Gate GM 80/500 MG Tablet 10

Gates India Pvt Ltd

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Composition

Gliclazide (80 Mg) + Metformin (500 Mg)

Gate GM 80/500 MG Tablet 10 is used to manage type 2 diabetes. It combines two antidiabetic agents: gliclazide and metformin. Gliclazide stimulates insulin release from the pancreas, while metformin decreases glucose production in the liver and improves insulin sensitivity.

This medicine is prescribed when individual therapy with either of its components doesn't provide satisfactory control over the patient's blood sugar levels.

Before you begin taking this medicine, it's crucial to consult your doctor about your dosage and frequency based on your specific health condition. Ensure you inform your doctor about any pre-existing conditions or ongoing medicines you're currently on. If you notice any side effects while taking this medicine, consult your doctor immediately. Continue taking this medicine for the duration prescribed by your doctor for optimal results.

Gate GM 80/500 MG Tablet 10 is used to manage type 2 diabetes. It combines Gliclazide, which stimulates insulin release, and Metformin, which improves insulin sensitivity and decreases glucose production in the liver, helping control blood sugar levels.

Swallow the tablet whole with a glass of water.
Do not crush or chew the tablet.
Take the medicine in the dosage and frequency prescribed by your doctor.
Do not stop taking this medicine without discussing it with your doctor.

Gate GM 80/500 MG Tablet 10 is taken orally.

Gate GM 80/500 MG Tablet 10 may have the following common side effects:

Nausea or vomiting
Stomach pain
Constipation
Diarrhoea
Headache
Dizziness
Blurred vision
Hypoglycaemia (low blood glucose levels)

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve upon discontinuing the medicine. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

You can also effectively manage common side effects like nausea, vomiting, diarrhoea, or stomach pain at home by taking the medicine with food.

Gate GM 80/500 MG Tablet 10 works in the human body in the following ways:

Gliclazide (80 mg): Gliclazide belongs to the group of sulphonylureas. It helps control blood glucose levels by stimulating your pancreas to release more insulin.
Metformin hydrochloride (500 mg): Metformin hydrochloride is classified as a biguanide. Its primary function is to lower glucose production in the liver and reduce intestinal glucose absorption. Additionally, it enhances insulin sensitivity by promoting peripheral glucose uptake and utilisation. This activity, in turn, helps reduce high blood sugar levels.

Pregnancy

Gate GM 80/500 MG Tablet 10 is contraindicated in pregnancy as it may cause harm to the foetus. Always consult your doctor before taking this medicine.

Breastfeeding

This medicine is contraindicated while breastfeeding as it may pass into breast milk and adversely affect the nursing infant. Always consult your doctor before starting this medicine.

Alcohol

Avoid alcohol consumption while on this medication as it could increase the risk of lactic acidosis (lactic acid built up in your body). Always consult your doctor regarding alcohol intake.

Liver

This medicine is contraindicated in patients with severe liver disorders as it could increase their risk of developing lactic acidosis. If you have liver issues, discuss them with your doctor before starting this medication.

Kidney

For those with severe kidney problems, especially severe renal impairment, Gate GM 80/500 MG Tablet 10 is contraindicated. Always consult your doctor before taking this medicine.

Using Machines & Driving

This medicine may cause dizziness or blurred vision in some individuals. If you feel dizzy or unwell, avoid doing activities such as driving or operating machinery until you feel better.

Allergy

Avoid taking this medicine if you are allergic to gliclazide, metformin hydrochloride, or any other ingredients in the tablet. Always discuss your allergies with your doctor.

Children

This medicine is not intended for use in children below 18 years. Always consult your doctor before giving any medicine to a child.

Older Patients

Elderly patients may have decreased hepatic or renal function, which puts them at a higher risk of developing lactic acidosis when taking Gate GM 80/500 MG Tablet 10. Exercise caution and consult your doctor for guidance based on your health status.

Drug-Drug Interactions

Gate GM 80/500 MG Tablet 10 may interact with the following medications:

Diuretics: Medicines like furosemide or hydrochlorothiazide may decrease the blood glucose-lowering effect of this tablet.
Corticosteroids: Medicines like prednisone can reduce the effectiveness of Gate GM 80/500 MG Tablet 10 in managing blood sugar levels.
Angiotensin-converting enzyme (ACE) inhibitors: ACE inhibitors such as ramipril or lisinopril can enhance the medicine's blood sugar-lowering effect, causing extremely low blood sugar levels.
Other antidiabetic agents: Medicines like insulin or glimepiride may interact with this tablet, increasing the risk of low blood sugar.

Drug-Food Interactions

Gate GM 80/500 MG Tablet 10 may interact with certain foods, such as:

High-fibre diet: A diet rich in fibre, like whole grains, legumes, and vegetables, may decrease the absorption and effectiveness of metformin hydrochloride.

Drug-Disease Interactions

Gate GM 80/500 MG Tablet 10 may interact with the following diseases:

Type 1 diabetes: This medicine is contraindicated in patients with type 1 diabetes.
Diabetic ketoacidosis: Patients with diabetic ketoacidosis are also contraindicated from taking this medicine.
Liver or kidney disease: This medicine is contraindicated if you have severe liver or kidney problems, as it could increase your risk of developing lactic acidosis, a rare but serious condition.
Heart failure: People with heart conditions like congestive heart failure are also contraindicated from taking this medicine.

Daily Dose

Your doctor will determine the recommended daily dose of Gate GM 80/500 MG Tablet 10, depending on individual factors such as the severity of your condition and your response to the medication.

Over Dose

If you accidentally take more than the prescribed dose, it can lead to common side effects such as nausea, diarrhoea, or headache. If you experience these symptoms, inform your doctor promptly.

Missed Dose

If you forget to take a dose of the medicine, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue with your regular schedule. Never double your dose to compensate for a missed one without consulting your doctor.

Keep Gate GM 80/500 MG Tablet 10 in a dry place, protected from light and moisture.
Store it at room temperature, below 30°C.
Avoid storing the medicine in heat or direct sunlight, as this could affect its effectiveness.
Ensure this medicine is out of reach of children to prevent accidental consumption.
Always use the medicine before its expiry date.

Consider following a balanced diet low in sugar, which can help control blood glucose levels.
Regular physical activity can also aid in controlling your blood glucose levels. Try incorporating exercise into your daily routine, even if it's just a brisk walk. Always consult your doctor before starting any new exercise regimen.

Fact Box

Available Dosage Types	Tablet
Habit Forming	No
Ailment	Type 2 Diabetes Mellitus
Drug Category	Sulphonylurea, Biguanide
Therapeutic Category	Antidiabetic

What is Gate GM 80/500 MG Tablet 10 used for?

It's a medicine used to manage type 2 diabetes mellitus in adults, particularly when individual components of the medicine, gliclazide or metformin hydrochloride, cannot adequately control blood sugar levels.

How does Gate GM 80/500 MG Tablet 10 work?

This medicine contains two active ingredients. Gliclazide stimulates the pancreas to secrete more insulin in your body, while metformin hydrochloride reduces glucose production in the liver and lowers intestinal glucose absorption. Together, they help reduce blood glucose levels.

Can I take Gate GM 80/500 MG Tablet 10 if I'm pregnant or breastfeeding?

No, this medicine is contraindicated during pregnancy or breastfeeding as it may cause harm to the baby. Always consult your doctor for safer alternatives.

Can children take Gate GM 80/500 MG Tablet 10?

This medicine is not indicated for use in children below 18 years old. Always consult your doctor before giving this medicine to a child.

Are there any side effects of Gate GM 80/500 MG Tablet 10?

Yes, some people may experience side effects like diarrhoea, nausea, vomiting, and hypoglycaemia. If these symptoms persist, consult your doctor.

Can I drink alcohol while taking Gate GM 80/500 MG Tablet 10?

No, it's best to avoid alcohol intake while on this medication, as it can increase the risk of lactic acidosis. Always consult your doctor regarding alcohol consumption.

What should I do if I overdose on Gate GM 80/500 MG Tablet 10?

In case of an overdose, seek immediate medical attention. Overdosing may lead to conditions like dizziness, blurred vision, or hypoglycaemia.

Last Updated On 26 Aug. 2025 | 9:35AM (IST)

Certified Content

Written by

Ashmita Borgohain

Medical Content Writer | 13 years

MSc (Applied Genetics)

Reviewed by

Dr. Divya Chauhan

Medical Content Writer & Reviewer | 7 years

BAMS, APG, PG

Check out Editorial Policy

Manufacturer details

GATES INDIA PVT. LTD., 3RD FLOOR, BLDG. # 10, TOWER C, DLF CYBER CITY, PHASE 2, GURGAON, HARYANA 122002

Country of origin: INDIA

Expiry on or after: February 2026

In case of any issues, contact us:

support@truemeds.in|09240250346

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

GLUCOPHAGE (metformin hydrochloride tablets). (n.d.). accessdata.fda.gov. https://www.accessdata.fda.gov/drugsatfda_docs/label/2000/21202lbl.pdf
Website, N. (2024c, March 26). Gliclazide. nhs.uk. https://www.nhs.uk/medicines/gliclazide/
Gliclazide: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB01120
Campbell, D., Lavielle, R., & Nathan, C. (1991). The mode of action and clinical pharmacology of gliclazide: a review. Diabetes Research and Clinical Practice, 14, S21–S36. https://doi.org/10.1016/0168-8227(91)90005-x
Corcoran, C., & Jacobs, T. F. (2023b, August 17). Metformin. StatPearls - NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK518983/#
Metformin: MedlinePlus drug information. (n.d.). https://medlineplus.gov/druginfo/meds/a696005.html
METFORMIN-INDUCED LACTIC ACIDOSIS COMPLICATED BY ACUTE LIVER FAILURE. (2023, October). journal.chestnet.org. https://journal.chestnet.org/article/S0012-3692(23)02332-2/fulltext

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Disclaimer

We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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