Hydrea 500 MG Capsule 10

Sarabhai Chemicals Ltd

Pack of 10 Units

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Composition

Hydroxyurea (500 Mg)

Hydrea 500 MG Capsule is used in the treatment of certain cancers, including leukaemia and head and neck cancer, and to alleviate painful episodes of sickle cell anaemia. As part of the antimetabolites group, it also helps reduce blood transfusion requirements and manage complications related to cervical cancer and squamous cell carcinoma. The dosage is tailored to your condition by your doctor, so it's crucial to follow their instructions carefully. Report any side effects promptly and continue the medication as prescribed for optimal results.

Hydrea 500 MG Capsule is used for the following:

Management of resistant chronic myeloid leukaemia
Management of locally advanced squamous cell cancer of the head and neck, excluding the lip
Management of cervical cancer
Reduction of painful crises and need for blood transfusions in sickle cell anaemia

Here's how to take Hydrea 500 MG Capsule:

Swallow the capsule whole with a glass of water.
Avoid splitting, chewing, or crushing the capsule.
Follow your doctor's instructions carefully.
It's crucial not to stop taking this medicine without consulting your doctor first.

Hydrea 500 MG Capsule is taken orally.

Hydrea 500 MG Capsule may have the following common side effects:

Nausea
Vomiting
Diarrhoea
Constipation
Fatigue
Headache
Dizziness
Skin rash
Hair loss
Mouth sores: These are small, painful ulcers that may appear inside your mouth.
Low blood cell counts: This is a decrease in the number of red and white blood cells and platelets in your blood.
Bleeding or bruising: You might notice that you bruise more easily or have nosebleeds.
Pale skin
Unusual tiredness

Managing the Side Effects:

Most side effects are temporary and generally harmless, which are resolved by discontinuing the use of Hydrea 500 MG Capsule. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Nausea: Try taking Hydrea 500 MG Capsule with food to lessen this effect.
Fatigue: Consider taking this medicine at night if it causes you to feel unusually tired during the day.

Hydrea 500 MG Capsule contains hydroxyurea (500 mg), which works on the body as follows:

Inhibits Ribonucleotide Reductase: Hydroxyurea works by blocking an enzyme called ribonucleotide reductase in your body. This enzyme plays a key role in producing DNA, which is necessary for cell division and growth.
Increases Fetal Haemoglobin Production: In cases of sickle cell anaemia, hydroxyurea boosts the production of fetal haemoglobin. This type of haemoglobin reduces the frequency of painful crises associated with the disease.

Pregnancy

Hydrea 500 MG Capsule is contraindicated during pregnancy. If you are pregnant or planning to conceive, make sure to discuss this with your doctor before starting this medicine.

Breastfeeding

Hydrea 500 MG Capsule is contraindicated for breastfeeding women. Consult your doctor to understand the potential risks and benefits.

Alcohol

There's limited data on the effects of alcohol with Hydrea 500 MG Capsule. It's advisable to discuss this with your doctor before taking the medicine.

Liver

Caution is advised while taking Hydrea 500 MG Capsule if you have liver issues. This medicine may affect liver function, so it's best to consult your doctor before starting.

Kidney

Caution is advised before using Hydrea 500 MG Capsule if you have a history of any kidney problems. Consulting your doctor before taking this medicine is recommended.

Using Machines & Driving

The impact of Hydrea 500 MG Capsule on driving or operating heavy machinery hasn't been established. It's wise to consult your doctor on this matter.

Allergy

If you are allergic to hydroxyurea or any other components of Hydrea 500 MG Capsule, do not take this medicine. Consult your doctor for alternatives.

Children

The safety and efficacy of Hydrea 500 MG Capsule in children have not been established. It's best to consult your doctor before giving this medicine to a child.

Older Patients

Older patients should take Hydrea 500 MG Capsule under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Hydrea 500 MG Capsule interacts with the following medicines:

Antiretroviral medicines: Medicines like didanosine or stavudine may interact with Hydrea 500 MG Capsule, potentially leading to altered effects or increased risk of side effects.
Myelosuppressive Agents: When taken with Hydrea 500 MG Capsule, myelosuppressive agents like methotrexate can increase the risk of low blood cell counts.
Live Virus Vaccines: Vaccines for diseases like measles, mumps or varicella may interact with Hydrea 500 MG Capsule. This could potentially reduce the effectiveness of the vaccine or increase the risk of side effects.

Drug-Food Interactions

Hydrea 500 MG Capsule does not have any known interactions with specific foods.

Drug-Disease Interactions

Hydrea 500 MG Capsule interacts with the following diseases:

Kidney Disease: Patients with kidney disease should exercise caution as Hydrea 500 MG Capsule could necessitate dose adjustments.
Liver Disease: Patients with liver disease might experience altered medicine metabolism due to this medicine.
High Uric Acid Levels: People suffering from conditions such as gout might see an increase in uric acid levels due to this medicine.
HIV: Patients who tested positive for HIV may need dose adjustments while taking Hydrea 500 MG Capsule.
History of Radiation Treatment: People who have undergone radiation treatment should use this medication cautiously as it may alter its effectiveness and risk profile.

Daily Dose

Your doctor will prescribe the daily dose of Hydrea 500 MG Capsule. This can vary based on your condition and reaction to the medicine. It's vital you follow the prescribed dosage and never exceed it without consulting your doctor.

Over Dose

In case you take more than the prescribed dose of Hydrea 500 MG Capsule, you might experience symptoms such as a drop in blood cells causing fatigue and increased susceptibility to infections. If these symptoms persist, it's important to inform your doctor.

Missed Dose

If you forget to take your Hydrea 500 MG Capsule at the designated time, take it as soon as you remember. However, if it's nearly time for your next dose, miss out on the forgotten one and go back to your usual schedule. Remember not to increase your dosage without talking to your doctor.

Store your Hydrea 500 MG Capsule in a cool, dry place where the temperature stays below 25°C.
Keep it out of direct sunlight and away from moisture.
Make sure it's safely out of reach of children.
Always use this medicine before its expiry date.

For Conditions Managed by Hydrea 500 MG Capsule:

If you're managing sickle cell anaemia, stay properly hydrated by drinking plenty of fluids. This can help lower the chance of painful crises.
If you're managing cancer, maintaining a balanced diet with adequate protein and calories is crucial. Regular light exercise, as advised by your doctor, can also help manage fatigue related to cancer and its management.

Fact Box

Available Dosage Types	Capsule
Habit Forming	No
Ailment	Chronic myeloid leukaemia, Squamous cell cancer, Sickle cell anaemia
Drug Category	Antimetabolite
Therapeutic Category	Anticancer

What is Hydrea 500 MG Capsule used for?

Hydrea 500 MG Capsule is used to manage certain cancers, including chronic myeloid leukaemia and cervical cancer, as well as sickle cell anaemia.

How does Hydrea 500 MG Capsule work?

This medicine inhibits an enzyme needed for DNA synthesis in cancer cells, preventing their growth. In sickle cell anaemia, it boosts the production of fetal haemoglobin.

How should I take Hydrea 500 MG Capsule?

You should take the capsule orally, either with or without food. The capsule must not be split, chewed or crushed.

What are the common side effects of Hydrea 500 MG Capsule?

Common side effects include nausea, diarrhoea, fatigue, headaches, dizziness, skin rashes, hair loss and mouth sores.

What precautions should I take while taking Hydrea 500 MG Capsule?

Avoid contact with people having infections like flu or chickenpox as the medicine can weaken your immune system. Regular blood tests are necessary to monitor low blood cell counts.

Are there any interactions between Hydrea 500 MG Capsule and other medicines?

Yes, it may interact with certain antiretroviral medicines and myelosuppressive agents. Always inform your doctor about all other medicines you are taking.

Can I take Hydrea 500 MG Capsule during pregnancy or while breastfeeding?

No, this medicine can harm the foetus during pregnancy and breastfeeding is not recommended during treatment. Effective contraception is advised for women of childbearing age.

Last Updated On 12 Nov. 2025 | 11:24AM (IST)

Certified Content

Written by

Ashmita Borgohain

Medical Content Writer | 13 years

MSc (Applied Genetics)

Reviewed by

Dr. Osama Ahmed

Medical Content Writer | 3 years

Bachelor of Dental Surgery

Check out Editorial Policy

Manufacturer details

Shantisadan, Mirzapur Road, Ahmedabad -380001

Expiry on or after: April 2026

In case of any issues, contact us:

support@truemeds.in|09240250346

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

MedlinePlus. (n.d.). Hydroxyurea: MedlinePlus Drug Information. Retrieved 1 April 2024, from https://medlineplus.gov/druginfo/meds/a682004.html
U.S. Food and Drug Administration. (1998). Approval Package for ANDA 75020. Retrieved 1 April 2024, from https://www.accessdata.fda.gov/drugsatfda_docs/anda/98/75020_Hydroxyurea.pdf
McGann, P. T., & Ware, R. E. (2015). Hydroxyurea therapy for sickle cell anemia. Expert opinion on drug safety, 14(11), 1749–1758. https://doi.org/10.1517/14740338.2015.1088827
National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 3657, Hydroxyurea. Retrieved November 16, 2024 from https://pubchem.ncbi.nlm.nih.gov/compound/Hydroxyurea
Musiałek, M. W., & Rybaczek, D. (2021). Hydroxyurea-The Good, the Bad and the Ugly. Genes, 12(7), 1096. https://doi.org/10.3390/genes12071096

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Disclaimer

We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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