Strip of 10 Units
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CompositionProvanol Plus 10 Tablet is used to prevent migraines by reducing the frequency, severity, and duration of migraine attacks. It combines propranolol and flunarizine to stabilise blood vessels and brain activity.
This medicine is not intended for treating acute migraine attacks. Take it regularly as prescribed. Inform your doctor about heart conditions or depression, and continue treatment consistently for long-term migraine prevention.
Provanol Plus 10 Tablet is used for the prevention and management of migraine headaches. It helps reduce the frequency, duration, and severity of common migraines and is also effective in managing classical migraines that may be associated with aura or sensory disturbances. This tablet is commonly prescribed as a preventive therapy for migraine with aura to help reduce the occurrence of future episodes.
Swallow the tablet whole with a glass of water.
Do not crush or chew the tablet as it is designed for sustained release.
Take this medicine regularly at the same time each day.
Always use this medicine as per your doctor's instructions. For specific advice tailored to your condition, consult your doctor.
Provanol Plus 10 Tablet is taken orally.
Provanol Plus 10 Tablet may cause fatigue, drowsiness, dry mouth or throat, and gastrointestinal disturbances such as nausea, diarrhoea, or constipation. Some people may also experience insomnia, low mood or depression, slow heart rate (bradycardia), and gradual weight gain. These effects vary from person to person. If any of these symptoms persist or worsen, consult your healthcare provider.
Gastrointestinal distress: Try taking Provanol Plus 10 Tablet with food to lessen this effect.
Insomnia: Consider taking this medicine at night if it interferes with your sleep.
Provanol Plus 10 Tablet comprises two active components:
Flunarizine (10 mg): As a selective calcium channel blocker with antihistamine properties, flunarizine enhances cerebral blood flow and affects the vascular system. It inhibits blood vessel contraction which is considered a contributor to migraine pain.
Propranolol (40 mg): This non-selective beta-adrenergic receptor blocking agent has anti-adrenergic effects and helps regulate blood vessel dilation. By doing so, propranolol increases the migraine threshold and reduces stimuli that may trigger attacks.
The combined action of these two components provides a comprehensive approach to migraine prevention.
Provanol Plus 10 Tablet is not recommended during the later stages of pregnancy. If you are pregnant or planning to conceive, discuss this with your doctor before starting this medicine.
Both flunarizine and propranolol are excreted in breast milk. Therefore, breastfeeding is not advised while taking Provanol Plus 10 Tablet, unless your doctor deems it necessary.
You should be cautious while consuming alcohol during treatment with Provanol Plus 10 Tablet as it might enhance the effects of the medicine and increase drowsiness and dizziness.
If you have liver problems, caution is advised while taking Provanol Plus 10 Tablet. This medication is contraindicated for severe liver diseases. Discuss your liver health with your doctor before starting this medicine.
If you have a history of kidney problems, it is advisable to consult your doctor before taking Provanol Plus 10 Tablet.
Provanol Plus 10 Tablet might cause drowsiness or dizziness. It is recommended that you refrain from driving or operating heavy machinery until you know how this medication affects you.
If you are allergic to flunarizine, propranolol, or any other components of Provanol Plus 10 Tablet, avoid using this medication. Contact your doctor for an alternative prescription.
Always consult your doctor before giving this medicine to a child as it may not be safe.
Older patients should take Provanol Plus 10 Tablet under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age. Your doctor will guide you based on your health status.
Sedatives: Flunarizine in this medication can enhance the effects of sedatives like diazepam and lorazepam.
Antidepressants: Flunarizine may amplify the effects of antidepressants such as fluoxetine and sertraline.
Antihypertensives: Propranolol may interact with antihypertensives like amlodipine and lisinopril, potentially enhancing their blood pressure-lowering effects.
Antiarrhythmics: Medicines like amiodarone and digoxin may interact with Propranolol, leading to altered medicine action or increased risk of side effects.
NSAIDs: Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) like ibuprofen can reduce the blood pressure-lowering effect of Propranolol.
Consumption of fatty foods can increase the absorption of Propranolol.
Liver disease: People with severe liver impairment should take care as this medicine could exacerbate their condition.
Cardiac conditions: Significant bradycardia, heart block, or cardiac failure might get worsened by this medicine.
Respiratory conditions: Bronchial asthma and chronic obstructive pulmonary disease patients should exercise caution while using this medicine.
You should take the Provanol Plus 10 Tablet as instructed by your doctor. The dosage might change based on your personal health condition and how you respond to the medicine. It's crucial to adhere to your prescribed dosage and never exceed it without a consultation with your doctor.
If you accidentally take more Provanol Plus 10 Tablets than prescribed, you might feel unusually tired, dizzy, or experience dry mouth. If these symptoms persist or worsen, it's important to inform your doctor.
If you forget to take your Provanol Plus 10 Tablet, take it as soon as you remember. However, if it's nearly time for your next dose, skip the forgotten one and continue with your regular schedule. Do not increase your dose without consulting your doctor.
Store Provanol Plus 10 Tablet in a cool, dry and dark place.
The ideal storage temperature is between 15°C and 30°C.
Keep the container tightly closed to protect from moisture.
It's important to keep this medicine out of reach of children.
Always check the expiry date before using the medicine.
Since Provanol Plus 10 Tablet is used for managing migraines, try to identify and avoid your migraine triggers such as certain foods, drinks, or stress.
Regular exercise can help reduce the frequency of migraines by relieving tension and promoting better sleep. Aim for at least 150 minutes of moderate aerobic activity or 75 minutes of vigorous activity weekly.
| Available Dosage Types | Tablet |
| Habit Forming | No |
| Ailment | Migraine Headaches |
| Drug Category | Calcium Channel Blocker, Beta-Blocker |
| Therapeutic Category | Anti-Migraine |
Provanol Plus 10 Tablet is used to prevent and manage migraine headaches, reducing their frequency, duration, and severity.
The medicine contains flunarizine and propranolol, which work together to improve cerebral blood flow and regulate the dilation of blood vessels, helping to prevent migraines.
You should swallow one tablet whole, once daily at night. It can be taken with or without food. Regularity in timing is important.
Common side effects include fatigue, dizziness, dry mouth, gastrointestinal distress, insomnia, slow heart rate and weight gain. Serious side effects are rare.
It's recommended to avoid this medication during pregnancy and breastfeeding unless deemed necessary by your doctor due to potential risks.
Yes, it may interact with other medications including antihypertensives, antiarrhythmics, NSAIDs and certain enzyme-metabolised medicines. Consult your doctor for more information.
If you overdose, seek immediate medical attention. Symptoms may include severe low blood pressure, slow heart rate, heart blockages, bronchospasm or seizures.
Check out Editorial Policy
AA PHARMA INC. (2010). PRODUCT MONOGRAPH FLUNARIZINE. https://www.aapharma.ca/downloads/en/PIL/2016/Flunarizine-PM.pdf
Flunarizine: uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB04841
Wyeth. (n.d.). Inderal. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/016418s080,016762s017,017683s008lbl.pdf
Propranolol: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00571
Raybarman, C. & India National Academy of Medical Sciences, Pediatric & Neurology Care Clinic. (2016). The efficacy of combined low-doses of propranolol and flunarizine in episodic migraine. In East J Med (Vol. 21, Issue 2, pp. 75–78). https://jag.journalagent.com/ejm/pdfs/EJM_21_2_75_78.pdf
Panigrahi, M., Marndi, G., & Beshra, S. (2022). Efficacy of propranolol plus flunarizine combination and valproate monotherapy in migraine prophylaxis in a tertiary care teaching hospital in Western Odisha. International Journal of Health Sciences (IJHS) (En LíNea), 13350–13354. https://doi.org/10.53730/ijhs.v6ns2.8588
Koshy, M. T., & Joseph, L. (2020). A prospective study of propranolol and flunarizine in the prophylactic therapy of migraine in a tertiary care hospital. Research Journal of Pharmacy and Technology, 13(5), 2159. https://doi.org/10.5958/0974-360x.2020.00388.1
We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.
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