Cefoperazone + Sulbactam

Dosage Forms Available

• Cefoperazone + Sulbactam is available as a dry powder in a vial for preparing an injection.
• It may be administered as an intravenous or intramuscular injection.
• It must be prepared and administered by a healthcare professional.

Age and Dose Restrictions

• Cefoperazone + Sulbactam may be used in adults and children.
• The dose depends on the patient’s age, weight, infection severity, ratio of the 2 components in the product, and kidney and liver function.
• Before administering it to premature babies or newborns, the doctor will carefully assess the potential benefits and risks.
• Follow the dose and treatment duration prescribed by the doctor.

Contraindications

• Do not use Cefoperazone + Sulbactam if you are allergic to cefoperazone, sulbactam, penicillins, cephalosporins or another beta-lactam antibiotic.
• Tell your doctor if an antibiotic has previously caused swelling of your face or throat, breathing difficulty or a severe skin reaction.
• Vitamin K deficiency is not a contraindication, but it may increase the risk of bleeding and require monitoring.

Other Medicines to Avoid With This Medicine

• Aminoglycoside antibiotics, such as amikacin, must not be mixed with Cefoperazone + Sulbactam in the same syringe or solution.
• If both antibiotics are required, administer them separately using different intravenous lines. Kidney function may need to be monitored.
• Blood-thinning medicines, such as warfarin, may increase the risk of bleeding.
• Tell your doctor about all medicines, vitamins and supplements you use.
• Avoid alcohol and alcohol-containing products during treatment and for at least 5 days after the last dose.

Overdose and Missed Dose

• An overdose may worsen the medicine’s side effects. Very high levels of beta-lactam antibiotics may cause neurological effects, including seizures.
• Tell your healthcare professional immediately if you suspect you have taken too much medicine.
• This injection is usually given by a doctor or nurse. Inform them as soon as possible if you miss a scheduled dose.
• Do not give a double dose to make up for a missed dose.

Driving and Operating Machinery

• Cefoperazone + Sulbactam is unlikely to affect your ability to drive or operate machinery.
• Do not drive or operate heavy machinery if you experience dizziness, headache or feel unwell.

Use in Pregnancy and Breastfeeding

• Use Cefoperazone + Sulbactam only when the doctor considers it clearly necessary.
• Small amounts of cefoperazone and sulbactam may pass into breast milk.
• Use it during breastfeeding only with caution and under medical supervision.

Caution in Other Conditions

• The sulbactam dose may need to be reduced in people with severe kidney disease.
• Dose adjustment and monitoring may be required in severe liver disease or when bile flow from the liver is blocked.
• Medicine levels may require monitoring if both kidney and liver function are impaired.
• People with poor nutrition, difficulty absorbing nutrients or prolonged intravenous feeding may have a higher risk of vitamin K deficiency and bleeding.
• During prolonged treatment, the doctor may monitor kidney function, liver function and blood cell counts.
• Tell your doctor if an antibiotic has previously caused severe diarrhoea or inflammation of the large intestine.

Special Dietary and Lifestyle Recommendations

• Do not drink alcohol during treatment or for at least 5 days after the last dose. Alcohol may cause flushing, sweating, headache and a rapid heartbeat.
• Drink enough water unless your doctor has advised you to limit fluids.
• Follow a balanced, nutritious diet.
• Wash your hands regularly and maintain good hygiene to help prevent the spread of infection.
• Complete the antibiotic course your doctor prescribed, even if you start feeling better.