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Clomifene

Uses of Clomifene

  • Clomifene is used for the management of female infertility associated with ovulation disorders. This medicine belongs to the group of selective oestrogen receptor modulator (SERM) medicines.
  • It is also indicated for anovulation, polycystic ovary syndrome (PCOS)-related infertility, irregular ovulation, and induction of ovulation in women trying to conceive.

Side effects of Clomifene

  • Hot flushes
  • Abdominal discomfort
  • Nausea
  • Breast tenderness
  • Headache
     

How Clomifene works

  • Clomifene is a fertility medicine.
  • It works by stimulating the release of hormones required for ovulation. It blocks the action of oestrogen at certain receptors in the brain, thereby increasing the release of follicle-stimulating hormone (FSH) and luteinising hormone (LH), which help induce ovulation.
     

Certified content

Written By

docImg
Dr. Sachin SinghMedical Team Lead & Reviewer| 7 years

MBBS

Reviewed By

Dr. Mandeep Chadha
Dr. Mandeep ChadhaLead Medical Content Reviewer| 12 years

MBBS, DNB (OBGY)

Expert Advice

Dosage Forms Available

  • This medicine is available for oral use in the form of tablets.

Age And Dose Restrictions

  • This medicine is intended for use in adult women of reproductive age, as advised by the doctor.

Contraindications

  • This medicine is contraindicated in patients with known hypersensitivity to Clomifene or any of the excipients. It is also contraindicated in pregnancy, liver disease, abnormal uterine bleeding of unknown cause, ovarian enlargement or ovarian cysts not related to PCOS, uncontrolled thyroid or adrenal disorders, and hormone-dependent tumours.

Other Medications To Avoid With This Medicine

  • This medicine may interact with hormone therapies, gonadotropins, and other fertility medicines. Concurrent use with other fertility medicines may increase the risk of ovarian hyperstimulation and other ovarian adverse effects.

Overdose And Missed Dose

  • Overdose of this medicine may cause nausea, vomiting, visual disturbances such as blurred vision, pelvic pain, and ovarian enlargement. Immediate medical attention may be required if these symptoms occur.
  • If you forget to take this medicine, contact your doctor for further advice. Do not take a double dose to make up for the missed dose.

Management Of Side Effects

  • Most side effects are temporary, mild, and usually resolve after discontinuation of the medicine. However, if you experience severe abdominal pain, visual disturbances, or worsening of any symptoms, consult your doctor immediately. Taking adequate rest and maintaining hydration may help reduce discomfort.

Use In Driving And Operating Machinery

  • This medicine may occasionally cause dizziness or visual disturbances in some individuals. Avoid driving or operating heavy machinery if you experience these symptoms.

Use In Pregnancy And Lactation

  • This medicine should not be used during pregnancy. Clomifene is generally not recommended during breastfeeding as it may suppress lactation.

Caution In Other Conditions

  • Caution is advised in patients with PCOS, endometriosis, uterine fibroids, depression, liver impairment, or a history of ovarian cysts.

Special Dietary And Lifestyle Recommendation

  • Maintain a healthy body weight, as obesity or being underweight may affect fertility and ovulation.
  • Follow a balanced diet rich in fruits, vegetables, whole grains, and proteins to support reproductive health.
  • Avoid smoking and alcohol consumption, as they may negatively affect fertility.
  • Engage in regular physical activity and stress-reducing activities such as yoga or meditation.
  • Follow ovulation monitoring and fertility guidance exactly as advised by your doctor.

Frequently asked questions

Yes, Clomifene is commonly used for the management of female infertility associated with ovulation disorders.

Yes, this medicine may increase the chance of multiple pregnancies, such as twins.

No, Clomifene is not a hormone, but it affects hormone release. It is a selective oestrogen receptor modulator that helps stimulate ovulation. 

Yes, this medicine is usually taken daily for a specific number of days during the menstrual cycle as prescribed by your doctor.

This medicine should be taken exactly as advised by your doctor, usually at the same time each day during the treatment cycle.

No, this medicine is used to improve ovulation and fertility during treatment. Consult your doctor for further information regarding long-term fertility outcomes.

Ovulation usually occurs 5–10 days after the last dose, although the response may vary among individuals. 

No, this medicine usually requires a prescription and should be used under medical supervision.

Yes, Clomifene may be used in women with PCOS-related ovulation disorders if prescribed by the doctor.

The duration of treatment depends on the response to therapy and should be decided by your doctor.

Terms & Conditions


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