Napra D 500 Tablet 10

Intas Pharmaceuticals Ltd

Strip of 10 Units

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Old MRP ₹129

MRP ~~₹120.94~~

₹96.75

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Prescription required for this medicine

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Composition

Domperidone (10 Mg) + Naproxen (500 Mg)

Napra-D 500 Tablet is used to prevent and relieve migraine headaches. It combines an anti-inflammatory pain reliever (NSAID) and an anti-emetic agent to reduce headache pain, nausea, and other migraine-related symptoms.

It is used as the first line of treatment for mild-moderate migraine headaches. It is also used in the reduction of pain and inflammation. It helps to reduce nausea and vomiting.

Inform your doctor duly about any pre-existing diseases and mention all the medicines. Your doctor will carefully review and decide regarding the dosage & frequency of use of Napra-D 500 Tablet.

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Napra-D 500 Tablet is used for:

Treatment and prevention of migraines

Take the Napra-D 500 Tablet with one whole glass of water.
Swallow the Napra-D 500 Tablet as a whole; do not open, crush, or chew it.
Napra-D 500 Tablet is recommended to be taken after meals.

Napra-D 500 Tablet has to be taken orally.

Common side effects of Napra-D 500 Tablet include:

Swelling on ankle/feet
Unusual tiredness
Mood changes
Hot flashes
Confusion
Headache
Ringing in the ears
Changes in sight

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the Napra-D 500 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Napra-D 500 Tablet comprises the following components:

Naproxen sodium (500 mg): It is a non-selective, non-steroidal anti-inflammatory agent that reduces prostaglandin synthesis through inhibition of COX1 and COX2 enzymes. The COX2 enzyme is responsible for the antipyretic, analgesic, and anti-inflammatory effects of naproxen.
Domperidone (10 mg): It is an anti-emetic agent that delays the gastrointestinal emptying. It is a prokinetic which shows the action by blocking dopamine receptors. The dopamine receptor blocking property is responsible for the antiemetic property of domperidone.

Pregnancy

Be cautious about the use of Napra-D 500 Tablet in pregnant women. It is not recommended to use Napra-D 500 Tablet in pregnancy. If the medicine is required to be taken, then consult your doctor before use.

Breastfeeding

It is safe to use the Napra-D 500 Tablet for breastfeeding. Please consult your doctor before use and advice.

Alcohol

It is recommended to avoid alcohol while taking this medication as consuming Napra-D 500 Tablet with alcohol can cause the risk of bleeding, ulcers, holes in the esophagus, an increase in heart rate, and dizziness.

Liver

Be cautious about the use of Napra-D 500 Tablet in persons suffering from liver diseases. Consult your doctor before using it in case you suffer from liver disease.

Kidney

Be cautious about using Napra-D 500 Tablet in persons suffering from kidney diseases. Consult your doctor before using it in case you suffer from kidney disease.

Using Machines & Driving

If you are allergic to domperidone, naproxen sodium, and other constituents of Napra-D 500 Tablet, then do not use it. If you previously had an undesirable experience, do not use the Napra-D 500 Tablet.

Allergy

It is best to avoid using machines and driving as drowsiness and sleepiness may occur after intake of Napra-D 500 Tablet.

Children

Napra-D 500 Tablet is suitable for children over twelve years of age. Please consult your doctor before giving this medicine to children.

Older Patients

Use the Napra-D 500 Tablet with caution in elderly people with liver, kidney, and cardiac diseases. Dosage adjustments may be required. Your doctor will check your history of illnesses, health and current body status and prescribe it accordingly.

Drug-Drug Interactions

Napra-D 500 Tablet can interact with drugs, including:

Anticoagulants such as warfarin. The effect of warfarin may be reduced upon the use of Napra D 500 Tablet.
NSAIDs such as ketorolac. NSAIDs may interact with the Napra-D 500 Tablet and may increase the risk of side effects of the Napra-D 500 Tablet.
Angiotensin-converting enzyme (ACE) inhibitors such as ramipril. ACE inhibitors may interact with Napra-D 500 Tablet and may increase the risk of kidney injury.
Corticosteroids such as prednisolone. Corticosteroids may interact with the Napra-D 500 Tablet and increase the risk of ulceration, bleeding, and inflammation.
Aminoglycoside antibiotics such as amikacin. Aminoglycoside antibiotics may interact with Napra-D 500 Tablet and may increase the risk of kidney injury.
Antiarrhythmic medicines such as quinidine may interact with the Napra-D 500 Tablet and decrease the effect of the quinidine.

Drug-Disease Interactions

Napra-D 500 Tablet can interact with diseases, including:

Allergy: It may worsen upon the use of Napra-D 500 Tablet.
Kidney disease: It may worsen upon the use of Napra-D 500 Tablet.
Asthma: It may worsen upon the use of Napra-D 500 Tablet.
Heart disease: It may worsen upon the use of Napra-D 500 Tablet.
Liver disease: It may worsen upon the use of Napra-D 500 Tablet.

Daily Dose

The daily dose of Napra-D 500 Tablet should be taken as prescribed by your doctor. The dosage may change based on individual factors such as the severity of the condition and response to treatment. It is essential to follow the prescribed dosage and not exceed it without consulting your doctor.

Over Dose

If you or someone else takes an excessive amount of Napra-D 500 Tablet by accident, it is essential to get immediate medical attention from your doctor or nearby hospital. The overdose symptoms for Napra-D 500 Tablet are extreme tiredness, drowsiness, stomach pain, heartburn, nausea, vomiting, sleepiness, uncontrolled eye movements, unusual movements of the tongue, and abnormal posture.

Missed Dose

If you forget to take Napra-D 500 Tablet, take it as soon as you remember. If the time for the next dosage is close, skip the missed one and resume your regular dosage pattern. Only increase your dosage after consulting your doctor.

Store Napra-D 500 Tablet at room temperature between 15-25ºC.
Protect Napra-D 500 Tablet from light and moisture.
Keep Napra-D 500 Tablet away from children.
Do not use the Napra-D 500 Tablet after the expiry date has passed.

Avoid skipping meals, as irregular eating patterns can contribute to migraines.
Practice stress-relief techniques like meditation, yoga, deep breathing, and mindfulness to reduce migraine triggers.
Try sleeping in a dark room during the migraine episodes.
Maintain a consistent sleep schedule and ensure you get enough restorative sleep each night.
Engage in regular physical activity, but avoid excessive exertion, especially during a migraine attack.
Apply a cold compress or ice pack to your forehead for about 15 minutes to ease pain and reduce blood vessel dilation.
Apply gentle pressure to specific points on your head, neck, and shoulders that are known to relieve headaches and migraine pain.

Fact Box

Available Dosage Types	Tablet
Habit Forming	No
Ailment	Migraine Headache
Drug Category	Non-steroidal anti-inflammatory drugs (NSAIDs) and anti-emetics
Therapeutic Category	Migraine

What is the full form of the Napra-D 500 Tablet?

The Napra-D 500 Tablet is a combination tablet. It is composed of naproxen sodium, and domperidone.

Does Napra-D 500 Tablet affect the kidney?

Caution is required while using the Napra-D 500 Tablet. Care should be observed in case of any kidney diseases. Consult your doctor before use and advice.

Does Napra-D 500 Tablet make you sleepy?

Napra-D 500 Tablet may cause sleepiness. Do not indulge in activities that require your focus and attention.

What category is the Napra-D 500 Tablet?

Napra-D 500 Tablet belongs to the category of analgesic and prokinetic medicines. It is used to relieve pain in migraine headaches, pain in arthritis, gout, dysmenorrhoea, strain, and sprains.

Is Napra-D 500 Tablet a steroid?

No, Napra-D 500 Tablet is not a steroid. It is a particular analgesia that is used for the prevention of migraine headaches.

Last Updated On 27 Oct. 2025 | 8:59AM (IST)

Certified Content

Written by

Dr. Sachin Singh

Medical Team Lead & Reviewer | 6 years

MBBS

Reviewed by

Dr. Mandeep Chadha

Lead Medical Content Reviewer | 11 years

MBBS, DNB (OBGY)

Check out Editorial Policy

Manufacturer details

Corporate House, Near Sola Bridge, S. G. Highway, Thaltej, Ahmedabad 380054, Gujarat, India

Country of origin: INDIA

Expiry on or after: February 2026

In case of any issues, contact us:

support@truemeds.in|09240250346

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

Naproxen 500 mg tablets - Patient Information Leaflet (PIL) - (emc). (n.d.). Org. uk. (Retrieved January 11, 2024), from https://www.medicines.org.uk/emc/product/543/pil.
Holder, M. A. (2018). Naproxen 250mg, 375mg and 500mg Gastro-resistant tablets. Simplymedsonline.co.uk. https://www.simplymedsonline.co.uk/storage/otherdocuments/naproxen_pil.pdf
Domperidone 10mg Tablets - Patient Information Leaflet (PIL) - (EMC). (n.d.). Org. uk. (Retrieved January 11, 2024), from https://www.medicines.org.uk/emc/product/556/pil
Durbin, K. (n.d.). Naproxen. Drugs.com. https://www.drugs.com/naproxen.html.
Naproxen. (n.d.). Medlineplus.gov. MedlinePlus drug information. (n.d.). MedlinePlus - Health Information from the National Library of Medicine. https://medlineplus.gov/druginfo/meds/a681029.html
Domperidone. (n.d.). DrugBank Online | Database for Drug and Drug Target Info. https://go.drugbank.com/drugs/DB01184

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Disclaimer

We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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CIN: U62099MH2019PTC320566

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