Siphene 100 Tablet 5

Serum Institute Of India Ltd

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Old MRP ₹78.05

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Composition

Clomifene (100 Mg)

Strength:

50 MG 100 MG

Siphene 100 Tablet 5 is a fertility medicine used to help women who are having difficulty conceiving because they do not ovulate (release an egg) regularly. It contains clomifene citrate and is the gold-standard treatment for infertility related to anovulation.

Clomifene citrate works by blocking oestrogen receptors in the brain, which tricks the body into producing more of the hormones that stimulate the ovaries, encouraging the release of an egg (ovulation).

Take this tablet as your doctor prescribes, generally for five days early in your menstrual cycle, and your doctor will monitor your response with scans or blood tests.

Tell your doctor about any liver disease, ovarian cysts, abnormal uterine bleeding or hormone-sensitive conditions before starting. Stop taking the medicine and contact your doctor immediately if you develop any visual disturbances, as treatment must not continue if this occurs.

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Siphene 100 Tablet 5 is used to treat female infertility by stimulating the release of hormones necessary for egg development and ovulation. It is particularly beneficial for women with PCOS.

Uses of Siphene 100 Tablet 5 are:

Female Infertility: Stimulates the release of hormones necessary for egg development and ovulation.
PCOS-Related Infertility: Particularly beneficial for women with polycystic ovary syndrome.

Swallow the tablet whole, without crushing or chewing it.
It can be taken with or without food.
Ensure you take it at the same time each day for maximum effectiveness.
Remember, this medicine should not be used for more than 3 menstrual cycles.

Siphene 100 Tablet 5 is taken orally.

Siphene 100 Tablet 5 may cause some side effects that are usually mild and go away as your body adjusts to the medicine.

A few common side effects of Siphene 100 Tablet 5:

Circulatory: Hot flushes may occur.
Digestive: Abdominal discomfort, bloating, nausea and vomiting can occur.
Reproductive: Breast tenderness has been reported.
Neurological: Headache and visual disturbances, such as blurred vision or seeing spots, may occur.

If side effects do not improve or become serious, speak to your doctor right away.

Management Of Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Siphene 100 Tablet 5. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some tips to manage common side effects:

Nausea and vomiting: Try taking Siphene 100 Tablet 5 with food or milk.
Hot flashes: Consider taking this medicine at night if it causes hot flashes during the day.

Siphene 100 Tablet 5 contains clomifene (100 mg) which works on the body in the following ways:

Binding to Oestrogen Receptors: Clomifene binds to estrogen receptors in a part of the brain called the hypothalamus. This area controls hormone production in your body.
Increasing Hormone Secretion: The binding action makes your body think there is less estrogen than there really is. This stimulates another part of your brain, the pituitary gland, to secrete more follicle-stimulating hormone (FSH) and luteinizing hormone (LH).
Promoting Ovulation: The increased levels of FSH and LH encourage the growth and release of mature eggs from your ovaries, which is known as ovulation.

Pregnancy

Siphene 100 Tablet 5 is not recommended during pregnancy. If you are pregnant or planning to conceive, discuss this with your doctor before starting this medicine.

Breastfeeding

Siphene 100 Tablet 5 is not advised if you're breastfeeding, as it may decrease milk production. Discuss the potential risks and benefits with your doctor before taking this medicine.

Alcohol

It's advisable to avoid alcohol consumption while taking Siphene 100 Tablet 5. Alcohol may interfere with the effectiveness of the medicine

Liver

If you have liver problems, caution is advised while taking Siphene 100 Tablet 5. This medication is contraindicated in cases of liver disease. Discuss this with your doctor before starting Siphene 100 Tablet 5.

Kidney

Before using Siphene 100 Tablet 5, caution is advised if you have a history of kidney problems. Consult your doctor about this before starting to take this medicine.

Use In Driving And Operating Machinery

There are no specific restrictions on using machinery or driving while taking Siphene 100 Tablet 5. However, if you experience side effects like visual disturbances, avoid these activities and consult your doctor.

Allergy

If you are allergic to clomifene or any other ingredients in Siphene 100 Tablet 5, do not take this medicine. Make sure to inform your doctor about any known allergies before starting treatment.

Children

Siphene 100 Tablet 5 is meant for adult use and should not be given to children under 18 years of age. Always consult your doctor before giving any medication to a child.

Older Patients

Elderly patients should take Siphene 100 Tablet 5 under medical supervision as they may be more susceptible to its side effects. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Siphene 100 Tablet 5 interacts with the following medicines:

Oestrogens and Oral Contraceptives: Taking Siphene 100 Tablet 5 alongside oestrogens and oral contraceptives like ethinylestradiol or levonorgestrel may reduce its effectiveness in stimulating ovulation.
Anti-Oestrogens: Medicines such as tamoxifen and raloxifene may interact with Siphene 100 Tablet 5, potentially leading to altered medicine effects and increased risk of side effects.
Certain Antidepressants: SSRIs and SNRIs, like fluoxetine or venlafaxine, when taken with Siphene 100 Tablet 5 may increase the risk of side effects.
Herbal Supplements: St. John's Wort may interact with Siphene 100 Tablet 5, potentially decreasing its effectiveness.

Drug-Food Interactions

No specific food interactions have been reported with Siphene 100 Tablet 5.

Drug-Disease Interactions

Siphene 100 Tablet 5 interacts with the following diseases:

Ovarian Cysts or Enlarged Ovaries (Not Due to PCOS): Women suffering from ovarian cysts or enlarged ovaries not caused by PCOS could experience worsening of their condition with this medication.
Uncontrolled Thyroid or Adrenal Dysfunction: Patients with thyroid or adrenal gland disorders should be careful as Siphene 100 Tablet 5 might affect hormone levels, potentially worsening these conditions.

Daily Dose

Take the daily recommended dose of Siphene 100 Tablet 5 as your doctor advises. Your dosage may vary based on individual factors like the severity of your condition and how you respond to the medicine. Always follow your doctor's prescribed dosage and never increase it without consulting them.

Over Dose

If an overdose occurs, you might experience common side effects such as hot flashes, abdominal discomfort, or nausea. If these symptoms persist or worsen, let your doctor know.

Missed Dose

If you forget to take Siphene 100 Tablet 5, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed one and continue with your usual schedule. Remember not to increase your dosage without consulting your doctor.

Store Siphene 100 Tablet 5 at a temperature below 30°C.
Protect the medicine from direct sunlight, heat, and moisture.
Keep the medicine in its original packaging until it's time to take it.
Ensure Siphene 100 Tablet 5 is kept out of reach of children.
Always check the expiry date before taking this medicine.

If you experience bloating or discomfort due to Siphene 100 Tablet 5, try eating smaller, frequent meals instead of three large ones.
Hot flashes are a common side effect of Siphene 100 Tablet 5. Dress in layers so you can adjust your clothing to manage any sudden changes in body temperature.

Fact Box

Dosage Forms Available	Tablet
Habit Forming	No
Ailment	Infertility, Polycystic Ovary Syndrome
Drug Category	Ovulatory Stimulant
Therapeutic Category	Infertility Management

What is Siphene 100 Tablet 5 used for?

It's used to manage infertility in women, specifically those unable to get pregnant due to ovulation issues or polycystic ovary syndrome (PCOS).

How does Siphene 100 Tablet 5 work?

It increases the release of hormones needed for ovulation by tricking the body into thinking estrogen levels are low, which helps regulate your menstrual cycle.

When should I take the Siphene 100 Tablet 5?

Take it at the same time each day, with or without food. The exact duration and schedule will be determined by your doctor.

Is it safe to use Siphene 100 Tablet 5 for a long time?

No, it's not recommended for long-term use. Typically, it's prescribed for a maximum of three menstrual cycles.

What should I do if I miss a dose?

If you miss a dose, take it as soon as you remember, but if it's nearly time for your next dose, skip it and regularise your dose.

Can Siphene 100 Tablet 5 cause multiple pregnancies?

Yes, there is an increased risk of multiple pregnancies (twins or triplets) because the medicine may stimulate the release of more than one egg during ovulation.

Can I take Siphene 100 Tablet 5 while breastfeeding?

No, it may decrease milk production and isn't recommended during breastfeeding. Please consult your doctor if you are considering taking this medicine while nursing.

Last Updated On 09 Sep. 2026 | 12:57PM (IST)

Certified Content

Written by

Dr Nikita Lobo

Medical Content Reviewer | 9 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Medical Content Writer | 10 years

BAMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

212/2, Hadapsar, Off Soli Poonawalla Road, Pune 411028 India

Country of origin: INDIA

Expiry on or after: January 2027

In case of any issues, contact us:

support@truemeds.in|09240250346

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

CLOMID. (n.d.) Fda.Gov. Retrieved August 27, 2024, from https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/016131s026lbl.pdf
Clomifene 50mg Tablets - Summary of Product Characteristics (SmPC) - (emc). (n.d.). Org.Uk. Retrieved August 27, 2024, from https://www.medicines.org.uk/emc/product/15080/smpc#gref
Clomifene: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs https://medlineplus.gov/druginfo/meds/a682704.html /DB00882
Clomiphene. (n.d.). Medlineplus.Gov. Retrieved August 27, 2024, from https://medlineplus.gov/druginfo/meds/a682704.html

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We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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CIN: U62099MH2019PTC320566

Telephone:09240250346

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