Glimepiride + Metformin + Pioglitazone
AntidiabeticUses of Glimepiride + Metformin + Pioglitazone
Glimepiride + Metformin + Pioglitazone combines three antidiabetic medicines used as third-line therapy for Type II diabetes mellitus in adult patients. This approach is recommended when glycemic control remains inadequate despite dietary measures, exercise, and previous interventions involving single agents or second-line therapy with two medications.
Side effects of Glimepiride + Metformin + Pioglitazone
- Upper respiratory tract infection
- Headache
- Sinusitis
- Myalgia
- Pharyngitis
- Metallic taste
How Glimepiride + Metformin + Pioglitazone works
- The principal mechanism by which glimepiride lowers blood glucose levels is believed to rely on stimulating insulin release from functional pancreatic beta cells. Furthermore, the activity of sulfonylureas, including glimepiride, may involve extrapancreatic effects.
- Metformin exerts its effects through multiple mechanisms, including the reduction of hepatic glucose production, inhibition of intestinal glucose absorption, and enhancement of insulin sensitivity through increased peripheral glucose uptake and utilisation. Significantly, compared to sulfonylureas (SUs), metformin does not induce hypoglycemia.
- Pioglitazone mitigates insulin resistance in peripheral tissues and the liver, leading to heightened insulin-dependent glucose disposal and diminished hepatic glucose output. Functioning as a potent and highly selective agonist, pioglitazone targets the peroxisome proliferator-activated receptor gamma (PPAR), notably in insulin-sensitive tissues such as adipose tissue, skeletal muscle, and the liver. The activation of PPAR nuclear receptors facilitates the transcriptional regulation of various insulin-responsive genes, thereby influencing the control of glucose and lipid metabolism.
Certified content
Written By
B. Pharm
Reviewed By
B. Pharm, MSc.
Expert Advice
Dosage Forms Available
- Glimepiride + Metformin + Pioglitazone is available for use via the oral route (tablets).
Age and Dose Restrictions
- This combination is meant for use in adults and children above 18 years of age.
Contraindications
- Glimepiride + Metformin + Pioglitazone is CONTRAINDICATED in patients with severe renal dysfunction, metabolic acidosis, and heart issues.
Other Medications To Avoid With This Medicine
- It is not recommended to use any drugs for bacterial infections (rifampicin, tetracycline, and clarithromycin), fungal infections (fluconazole), other oral diabetes medications, and gout medications (probenecid). Before using any prescription or over-the-counter medications, you must consult your doctor.
Overdose and Missed Dose
- Overdose of this combination can cause hypoglycemia. Inform your doctor regarding these effects and follow the advice accordingly.
- If you forget to take a dose of this combination, take it as soon as you remember. But avoid repeating the dose.
Use In Driving And Operating Machinery
- This combination does not directly impact your ability to drive or operate machinery. However, they may lead to hypoglycemia which can cause dizziness. Taking precautions to prevent low blood sugar while driving or handling machinery is essential.
Use in Pregnancy and Lactation
- Glimepiride + Metformin + Pioglitazone is not recommended in pregnant and breastfeeding women.
Special Dietary & Lifestyle Recommendation
- Making lifestyle changes, including dietary modifications and regular exercise, is essential when taking Glimepiride + Metformin + Pioglitazone to control blood sugar levels properly.
- After initiating treatment with Glimepiride + Metformin + Pioglitazone, it's recommended to have your blood sugar levels reassessed after 15 days and, subsequently, at regular intervals every 3-6 months. This monitoring helps track the progress of the disease and allows for dose adjustments as needed.
- If hypoglycemia occurs, it's essential to have a quick source of sugar readily available. Carry sugar candies, glucose tablets, or sugary foods and drinks without fat or protein, such as fruit juice, to promptly address low blood sugar episodes.
Frequently asked questions
How much does Glimepiride + Metformin + Pioglitazone take to work?
This combination may start to work within a few hours, but it may take some time to see the full effects. It's important to continue taking it as your doctor prescribes, even if you start feeling better.
What warnings and precautions should I take while taking Glimepiride + Metformin + Pioglitazone?
While taking this combination, be cautious to avoid hypoglycemia (low blood sugar). Avoid taking it if you are allergic to either of the components of this combination.
Should I stop taking Glimepiride + Metformin + Pioglitazone if I feel healthy?
Do not stop taking this combination without consulting your doctor, even if you feel healthy. Abruptly discontinuing this medication can lead to uncontrolled blood sugar levels.
Does Glimepiride + Metformin + Pioglitazone affect fertility?
This combination typically does not affect fertility. However, if you have concerns about fertility and its impact on diabetes management, discuss them with your doctor.
Glimepiride + Metformin + Pioglitazone in other salts
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