Bio Enox Prefilled Syringe 0.4 Ml is used to prevent and treat harmful blood clots, including deep vein thrombosis (DVT) and pulmonary embolism (PE). It is also used to reduce clot-related complications after certain surgeries, during severe immobility, and in some heart conditions.
It contains enoxaparin, an anticoagulant that reduces the formation and growth of blood clots. It is given under the skin or into a vein by a doctor or nurse, as prescribed.
Because this medicine increases the risk of bleeding, take care to avoid injury, use a soft toothbrush, and tell any doctor or dentist treating you that you are receiving it.
Before receiving this medicine, tell your doctor about any active bleeding, previous heparin-induced thrombocytopenia, kidney or liver problems, recent surgery, or other medicines that affect bleeding. Seek urgent medical help for bleeding that does not stop, blood in urine or stools, severe headache, or unusual weakness.
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Bio Enox Prefilled Syringe 0.4 Ml
Pack of 0.40 ML
Old MRP ₹221
MRP ₹207.19
₹165.75
₹517.97/ML
100% genuine medicines
Safe & secure payments
15 days Easy returns
Prescription required for this medicine
Store Below 30° C
CompositionAbout Bio Enox Prefilled Syringe 0.4 Ml
Uses of Bio Enox Prefilled Syringe 0.4 Ml
Bio Enox Prefilled Syringe 0.4 Ml is used to prevent and treat harmful blood clots.
Uses of Bio Enox Prefilled Syringe 0.4 Ml are:
- Deep Vein Thrombosis and Pulmonary Embolism: Prevents and treats clots in the legs and lungs.
- Surgery and Immobility: Helps prevent blood clots after major surgery or during severe immobility.
- Heart Conditions: Helps reduce clot-related complications in unstable angina and certain types of heart attack.
Directions for Use of Bio Enox Prefilled Syringe 0.4 Ml
Administer Bio Enox Prefilled Syringe 0.4 Ml as follows:
- Ensure the injection site is clean and dry before use.
- A healthcare professional administers this medicine subcutaneously (under the skin) or intravenously (into a vein).
- Follow your doctor's directions on the timing and frequency of injections.
- Do not self-inject this medicine unless you are properly trained.
Route of Administration
Bio Enox Prefilled Syringe 0.4 Ml is administered subcutaneously (under the skin) or intravenously (into a vein) by a healthcare professional.
Side Effects of Bio Enox Prefilled Syringe 0.4 Ml
Bio Enox Prefilled Syringe 0.4 Ml may cause side effects, although not everyone gets them.
Possible side effects of Bio Enox Prefilled Syringe 0.4 Ml include:
- Bleeding: Bruising or bleeding may occur more easily. Seek urgent medical help for severe or persistent bleeding.
- Injection Site: Pain, irritation, bruising or swelling where the injection is given.
- Blood and Liver Tests: Reduced red blood cells, a low platelet count, or raised liver enzymes may occur.
- Other: Nausea, diarrhoea, fever, confusion or swelling caused by fluid build-up.
If side effects do not improve or become serious, speak to your doctor right away.
Management Of Side Effects:
Most side effects are temporary and generally harmless, and they resolve when you discontinue using Bio Enox Prefilled Syringe 0.4 Ml. However, if you experience serious side effects or worsening symptoms, please consult your doctor.
How Bio Enox Prefilled Syringe 0.4 Ml Works?
Enoxaparin (40 mg) is the active ingredient in Bio Enox Prefilled Syringe 0.4 Ml and has a specific mechanism of action:
- Enhances Antithrombin III (ATIII) Activity: Enoxaparin functions by binding to and boosting the performance of antithrombin III (ATIII). This natural substance in your body is crucial in limiting blood clotting factors, particularly factor Xa and thrombin (factor IIa).
- Prevents Blood Clot Formation: Enoxaparin effectively stops the formation and growth of blood clots in your veins and arteries by suppressing these clotting factors. This action helps maintain smooth blood flow, reducing the risk of serious health complications.
Safety Measures & Warnings
Pregnancy
If you're pregnant, caution is advised while taking Bio Enox Prefilled Syringe 0.4 Ml. Discuss potential benefits and risks with your doctor before starting this medicine.
Breastfeeding
Use of Bio Enox Prefilled Syringe 0.4 Ml while breastfeeding should be done with caution. The active ingredient, enoxaparin, is unknown to be excreted in human milk. Hence, it's best to consult your doctor.
Alcohol
Avoid alcohol when taking Bio Enox Prefilled Syringe 0.4 Ml. Alcohol might influence the medicine's efficacy.
Liver
Although there isn't specific information on how Bio Enox Prefilled Syringe 0.4 Ml impacts liver health, it's always prudent to share details of your liver condition with your doctor before starting this medicine.
Kidney
If you have a history of kidney problems, be cautious while taking Bio Enox Prefilled Syringe 0.4 Ml. Your dosage may need to be adjusted based on your kidney function. Consult your doctor for appropriate guidance.
Use In Driving And Operating Machinery
Bio Enox Prefilled Syringe 0.4 Ml doesn't generally affect your ability to drive or operate machinery. However, if you experience side effects like confusion or dizziness, avoid such activities until you feel better.
Allergy
Avoid using Bio Enox Prefilled Syringe 0.4 Ml if you're allergic to enoxaparin, heparin, pork products or benzyl alcohol (in multi-dose vials). Make sure to inform your doctor about any allergies you have.
Children
Bio Enox Prefilled Syringe 0.4 Ml is not recommended for children as its safety and effectiveness haven't been established in this age group. Always consult your doctor before giving any medicine to a child.
Older Patients
Older patients should take Bio Enox Prefilled Syringe 0.4 Ml under medical supervision as they may be more susceptible to its side effects. This is particularly important if patients have kidney impairment or are on other medications.
Interactions of Bio Enox Prefilled Syringe 0.4 Ml
Drug-Drug Interactions
Bio Enox Prefilled Syringe 0.4 Ml may interact with the following medicines:
- Anticoagulants and Thrombolytics like warfarin, heparin or alteplase can increase the risk of bleeding when used alongside Bio Enox Prefilled Syringe 0.4 Ml.
- Anti-platelet Agents such as aspirin or clopidogrel taken with this injection could potentially enhance the risk of bleeding.
- NSAIDs and Aspirin: Non-steroidal anti-inflammatory medications (NSAIDs) like ibuprofen or aspirin may elevate the risk of bleeding when administered with Bio Enox Prefilled Syringe 0.4 Ml.
- Selective Serotonin Reuptake Inhibitors (SSRIs) like fluoxetine or sertraline can increase the likelihood of bleeding when used in combination with this injection.
- Medications Affecting Haemostasis, such as dextran, vitamin K antagonists or systemic glucocorticoids, can interact with Bio Enox Prefilled Syringe 0.4 Ml, potentially increasing the risk of bleeding.
Drug-Food Interactions
There are no known food interactions with Bio Enox Prefilled Syringe 0.4 Ml.
Drug-Disease Interactions
Bio Enox Prefilled Syringe 0.4 Ml may interact with the following diseases:
- Active Major Bleeding: This Injection should not be used if you have active major bleeding as it could exacerbate the condition.
- History of Heparin-Induced Thrombocytopenia (HIT): If you had HIT within the past 100 days or in the presence of circulating antibodies, using Bio Enox Prefilled Syringe 0.4 Ml might cause complications.
- Severe Renal Impairment: The use of this Injection could increase the risk of bleeding in individuals with severe renal impairment.
Dosage of Bio Enox Prefilled Syringe 0.4 Ml
Daily Dose
The daily dose of Bio Enox Prefilled Syringe 0.4 Ml must be administered as directed by your doctor. Individual factors like your health condition and how well you respond to the medicine can influence the dosage. It's crucial not to alter your dosage without consulting your doctor.
Over Dose
If you have accidentally administered more than the recommended dose of Bio Enox Prefilled Syringe 0.4 Ml, you may experience symptoms such as excessive bleeding and bruising. In such a case, inform your doctor promptly.
Missed Dose
If you miss a dose of Bio Enox Prefilled Syringe 0.4 Ml, administer it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue with your regular schedule.
Storage
- Store Bio Enox Prefilled Syringe 0.4 Ml at temperatures below 25°C.
- Keep it away from direct light, and don't freeze it.
- Always keep it out of the reach and sight of children.
- Use the medicine before its expiry date, which is mentioned on the package.
Special Dietary And Lifestyle Recommendation
- If you're taking Bio Enox Prefilled Syringe 0.4 Ml to manage deep vein thrombosis or pulmonary embolism, try to move around regularly if you can. Long periods of immobility can increase your risk of such conditions.
- Heart-healthy foods are recommended if you're using this medicine for heart-related conditions. Incorporating more fruits, vegetables, whole grains, lean proteins, and omega-3 fatty acids into your diet may help.
Fact Box
| Dosage Forms Available | Pre-filled Syringe |
| Habit Forming | No |
| Ailment | Deep Vein Thrombosis, Pulmonary Embolism, Heart Attack |
| Drug Category | Anticoagulant |
| Therapeutic Category | Antithrombotic |
Frequently Asked Questions (FAQs)
What is Bio Enox Prefilled Syringe 0.4 Ml used for?
Bio Enox Prefilled Syringe 0.4 Ml is used to prevent harmful blood clots that might cause serious conditions like deep vein thrombosis, heart attack, or stroke.
How does Bio Enox Prefilled Syringe 0.4 Ml work?
It contains enoxaparin, which enhances the activity of antithrombin III, a natural inhibitor of blood clotting factors, thus preventing the formation and growth of blood clots.
How is Bio Enox Prefilled Syringe 0.4 Ml administered?
Bio Enox Prefilled Syringe 0.4 Ml is administered subcutaneously (under the skin) or intravenously (into a vein) by a doctor or a healthcare professional.
Who should not use Bio Enox Prefilled Syringe 0.4 Ml?
People with active major bleeding, a history of heparin-induced thrombocytopenia, or hypersensitivity to enoxaparin or pork products should avoid this medicine.
What are the possible side effects of Bio Enox Prefilled Syringe 0.4 Ml?
Common side effects include bleeding, anaemia, liver enzyme elevation, injection site reactions (pain, haematoma), nausea, diarrhoea, peripheral oedema, confusion and fever.
Can I take other medicines while using Bio Enox Prefilled Syringe 0.4 Ml?
Some medicines such as dextran, vitamin K, fluoxetine and sertraline may interact with Bio Enox Prefilled Syringe 0.4 Ml and increase the risk of bleeding. Always consult your doctor before starting any new medicine.
How should I store Bio Enox Prefilled Syringe 0.4 Ml?
Store it at temperatures below 25°C. Protect from light and do not freeze. Discard unused portions from multi-dose vials 28 days after first use.
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Manufacturer details
Country of origin: INDIA
References
- U.S. National Library of Medicine. (2021). Enoxaparin sodium injection, solution [Cutenox G]. DailyMed. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=3d263380-4f44-4fd8-aa2a-e69702ab258f
- U.S. Food and Drug Administration. (1996). Enoxaparin Sodium Injection, USP. https://www.accessdata.fda.gov/drugsatfda_docs/label/pre96/20-164_lbl.pdf
- Enoxaparin: Uses, Interactions, Mechanism of Action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB01225
- PubChem. (n.d.-ab). Enoxaparin. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/enoxaparin
- Iqbal, Z., & Cohen, M. (2011). Enoxaparin: a pharmacologic and clinical review. Expert Opinion on Pharmacotherapy, 12(7), 1157–1170. https://doi.org/10.1517/14656566.2011.570261
- Enoxaparin Injection: MedlinePlus Drug Information. (n.d.). https://medlineplus.gov/druginfo/meds/a601210.html
Disclaimer
We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.
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