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Prescription required for this medicine
Store Below 30° C
CompositionLobula 0.5 Tablet is used to manage type 2 diabetes mellitus in adults when diet and exercise are insufficient for blood sugar control. As a thiazolidinedione (TZD), it improves insulin sensitivity to prevent long-term complications.
This treatment helps maintain steady glucose levels, reducing the risk of damage to your heart and kidneys. Take the tablet exactly as prescribed by your doctor and report any side effects promptly for safe management.
Lobula 0.5 Tablet is used for the following:
Managing type 2 diabetes mellitus in adults
Improving blood sugar control
Enhancing insulin sensitivity in the body
Reducing high blood glucose levels
Preventing long-term diabetes complications
Supporting patients when diet and exercise are not enough
Improving glucose uptake in muscle and fat cells
Complementing lifestyle modifications for diabetes management
Follow these instructions while taking Lobula 0.5 Tablet:
Swallow the tablet whole with a glass of water.
Do not crush, break, or chew the tablet.
Take this medicine at the same time each day.
Lobula 0.5 Tablet is taken orally.
Lobula 0.5 Tablet may have the following common side effects:
Peripheral oedema: Swelling in your legs and ankles due to fluid retention
Weight gain
Fatigue
Upper respiratory tract infections
Headaches
Most side effects are temporary and generally harmless and are resolved by discontinuing the use of Lobula 0.5 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.
Here are some general guidelines for managing common side effects:
Fatigue: Taking this medicine at bedtime may help reduce feelings of tiredness during the day.
Peripheral oedema: Taking the medicine with meals can sometimes help minimise fluid retention and swelling.
Lobula 0.5 Tablet contains lobeglitazone sulphate (0.5 mg), which works on the body as follows:
PPARγ activation: Lobeglitazone binds to and activates peroxisome proliferator-activated receptor gamma (PPARγ), a type of nuclear receptor found mainly in fat tissue that regulates how cells use glucose.
Insulin sensitivity enhancement: It increases how well your body's cells respond to insulin, particularly in muscle and fat tissues, allowing them to take up glucose from your bloodstream more efficiently.
Blood sugar reduction: By improving insulin binding at cellular receptors, the medicine helps lower blood glucose levels and decreases haemoglobin A1c (HbA1c), a marker that shows average blood sugar over the past two to three months.
Metabolic improvements: Beyond glucose control, it positively affects lipid profiles and liver function markers, contributing to overall metabolic health.
Caution is advised while taking Lobula 0.5 Tablet if you are pregnant. It is best to consult your doctor before taking this medicine.
Caution is advised while taking Lobula 0.5 Tablet during breastfeeding. It is best to consult your doctor before taking this medicine.
Avoid consuming alcohol while taking Lobula 0.5 Tablet. Alcohol may worsen liver-related side effects or interfere with blood glucose control. Avoid or limit alcohol consumption while on this medicine.
Lobula 0.5 Tablet is contraindicated in patients with active or severe liver disease. If you have any liver-related issues, consult your doctor for monitoring during treatment.
Caution is advised before using Lobula 0.5 Tablet if you have a history of kidney problems. It is a good idea to consult your doctor before taking this medicine.
You may experience fatigue while taking Lobula 0.5 Tablet. If you feel dizzy or tired, avoid driving or operating heavy machinery until you feel better.
If you have a history of hypersensitivity to lobeglitazone sulphate or any ingredients in this medicine, do not take Lobula 0.5 Tablet. Inform your doctor about all allergies before starting treatment.
Lobula 0.5 Tablet is not intended for use in children and adolescents under 18 years of age. This medicine is specifically designed for managing type 2 diabetes in adults.
Older patients should take Lobula 0.5 Tablet under medical supervision, as they may be more susceptible to side effects. Your doctor may adjust your dosage based on your health status.
Lobula 0.5 Tablet interacts with the following medicines:
Insulin medicines: Medicines like insulin glargine or insulin aspart may increase the risk of hypoglycaemia (low blood sugar) when taken with Lobula 0.5 Tablet.
Sulfonylureas: Medicines such as glibenclamide or gliclazide can increase the risk of hypoglycaemia when combined with Lobula 0.5 Tablet.
Beta-blockers: Medicines like propranolol or metoprolol may affect blood glucose control when used alongside Lobula 0.5 Tablet.
Lobula 0.5 Tablet interacts with the following diseases:
Heart failure: This medicine may worsen fluid retention and could potentially aggravate heart failure symptoms.
Bladder cancer: This medicine is contraindicated in patients with active bladder cancer or uninvestigated blood in urine.
Type 1 diabetes: Lobula 0.5 Tablet is not effective for managing type 1 diabetes and should not be used in this condition.
The daily dose of Lobula 0.5 Tablet should be taken as prescribed by your doctor. The dosage may vary based on your blood sugar levels and response to treatment. Never change your dose without consulting your doctor.
Overdosing on Lobula 0.5 Tablet may cause increased swelling in your legs and ankles, rapid weight gain, and severe tiredness. You might also experience extremely low blood sugar levels, leading to dizziness, confusion, and weakness. Contact your doctor if these symptoms occur.
If you forget to take a dose, take it as soon as you remember. If it is nearly time for your next dose, skip the missed one and continue with your regular schedule. Never take a double dose to make up for a missed one.
Store Lobula 0.5 Tablet below 30°C in a cool, dry place.
Keep away from direct sunlight and moisture.
Do not store in bathrooms due to humidity concerns.
Keep out of reach of children.
Check the expiry date, and do not use it after this date.
Monitor your carbohydrate intake by choosing complex carbohydrates (whole grains, vegetables) over simple sugars (sweets, soft drinks) to help maintain steady blood glucose levels throughout the day.
Aim for regular physical activity (at least 30 minutes of moderate exercise like brisk walking) most days of the week, as this improves your body's insulin sensitivity and helps control your blood sugar.
| Dosage Forms Available | Tablet |
| Habit Forming | No |
| Ailment | Type 2 diabetes |
| Drug Category | Insulin sensitiser |
| Therapeutic Category | Antidiabetic |
Lobula 0.5 Tablet helps manage type 2 diabetes when diet and exercise are not enough. It improves how your body responds to insulin, helping control blood sugar levels.
It works as an insulin sensitiser, activating special receptors in fat tissues. This helps your body respond more effectively to its own insulin, thereby improving glucose uptake from your bloodstream.
Common side effects include swelling in the legs and ankles, weight gain, fatigue, headaches, and upper respiratory infections. Most are mild and manageable.
Yes, maintaining a balanced diabetic diet and regular exercise is essential. Lobula 0.5 Tablet works best when combined with proper lifestyle changes.
Store below 30°C in a cool, dry place away from direct sunlight and moisture. Keep out of reach of children and away from bathroom humidity.
No, do not stop taking this medicine without consulting your doctor. Sudden discontinuation may cause dangerous spikes in blood sugar levels.
Take it as soon as you remember. If it is almost time for your next dose, skip the missed one. Never take two doses together to make up for the missed one.
Check out Editorial Policy
DrugBank. (n.d.). Lobeglitazone. Retrieved 1 April 2025, from https://go.drugbank.com/drugs/DB09198
M, B., S, S., & R, R. (2023). Lobeglitazone and its therapeutic benefits: A review. Cureus, 15(2). https://doi.org/10.7759/cureus.50085
Joshi, S., Tandon, M., Kodgule, R., Wu, W., Jadhao, V., Suryawanshi, S., & Barkate, H. (2024). Randomized, double-blind, phase III trial of lobeglitazone add-on to metformin in Type 2 diabetes (SENSITIZE INDIA). Journal of the Association of Physicians of India, 72(1), 32–42. https://doi.org/10.59556/japi.71.0445
Bae, J., Park, T., Kim, H., Lee, M., & Cha, B. (2021). Lobeglitazone: A novel thiazolidinedione for the management of type 2 diabetes mellitus. Diabetes & Metabolism Journal, 45(3), 326–336. https://doi.org/10.4093/dmj.2020.0272
Dutta, D., Bhattacharya, S., Kumar, M., Datta, P. K., Mohindra, R., & Sharma, M. (2022). Efficacy and safety of novel thiazolidinedione lobeglitazone for managing type-2 diabetes a meta-analysis. Diabetes & Metabolic Syndrome Clinical Research & Reviews, 17(1), 102697. https://doi.org/10.1016/j.dsx.2022.102697
We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.
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