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CompositionCefofit 1.5 Injection 1 is a potent antibiotic used to treat severe bacterial infections, including those that are resistant to other drugs. It is effective against respiratory tract infections (sinusitis, pneumonia), urinary tract infections, intra-abdominal infections, septicaemia (blood infections), and CNS infections like meningitis. It supports faster recovery by fighting tough bacteria.
Cefofit 1.5 Injection 1 used to treat various severe bacterial infections by disrupting the bacterial cell wall and overcoming resistance. It is prescribed for serious infections in the respiratory and urinary tracts, skin and soft tissues, intra-abdomen, and for systemic conditions like septicaemia and meningitis. This injectable combination (likely Cefoperazone/Sulbactam) competes with other powerful, broad-spectrum injectable antibiotics such as Meropenem and Piperacillin/Tazobactam for hospital use.
This medication is administered as an intravenous or intramuscular injection by a healthcare professional.
It's important to complete the full course of this medicine, even if symptoms improve.
Always consult your doctor for any specific advice or concerns regarding the use of this medicine.
Cefofit 1.5 Injection 1 is administered intravenously or via an intramuscular route.
Cefofit 1.5 Injection 1 may cause side effects like pain at the injection site, nausea, vomiting, diarrhoea, indigestion, headache, dizziness, drowsiness and fatigue. Consult your doctor if these side effects persist or worsen.
Most side effects are temporary and generally harmless, which resolve upon discontinuing the medicine. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.
You can also effectively manage common side effects like pain and inflammation at the injection site by applying a cold pack to that area.
Cefofit 1.5 Injection 1 works in the human body in the following ways:
Cefoperazone (1000 mg): Cefoperazone inhibits the synthesis of bacterial cell walls by binding to penicillin-binding proteins (PBPs) located inside the cell walls. This activity eventually leads to bacterial cell lysis, which causes the bacteria's death.
Sulbactam (500 mg): This ingredient is a beta-lactamase inhibitor. It blocks the activity of beta-lactamase enzymes, preventing them from destroying beta-lactam antibiotics like cephalosporins. This, in turn, enhances the effectiveness of cefoperazone against bacteria.
Caution is advised while using Cefofit 1.5 Injection 1 if you are pregnant. It is best to consult your doctor before administering this medicine.
Exercise caution while using this medicine during breastfeeding as the medicine may pass into breast milk and lead to adverse effects in nursing infants. Always consult your doctor to understand the potential risks and benefits.
Avoid alcohol consumption while on this medication as it may intensify certain side effects such as dizziness or drowsiness. It can also increase the risk of developing disulfiram-like reactions. Always consult your doctor regarding alcohol intake.
Caution is advised before administering this medicine if you have any liver issues. Always discuss your liver health concerns with your doctor before starting this medicine.
If you have a history of kidney problems, caution is advised while using this medicine. Your doctor will guide you based on your health status.
Cefofit 1.5 Injection 1 can cause side effects like dizziness and sleepiness, which may affect your ability to drive or operate machinery. Avoid doing such activities while on this medication until you know how this medicine affects you.
This medicine is contraindicated in patients with known allergies to cefoperazone, sulbactam, or other cephalosporins. Always discuss your allergies with your doctor.
This medicine is not indicated for use in children without medical advice. Always consult your doctor before giving any medicine to a child.
Older patients, especially those with liver or kidney problems, should use this medicine under medical supervision as they may be more susceptible to its side effects. Your doctor will guide you based on your health status.
Cefofit 1.5 Injection 1 may interact with the following medications:
Aminoglycosides: When used with this medicine, antibiotics like gentamicin and amikacin can increase the risk of kidney damage.
Anticoagulants: Blood-thinning medications like warfarin and heparin may interact with Cefofit 1.5 Injection 1, potentially leading to an increased risk of bleeding.
Medications for gout, such as Probenecid: can increase the levels of cefoperazone in your body, causing adverse effects.
Live typhoid vaccine: Cefoperazone in the medicine may inactivate this vaccine, reducing its effectiveness.
There are no specific food interactions with Cefofit 1.5 Injection 1.
Cefofit 1.5 Injection 1 may interact with the following diseases:
Hypoprothrombinaemia: Patients with active bleeding or hypoprothrombinaemia (a condition in which the blood clotting substance prothrombin is deficient) should use this medicine cautiously, as it may increase the risk of bleeding.
Liver or kidney disease: Those with liver or kidney problems should exercise caution as this medicine could worsen their condition.
The recommended dose of Cefofit 1.5 Injection 1 should be administered as prescribed by your doctor. The dosage may vary based on the severity of the condition and your response to treatment.
Overdose of this injection is unlikely as it is administered by a healthcare professional.
If you forget to get this injection administered at the scheduled time, do it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue with your regular schedule. Never increase the dosage without consulting your doctor.
Store Cefofit 1.5 Injection 1 below 25°C.
Protect the vials from light and moisture to maintain their efficacy.
Keep the product out of children's reach.
Always check the expiry date before use, and avoid using any injection past its expiry date.
If you have a respiratory or urinary tract infection, drinking plenty of fluids can help flush bacteria out of your system. Fluids like water or herbal teas can also help manage these conditions.
Maintaining good hygiene is crucial for skin and soft tissue infections. Regularly clean affected areas with mild soap and water to prevent further bacterial growth.
| Available Dosage Types | Injection |
| Habit Forming | No |
| Ailment | Pneumonia, Bronchitis, Intra-abdominal Infections |
| Drug Category | Cell Wall Synthesis Inhibitor |
| Therapeutic Category | Antibiotic |
This injection is used to manage various bacterial infections, such as respiratory tract infections, urinary tract infections, skin and soft tissue infections, and bone and joint infections.
This medicine combines two active ingredients: cefoperazone and sulbactam. Cefoperazone inhibits the synthesis of bacterial cell walls, whereas sulbactam prevents the beta-lactamase enzymes from degrading cefoperazone. Together, they work to weaken and destroy bacteria, managing the infection effectively.
If you have a penicillin allergy, you must consult your doctor before using this medication, as cross-sensitivity may occur.
The injection should be administered during pregnancy and breastfeeding only when the potential benefits outweigh the risks to the baby. Always consult your doctor before starting this medicine.
Some typical side effects of the medicine may include pain and inflammation at the injection site, nausea, vomiting, and diarrhoea. If these symptoms persist or worsen, consult your doctor.
This medicine starts functioning shortly after administration with symptoms usually improving within 48-72 hours; however, always complete the full course of medication to prevent relapse.
If you forget to administer the medicine at the scheduled time, do it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue with your regular schedule. Never increase the dosage without consulting your doctor.
Check out Editorial Policy
CEFOBID. (n.d.). CEFOBID. https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/050551s043lbl.pdf
Entasis Therapeutics Inc. (2023). Highlights of prescribing information for XACDURO [Press release]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/216974Orig1s000Correctedlbl.pdf
CefOperaZone: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB01329#
Sulbactam: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB09324
Sulbactam. (n.d.). pubchem.ncbi.nlm.nih.gov. https://pubchem.ncbi.nlm.nih.gov/compound/Sulbactam
Clinical Efficacy and Safety of Cefoperazone–Sulbactam in Treatment of Intra-Abdominal Infections: A Systematic Review and Meta-Analysis. (2021, February). researchgate.net. https://www.researchgate.net/publication/349580223_Clinical_Efficacy_and_Safety_of_Cefoperazone-Sulbactam_in_Treatment_of_Intra-Abdominal_Infections_A_Systematic_Review_and_Meta-Analysis
Bai, H., Li, H., Nie, X., Yao, Y., Han, X., Wang, J., & Peng, L. (2023). Development and validation of a nomogram for predicting cefoperazone/sulbactam-induced hypoprothrombinaemia in Hospitalized adult patients. PloS One, 18(9), e0291658. https://doi.org/10.1371/journal.pone.0291658
We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.
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