Mestrolyst 40 Tablet 10

Septalyst Lifesciences Pvt Ltd

Strip of 10 Units

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MRP ~~₹316.88~~

₹272.52

₹31.69/Units

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Composition

Megestrol (40 Mg)

MESTROLYST 40 TABLET 10 is used to manage hormone-dependent cancers, specifically advanced breast cancer and endometrial cancer. This synthetic progestogen helps manage symptoms related to hormone imbalances, including appetite stimulation for patients suffering from significant weight loss in advanced stages of cancer or AIDS.

Before starting this medication, it's essential to inform your doctor about your health history and ongoing treatments. If you experience any side effects, notify your doctor immediately. Continue taking the medicine for the entire prescribed duration to achieve optimal results.

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MESTROLYST 40 TABLET 10 is used to treat advanced breast cancer and endometrial cancer. It helps slow the growth of hormone-dependent cancers, stimulates appetite in cancer patients, combats weight loss, and addresses hormonal imbalances, especially in advanced stages or AIDS-related conditions.

Follow these instructions while taking MESTROLYST 40 TABLET 10:

Swallow the tablet whole with a full glass of water.
Do not crush, break, or chew the tablet.
Take this medicine at the same time each day for the best results.
You can take this tablet with or without food.

MESTROLYST 40 TABLET 10 is taken orally.

MESTROLYST 40 TABLET 10 may cause side effects including weight gain, high blood pressure, constipation, mood changes, hair loss, fatigue, nausea, edema (swelling), moon face (puffy appearance), and hot flushes. If these symptoms persist, consult your doctor.

Management Of Side Effects:

Most side effects are temporary and generally harmless, which often improve over time or resolve upon dose adjustment or discontinuation. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Nausea: Taking the medicine with food may help reduce feelings of sickness.
Constipation: Taking this medicine with plenty of water and after meals can help manage this side effect.

MESTROLYST 40 TABLET 10 contains megestrol (40 mg), which works in the following ways:

Hormone receptor binding: Megestrol binds to progesterone receptors in the body, affecting hormonal balance and helping to slow the growth of hormone-dependent cancer cells.
Gonadotropin suppression: This medicine inhibits the secretion of gonadotropin hormones from the pituitary gland, which subsequently reduces oestrogen production in the body.
Appetite regulation: Megestrol influences the hypothalamus, the part of the brain that controls appetite, though the exact mechanism for appetite stimulation is not fully understood.
Anti-tumour activity: The medicine helps slow the growth and spread of certain cancer cells that depend on specific hormones to grow.

Pregnancy

MESTROLYST 40 TABLET 10 is contraindicated during pregnancy. If you are pregnant or planning to conceive, make sure to discuss this with your doctor before starting this medicine.

Breastfeeding

MESTROLYST 40 TABLET 10 is contraindicated for breastfeeding women. The active ingredient, megestrol, may pass into breast milk. Consult your doctor to understand the potential risks and benefits.

Alcohol

Avoid consuming alcohol while taking MESTROLYST 40 TABLET 10. Alcohol might increase certain side effects of this medicine, such as dizziness or tiredness.

Liver

Caution is advised while taking MESTROLYST 40 TABLET 10 if you have liver problems. If you have any history of liver disease, discuss this with your doctor before starting this medicine.

Kidney

Caution is advised before using MESTROLYST 40 TABLET 10 if you have a history of any kidney problems. Your doctor may need to adjust your dosage or monitor your kidney function regularly during treatment.

Use In Driving And Operating Machinery

This medicine may cause dizziness or affect your concentration. If you experience these effects, avoid driving or operating heavy machinery until you feel better.

Allergy

If you have any known allergies to megestrol or any ingredients in MESTROLYST 40 TABLET 10, inform your doctor immediately.

Children

Caution is advised while giving MESTROLYST 40 TABLET 10 to children under 18 years of age. This medicine is primarily meant for adult use. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should take MESTROLYST 40 TABLET 10 under medical supervision, as they may be more susceptible to its side effects. Your doctor will guide you based on your overall health condition.

Drug-Drug Interactions

MESTROLYST 40 TABLET 10 interacts with the following medicines:

Hormonal medicines: When taken with other hormonal medicines like tamoxifen or letrozole, this medicine may have altered effectiveness or increased side effects.
Diabetes medicines: Megestrol may affect blood glucose levels, potentially reducing the effectiveness of medicines like metformin or insulin.
Blood pressure medicines: Concurrent use with medicines like amlodipine or atenolol may require dose adjustments, as megestrol can cause high blood pressure.
Liver enzyme-affecting medicines: Medicines like rifampicin or carbamazepine may alter how your body processes megestrol, potentially changing its effectiveness.

Drug-Disease Interactions

MESTROLYST 40 TABLET 10 interacts with the following diseases:

Diabetes: Megestrol may affect blood sugar control, requiring closer monitoring of glucose levels.
History of blood clots: This medicine may increase the risk of developing new blood clots in patients with previous thrombosis.

Daily Dose

The daily dose of MESTROLYST 40 TABLET 10 should be taken as prescribed by your doctor. The dosage may change based on the severity of your condition and how your body responds to treatment. Always follow the prescribed dosage and never alter it without consulting your doctor.

Over Dose

An overdose of MESTROLYST 40 TABLET 10 may cause severe constipation, extreme mood changes, unusual fatigue, and excessive swelling in limbs. Contact your doctor if you experience any concerning symptoms.

Missed Dose

If you forget to take a dose, take it as soon as you remember. If it is nearly time for your next dose, skip the missed one and continue with your regular schedule. Never take a double dose to make up for a forgotten one.

Store MESTROLYST 40 TABLET 10 at room temperature (below 25°C).
Protect from excessive heat and moisture.
Store away from children's reach.
Check the expiry date on the package, and do not use the medicine after this date.

For patients with hormone-dependent cancers, consider including more plant-based foods in your diet, as they contain natural compounds that may help support hormonal balance.
If you are taking MESTROLYST 40 TABLET 10 for appetite stimulation, try eating smaller, more frequent meals throughout the day rather than three large meals to help manage weight loss.

Fact Box

Dosage Forms Available	Tablet
Habit Forming	No
Ailment	Hormone-dependent cancers, appetite loss
Drug Category	Synthetic progestogen
Therapeutic Category	Anti-neoplastic

What is MESTROLYST 40 TABLET 10 used for?

MESTROLYST 40 TABLET 10 is used to manage hormone-dependent breast and endometrial cancers. It also helps stimulate appetite in people with cancer or AIDS who have lost weight.

How does MESTROLYST 40 TABLET 10 work in the body?

It works as a synthetic progestogen (artificial progesterone hormone) that binds to hormone receptors. This helps slow down cancer cell growth and stimulates your appetite through brain signalling.

What are the common side effects of this medicine?

Common side effects include weight gain, increased appetite, constipation, mood changes, hair loss, tiredness, nausea, swelling, a rounded face appearance, and hot flushes.

Can I drive while taking MESTROLYST 40 TABLET 10?

You should avoid driving if you experience dizziness or concentration problems while taking this medicine. These side effects may affect your ability to drive safely.

What should I do if I miss a dose?

Take the missed dose as soon as you remember. If it is nearly time for your next dose, skip the missed one. Never take a double dose to make up for the missed one.

Is MESTROLYST 40 TABLET 10 safe during pregnancy?

No. This medication is not safe during pregnancy and is contraindicated due to the risk of fetal harm.

What monitoring will I need while taking this medicine?

Regular monitoring of blood pressure, blood glucose levels, liver and kidney function, and hormone levels will be needed throughout your treatment period.

Last Updated On 03 Feb. 2026 | 11:34AM (IST)

Certified Content

Written by

Dr Nikita Lobo

Medical Content Reviewer | 9 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Medical Content Writer | 10 years

BAMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

Arcadia Complex, 208, Ghodbunder Rd, Hiranandani Estate, Thane West, Maharashtra 400607

Country of origin: INDIA

Expiry on or after: December 2026

In case of any issues, contact us:

support@truemeds.in|09240250346

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

MedlinePlus. (n.d.). Megestrol. Retrieved 1 April 2025, from https://medlineplus.gov/druginfo/meds/a682003.html
Lim, Y. L., Teoh, S. E., Yaow, C. Y. L., Lin, D. J., Masuda, Y., Han, M. X., Yeo, W. S., & Ng, Q. X. (2022). A Systematic Review and Meta-Analysis of the Clinical Use of Megestrol Acetate for Cancer-Related Anorexia/Cachexia. Journal of Clinical Medicine, 11(13), 3756. https://doi.org/10.3390/jcm11133756
Manikkuttiyil, C., & Nguyen, H. (2023, June 26). Megestrol. StatPearls - NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK559205/
DrugBank. (n.d.). Megestrol. Retrieved 1 April 2025, from https://go.drugbank.com/drugs/DB19378
Loprinzi, C. L., Ellison, N. M., Schaid, D. J., Krook, J. E., Athmann, L. M., Dose, A. M., Mailliard, J. A., Johnson, P. S., Ebbert, L. P., & Geeraerts, L. H. (1990). Controlled trial of megestrol acetate for the treatment of cancer anorexia and cachexia. JNCI Journal of the National Cancer Institute, 82(13), 1127–1132. https://doi.org/10.1093/jnci/82.13.1127

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We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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Telephone:09240250346

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