Donep M Forte Tablet 15

Alkem Laboratories Ltd.

Strip of 15 Units

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MRP ~~₹457.5~~

₹366

₹30.5/Units

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Composition

Donepezil (5 Mg) + Memantine (10 Mg)

Donep-M Forte Tablet is used in managing moderate to severe dementia associated with Alzheimer’s disease by improving cognitive function and daily activity performance. Its combination of cholinesterase inhibitor and NMDA antagonist helps regulate neurotransmitters.

Beyond dementia management, it is particularly useful in patients previously treated with donepezil, offering additional cognitive support. Take this medicine as prescribed, inform your doctor about any health issues or medications, and report side effects immediately. Continue the treatment for the duration your doctor recommends.

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Donep-M Forte Tablet is used to manage moderate to severe Alzheimer’s dementia by improving memory, alertness, and daily functioning. It supports better communication, attention, and cognitive ability in affected individuals. By regulating important brain chemicals, it helps reduce symptom progression and enhances the patient’s ability to perform everyday tasks more independently.

Follow these instructions while taking Donep-M Forte Tablet:

Swallow the tablet whole with a glass of water.
Always ensure you follow your doctor's advice on how and when to take this medicine.

Donep-M Forte Tablet is taken orally.

Donep-M Forte Tablet may cause side effects including nausea, vomiting, diarrhoea, loss of appetite, weight loss, headache, dizziness, fatigue, muscle cramps, joint pain, stiffness, sleep disturbances, confusion, and behavioural changes. Seek medical help if these side effects persist.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve upon discontinuing the use of Donep-M Forte Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some guidelines for managing common side effects:

Nausea and Vomiting: Try taking Donep-M Forte Tablet with food to lessen these effects.
Diarrhoea: Consume plenty of water and healthy fluids to avoid dehydration.

Donep-M Forte Tablet is a combination medicine which contains:

Donepezil (5 mg): This component acts by reversibly inhibiting acetylcholinesterase, an enzyme that breaks down acetylcholine in the brain. By increasing the levels of acetylcholine, donepezil enhances neurological functions including memory and cognition.
Memantine (10 mg): Memantine works differently to donepezil. This ingredient uncompetitively blocks NMDA receptors activated by glutamate, an excitatory neurotransmitter. By preventing overstimulation of NMDA receptors, it can avoid neuronal damage. Furthermore, memantine does not interfere with the reversible inhibition of acetylcholinesterase by donepezil.

Pregnancy

Donep-M Forte Tablet is not recommended during pregnancy. If you are pregnant or planning to conceive, discuss this with your doctor before starting this medicine.

Breastfeeding

Donep-M Forte Tablet is not recommended for breastfeeding women. As a safety measure, always consult your doctor to understand the potential risks and benefits.

Alcohol

Caution is advised and it's best to consult your doctor for advice.

Liver

This medicine is often prescribed for older patients, who may be more susceptible to liver health issues. It is advisable to discuss any liver-related concerns with your doctor before starting treatment with Donep-M Forte Tablet. They will evaluate if this medicine is suitable for you.

Kidney

Caution is advised while taking Donep-M Forte Tablet if you have a history of kidney problems. It's always a good idea to consult your doctor before taking this medicine.

Using Machines & Driving

Donep-M Forte Tablet may cause dizziness. Avoid driving or operating heavy machinery until you know how the medication affects you.

Allergy

Donep-M Forte Tablet is not recommended for children under 18 years of age. Always consult your doctor before giving any medicine to a child.

Children

Donep-M Forte Tablet is not recommended for children under 18 years of age. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should take Donep-M Forte Tablet under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Donep-M Forte Tablet interacts with the following medicines:

Anticholinergics: Medicines like atropine and dicyclomine may reduce the effectiveness of Donep-M Forte Tablet by inhibiting its action on acetylcholine.
Cholinergic Agonists: Medicines such as bethanechol might cause overstimulation of acetylcholine receptors when taken with Donep-M Forte Tablet.
NMDA Antagonists: Medicines like amantadine, ketamine, and dextromethorphan could interfere with the action of memantine in Donep-M Forte Tablet.
Medicines for Alkalinize Urine: Sodium bicarbonate or carbonic anhydrase inhibitors can alter the excretion of memantine in Donep-M Forte Tablet.

Drug-Food Interactions

There are no known specific food interactions with Donep-M Forte Tablet.

Drug-Disease Interactions

Donep-M Forte Tablet interacts with the following diseases:

Asthma, COPD, or other Lung Diseases: The medicine may worsen breathing difficulties in patients suffering from these conditions.
Heart Disease or Irregular Heartbeat: Donep-M Forte Tablet may cause changes in heart rate, which could be problematic for these patients.
Seizures: This medicine could potentially trigger seizures in patients with a history of this condition.
Ulcers: There is a risk of aggravating stomach ulcers due to Donep-M Forte Tablet.
Urinary Retention or Enlarged Prostate: The medication might exacerbate urinary problems in patients with these conditions.
Kidney or Liver Impairment: Patients with kidney or liver issues may need dosage adjustments as these organs play a role in the metabolism and excretion of Donep-M Forte Tablet.

Daily Dose

The daily dose of Donep-M Forte Tablet should be taken as prescribed by your doctor. The dosage may vary based on individual factors such as the severity of your condition and how you respond to the medicine. It's crucial to adhere to the prescribed dosage and not exceed it without consulting your doctor.

Over Dose

If you happen to take more than the recommended dose of Donep-M Forte Tablet, you might experience common symptoms such as nausea, diarrhoea, or a rapid heartbeat. In such a case, inform your doctor about this situation.

Missed Dose

In case you forget to take your regular dose of Donep-M Forte Tablet, take it as soon as you remember. However, if it's almost time for your next dose, skip the one you missed and go back to your usual schedule. Never adjust your dosage without consulting your doctor.

Store Donep-M Forte Tablet at room temperature.
Keep the medicine in its original, tightly closed container to protect it from moisture.
Avoid exposure to direct sunlight.
Always keep the medicine out of reach of children.
Use Donep-M Forte Tablet before its expiry date for best results.

Regular physical activity can help manage Alzheimer's symptoms. Try to engage in gentle exercises like walking or stretching daily, as these can assist with memory and cognition.
A diet rich in fruits, vegetables, lean proteins and whole grains may support brain health. Foods high in antioxidants, like berries and leafy greens, could be beneficial for those taking Donep-M Forte Tablet. Always consult your doctor for personalized advice based on your specific needs.

Fact Box

Available Dosage Types	Tablet
Habit Forming	No
Ailment	Alzheimer's Dementia
Drug Category	Cholinesterase Inhibitor, NMDA Antagonist
Therapeutic Category	Anti-dementia

What does Donep-M Forte Tablet do?

It helps manage symptoms of moderate to severe Alzheimer's dementia, improving memory, awareness and daily functioning, but it doesn't cure the disease.

How does Donep-M Forte Tablet work?

The tablet contains two active substances that regulate neurotransmitters in the brain, helping to improve neurological symptoms like memory and cognition.

Can I take Donep-M Forte Tablet with food?

You must take the medicine as directed by your doctor.

What if I forget to take my Donep-M Forte Tablet dose?

Take your missed dose as soon as you remember unless it's nearly time for your next dose. Never take a double dose to catch up.

Can I stop taking Donep-M Forte Tablet if my symptoms improve?

No, don't stop taking your medicine without consulting your doctor, as it could worsen your symptoms.

Is Donep-M Forte Tablet safe for long-term use?

Yes, this medicine is generally safe when used as prescribed, but regular monitoring by a doctor is necessary to assess benefits and risks.

What are some common side effects of Donep-M Forte Tablet?

Common side effects may include nausea, vomiting, diarrhoea, loss of appetite, weight loss and dizziness among others; consult your doctor if they persist.

Last Updated On 11 Dec. 2025 | 8:13AM (IST)

Certified Content

Written by

Dr Nikita Lobo

Medical Content Reviewer | 8 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Medical Content Writer | 9 years

BAMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

Alkem House, Senapati Bapat Marg, Lower Parel, Mumbai Maharashtra- 400013

Country of origin: INDIA

Expiry on or after: June 2026

In case of any issues, contact us:

support@truemeds.in|09240250346

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

Kumar, A., Gupta, V., & Sharma, S. (2023, August 17). Donepezil. StatPearls - NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK513257/
DailyMed - DONEPEZIL HYDROCHLORIDE- donepezil tablet, film coated. (n.d.). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e8ac5d36-8116-456f-8274-3defac54bb24
Donepezil: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00843
DailyMed - MEMANTINE HYDROCHLORIDE capsule, extended release. (n.d.). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f2b7538d-8ca1-4ac7-a172-d268e2fa9a52
Memantine: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB01043

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Disclaimer

We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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