Pexos 0.125 Tablet 10

Chemo Health Care Pvt Ltd

Strip of 10 Units

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MRP ~~₹60~~

₹29.94

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Composition

Pramipexole (0.125 Mg)

Strength:

0.5 MG 0.25 MG 0.75 MG 0.125 MG

Pexos 0.125 Tablet 10 is used to manage the motor symptoms of Parkinson's disease, such as tremors, stiffness, and slow movement. It belongs to a class of medications called dopamine agonists.

In addition to Parkinson's disease, this medicine is also used to manage restless legs syndrome (RLS). RLS causes uncomfortable sensations and an irresistible urge to move the legs, particularly at night. By helping to relieve these sensations, the medicine can improve sleep quality and daily functioning for people with this condition.

This medicine should be taken as directed by your doctor. Inform your doctor about any pre-existing medical conditions or ongoing medications before starting this medicine. If you experience side effects, notify your doctor immediately. Continue taking the medicine for the duration prescribed by your doctor for optimal results.

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Pexos 0.125 Tablet 10 is used for the following:

Managing Parkinson's disease
Managing tremors and stiffness
Improving movement and coordination
Reducing the slowness of movement
Helping with balance difficulties
Managing RLS

Follow these instructions while taking Pexos 0.125 Tablet 10:

Swallow the tablet whole with a glass of water.
Do not crush, break, or chew the tablet.
Take this medicine at the same time each day to maintain consistent levels in your body.

Pexos 0.125 Tablet 10 is taken orally.

Pexos 0.125 Tablet 10 may have the following common side effects:

Nausea
Drowsiness
Dizziness
Constipation
Dry mouth
Fatigue
Insomnia
Abnormal dreams
Confusion

Managing the Side Effects:

Most side effects are temporary and generally harmless and are resolved by discontinuing the use of Pexos 0.125 Tablet 10. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some tips for managing common side effects:

Nausea: Try taking the medicine with meals to reduce feelings of sickness.
Drowsiness: Consider taking this medicine at bedtime if it makes you sleepy during the day.

Pexos 0.125 Tablet 10 contains pramipexole (0.125 mg), which works on the body as follows:

Dopamine Receptor Stimulation: Pramipexole mimics the action of dopamine, a natural chemical in your brain that helps control movement and coordination.
D2 and D3 Receptor Activation: It specifically targets and activates dopamine receptors called D2 and D3 in the brain, which are important for regulating movement.
Compensation Mechanism: By stimulating these receptors, pramipexole compensates for the shortage of natural dopamine that occurs in Parkinson's disease.
Neurotransmitter Modulation: The medicine helps modulate abnormal nerve signalling in the brain regions responsible for controlling movement and sensations.

Pregnancy

Caution is advised while taking Pexos 0.125 Tablet 10 if you are pregnant. It is best to consult your doctor before taking this medicine.

Breastfeeding

Caution is advised while taking Pexos 0.125 Tablet 10 if you are breastfeeding. It is best to consult your doctor before taking this medicine.

Alcohol

Consuming alcohol while taking Pexos 0.125 Tablet 10 may increase drowsiness and dizziness. Avoid alcohol during your treatment with this medicine.

Liver

Caution is advised while taking Pexos 0.125 Tablet 10 if you have liver problems. Your doctor may need to adjust your dose based on your liver function.

Kidney

Caution is advised before using Pexos 0.125 Tablet 10 if you have a history of any kidney problems. Consult your doctor before taking this medicine.

Using Machines & Driving

Pexos 0.125 Tablet 10 may cause drowsiness or sudden sleep onset. Avoid driving, operating machinery, or engaging in activities requiring alertness until you know how this medicine affects you.

Allergy

If you have any known allergies to pramipexole or other ingredients in Pexos 0.125 Tablet 10, inform your doctor immediately.

Children

Caution is advised while giving Pexos 0.125 Tablet 10 to children under 18 years of age. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should take Pexos 0.125 Tablet 10 under medical supervision, as they may be more susceptible to its side effects. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Pexos 0.125 Tablet 10 interacts with the following medicines:

Antipsychotics: Medicines like chlorpromazine and haloperidol may reduce the effectiveness of this medicine, potentially diminishing its benefits for Parkinson's symptoms.
Sedatives: When taken with Pexos 0.125 Tablet 10, sedatives such as diazepam and zolpidem can enhance drowsiness and increase the risk of suddenly falling asleep.
Antiemetics: Some anti-nausea medicines like metoclopramide and prochlorperazine can reduce pramipexole's effectiveness by blocking dopamine receptors.

Drug-Disease Interactions

Pexos 0.125 Tablet 10 interacts with the following diseases:

Kidney Disease: Your body may clear pramipexole more slowly, potentially causing higher medicine levels and more side effects.
Psychotic Disorders: This medicine may worsen hallucinations or psychotic symptoms in patients with pre-existing mental health conditions.
Cardiovascular Disease: Pramipexole may cause low blood pressure (hypotension), potentially worsening symptoms in patients with heart problems.
Sleep Disorders: This medicine might cause sudden sleep onset, which could be particularly problematic for those with existing sleep conditions

Daily Dose

The daily dose of Pexos 0.125 Tablet 10 should be taken exactly as prescribed by your doctor. Your dosage may change based on the severity of your condition and how well you respond to treatment. Always follow the prescribed dosage and never alter it without consulting your doctor.

Over Dose

Overdosing on Pexos 0.125 Tablet 10 may cause excessive drowsiness, nausea, vomiting, dizziness, or abnormal movements. If you suspect an overdose, contact your doctor for guidance.

Missed Dose

If you forget to take a dose, take it as soon as you remember. If it is nearly time for your next dose, skip the missed one and continue with your regular schedule. Never take a double dose to make up for a missed one.

Store at room temperature (below 30°C).
Keep away from direct sunlight and moisture.
Store in the original packaging to protect from light exposure.
Always keep out of reach of children and pets.
Check the expiry date before use and do not use after this date.

Regular gentle exercise like walking or swimming can help manage Parkinson's symptoms by improving mobility and balance, complementing the effects of this medicine.
Establishing a regular bedtime routine can help manage restless legs syndrome symptoms, which often worsen in the evening and disturb sleep.

Fact Box

Available Dosage Types	Tablet
Habit Forming	No
Ailment	Parkinson's disease, Restless Legs Syndrome
Drug Category	Dopamine agonist
Therapeutic Category	Antiparkinson agent

How does Pexos 0.125 Tablet 10 work?

Pexos 0.125 Tablet 10 works by mimicking dopamine, a brain chemical that controls movement. It activates dopamine receptors to help improve movement problems when natural dopamine levels are low.

What conditions does Pexos 0.125 Tablet 10 manage?

This medicine manages Parkinson's disease symptoms like tremors and stiffness. It also helps with restless legs syndrome, which causes uncomfortable leg sensations and urges to move.

Does Pexos 0.125 Tablet 10 cause low blood pressure?

Yes, it may cause orthostatic hypotension (blood pressure drop when standing up), especially in older patients. This might make you feel dizzy or faint when you stand.

Can Pexos 0.125 Tablet 10 make me sleepy during the day?

Yes, this medicine can cause drowsiness and sometimes sudden sleep episodes. Avoid driving or using machinery until you know how it affects you.

What should I do if I miss a dose of Pexos 0.125 Tablet 10?

Take it as soon as you remember. If it is nearly time for your next dose, skip the missed one. Never take a double dose to make up for a forgotten one.

What are the common side effects of Pexos 0.125 Tablet 10?

Common side effects include nausea, dizziness, drowsiness, constipation, headache, fatigue, and dry mouth. Most are mild and often improve with continued use.

Can I stop taking Pexos 0.125 Tablet 10 suddenly?

No, never stop taking this medicine abruptly. Sudden discontinuation may worsen your symptoms. Your doctor will help you reduce the dose gradually if needed.

Last Updated On 10 Jun. 2025 | 8:27AM (IST)

Certified Content

Written by

Ashmita Borgohain

Medical Content Writer | 12 years

MSc (Applied Genetics)

Reviewed by

Dr. Chhavi Rosha

Medical Content Writer | 9 years

BAMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

PLOT NO : 1, NEW AHMEDABAD INDL. ESTATE, VILL. MORRAIYA, TAL, Sanand Rd, Changodar, Gujarat 382213

Country of origin: INDIA

Expiry on or after: November 2025

In case of any issues, contact us:

support@truemeds.in|08069808861

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

DailyMed. (n.d.). Pramipexole dihydrochloride tablet, film coated. U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=04bf2b80-5371-4641-bbf5-e19587c0e9cf&type=display (Accessed 1 April 2025)
Singh, R., & Parmar, M. (2023, April 17). Pramipexole. StatPearls - NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK557539/
Shannon, K. M., Bennett, J. P., Jr, & Friedman, J. H. (1997). Efficacy of pramipexole, a novel dopamine agonist, as monotherapy in mild to moderate Parkinson's disease. The Pramipexole Study Group. Neurology, 49(3), 724–728. https://doi.org/10.1212/wnl.49.3.724
DrugBank. (n.d.). Pramipexole. https://go.drugbank.com/drugs/DB00413 (Accessed 1 April 2025)
Li, T., Zou, S., Zhang, Z., Liu, M., & Liang, Z. (2022). Efficacy of pramipexole on quality of life in patients with Parkinson’s disease: a systematic review and meta-analysis. BMC Neurology, 22(1). https://doi.org/10.1186/s12883-022-02830-y

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We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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