Loyzide M 60/500Mg Tablet Xr 10

Lloyd Healthcare Pvt.Ltd

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Composition

Gliclazide (60 Mg) + Metformin (500 Mg)

Loyzide M 60/500mg Tablet Xr 10 is used to help control blood sugar levels. It is a combination antidiabetic medicine containing gliclazide and metformin.

This medicine helps control blood sugar when a single medicine alone is not enough. It is also used alongside diet and exercise to manage type 2 diabetes.

Regular meals, a balanced diet and physical activity can support blood sugar control alongside this medicine.

Before starting, tell your doctor about your medical conditions and allergies. Tell the doctor about all other medicines, supplements or herbal products you take. Tell your doctor if you are pregnant, planning a pregnancy or breastfeeding. Attend any monitoring appointments advised by your doctor. Report persistent or serious side effects to your doctor. Do not stop taking or using the medicine unless your doctor advises you to do so.

Loyzide M 60/500mg Tablet Xr 10 is used to help control blood sugar levels.

Uses of Loyzide M 60/500mg Tablet Xr 10 are:

Blood Sugar Control: Helps control blood sugar when a single medicine alone is not enough.
Diet and Exercise Support: Used alongside diet and exercise to manage type 2 diabetes.

Here's how you should take Loyzide M 60/500mg Tablet Xr 10:

Swallow the tablet whole with a glass of water.
To be taken as advised by your doctor before food
Avoid crushing, chewing, or splitting the tablet.
Do not adjust your dose without consulting your doctor first.

Loyzide M 60/500mg Tablet Xr 10 is taken orally.

Loyzide M 60/500mg Tablet Xr 10 may cause some side effects that are usually mild and go away as your body adjusts to the medicine.

A few common side effects of Loyzide M 60/500mg Tablet Xr 10:

Digestive: feeling sick (nausea), vomiting, loose motions (diarrhoea) and stomach pain.
General: loss of appetite and a change in your sense of taste.

If any side effect does not improve or becomes serious, speak to your doctor. Do not stop taking the medicine unless your doctor advises you to do so.

Management Of Side Effects:

Most side effects are temporary and generally harmless, which resolve upon discontinuing Loyzide M 60/500mg Tablet Xr 10. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Diarrhoea: Drink plenty of water to prevent dehydration.
Nausea: Consider taking this medicine during meals to lessen the feeling of sickness.

Loyzide M 60/500mg Tablet Xr 10 contains two active ingredients:

Gliclazide (60 mg): This sulfonylurea stimulates your pancreas to secrete more insulin and increases your body's efficiency in using insulin. These actions contribute to lowering your blood sugar levels.
Metformin (500 mg): This biguanide reduces the amount of glucose produced by your liver and enhances insulin sensitivity, enabling your body to use insulin more effectively. It also minimises the absorption of glucose from your intestines.

Pregnancy

Loyzide M 60/500mg Tablet Xr 10 should be taken with caution during pregnancy. It is best to consult your doctor before taking this medicine.

Breastfeeding

If you are breastfeeding, consult your doctor before starting Loyzide M 60/500mg Tablet Xr 10.

Alcohol

Alcohol consumption can increase the risk of low blood sugar (hypoglycaemia) and lactic acidosis. Therefore, caution is advised when consuming alcohol while taking Loyzide M 60/500mg Tablet Xr 10.

Liver

Caution is advised when taking Loyzide M 60/500mg Tablet Xr 10 if you have mild-to-moderate liver impairment. For those with severe liver disease, this medicine may not be recommended. Always discuss your liver health with your doctor before starting this medication.

Kidney

Loyzide M 60/500mg Tablet Xr 10 is contraindicated if you have severe kidney impairment. If you have a history of an underlying kidney condition, it is advisable to consult your doctor before taking this medicine.

Use In Driving And Operating Machinery

This medicine can cause side effects like dizziness or confusion due to low blood sugar levels. This could affect your ability to drive or operate machinery. Be careful until you know how Loyzide M 60/500mg Tablet Xr 10 affects you.

Allergy

If you are allergic to gliclazide, metformin, or any other ingredients in Loyzide M 60/500mg Tablet Xr 10, avoid using this medication.

Children

Loyzide M 60/500mg Tablet Xr 10 is not intended for use in children under 18 years of age. Always consult your doctor before giving any medicine to a child.

Older Patients

Elderly patients should take Loyzide M 60/500mg Tablet Xr 10 under medical supervision, as they may be more susceptible to its side effects. Extra caution is advised for those above 70 years of age, as they may also have liver or kidney conditions or be on other medications. Your doctor will guide you based on your overall health status.

Drug-Drug Interactions

Loyzide M 60/500mg Tablet Xr 10 interacts with the following medicines:

Anti-diabetic agents: Other anti-diabetic medications like insulin or glimepiride can intensify the hypoglycemic effect, leading to low blood sugar levels.
ACE inhibitors: Medicines such as captopril or lisinopril may enhance the hypoglycemic action, resulting in decreased blood sugar levels.
Non-steroidal anti-inflammatory drugs (NSAIDs): Medications like ibuprofen and naproxen can increase the risk of hypoglycaemia when taken along with Loyzide M 60/500mg Tablet Xr 10.
Corticosteroids: Medicines like prednisolone can decrease the hypoglycemic effect of this medicine, leading to higher blood sugar levels.

Drug-Food Interactions

Certain food items can interact with Loyzide M 60/500mg Tablet Xr 10:

High-fat meals: Consuming fatty foods can slow down the absorption of metformin, potentially reducing its effectiveness.

Drug-Disease Interactions

Loyzide M 60/500mg Tablet Xr 10 interacts with the following diseases:

Liver impairment: Patients with liver problems should use this medication cautiously, as it could potentially worsen their condition.
Kidney disease: Individuals with kidney disorders should exercise caution while taking Loyzide M 60/500mg Tablet Xr 10, as it could lead to lactic acidosis, a serious side effect.
Heart failure: Patients with heart conditions should be careful, as this medication may exacerbate their symptoms.

Daily Dose

Your doctor will prescribe the daily dose of Loyzide M 60/500mg Tablet Xr 10. This depends on individual factors, such as your body's response to treatment and the severity of your condition. Follow the prescribed dosage without exceeding it, and consult your doctor for any changes.

Over Dose

Overdosing on Loyzide M 60/500mg Tablet Xr 10 may result in symptoms like extreme weakness, blurred vision, sweating, trembling, confusion, and headaches. If you experience these symptoms or suspect an overdose, inform your doctor for appropriate advice.

Missed Dose

If you forget to take Loyzide M 60/500mg Tablet Xr 10, take it as soon as you remember. However, if it’s almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double your dose to make up for a missed one, and always consult your doctor before making any adjustments to your dosage.

Store Loyzide M 60/500mg Tablet Xr 10 in a cool place, protected from light and moisture.
Always keep this medicine out of the reach of children.
Ensure you use the tablet before the expiry date shown on the package.

Incorporate a balanced diet with low sugar content into your daily routine to help manage blood sugar levels alongside taking Loyzide M 60/500mg Tablet Xr 10.
Regular physical activity is also beneficial. Exercise can enhance insulin sensitivity, making your body's insulin more effective in controlling blood sugar levels.

Fact Box

Dosage Forms Available	Tablet
Habit Forming	No
Ailment	Type 2 Diabetes
Drug Category	Sulfonylurea, Biguanide
Therapeutic Category	Anti-diabetic

What is Loyzide M 60/500mg Tablet Xr 10 used for?

Loyzide M 60/500mg Tablet Xr 10 is used to manage blood sugar levels in adults with type 2 diabetes, along with a balanced diet and regular exercise.

How does Loyzide M 60/500mg Tablet Xr 10 work?

Loyzide M 60/500mg Tablet Xr 10 contains gliclazide, which stimulates insulin production, and metformin, which reduces glucose production by the liver, together improving overall blood sugar control.

Can I take this medicine if I have type 1 diabetes?

No, Loyzide M 60/500mg Tablet Xr 10 should not be used for managing type 1 diabetes or diabetic ketoacidosis. Always consult your doctor before starting any new medicine.

What are the common side effects of Loyzide M 60/500mg Tablet Xr 10?

Common side effects include nausea, vomiting, diarrhoea, abdominal pain, loss of appetite, taste disturbance, and weight gain.

What precautions should I take when using Loyzide M 60/500mg Tablet Xr 10?

Use this medicine cautiously if you are elderly, have liver impairment, heart disease, or are at risk of hypoglycaemia. Regularly check your kidney function and vitamin B12 levels.

Can other medicines affect how Loyzide M 60/500mg Tablet Xr 10 works?

Yes, certain medicines can interact with the components of Loyzide M 60/500mg Tablet Xr 10, causing hypoglycaemia or reducing its effectiveness. Examples include captopril, ibuprofen, and prednisolone. Always consult your doctor before starting new medications.

What should I do if I overdose on Loyzide M 60/500mg Tablet Xr 10?

Overdose can cause severe symptoms such as weakness, blurred vision, confusion, and seizures. If a suspected overdose occurs, seek emergency medical attention immediately.

Last Updated On 09 Sep. 2026 | 1:06PM (IST)

Certified Content

Written by

Dr. Michelle Frank

Medical Content Writer | 10 years

Doctor of Medicine

Reviewed by

Dr. Alina Panjwani

Medical Content Writer | 8 years

BDS

Check out Editorial Policy

Manufacturer details

702, Balaji Buisness Park, Andheri Kurla Road, Marol Naka, Andheri East, Mumbai, Maharashtra 400059

Country of origin: INDIA

Expiry on or after: January 2027

In case of any issues, contact us:

support@truemeds.in|09240250346

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

Label: GLUCOPHAGE ® (metformin hydrochloride). (2017). U.S Food and Drug Administration. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020357s037s039,021202s021s023lbl.pdf
Metformin: MedlinePlus drug information. (n.d.). MedlinePlus - Health Information from the National Library of Medicine. https://medlineplus.gov/druginfo/meds/a696005.html
Metformin: A medicine to treat type 2 diabetes. (2022, March 25). NHS. https://www.nhs.uk/medicines/metformin/
About gliclazide. (2022, April 1). NHS. https://www.nhs.uk/medicines/gliclazide/about-gliclazide/
Campbell DB, Lavielle R, Nathan C. The mode of action and clinical pharmacology of gliclazide: a review. Diabetes Res Clin Pract. 1991;14 Suppl 2:S21-36. Retrieved from https://pubmed.ncbi.nlm.nih.gov/1794262/
Gliclazide. (n.d.). DrugBank Online | Database for Drug and Drug Target Info. https://go.drugbank.com/drugs/DB01120

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Disclaimer

We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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Intellihealth Solutions Private Limited

Unit-301 & 304, Lightbridge Tunga Village, Saki Vihar Rd, Chandivali, Powai, Mumbai, Maharashtra, India, 400072.

CIN: U62099MH2019PTC320566

Telephone:09240250346

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Name: Kishor Kumar

Email: grievance-officer@truemeds.in

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