Pregvance 8% Gel 1.125gm is a hormone medicine applied inside the vagina, used to support fertility treatment and early pregnancy, to protect the womb lining during hormone therapy, and to help restore periods that have stopped because of low progesterone. It is a single-ingredient medicine containing natural micronised progesterone, and belongs to a class of medicines called progestogens (female sex hormones).
This medicine works by supplying progesterone, which prepares and supports the womb lining, helping to regulate the menstrual cycle and support a pregnancy. When used in hormone therapy, it is taken together with oestrogen to protect the womb lining. Wash your hands first, insert the gel into the vagina with the applicator as directed, and continue for the period your doctor advises.
Avoid using other vaginal products within 6 hours before or after applying this gel, as they may affect how well it works.
Before using this medicine, tell your doctor about your full medical history, including any blood clots, liver problems, breast conditions or unexplained vaginal bleeding, and about all other medicines you use. Seek urgent medical help for severe headache, calf pain or swelling, chest pain or breathlessness.
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Pregvance 8% Gel 1.125Gm
Tube of 1.12 GM
MRP ₹225
₹112.5
₹100/GM
100% genuine medicines
Safe & secure payments
15 days Easy returns
Prescription required for this medicine
Store Below 30° C
CompositionAbout Pregvance 8% Gel 1.125Gm
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Uses of Pregvance 8% Gel 1.125Gm
Pregvance 8% Gel 1.125gm is used to supply progesterone, and it helps by preparing and supporting the womb lining so that it can sustain a pregnancy or be protected during hormone therapy.
Uses of Pregvance 8% Gel 1.125gm are:
- Fertility support: Supports the womb lining during fertility treatment and early pregnancy.
- Hormone therapy: Protects the womb lining when used together with oestrogen.
- Absent periods: Helps restore periods that have stopped because of low progesterone.
Directions for Use of Pregvance 8% Gel 1.125Gm
Administer Pregvance 8% Gel 1.125gm as follows:
- Ensure that your hands are clean before application.
- The gel is intended for vaginal use only.
- Carefully insert the applicator into your vagina to apply the gel.
- Avoid using other vaginal products within 6 hours before or after applying Pregvance 8% Gel 1.125gm.
- If you have any doubts or questions, consult your doctor for specific directions on how to use this gel.
Route of Administration
Pregvance 8% Gel 1.125gm is applied vaginally.
Side Effects of Pregvance 8% Gel 1.125Gm
Pregvance 8% Gel 1.125gm may cause some side effects that are usually mild and go away as your body adjusts to the medicine.
A few common side effects of Pregvance 8% Gel 1.125gm:
- Local: Vaginal discharge and irritation.
- Hormonal: Breast tenderness, bloating and mood changes.
- Nervous system and digestive: Headache, nausea, dizziness and drowsiness.
If any side effect does not improve or becomes serious, speak to your doctor. Do not stop using the medicine unless your doctor advises you to do so.
Management Of Side Effects:
Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Pregvance 8% Gel 1.125gm. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.
Here are some general guidelines for managing common side effects:
- Nausea: Try using Pregvance 8% Gel 1.125gm with food to lessen this effect.
- Dizziness or drowsiness: Consider using this medicine at night if it makes you feel light-headed or sleepy during the day.
How Pregvance 8% Gel 1.125Gm Works?
Pregvance 8% Gel 1.125gm contains natural micronised progesterone (8 %). Here's how it works:
- Transforms Endometrium: Progesterone transforms the proliferative endometrium into a secretory endometrium. This transformation is necessary for developing decidual tissue, which is essential for pregnancy.
- Decreases Gonadotropin Levels: Progesterone reduces the levels of gonadotropins (FSH and LH) in the body through a negative feedback mechanism.
- Reduces Risk of Hyperplasia and Cancer: When used in hormone replacement therapy (HRT), progesterone counteracts the proliferative effects of oestrogen on the endometrium. This action reduces the risk of endometrial hyperplasia and cancer.
Safety Measures & Warnings
Pregnancy
Pregvance 8% Gel 1.125gm is not recommended when you're pregnant, unless your doctor prescribes it to support early pregnancy in cases of progesterone deficiency. Always consult your doctor before using this medicine while pregnant.
Breastfeeding
If you are breastfeeding, it's best to seek your doctor's advice before using Pregvance 8% Gel 1.125gm.
Alcohol
There's no known interaction between Pregvance 8% Gel 1.125gm and alcohol. However, it's always wise to limit your alcohol consumption for overall health and wellness.
Liver
Caution is advised when using Pregvance 8% Gel 1.125gm if you have liver problems. This medicine may affect liver function, so it's important to consult your doctor before starting this medication.
Kidney
If you have a history of kidney issues, use Pregvance 8% Gel 1.125gm with caution. It's recommended to discuss this with your doctor before starting this medicine.
Use In Driving And Operating Machinery
Pregvance 8% Gel 1.125gm is not known to impact your ability to drive or operate using machines.
Allergy
If you know or suspect you're allergic to progesterone or any component of the gel, avoid using Pregvance 8% Gel 1.125gm. Always inform your doctor about your allergies before starting any new medication.
Children
Pregvance 8% Gel 1.125gm is not intended for use in children under 18 years of age. It's always best to consult a doctor before giving any medicine to a child.
Older Patients
If you are an older patient, make sure to take Pregvance 8% Gel 1.125gm under medical supervision. Older patients might be more susceptible to its side effects or they might be on other medications. Your doctor will guide you based on your health status.
Interactions of Pregvance 8% Gel 1.125Gm
Drug-Drug Interactions
Pregvance 8% Gel 1.125gm may interact with the following medicines:
- Hepatic enzyme inducers such as barbiturates, carbamazepine, phenytoin, and rifampin can reduce the levels of progesterone in your body. This might weaken the effectiveness of Pregvance 8% Gel 1.125gm.
- Antifungal medications: Ketoconazole, a common antifungal medication, can increase progesterone levels in your body. This could potentially enhance the effects of Pregvance 8% Gel 1.125gm.
- Corticosteroids such as prednisone, hydrocortisone for conditions like asthma or arthritis, be aware that progesterone can enhance their adverse or toxic effects.
Drug-Food Interactions
There are no known food interactions with Pregvance 8% Gel 1.125gm.
Drug-Disease Interactions
Pregvance 8% Gel 1.125gm can interact with the following diseases:
- Breast or genital tract malignancy: If you have a known or suspected malignancy in your breast or genital tract, you should avoid using Pregvance 8% Gel 1.125gm.
- Thromboembolic disorders: Progesterone may increase the risk of blood clot formation. Therefore, if you have active thrombophlebitis or thromboembolic disorders, avoid using Pregvance 8% Gel 1.125gm.
Dosage of Pregvance 8% Gel 1.125Gm
Daily Dose
The daily dose of Pregvance 8% Gel 1.125gm should be applied as directed by your doctor. Your dosage may vary depending on factors such as the severity of your condition and how you respond to the medicine. Remember, it's crucial to follow your doctor's prescribed dosage and never exceed it without consulting your doctor.
Over Dose
If you accidentally apply more Pregvance 8% Gel 1.125gm than instructed, you might experience common side effects like vaginal discharge or irritation, and nausea. Simply wash the area with cool water. If these symptoms persist or worsen, it's important to inform your doctor.
Missed Dose
If you forget to apply Pregvance 8% Gel 1.125gm at the usual time, do so as soon as you remember. However, if it's almost time for your next dose, skip the missed one and continue with your regular schedule. Never apply extra gel to make up for a missed dose without consulting your doctor.
Storage
- Keep Pregvance 8% Gel 1.125gm in a cool place.
- Do not freeze the gel.
- Protect it from excessive light and moisture.
- Ensure the gel is securely stored, out of reach of children.
- Check the expiry date on the package and use before it.
Special Dietary And Lifestyle Recommendation
- During menopause, incorporate foods rich in calcium and Vitamin D into your diet, such as dairy products, green leafy vegetables, and fish. This can help manage symptoms like hot flushes and night sweats that Pregvance 8% Gel 1.125gm is used to manage.
- Regular gentle exercise like yoga or walking can help improve mood changes associated with menopause and infertility, conditions for which Pregvance 8% Gel 1.125gm is often prescribed.
Fact Box
| Dosage Forms Available | Vaginal Gel |
| Habit Forming | No |
| Ailment | Menopause Symptoms, Female Infertility |
| Drug Category | Progesterone Receptor Modulator |
| Therapeutic Category | Hormone Replacement Therapy |
Frequently Asked Questions (FAQs)
What is Pregvance 8% Gel 1.125gm used for?
Pregvance 8% Gel 1.125gm primarily manages menopause symptoms and helps with female infertility by preparing the uterus for pregnancy.
How does Pregvance 8% Gel 1.125gm work?
Pregvance 8% Gel 1.125gm contains progesterone, which prepares the womb lining for a possible pregnancy and helps regulate menstruation.
Can Pregvance 8% Gel 1.125gm be used during pregnancy?
It's generally not advised to use Pregvance 8% Gel 1.125gm during pregnancy, unless instructed by your doctor to support early stages of pregnancy.
How long does Pregvance 8% Gel 1.125gm take to work?
The time taken varies depending on the individual and the purpose of use. Effects may take several weeks to months to show.
Can I use other vaginal products with Pregvance 8% Gel 1.125gm?
Avoid using other vaginal products within six hours before or after applying Pregvance 8% Gel 1.125gm as they could affect its absorption and efficacy.
What should I do if I miss a dose of Pregvance 8% Gel 1.125gm?
If you miss a dose, apply it as soon as you remember. If it's nearly time for your next dose, skip the missed dose.
Are there any side effects of using Pregvance 8% Gel 1.125gm?
Side effects can include vaginal discharge, breast tenderness, headaches, nausea, bloating, or mood changes. Consult your doctor if these persist or worsen.
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Manufacturer details
Country of origin: INDIA
References
- U.S. National Library of Medicine. (2022). CRINONE- progesterone gel. DailyMed. Retrieved from https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=75e97aa1-daa4-45f9-b2e2-1a371302914e
- Unknown. (n.d.). PROMETRIUM. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/019781s017,020843s011lbl.pdf
- Progesterone: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00396
- DailyMed - PROGESTERONE capsule. (n.d.). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4de0715d-a3b9-42fa-b4e4-6371151fd75c
- Progesterone: MedlinePlus drug information. (n.d.). https://medlineplus.gov/druginfo/meds/a604017.html
Disclaimer
We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.
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