Acostin 1 MIU Injection 10 ML

Ranbaxy Laboratories Ltd

Pack of 10 ML

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MRP ~~₹810.42~~

₹648.34

₹81.04/ML

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Prescription required for this medicine

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Composition

Colistin (1 Miu)

Acostin 1 MIU Injection is a powerful antibiotic used to manage severe bacterial infections, particularly those caused by multidrug-resistant Gram-negative bacteria. This medicine is part of a group known as antibiotics.

It is also effective for infections that may not respond to other treatments, including respiratory, urinary tract, abdominal, and bloodstream infections.

Before taking this injection, consult your doctor, who will determine the appropriate dosage and frequency. Make sure you inform your doctor about any pre-existing conditions or ongoing medication. If you notice any side effects while on this medicine, notify your doctor immediately. It is important to continue taking the medicine for the duration prescribed by your doctor for optimal results.

Acostin 1 MIU Injection is used for the following:

Treats severe bacterial infections caused by multidrug-resistant Gram-negative bacteria
Treats respiratory tract, urinary tract, bloodstream, or abdominal infections

Administer Acostin 1 MIU Injection as advised below:

This injection will be administered by a healthcare professional.
Be sure to stay well-hydrated before and after each dose.
Since this treatment is managed by a healthcare professional, you will receive detailed instructions during administration. Always consult your doctor for personalised guidance.

Acostin 1 MIU Injection can be administered intravenously or intramuscularly.

Acostin 1 MIU Injection may cause the following side effects:

Nausea and vomiting
Dizziness
Muscle weakness
increase in urine output
Fatigue

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve upon discontinuing the use of Acostin 1 MIU Injection. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Nausea and Vomiting: Avoid spicy or greasy foods that can aggravate nausea.
Dizziness: Sit or lie down immediately if you feel dizzy to avoid falls. Avoid sudden movements, such as getting up quickly from a seated or lying position.
Increase in Urine Output: Limit caffeine or diuretics, which can further increase urine production.

Acostin 1 MIU Injection contains Colistimethate sodium (1 MIU), which works in the following ways:

Targets Specific Bacteria: Colistin specifically targets gram-negative bacteria, which are responsible for certain types of infections.
Disrupts Bacterial Cell Membrane: Colistin interacts with the membrane of the bacterial cell, causing it to become leaky. This causes essential substances inside the bacterium to leak out, leading to its death.
Halts Bacterial Growth: By disrupting the bacterial cell membrane, colistin inhibits the growth and multiplication of the bacteria, helping to control and eliminate the infection.

Pregnancy

This medication should only be used in pregnancy if deemed absolutely necessary by a doctor. It carries risks for the developing foetus, so effective contraception is recommended during treatment.

Breastfeeding

Acostin 1 MIU Injection may pass into breast milk and could harm an infant. Discuss alternatives or consider temporarily stopping breastfeeding while using this medication.

Alcohol

Avoid alcohol during treatment, as it can amplify side effects like nausea and kidney strain. Always consult your doctor for personalised advice.

Liver

Patients with existing liver conditions should exercise caution while using Acostin 1 MIU Injection, as it may exacerbate liver problems.

Kidney

Acostin 1 MIU Injection may also affect kidney function, particularly in individuals with pre-existing kidney issues. Discuss your kidney health with your doctor, who may recommend dosage adjustments or additional monitoring during treatment.

Using Machines & Driving

This medicine can cause dizziness, fatigue, or muscle weakness, which may impair your ability to operate machinery or drive. Avoid such activities until you know how the medicine affects you.

Allergy

Avoid using this medication if you are allergic to Colistin or any of its components. Seek immediate medical attention if you experience rash, swelling, or breathing difficulties.

Children

Acostin 1 MIU Injection can be used in children. Your doctor will guide you to the appropriate dosage before administering.

Older Patients

Older adults, particularly those above 70 years of age, are more susceptible to the side effects of Acostin 1 MIU Injection. Caution and close monitoring by a healthcare professional are recommended for this age group.

Drug-Drug Interactions

Acostin 1 MIU Injection interacts with the following medicines:

Antibiotics: There is an enhanced risk of kidney damage with aminoglycosides (e.g., gentamicin).
Muscle Relaxants: There is an increased muscle weakness risk with neuromuscular blockers such as tubocurarine.

Drug-Disease Interactions

Acostin 1 MIU Injection interacts with the following diseases:

Kidney Disease: Acostin 1 MIU Injection can be nephrotoxic, potentially causing or worsening kidney damage. Patients with kidney issues may require dose adjustments and regular monitoring of kidney function.
Myasthenia gravis: This medicine can exacerbate muscle weakness, a hallmark of myasthenia gravis. This medicine's interaction with neuromuscular functions may cause breathing difficulties.
Porphyria: Porphyria is a rare genetic disorder, and some antibiotics, including colistin, may trigger attacks. Using Acostin 1 MIU Injection could worsen symptoms like abdominal pain, neuropathy, or mental health disturbances.
Asthma: Colistin can cause breathing difficulties or trigger bronchospasms in sensitive individuals. Asthmatic patients may experience an increased risk of respiratory side effects.

Daily Dose

The dose of Acostin 1 MIU Injection should be administered as recommended by your doctor. The dosage may vary based on individual factors, such as the severity of the condition and response to treatment. It's crucial to adhere to the prescribed dosage and not to exceed it without consulting your doctor.

Over Dose

Overdosing on Acostin 1 MIU Injection might result in symptoms similar to its side effects, such as muscle weakness and breathlessness. However, overdose is unlikely as it is administered by a healthcare professional. If you suspect an overdose, you should inform your doctor about it.

Missed Dose

If you forget to administer your scheduled dose of Acostin 1 MIU Injection, contact your healthcare provider. Do not increase the dosage without consulting your doctor.

Store Acostin 1 MIU Injection in temperature 2–8°C.
Keep it away from direct sunlight and damp areas like the bathroom or kitchen.
Ensure it is stored out of the reach and sight of children.
Make sure to use this medicine before its expiry date

Incorporate yoghurt or other probiotic-rich foods to restore healthy gut bacteria, which can be affected by antibiotics.
Avoid processed and greasy foods that can strain digestion and weaken your recovery.
Avoid caffeinated and sugary beverages, which can dehydrate the body.

Fact Box

Available Dosage Types	Injection
Habit Forming	No
Ailment	Bacterial infections
Drug Category	Polymyxin antibiotic
Therapeutic Category	Antibiotic

What is Acostin 1 MIU Injection used for?

Acostin 1 MIU Injection is a powerful antibiotic used to treat severe bacterial infections caused by multidrug-resistant Gram-negative bacteria. It is typically prescribed for serious conditions, such as respiratory, urinary tract, abdominal, and bloodstream infections. Due to its potency, it is often reserved for severe or hard-to-treat cases.

How is Acostin 1 MIU Injection administered?

Acostin 1 MIU Injection is given intravenously (IV) by a healthcare professional. The exact dosage depends on the type and severity of the infection, as well as the patient's kidney function. Regular monitoring is required to ensure the injection is administered safely and effectively, helping to minimise side effects.

Can I drink alcohol while using Acostin 1 MIU Injection?

It is recommended to avoid alcohol during treatment with Acostin 1 MIU Injection. Alcohol can increase the risk of side effects, such as nausea and strain on the kidneys. Always consult your doctor for personalised advice based on your individual condition.

Can I use this medicine during pregnancy or breastfeeding?

Acostin 1 MIU Injection should only be used during pregnancy if deemed absolutely necessary by a doctor. If you are breastfeeding, caution is advised as the medication may pass into breast milk. Speak to your healthcare provider to understand the potential risks and benefits before using this medicine.

What are the potential side effects of Acostin 1 MIU Injection?

Common side effects include nausea, dizziness, and fatigue. More serious side effects could involve kidney or nerve damage, difficulty breathing, or severe allergic reactions. If you experience any unusual or severe symptoms, contact your doctor immediately.

Does this medicine interact with other medicines or food?

Acostin 1 MIU Injection may interact with other medications, such as aminoglycosides, diuretics, and neuromuscular blockers, which can increase the risk of side effects. While no major food interactions have been noted, it is advised to follow a kidney-friendly diet during treatment. Always inform your doctor of any other medications or supplements you are taking.

How should I store Acostin 1 MIU Injection?

Store Acostin 1 MIU Injection in the refrigerator at 2–8°C, and avoid freezing. Use the medication immediately after it has been prepared by a healthcare professional. Keep it out of reach of children, and properly dispose of any unused portions.

Last Updated On 15 Aug. 2025 | 5:17PM (IST)

Certified Content

Written by

Dr. Divya Mandial

Medical Content Writer | 9 years

PhD in Chemistry

Reviewed by

Dr. Betina Chandolia

Lead Medical Content Reviewer | 10 years

BDS, MDS, PGCCL, PGDMH

Check out Editorial Policy

Manufacturer details

A-41 Industrial Area Phase VIII-A SAS Nagar PB 160071 IN ,

Country of origin: INDIA

Expiry on or after: January 2026

In case of any issues, contact us:

support@truemeds.in|09240250346

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

Colistimethate for Injection. (N.d.). Fda.Gov. Retrieved November 18, 2024, from https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/050108s033lbl.pdf
Colistin. (n.d.). RxList. Retrieved November 18, 2024, from https://www.rxlist.com/colistin/generic-drug.htm
Colistin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00803

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We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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