reach of children.

Fact Box

Dosage Forms Available	Tablet
Habit Forming	No
Ailment	HIV-1 Infection
Drug Category	Antiretroviral
Therapeutic Category	HIV Treatment

What is Spegra Tablet used for?

Spegra Tablet is primarily used to treat HIV-1 infection in adults and adolescents weighing at least 40 kg. It helps control the virus, reducing the viral load and boosting immune function.

How does Spegra Tablet work?

Spegra Tablet contains three active ingredients—Dolutegravir, Emtricitabine, and Tenofovir Alafenamide—that work together to inhibit the replication and spread of HIV within the body. By targeting different stages of the viral life cycle, this combination effectively suppresses the virus.

Are there any precautions for Spegra Tablet?

This tablet should be used cautiously in patients with liver or kidney issues. Pregnant women and breastfeeding mothers should avoid using Spegra Tablet unless specifically prescribed by their doctor.

Can Spegra Tablet interact with other medicines?

Yes, it interacts with medicines like dofetilide, rifampin, and anticonvulsants. Inform your doctor about all current medications.

What are the side effects of Spegra Tablet?

Common side effects include headache, nausea, diarrhoea, and abdominal pain. Serious side effects like liver damage or hypersensitivity reactions are rare but require immediate medical attention.

Last Updated On 28 Aug. 2026 | 11:18AM (IST)

Certified Content

Written by

Dr. Sachin Singh

Medical Team Lead & Reviewer | 7 years

MBBS

Reviewed by

Dr. Mandeep Chadha

Lead Medical Content Reviewer | 12 years

MBBS, DNB (OBGY)

Check out Editorial Policy

Manufacturer details

Emcure House, T 184, M.I.D.C. Bhosari, Pune 411026

Country of origin: INDIA

Expiry on or after: February 2027

In case of any issues, contact us:

support@truemeds.in|09240250346

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

Dolutegravir, Emtricitabine and Tenofovir Alafenamide tablets. Fda.Gov. Retrieved December 30, 2024, from https://www.accessdata.fda.gov/drugsatfda_docs/pepfar/210237PI.pdf
DOLUTEGRAVIR, EMTRICITABINE and TENOFOVIR tablets. Fda.Gov. Retrieved December 30, 2024, from https://www.accessdata.fda.gov/drugsatfda_docs/pepfar/213681PI.pdf
Dolutegravir, Emtricitabine and Tenofovir Alafenamide Tablets. Gov.Et. Retrieved December 30, 2024, from http://www.efda.gov.et/wp-content/uploads/2023/12/Dolutegravir-Emtricitabine-Tenofovir-Alafenamide-Tablets-50-mg-200-mg-25-mg.pdf

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Disclaimer

We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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Intellihealth Solutions Private Limited

Unit-301 & 304, Lightbridge Tunga Village, Saki Vihar Rd, Chandivali, Powai, Mumbai, Maharashtra, India, 400072.

CIN: U62099MH2019PTC320566

Telephone:09240250346

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