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CompositionCogmentin 5/10mg Tablet 10 is a combination of anti-dementia medications used to manage symptoms of moderate to severe Alzheimer's disease. It combines donepezil (cholinesterase inhibitor) and memantine (NMDA receptor antagonist). It works by regulating important brain chemicals (neurotransmitters) to improve mental function and slow the progression of Alzheimer's symptoms.
Cogmentin 5/10mg Tablet 10 is used for the treatment of moderate to severe Alzheimer's disease and the management of memory problems associated with it. It is prescribed for the improvement of thinking ability in dementia, the enhancement of daily functioning in patients with Alzheimer's disease, and the slowing of cognitive decline in neurodegenerative disorders. It works by regulating brain neurotransmitters in dementia and supporting mental function in progressive memory disorders, often serving as a complementary therapy for patients already taking donepezil.
Follow these instructions while taking Cogmentin 5/10mg Tablet 10:
Swallow the tablet whole with a glass of water.
You may take it with or without food.
Do not crush, divide or chew the tablet.
Continue taking the medicine regularly for the best results.
Never stop taking this medicine suddenly without consulting your doctor.
Cogmentin 5/10mg Tablet 10 is taken orally.
Cogmentin 5/10mg Tablet 10 may cause side effects like nausea, diarrhoea, dizziness, headache, insomnia, anorexia (loss of appetite), abnormal dreams, agitation, tremor (shaking), or confusion. If these persist, consult your doctor.
Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Cogmentin 5/10mg Tablet 10. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor. Here are some general guidelines for managing common side effects:
Nausea: Try taking Cogmentin 5/10mg Tablet 10 with or after meals to reduce stomach upset.
Dizziness: To minimise the impact of dizziness during daily activities, consider taking this medicine in the evening before bedtime.
Cogmentin 5/10mg Tablet 10 contains two active ingredients:
Donepezil (5 mg): This component works as an acetylcholinesterase inhibitor. It prevents the breakdown of acetylcholine, an important chemical messenger in the brain that helps with memory and thinking, thereby increasing its levels and improving communication between nerve cells.
Memantine (10 mg): This acts as an N-methyl-D-aspartate (NMDA) receptor antagonist. It regulates the activity of glutamate, a brain chemical involved in learning and memory, by blocking the effects of excess glutamate that can damage nerve cells.
Caution is advised while taking Cogmentin 5/10mg Tablet 10 if you are pregnant. It is best to consult with your doctor before taking this medicine.
Caution is advised while taking Cogmentin 5/10mg Tablet 10 if you are breastfeeding. It is ideal to talk with your doctor before taking this medicine.
Alcohol may increase the risk of side effects or reduce the effectiveness of this medicine, so be careful when consuming alcohol while taking Cogmentin 5/10mg Tablet 10.
If you have any liver problems, your doctor may need to monitor your liver function during treatment with Cogmentin 5/10mg Tablet 10.
Cogmentin 5/10mg Tablet 10 is not recommended for people with severe kidney problems. However, if you have mild to moderate kidney issues, your doctor may adjust your dose accordingly.
Cogmentin 5/10mg Tablet 10 may cause dizziness or drowsiness in some people. It is advisable to see how this medicine affects you before driving or operating machinery.
Do not take this medicine if you have any known allergies to donepezil, memantine, or any other ingredients in Cogmentin 5/10mg Tablet 10. Tell your doctor about all your allergies before starting treatment.
Cogmentin 5/10mg Tablet 10 is not recommended for children. This medicine is specifically designed to manage Alzheimer's dementia, which primarily affects adults.
Older patients should take Cogmentin 5/10mg Tablet 10 under medical supervision, as they may be more sensitive to side effects. Your doctor will guide you based on your overall health, especially if you have liver or kidney concerns.
Cogmentin 5/10mg Tablet 10 interacts with the following medicines:
Anticholinergic medicines: Medicines like oxybutynin and tolterodine may reduce the effectiveness of donepezil in Cogmentin 5/10mg Tablet 10.
Cholinomimetic medicines: When taken with bethanechol or pilocarpine, Cogmentin 5/10mg Tablet 10 may cause increased cholinergic effects, potentially leading to nausea or a slow heart rate.
NMDA antagonists: Medicines such as dextromethorphan and ketamine may interact with the memantine component, possibly altering therapeutic effects.
Antacids: Medicines like ranitidine and omeprazole may reduce the absorption of memantine in Cogmentin 5/10mg Tablet 10.
Cogmentin 5/10mg Tablet 10 interacts with the following diseases:
Cardiovascular conditions: May cause bradycardia (slow heart rate) or heart block in patients with pre-existing heart problems.
Asthma/COPD: The donepezil component may worsen symptoms due to its cholinomimetic actions.
Ulcer disease: May increase the risk of gastrointestinal bleeding in patients with active or a history of ulcers.
Seizure disorders: May trigger seizures in sensitive individuals with a history of epilepsy.
Bladder problems: Can cause urinary retention, especially in patients with bladder outflow obstruction.
The daily dose of Cogmentin 5/10mg Tablet 10 should be taken as prescribed by your doctor. The dosage may change based on individual factors such as the severity of your dementia and your response to treatment. Always follow the prescribed dosage schedule.
Taking more than the prescribed dose of Cogmentin 5/10mg Tablet 10 may cause nausea, vomiting, excessive sweating, slow heartbeat, low blood pressure, and breathing problems. Contact your doctor if you suspect an overdose has occurred.
If you forget to take Cogmentin 5/10mg Tablet 10, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed dose and continue with your regular schedule. Never double your dose.
Store Cogmentin 5/10mg Tablet 10 at room temperature (below30°C).
Keep in a dry place, away from direct sunlight and moisture.
Store in the original packaging to protect the medicine.
Keep out of reach and sight of children.
Do not use this medicine after the expiry date printed on the package.
Engage in regular mental exercises like puzzles, reading, or memory games to help maintain cognitive function alongside your Alzheimer's medicine.
Follow a Mediterranean-style diet rich in vegetables, fruits, whole grains, and healthy fats, which research suggests may support brain health in persons with dementia.
| Available Dosage Types | Tablet |
| Habit Forming | No |
| Ailment | Alzheimer's dementia, Cognitive decline, Memory impairment |
| Drug Category | Acetylcholinesterase inhibitor, NMDA antagonist |
| Therapeutic Category | Anti-dementia medication |
Cogmentin 5/10mg Tablet 10 is used for managing moderate to severe dementia associated with Alzheimer's disease. It helps improve memory, thinking, and daily functioning.
It works through two mechanisms: donepezil increases acetylcholine (a brain chemical for memory), while memantine regulates glutamate (another brain messenger). Together, they improve brain function.
No, it cannot cure Alzheimer's disease. It helps manage symptoms and may slow the progression, but it doesn't completely reverse or stop the disease.
Common side effects include nausea, diarrhoea, headache, dizziness, insomnia, muscle cramps, and fatigue. Most side effects are mild and temporary.
You can take Cogmentin 5/10mg Tablet 10 with or without food. Swallow the tablet whole.
Consult your doctor before taking any other medicines with Cogmentin 5/10mg Tablet 10, as it may interact with certain medications, such as anticholinergics and antacids.
Store at room temperature (below 30°C) in a dry place. Keep away from direct sunlight and moisture. Always keep out of children's reach.
Check out Editorial Policy
Alzheimer's disease - a multicentre RCT. NIH: National Library of Medicine, National center of biotechnology Information Pubmed.gov. https://pubmed.ncbi.nlm.nih.gov/19630974/
Amneal Pharmaceuticals. (2016, October). DailyMed. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2335950c-be3b-4248-ad04-e9763aee47d2
Donepezil. (2025, May 5). DrugBank Online | Database for Drug and Drug Target Info. https://go.drugbank.com/drugs/DB00843
Memantine: MedlinePlus drug information. (2016, April 15). MedlinePlus - Health Information from the National Library of Medicine. https://medlineplus.gov/druginfo/meds/a604006.html
Donepezil - StatPearls - NCBI bookshelf. (2023, August 17). National Center for Biotechnology Information. https://www.ncbi.nlm.nih.gov/books/NBK513257/
We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.
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