Loyzide M 40 Tablet 15

Lloyd Healthcare Pvt.ltd

Strip of 15 Units

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MRP ~~₹101~~

₹80.8

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Composition

Gliclazide (40 Mg) + Metformin (500 Mg)

Loyzide M 40 Tablet 15 is used to manage type 2 diabetes mellitus in adults when diet and exercise alone are not enough to control blood sugar levels. It is a combination medicine that belongs to the class of oral anti-diabetic medications.

This medicine helps prevent complications associated with diabetes, such as skin infections, eye problems (retinopathy), nerve damage (neuropathy), kidney disease (nephropathy), foot ulcers, high blood pressure, and stroke. Maintaining optimal blood sugar control reduces the risk of these serious health issues that can develop over time.

This medicine should be taken orally as directed by your doctor, preferably at the same time each day with food. Before starting this medicine, inform your doctor about any pre-existing conditions or ongoing medications you may have. If you notice any side effects while taking this medicine, notify your doctor immediately. Continue taking the medicine for the duration prescribed by your doctor for optimal results.

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Loyzide M 40 Tablet 15 is used for the following:

Managing type 2 diabetes mellitus in adults
Controlling high blood sugar levels
Preventing diabetes-related skin infections
Reducing the risk of diabetic eye problems
Preventing diabetic nerve damage
Lowering the risk of diabetes-related kidney disease
Preventing diabetic foot ulcers
Reducing the risk of high blood pressure from diabetes
Decreasing the chance of diabetes-related stroke

Follow these instructions while taking Loyzide M 40 Tablet 15:

Take the tablet whole with a glass of water.
Do not crush, break or chew the tablet.
Try to take it at the same time each day.
Continue taking this medicine regularly as advised.
Consult your doctor if you have questions about using this medicine.

Loyzide M 40 Tablet 15 is taken orally.

Loyzide M 40 Tablet 15 may have the following common side effects:

Hypoglycaemia: This refers to low blood sugar, which may cause symptoms like sweating, dizziness, shakiness, and hunger pangs.
Nausea
Vomiting
Diarrhoea
Stomach pain
Headache
Taste changes: You may experience an unusual or altered sense of taste while taking this medicine.

Managing the Side Effects:

Most side effects are temporary and generally harmless and are resolved by discontinuing the use of Loyzide M 40 Tablet 15. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Nausea: Take Loyzide M 40 Tablet 15 with meals to reduce feelings of sickness.
Hypoglycaemia: Taking this medicine with food can help prevent low blood sugar episodes.

Loyzide M 40 Tablet 15 contains two active ingredients:

Gliclazide (40 mg): This component stimulates the pancreatic beta cells to release more insulin. It helps lower blood glucose levels by encouraging your muscles to use glucose more effectively and reducing glucose production in your liver.
Metformin (500 mg): As a biguanide, metformin works by decreasing glucose production in your liver. It also delays the absorption of glucose from your intestines and improves insulin sensitivity, which means your body can use insulin more efficiently to process sugar.

Pregnancy

Caution is advised while taking Loyzide M 40 Tablet 15 if you are pregnant. It is best to consult your doctor before taking this medicine. Your doctor may recommend insulin instead during pregnancy as it might be safer for managing your blood sugar.

Breastfeeding

Caution is advised while taking Loyzide M 40 Tablet 15 if you are breastfeeding. It is best to consult your doctor before taking this medicine.

Alcohol

Avoid drinking alcohol while taking Loyzide M 40 Tablet 15. Alcohol can increase your risk of low blood sugar (hypoglycaemia) and, in rare cases, may lead to a serious condition called lactic acidosis. These effects can be dangerous for people with diabetes.

Liver

Caution is advised while taking Loyzide M 40 Tablet 15 in case of liver problems. This medicine is not recommended if you have severe liver disease. If you have any liver issues, discuss them with your doctor before starting this medicine.

Kidney

Caution is advised before using Loyzide M 40 Tablet 15 if you have kidney problems. This medicine is not recommended for people with severe kidney disease. Your doctor will need to check your kidney function before prescribing this medicine.

Using Machines & Driving

Be careful when driving or operating machinery while taking Loyzide M 40 Tablet 15. This medicine may cause low blood sugar (hypoglycaemia), which can make you feel dizzy, shaky, or affect your concentration and vision.

Allergy

If you have any known allergies to gliclazide, metformin, or similar medicines, inform your doctor before taking Loyzide M 40 Tablet 15. Stop taking the medicine and seek medical help immediately if you experience any signs of an allergic reaction, such as rash, swelling, or breathing difficulty.

Children

Caution is advised while giving Loyzide M 40 Tablet 15 to children under 18. It is best to consult your doctor before giving this medicine to a child. This medicine is generally not recommended for children.

Older Patients

Older patients should take Loyzide M 40 Tablet 15 under medical supervision, as they may be more likely to experience side effects. Your doctor may start with a lower dose and monitor you more closely, especially if you have kidney problems or are taking other medicines.

Drug-Drug Interactions

Loyzide M 40 Tablet 15 interacts with the following medicines:

Corticosteroids: Medicines like prednisolone or dexamethasone can reduce the blood glucose-lowering effects of Loyzide M 40 Tablet 15, potentially worsening diabetes control.
Thiazide diuretics: Medicines such as hydrochlorothiazide or indapamide may decrease the effectiveness of Loyzide M 40 Tablet 15 by raising blood glucose levels.
Antipsychotics: Certain medicines like olanzapine or risperidone can interfere with blood sugar control when taken with Loyzide M 40 Tablet 15.
Contrast dyes: Iodinated contrast agents used in X-ray procedures may increase the risk of kidney problems when used with metformin in Loyzide M 40 Tablet 15.

Drug-Disease Interactions

Loyzide M 40 Tablet 15 interacts with the following diseases:

Kidney disease: Patients with severe kidney problems should avoid this medicine as it may increase the risk of lactic acidosis, a rare but serious condition.
Liver dysfunction: This medicine should be used cautiously in patients with liver problems, as it may affect how the medicine is processed.
Metabolic acidosis: Loyzide M 40 Tablet 15 is not suitable for people with this condition as it could worsen the acid imbalance in the body.

Daily Dose

The daily dose of Loyzide M 40 Tablet 15 should be taken as prescribed by your doctor. The dosage may vary based on your blood sugar levels and response to treatment. Never adjust your dose without consulting your doctor first.

Over Dose

Taking more than the prescribed dosage of Loyzide M 40 Tablet 15 may cause low blood sugar (hypoglycaemia). You might feel sweaty, dizzy, shaky, hungry, or have a racing heart. Consuming sugar items like fruit juice can help manage mild symptoms.

Missed Dose

If you forget to take Loyzide M 40 Tablet 15, take it as soon as you remember. If it's nearly time for your next dose, skip the missed one and continue your regular schedule. Never take a double dose to make up.

Store Loyzide M 40 Tablet 15 at room temperature (below 30°C).
Keep away from direct sunlight, heat, and moisture.
Store in the original packaging to protect the medicine.
Keep out of reach of children.
Check the expiry date before use and do not take Loyzide M 40 Tablet 15 after this date.

Follow a low-carbohydrate diet with plenty of vegetables, whole grains, and lean proteins to help maintain stable blood glucose (sugar) levels throughout the day.
Engage in regular physical activity—aim for at least 30 minutes of moderate exercise like brisk walking, swimming, or cycling most days of the week to improve your body's insulin sensitivity.

Fact Box

Available Dosage Types	Tablet Er
Habit Forming	No
Ailment	Type 2 diabetes, Hyperglycaemia
Drug Category	Insulin secretagogue, Biguanide
Therapeutic Category	Anti-diabetic medication

How to use Loyzide M 40 Tablet 15?

To reduce stomach problems, take this medicine orally with food. For the best results, try to take it at the same time each day.

What does Loyzide M 40 Tablet 15 do in the body?

It contains gliclazide, which helps the pancreas release more insulin, and metformin, which reduces glucose production in the liver. Together, they control blood sugar levels.

Can I drink alcohol while taking Loyzide M 40 Tablet 15?

No, you should avoid alcohol completely while taking this medicine as it increases the risk of low blood sugar and rare, serious side effects.

What should I do if I experience low blood sugar?

Carry something sugary, like sweets or fruit juice, with you. If you feel dizzy, sweaty, shaky or unusually hungry, take some sugar immediately.

Can I take Loyzide M 40 Tablet 15 during pregnancy?

This medicine is generally not recommended during pregnancy. Your doctor might suggest using insulin instead to manage your diabetes during this time.

What should I tell my doctor before taking Loyzide M 40 Tablet 15?

To avoid potential complications, inform your doctor about any kidney or liver problems, allergies, and all other medicines you are taking.

What are the common side effects of Loyzide M 40 Tablet 15?

Common side effects include stomach discomfort, nausea, diarrhoea, and sometimes low blood sugar. Most side effects improve as your body adjusts to the medicine.

Last Updated On 19 May. 2025 | 1:14PM (IST)

Certified Content

Written by

Ashmita Borgohain

Medical Content Writer | 12 years

MSc (Applied Genetics)

Reviewed by

Dr. Meenakshi Maruwada

Medical Content Writer | 8 years

BDS, PGCAD, GMHE (IIM-B)

Check out Editorial Policy

Manufacturer details

702, Balaji Buisness Park, Andheri Kurla Road, Marol Naka, Andheri East, Mumbai, Maharashtra 400059

Country of origin: INDIA

Expiry on or after: October 2025

In case of any issues, contact us:

support@truemeds.in|08069808861

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

Metformin: MedlinePlus drug information. (2024, February 15). MedlinePlus - Health Information from the National Library of Medicine. https://medlineplus.gov/druginfo/meds/a696005.html
National Health Service. (n.d.). About gliclazide.
https://www.nhs.uk/medicines/gliclazide/about-gliclazide/
Metformin ER 500 mg tablet metformin ER 750 mg tablet. (n.d.). DailyMed. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=b857eccf-b9ff-45ba-8241-f47f5caada2a
U.S. Food and Drug Administration. (2013). Medical review(s). https://www.accessdata.fda.gov/drugsatfda_docs/nda/2013/204042Orig1s000MedR.pdf

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We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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Office Unit no. 1, 2, 5, & 7, 6th floor Urmi Corporate Park Solaris, Saki Vihar Rd, Opp. L&T Flyover, New Mhada Colony, Budhia Jadhav Wadi, Mumbai, Maharashtra 400072.

CIN: U85320MH2019PTC320566

Telephone:09240250346

Grievance Officer

Name: Chandrasekhar Swaminathan

Email: grievance-officer@truemeds.in

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