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Piotame MG 2/500/15 MG Tablet 10 is a combination therapy of Glimepiride, Metformin, and Pioglitazone used to manage Type 2 Diabetes through multiple mechanisms of blood sugar control.
Consult your doctor for the appropriate dosage based on your overall health. Inform them of any pre-existing conditions or current treatments, and report any side effects promptly to maintain the best results.
Piotame MG 2/500/15 MG Tablet 10 is used for managing type 2 diabetes mellitus. It lowers both fasting and post-meal blood glucose levels, helps prevent complications like cardiovascular disease, kidney damage, and nerve problems, and reduces the risk of blindness and limb amputations caused by diabetes.
Swallow the tablet whole with a glass of water.
The tablet should not be split, crushed or chewed.
Piotame MG 2/500/15 MG Tablet 10 is taken orally.
Piotame MG 2/500/15 MG Tablet 10 may cause upper respiratory tract infections, diarrhea, nausea, vomiting, headache, dizziness, and hypoglycemia. Consult your doctor if side effects persist.
Most side effects are temporary and typically harmless, which resolves on discontinuing the use of Piotame MG 2/500/15 MG Tablet 10. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.
Here are a few tips:
Hypoglycaemia: Carry a fast-acting source of sugar like glucose tablets or fruit juice with you to quickly raise your blood sugar if it gets low.
Nausea/Vomiting: Try taking Piotame MG 2/500/15 MG Tablet 10 with food to lessen this effect.
Piotame MG 2/500/15 MG Tablet 10 contains three active ingredients that work together to improve blood sugar control:
Metformin (500 mg): This ingredient suppresses glucose production by the liver. It increases insulin sensitivity, enhances the uptake of glucose from outside the body, and slows down glucose absorption from the intestine.
Pioglitazone (15 mg): This component works as an insulin sensitiser by stimulating a nuclear receptor in our body called peroxisome proliferator-activated receptor gamma (PPAR-γ). It improves the body's response to insulin and decreases resistance to it in peripheral parts of the body and liver.
Glimepiride (2 mg): This component stimulates the pancreas to secrete more insulin. It enhances insulin release and increases the sensitivity of tissues outside the pancreas to insulin.
Piotame MG 2/500/15 MG Tablet 10 is not recommended during pregnancy. If you are pregnant or planning to conceive, make sure to discuss this with your doctor before starting this medicine.
Caution is advised while taking Piotame MG 2/500/15 MG Tablet 10 if you are breastfeeding. Metformin, one of the active ingredients, is excreted in breast milk. It's best to consult your doctor before taking this medicine.
Consuming alcohol while taking Piotame MG 2/500/15 MG Tablet 10 might increase the risk of hypoglycemia (low blood sugar) and lactic acidosis (a dangerous buildup of lactic acid). It's best to limit alcohol consumption while on this medication.
If you have a history of liver disease, discuss it with your doctor before starting Piotame MG 2/500/15 MG Tablet 10. This medicine might affect liver function and increase the risk of lactic acidosis due to metformin.
Piotame MG 2/500/15 MG Tablet 10 is advised against use in patients with severe kidney impairment and should be used with caution in those with moderate kidney impairment. If you have kidney problems, ensure to discuss them with your doctor before starting this medicine.
Piotame MG 2/500/15 MG Tablet 10 may cause dizziness or confusion due to hypoglycaemia. Be careful when driving or operating heavy machinery until you know how this medication affects you.
If you know you're allergic to glimepiride, metformin, pioglitazone, or any other ingredients in Piotame MG 2/500/15 MG Tablet 10, do not take this medicine. Always inform your doctor about any known allergies before starting a new medication.
Piotame MG 2/500/15 MG Tablet 10 is designed for adult use. It should not be given to children under 18 years of age. Always consult your doctor before giving any medicine to a child.
Elderly patients might respond differently to Piotame MG 2/500/15 MG Tablet 10 due to age-related changes in kidney function and increased risk of heart failure and hypoglycemia. Such patients should take this medicine under medical supervision.
Piotame MG 2/500/15 MG Tablet 10 may interact with the following medicines:
Insulin and other anti-diabetic medications: When used with Piotame MG 2/500/15 MG Tablet 10, medicines such as insulin or glibenclamide could increase the risk of low blood sugar (hypoglycaemia).
Thiazide diuretics like hydrochlorothiazide or metolazone may worsen blood sugar control when taken with Piotame MG 2/500/15 MG Tablet 10.
Corticosteroids and sympathomimetics: Specific medications like prednisolone, epinephrine, and norepinephrine may reduce the effectiveness of Piotame MG 2/500/15 MG Tablet 10.
Thyroid products like levothyroxine can decrease the effect of Piotame MG 2/500/15 MG Tablet 10 on blood sugar control.
Calcium-channel blockers such as nifedipine or nicardipine can increase the absorption and blood sugar-lowering effect of metformin in Piotame MG 2/500/15 MG Tablet 10.
Cationic medicines such as amiloride, digoxin, ranitidine, and vancomycin can reduce kidney clearance, leading to a higher risk of metformin toxicity.
Certain foods can interact with Piotame MG 2/500/15 MG Tablet 10.
High-fat meals: Consuming high-fat meals might slow down the absorption of glimepiride in Piotame MG 2/500/15 MG Tablet 10, affecting its glycaemic control.
Piotame MG 2/500/15 MG Tablet 10 can interact with the following diseases:
Kidney disease: People with severe kidney impairment should be cautious as this medication could exacerbate their condition.
Liver disease: Patients with liver disease should exercise caution since impaired liver function can increase the risk of lactic acidosis due to metformin in Piotame MG 2/500/15 MG Tablet 10.
Congestive heart failure: The pioglitazone in Piotame MG 2/500/15 MG Tablet 10 can worsen fluid retention and swelling in patients with congestive heart failure.
Take the daily dosage of Piotame MG 2/500/15 MG Tablet 10 as directed by your doctor. The dosage may vary depending on factors like how severe your condition is and how well you respond to the medicine. Make sure to follow your doctor's instructions and avoid changing the dose without their advice.
If you accidentally take more Piotame MG 2/500/15 MG Tablet 10 than prescribed, you might experience common symptoms such as nausea, dizziness, or rapid heartbeat. In case of an overdose, it's crucial to inform your doctor right away.
If you forget to take your Piotame MG 2/500/15 MG Tablet 10 dose, take it as soon as you remember. But if it's almost time for the next dose, skip the missed one and continue with your regular schedule. Remember, never increase your dosage without first consulting your doctor.
Store Piotame MG 2/500/15 MG Tablet 10 at temperatures of 10°C to 25°C in a dark and dry place.
Keep the product in its original packaging to protect it from light and moisture.
Ensure the medicine is out of children's reach.
Always check the expiry date before use and discard any past this date.
Maintain a balanced diet low in sugars: This helps manage blood sugar levels, reducing the risk of hyperglycemia, a condition where blood sugar is too high, which Piotame MG 2/500/15 MG Tablet 10 helps manage.
Regular exercise: A consistent exercise routine can improve insulin sensitivity, helping your body use insulin more effectively, which is crucial when managing type 2 diabetes.
| Dosage Forms Available | Tablet |
| Habit Forming | No |
| Ailment | Type 2 Diabetes Mellitus |
| Drug Category | Sulfonylurea, Biguanide, Thiazolidinedione |
| Therapeutic Category | Antidiabetic |
Piotame MG 2/500/15 MG Tablet 10 is used to manage blood sugar levels in adults with type 2 diabetes.
It contains three active ingredients that work together to enhance insulin release, increase insulin sensitivity, and decrease glucose production in the body.
Yes, take it as soon as you remember. If it's nearly time for your next dose, skip the missed one.
Common side effects include upper respiratory infections, diarrhoea, nausea, headache, dizziness, and oedema (swelling due to fluid retention).
You should avoid skipping meals and excessive alcohol consumption while taking this medicine.
Some medicines, such as insulin or glibenclamide, prednisolone and epinephrine, can interact with Piotame MG 2/500/15 MG Tablet 10. Always consult your doctor before starting any new medication.
Store them at room temperature between 10°C and 25°C, away from light and moisture, and out of children's reach.
Check out Editorial Policy
NHS UK. (n.d.). Glimepiride: How and when to take Glimepiride. Retrieved from https://www.nhs.uk/medicines/glimepiride/how-and-when-to-take-glimepiride/
NHS UK. (n.d.). Glimepiride: How and when to take Pioglitazone . Retrieved from
https://www.nhs.uk/medicines/pioglitazone/how-and-when-to-take-pioglitazone/
MedlinePlus. (2022, February 15). Glimepiride. Retrieved from https://medlineplus.gov/druginfo/meds/a696005.html
MedlinePlus. (2022, February 15). Pioglitazone. Retrieved from
Chaudhury, A., Duvoor, C., Reddy Dendi, V. S., Kraleti, S., Chada, A., Ravilla, R., Marco, A., Shekhawat, N. S., Montales, M. T., Kuriakose, K., Sasapu, A., Beebe, A., Patil, N., Musham, C. K., Lohani, G. P., & Mirza, W. (2017). Clinical Review of Antidiabetic Drugs: Implications for Type 2 Diabetes Mellitus Management. Frontiers in endocrinology, 8, 6. https://doi.org/10.3389/fendo.2017.00006
U.S. Food and Drug Administration. (2011, June 10). FDA Approval Letter. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/appletter/2011/021071s038,021410s026,021700s010ltr.pdf
U.S. Food and Drug Administration. (2006, November). FDA Label. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/021748s002lbl.pdf
We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.
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