Topiroxo 40 Tablet is used in the treatment of elevated uric acid levels in the blood (hyperuricaemia) and is essential for the prevention and management of acute gout attacks. Classified as a selective xanthine oxidase inhibitor, this medicine works by specifically reducing the body's production of uric acid, which in turn lowers the concentration of uric acid in the blood and helps prevent the formation of the urate crystals that cause the painful inflammation associated with gout.
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Topiroxo 40 Tablet 10
Strip of 10 Units
Old MRP ₹217.5
MRP ₹203.91
₹163.13
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CompositionAbout Topiroxo 40 Tablet 10
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Uses of Topiroxo 40 Tablet 10
Topiroxo 40 Tablet is used for the long-term management of hyperuricaemia in patients with gout, working to reduce elevated uric acid levels to prevent gout attacks, control recurrent flares, and manage complications like chronic tophaceous gout and joint inflammation.
Directions for Use of Topiroxo 40 Tablet 10
To use Topiroxo 40 Tablet correctly, follow these steps:
- Swallow the tablet whole with a glass of water.
- Avoid crushing or chewing the tablet.
- Remember to take the medication at the same time each day for optimal results.
- You may take this medicine with or without food.
Route of Administration
Topiroxo 40 Tablet is taken orally.
Side Effects of Topiroxo 40 Tablet 10
Topiroxo 40 Tablet may cause upset stomach, diarrhoea, nausea, drowsiness, headache, and increased liver enzymes. Speak to your healthcare provider if these symptoms persist.
Managing the Side Effects:
Most side effects are temporary and generally harmless, which resolve upon discontinuing the use of Topiroxo 40 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.
Here are some guidelines for managing common side effects:
- Upset stomach: Try taking the medicine with food.
- Nausea: Try taking this medicine after meals to minimise feelings of sickness.
How Topiroxo 40 Tablet 10 Works?
Topiroxo 40 Tablet contains topiroxostat (40 mg), which acts upon your body in the following ways:
- Xanthine Oxidase Inhibition: Topiroxostat works by blocking an enzyme called xanthine oxidase in your body. This enzyme is crucial for the production of uric acid in your body.
- Uric Acid Reduction: By inhibiting the activity of xanthine oxidase, topiroxostat effectively reduces the production and overall levels of uric acid in the blood. This, in turn, helps manage hyperuricaemia and prevent gout attacks.
- Crystal Formation Prevention: Lower uric acid levels mean fewer uric acid crystals form in your joints, which helps reduce the painful inflammation associated with gout.
Safety Measures & Warnings
Pregnancy
Caution is advised while taking Topiroxo 40 Tablet if you are pregnant. Consult your doctor before taking this medicine.
Breastfeeding
Breastfeeding women should exercise caution when taking this medicine. Consult your doctor to understand the potential risks and benefits.
Alcohol
Avoid consuming alcohol while on this medication. Alcohol may interact with Topiroxo 40 Tablet, potentially reducing its effectiveness.
Liver
Caution is advised while taking Topiroxo 40 Tablet if you have liver problems. This medicine may affect liver enzymes. If you have any history of liver disease, inform your doctor before starting this medicine.
Kidney
Exercise caution when using Topiroxo 40 Tablet if you have any kidney conditions. Consult your doctor before taking this medicine.
Using Machines & Driving
Topiroxo 40 Tablet can cause drowsiness, which may affect your ability to drive or operate machinery.
Allergy
If you have any known allergies to topiroxostat or any other ingredients in Topiroxo 40 Tablet, do not take this medicine. Always inform your doctor about any known allergies.
Children
Topiroxo 40 Tablet is not recommended for use in children under 18 years of age.
Older Patients
Older patients should take Topiroxo 40 Tablet under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age. Your doctor will guide you based on your health status.
Interactions of Topiroxo 40 Tablet 10
Drug-Drug Interactions
Topiroxo 40 Tablet interacts with the following medicines:
Immunosuppressive medicines: Topiroxo 40 Tablet may interact with immunosuppressives like azathioprine, potentially altering their effectiveness or increasing the risk of side effects.
Anticancer medicines: Medications such as mercaptopurine can interact with Topiroxo 40 Tablet, potentially leading to increased toxicity or reduced effectiveness.
Cardiovascular medicines: There may be interactions between Topiroxo 40 Tablet and cardiovascular medications like rosuvastatin, possibly altering their effectiveness.
Respiratory medicines: Medicines like theophylline can interact with Topiroxo 40 Tablet, potentially causing increased side effects or reduced effectiveness.
Drug-Disease Interactions
Topiroxo 40 Tablet interacts with the following diseases:
Heart Disease: People with pre-existing heart conditions should exercise caution when taking this medicine, as it may interact with cardiovascular function.
Kidney Disease: This medicine should be used with caution in patients with kidney problems, as it affects uric acid levels and excretion.
Liver Disease: Individuals with liver disease should exercise caution as this medicine may affect liver enzymes and potentially worsen liver function.
Dosage of Topiroxo 40 Tablet 10
Daily Dose
The daily dose of Topiroxo 40 Tablet should be taken as prescribed by your doctor. The dosage may vary based on individual factors such as the severity of your condition and response to the medicine. It is important to adhere to the advised dosage and not alter it without consulting your doctor.
Over Dose
Taking more than the recommended dose of Topiroxo 40 Tablet may lead to side effects such as an upset stomach, diarrhoea, and increased liver enzymes. If you suspect an overdose, contact your doctor promptly.
Missed Dose
If you forget to take the medicine at the scheduled time, take it as soon as you remember. However, if it is nearly time for your next dose, skip the missed one and continue with your regular schedule. Never adjust your dosage without consulting your doctor.
Storage
- Store at room temperature, ideally between 20-25°C.
- Shield from direct sunlight and damp places to maintain its effectiveness.
- Keep out of reach of children.
- Do not use this medicine after the expiry date printed on the package.
Diet & Lifestyle
- A diet low in purine-rich foods like red meat, seafood, and alcohol is advisable. This can help reduce uric acid levels in your blood, thus easing the symptoms of gout.
- Regular exercise, such as walking or swimming, can also be beneficial as it helps maintain healthy joints and promotes a healthy body weight, which is essential for managing gout effectively.
Fact Box
| Available Dosage Types | Tablet |
| Habit Forming | No |
| Ailment | Hyperuricaemia, Gout |
| Drug Category | Selective Xanthine Oxidase Inhibitor |
| Therapeutic Category | Anti-Gout Medicine |
Frequently Asked Questions (FAQs)
What Is the Active Ingredient in Topiroxo 40 Tablet?
The active ingredient in Topiroxo 40 Tablet is topiroxostat, which helps manage gout by reducing uric acid production in your body.
How does Topiroxo 40 Tablet work?
Topiroxo 40 Tablet works by inhibiting an enzyme called xanthine oxidase, responsible for producing uric acid, thereby managing symptoms of gout.
Can I take Topiroxo 40 Tablet with food?
Yes, you can take Topiroxo 40 Tablet with or without food. However, it is recommended to take it at the same time each day for optimal results.
What should I Do if I Experience Side Effects from Topiroxo 40 Tablet?
If you experience any side effects such as upset stomach, diarrhoea, or headaches, consult your doctor immediately for advice and possible management options.
Can I Drink Alcohol While Taking Topiroxo 40 Tablet?
Avoid alcohol while taking this medicine. Alcohol may worsen your gout and reduce how well the medicine works in your body.
Are There Any Notable Interactions With Topiroxo 40 Tablet?
Topiroxo 40 might interact with certain medications like azathioprine, mercaptopurine, rosuvastatin, and theophylline. Always inform your doctor about your current medications.
How Should I Store My Topiroxo 40 Tablets?
Store your Topiroxo 40 Tablets at room temperature, away from direct sunlight and moisture, ensuring they are out of reach of children and pets.
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Manufacturer details
Alkem House, Senapati Bapat Marg, Lower Parel, Mumbai Maharashtra- 400013
Country of origin: INDIA
Country of origin: INDIA
Expiry on or after: May 2026
In case of any issues, contact us:
support@truemeds.in|09240250346
Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071
References
- DrugBank. (n.d.). Topiroxostat. https://go.drugbank.com/drugs/DB01685
- Hosoya, T., Ishikawa, T., Ogawa, Y., Sakamoto, R., & Ohashi, T. (2018). Multicenter, Open-Label Study of Long-Term Topiroxostat (FYX-051) Administration in Japanese Hyperuricemic Patients with or Without Gout. Clinical Drug Investigation, 38(12), 1135–1143. https://doi.org/10.1007/s40261-018-0699-0
- Sakuma, M., Toyoda, S., Arikawa, T., Koyabu, Y., Kato, T., Adachi, T., Suwa, H., Narita, J. I., Anraku, K., Ishimura, K., Yamauchi, F., Sato, Y., & Inoue, T. (2022). Topiroxostat versus allopurinol in patients with chronic heart failure complicated by hyperuricemia: A prospective, randomized, open-label, blinded-end-point clinical trial. PloS One, 17(1), e0261445. https://doi.org/10.1371/journal.pone.0261445
- Wada, T., Hosoya, T., Honda, D., Sakamoto, R., Narita, K., Sasaki, T., Okui, D., & Kimura, K. (2018). Uric acid-lowering and renoprotective effects of topiroxostat, a selective xanthine oxidoreductase inhibitor, in patients with diabetic nephropathy and hyperuricemia: a randomized, double-blind, placebo-controlled, parallel-group study (UPWARD study). Clinical and Experimental Nephrology, 22(4), 860–870. https://doi.org/10.1007/s10157-018-1530-1
- Ishikawa, T., Maeda, T., Hashimoto, T., Nakagawa, T., Ichikawa, K., Sato, Y., & Kanno, Y. (2020). Long-Term Safety and Effectiveness of the Xanthine Oxidoreductase Inhibitor, Topiroxostat in Japanese Hyperuricemic Patients with or Without Gout: A 54-week Open-label, Multicenter, Post-marketing Observational Study. Clinical Drug Investigation, 40(9), 847–859. https://doi.org/10.1007/s40261-020-00941-3
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We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.
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Intellihealth Solutions Private Limited
Unit-301 & 304, Lightbridge Tunga Village, Saki Vihar Rd, Chandivali, Powai, Mumbai, Maharashtra, India, 400072.
CIN: U62099MH2019PTC320566
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