Pioglar Mf 15/500 MG Tablet Er 10

Ranbaxy Laboratories Ltd

Pack of 10 Units

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Composition

Metformin (500 Mg) + Pioglitazone (15 Mg)

Pioglar Mf 15/500 MG Tablet Er 10 is used to manage type 2 diabetes mellitus in adults when lifestyle modifications alone are not sufficient for controlling blood glucose levels. It is a combination medicine that belongs to the class of oral antidiabetic medications.

This medicine helps improve glycemic control by lowering both fasting and postprandial (after meal) blood glucose concentrations. It is particularly useful when monotherapy with a single antidiabetic medicine proves inadequate for achieving optimal blood sugar control in patients with insulin resistance and defective insulin secretion.

You should take this medicine exactly as directed by your doctor, who will determine the appropriate dosage based on your individual needs. Before starting this medicine, inform your doctor about any pre-existing conditions or ongoing medications you might be taking. If you notice any side effects while using this medicine, inform your doctor immediately. Continue taking the medicine for the full duration prescribed by your doctor for best results.

Pioglar Mf 15/500 MG Tablet Er 10 is used for the following:

Management of type 2 diabetes mellitus
Control of blood glucose levels
Treatment when lifestyle changes are insufficient
Second-line treatment after monotherapy fails
Reduction of insulin resistance
Improvement of glucose utilisation
Lowering of fasting blood glucose concentrations
Prevention of diabetic complications

Follow these instructions while taking Pioglar Mf 15/500 MG Tablet Er 10:

Swallow the tablet whole with a glass of water.
Do not break, crush, or chew the tablet as it is an extended-release formulation.
Take this medicine regularly at the same time each day.
Do not stop taking this medicine suddenly without consulting your doctor.
If you miss taking your medicine, consult your doctor for advice.

Pioglar Mf 15/500 MG Tablet Er 10 is taken orally.

Pioglar Mf 15/500 MG Tablet Er 10 may have the following common side effects:

Nausea
Diarrhoea
Abdominal pain
Headache
Oedema: This refers to fluid retention or swelling, typically noticeable in your ankles, feet, or hands.
Upper respiratory tract infection: This includes common conditions like the common cold, affecting your nose, throat, and airways.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Pioglar Mf 15/500 MG Tablet Er 10. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor. Here are some general guidelines for managing common side effects:

Nausea: Taking Pioglar Mf 15/500 MG Tablet Er 10 with meals can help reduce feelings of sickness.
Diarrhoea: Try taking this medicine with food to lessen this digestive disturbance.

Pioglar Mf 15/500 MG Tablet Er 10 contains two active ingredients that work together to control blood glucose levels:

Pioglitazone (15 mg): Acting as a peroxisome proliferator-activated receptor-gamma (PPAR-γ) agonist, it improves insulin sensitivity in fat tissue, skeletal muscle, and the liver, enabling your body to use insulin more efficiently.
Metformin (500 mg): This is a biguanide that enhances insulin sensitivity in peripheral tissues such as muscles, allowing your cells to absorb and use glucose more effectively.

Pregnancy

Take care while taking Pioglar Mf 15/500 MG Tablet Er 10 if you are pregnant. It is ideal to discuss with your doctor before taking this medicine.

Breastfeeding

Be careful while taking Pioglar Mf 15/500 MG Tablet Er 10 if you are breastfeeding. Both metformin and pioglitazone can pass into breast milk. It is best to talk with your doctor before taking this medicine.

Alcohol

Avoid alcohol while taking Pioglar Mf 15/500 MG Tablet Er 10. Combining alcohol with this medicine may increase your risk of developing lactic acidosis (a condition where there's too much acid in your blood) and low blood sugar.

Liver

Pioglar Mf 15/500 MG Tablet Er 10 should be used carefully if you have mild to moderate liver issues. Regular monitoring of liver function may be needed during treatment.

Kidney

Care is advised before using Pioglar Mf 15/500 MG Tablet Er 10 if you have a history of kidney problems. This medicine contains metformin, which is removed from your body by your kidneys. It is a good idea to discuss this with your doctor before taking it.

Using Machines & Driving

You may drive and use machines while taking Pioglar Mf 15/500 MG Tablet Er 10. However, if you experience dizziness or low blood sugar symptoms, avoid these activities until you feel better.

Allergy

Inform your doctor about any previous allergic reactions to metformin, pioglitazone, or other medicines. Stop taking this medicine and seek immediate medical help if you develop a rash, itching, swelling, or breathing difficulties.

Children

Pioglar Mf 15/500 MG Tablet Er 10 is not recommended for children as it is meant for managing type 2 diabetes in adults. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should take Pioglar Mf 15/500 MG Tablet Er 10 under medical supervision, as they may be more sensitive to side effects. They might also have liver and kidney issues and might be on other medications.

Drug-Drug Interactions

Pioglar Mf 15/500 MG Tablet Er 10 interacts with the following medicines:

Cationic medicines: Medications like amiloride, digoxin, and morphine may reduce metformin elimination, potentially increasing the risk of side effects.
Carbonic anhydrase inhibitors: Medicines such as topiramate and zonisamide can increase your risk of lactic acidosis (dangerous acid buildup in your blood) when taken with Pioglar Mf 15/500 MG Tablet Er 10.
CYP2C8 inhibitors: Medicines like gemfibrozil may enhance pioglitazone exposure in your body, potentially increasing side effects.
Insulin or insulin secretagogues: Using these with Pioglar Mf 15/500 MG Tablet Er 10 can increase your risk of hypoglycaemia (low blood sugar).

Drug-Disease Interactions

Pioglar Mf 15/500 MG Tablet Er 10 interacts with the following diseases:

Kidney impairment: This medicine is not recommended if you have severe kidney problems (eGFR below 30 ml/min/1.73m²) due to the increased risk of lactic acidosis.
Liver impairment: Use with caution if you have liver problems as it may affect how your body processes the medicine.
Congestive heart failure: The Pioglitazone component may worsen fluid retention in patients with heart failure.
Metabolic acidosis: This medicine is not recommended if you have this condition, as it may worsen the acid imbalance.

Daily Dose

The daily dose of Pioglar Mf 15/500 MG Tablet Er 10 should be taken as prescribed by your doctor. Your dosage may vary based on your blood glucose levels and how well you respond to treatment. Never change your dose without consulting your doctor.

Over Dose

Taking more than the prescribed dosage of Pioglar Mf 15/500 MG Tablet Er 10 may cause stomach discomfort, nausea, vomiting, diarrhoea, excessive hunger, sweating, and dizziness. You might also experience swelling in your legs and ankles. Contact your doctor if these symptoms occur.

Missed Dose

If you forget to take Pioglar Mf 15/500 MG Tablet Er 10, take it as soon as you remember. If it's almost time for your next dose, skip the missed one and continue with your regular schedule. Never double your dose to make up for a missed one.

Store Pioglar Mf 15/500 MG Tablet Er 10 at room temperature (below 30°C).
Keep the tablets in their original container and protected from light and moisture.
Store in a dry place away from direct heat or sunlight.
Keep all medicines out of sight and reach of children.
Do not use this medicine after the expiry date printed on the packaging.

Follow a low-carbohydrate diet with plenty of vegetables, whole grains, and lean proteins to help manage your blood glucose levels and improve insulin sensitivity.
Engage in regular physical activity, such as brisk walking for 30 minutes daily. Exercise helps your body use glucose more effectively and reduces insulin resistance.

Fact Box

Available Dosage Types	Tablet ER
Habit Forming	No
Ailment	Type 2 diabetes
Drug Category	Insulin sensitiser
Therapeutic Category	Anti-diabetic medication

What is Pioglar Mf 15/500 MG Tablet Er 10 used for?

Pioglar Mf 15/500 MG Tablet Er 10 is used to manage type 2 diabetes when diet, exercise, or single medicines alone don't control your blood sugar levels adequately.

How does Pioglar Mf 15/500 MG Tablet Er 10 work?

It works through two mechanisms: metformin reduces glucose production in your liver, while pioglitazone helps your body use insulin more effectively.

Can I stop taking Pioglar Mf 15/500 MG Tablet Er 10 after I feel better?

No, don't stop taking this medicine even if you feel better. Stopping suddenly can cause your blood sugar levels to rise dangerously.

What are the common side effects of Pioglar Mf 15/500 MG Tablet Er 10?

Common side effects include stomach discomfort, nausea, diarrhoea, headache, and mild swelling. Most side effects typically improve with time.

Can I take Pioglar Mf 15/500 MG Tablet Er 10 during pregnancy?

The safety during pregnancy isn't fully established. Consult your doctor if you're pregnant or planning pregnancy before taking this medicine.

Should I take Pioglar Mf 15/500 MG Tablet Er 10 with or without food?

Take this medicine with meals. This helps reduce stomach-related side effects and improves how your body absorbs the medicine.

What should I do if I miss a dose of Pioglar Mf 15/500 MG Tablet Er 10?

Take the missed dose as soon as you remember. If it's nearly time for your next dose, skip the missed dose and continue with your regular schedule.

Last Updated On 16 May. 2025 | 10:19AM (IST)

Certified Content

Written by

Ashmita Borgohain

Medical Content Writer | 13 years

MSc (Applied Genetics)

Reviewed by

Dr. Meenakshi Maruwada

Medical Content Writer | 9 years

BDS, PGCAD, GMHE (IIM-B)

Check out Editorial Policy

Manufacturer details

A-41 Industrial Area Phase VIII-A SAS Nagar PB 160071 IN ,

Country of origin: INDIA

Expiry on or after: March 2026

In case of any issues, contact us:

support@truemeds.in|09240250346

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

Ceriello, A., Johns, D., Widel, M., Eckland, D. J., Gilmore, K. J., & Tan, M. H. (2005). Comparison of effect of pioglitazone with metformin or sulfonylurea (monotherapy and combination therapy) on postload glycemia and composite insulin sensitivity index during an oral glucose tolerance test in patients with type 2 diabetes. Diabetes Care, 28(2), 266-272.https://doi.org/10.2337/diacare.28.2.266
Kaku, K. (2009). Efficacy and safety of therapy with metformin plus pioglitazone in the treatment of patients with type 2 diabetes: a double-blind, placebo-controlled clinical trial. Current Medical Research and Opinion, 25(5), 1111-1119. https://doi.org/10.1185/03007990902820816
Pioglitazone: MedlinePlus drug information. (2024, December 15). MedlinePlus - Health Information from the National Library of Medicine. https://medlineplus.gov/druginfo/meds/a699016.html
Metformin - StatPearls - NCBI bookshelf. (2023, August 17). National Center for Biotechnology Information. https://www.ncbi.nlm.nih.gov/books/NBK518983/

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