Megesta 160 Tablet 10

Rencord Life Sciences Pvt Ltd

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Composition

Megestrol (160 Mg)

Megesta-160 Tablet is used for the treatment of advanced breast cancer and endometrial cancer, particularly hormone-dependent types that have spread to other parts of the body. It belongs to a class of medicines known as progestogens, which are synthetic derivatives of the naturally occurring hormone progesterone.

In addition to its primary use in cancer treatment, this medicine is also used to manage anorexia, cachexia, and significant weight loss in patients with AIDS. It helps stimulate appetite and promote weight gain in these individuals when they are experiencing severe nutritional challenges due to their condition.

This medicine should be taken orally as directed by your doctor, who will determine the appropriate dosage based on your condition. Before beginning treatment, inform your doctor about any pre-existing conditions you have or medications you are currently taking. If you notice any side effects while taking this medicine, notify your doctor promptly. Continue taking the medicine for the entire duration prescribed by your doctor for optimal results.

Megesta-160 Tablet is used for the following:

Treatment of advanced breast cancer
Management of endometrial cancer
Hormone-dependent cancers that have spread
Stimulating appetite in AIDS patients
Managing significant weight loss in patients with AIDS
Treating cachexia in AIDS patients
Counteracting the effects of oestrogen on cancer cells
Palliative care for certain hormone-sensitive cancers

Directions for Use of Megesta 160 Tablet 10

Follow these instructions while taking Megesta-160 Tablet:

Swallow the tablet whole with a glass of water.
Do not crush or chew the tablet.
Take this medicine at the same time each day for consistent effects.
Do not stop taking this medicine suddenly without consulting your doctor.

Megesta-160 Tablet is taken orally.

Megesta-160 Tablet may have the following common side effects:

Weight gain
Increased appetite
Constipation
Shortness of breath
Hot flashes
Hyperglycaemia: This refers to high blood sugar levels, which may be particularly concerning if you have diabetes.
Cushing's syndrome: This condition can cause a rounded face, fat deposits on the upper back and abdomen, and thinning of the skin.
Hypertension: This means high blood pressure, which might not cause noticeable symptoms but can be detected during check-ups.
Insomnia
Decreased libido: This means reduced sexual desire or interest in sexual activity.

Managing the Side Effects:

Most side effects are temporary and generally harmless, and they resolve when the use of Megesta-160 Tablet is discontinued. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Nausea: Taking Megesta-160 Tablet with food may help reduce feelings of sickness.
Constipation: Taking this medicine with plenty of water and after breakfast may help maintain regular bowel movements.

Megesta-160 Tablet contains megestrol (160 mg), which works on the body as follows:

Progesterone Receptor Binding: Megestrol binds to and activates progesterone receptors in your body, mimicking the effects of the natural hormone progesterone.
Anti-oestrogen Activity: In hormone-sensitive cancers, megestrol counteracts the effects of oestrogen on cancer cells, which helps slow down their growth and spread throughout the body.
Cytokine Regulation: For appetite stimulation, megestrol alters the production and release of certain cytokines (chemical messengers in your immune system) that are involved in regulating appetite and metabolism.
Adrenal Influence: Megestrol affects your adrenal glands, which can lead to changes in hormone levels that contribute to increased appetite and weight gain in patients experiencing significant weight loss.

Pregnancy

Megesta-160 Tablet is contraindicated during pregnancy. If you are pregnant or planning to conceive, make sure to discuss this with your doctor before starting this medicine. It may cause birth defects if taken during pregnancy.

Breastfeeding

Megesta-160 Tablet is contraindicated for breastfeeding women. The active ingredient, megestrol, can pass into breast milk and may harm your baby. Consult your doctor to understand the potential risks and benefits.

Alcohol

Caution is advised while taking Megesta-160 Tablet when consuming alcohol. Alcohol might increase your risk of certain side effects. It is best to consult your doctor about alcohol consumption during your treatment.

Liver

Caution is advised while taking Megesta-160 Tablet if you have liver problems. This medicine may affect blood sugar levels and might require additional monitoring if you have liver impairment. Discuss any liver concerns with your doctor before starting this treatment.

Kidney

Caution is advised before using Megesta-160 Tablet if you have a history of kidney problems. It is a good idea to consult your doctor before taking this medicine, especially if you have existing kidney issues.

Using Machines & Driving

Caution is advised when driving or operating machinery while taking Megesta-160 Tablet. Some side effects, like dizziness or shortness of breath, might affect your ability to perform these tasks safely. Assess how this medicine affects you before driving.

Allergy

Caution is advised if you have allergies to megestrol or any of the ingredients in Megesta-160 Tablet. Before starting this treatment, tell your doctor about all your allergies, including to medicines, foods, or other substances.

Children

Caution is advised while giving Megesta-160 Tablet to children under 18. This medicine is primarily meant for adult use. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should take Megesta-160 Tablet under medical supervision as they may be more susceptible to its side effects. There is an increased risk of blood clots and adrenal suppression in elderly patients. Your doctor will guide you based on your overall health status.

Drug-Drug Interactions

Megesta-160 Tablet interacts with the following medicines:

Antifungal medicines: Medicines like ketoconazole may increase megestrol levels in your bloodstream, potentially enhancing both therapeutic effects and side effects.
HIV medicines: Specific antiretrovirals such as indinavir and zidovudine can interact with Megesta-160 Tablet, potentially altering the effectiveness of both medicines.
Antibiotics: Rifampin and similar antibiotics may decrease the effectiveness of megestrol by increasing its breakdown in the liver.

Drug-Food Interactions

Drug-Disease Interactions

Megesta-160 Tablet interacts with the following diseases:

Diabetes: This medicine may raise blood sugar levels, making diabetes more difficult to control.
Thrombophlebitis: Patients with a history of blood clots are at an increased risk of developing new clots while taking this medicine.
Adrenal insufficiency: Long-term use can suppress adrenal function, potentially worsening existing adrenal problems.

Daily Dose

The daily dose of Megesta-160 Tablet should be taken as prescribed by your doctor. The dosage may change based on your condition, treatment response, and overall health. Never adjust the dosage without consulting your doctor.

Over Dose

Taking Megesta-160 Tablet in excess may cause increased breathing difficulties, severe constipation, extreme weight gain, high blood pressure, and elevated blood sugar levels. Contact your doctor if you experience these symptoms after taking extra tablets.

Missed Dose

If you forget to take Megesta-160 Tablet, take it as soon as you remember. If it's nearly time for your next dose, skip the missed one and continue your regular schedule. Never double the dose to make up for a missed one.

Store Megesta-160 Tablet protect from light and moisture.
Keep the medicine in its original packaging.
Do not refrigerate or freeze the tablets.
Keep out of reach of children and pets.
Do not use after the expiry date printed on the package.

If you are taking Megesta-160 Tablet for appetite stimulation, try eating several small, nutrient-dense meals throughout the day rather than three large meals to maximise nutritional intake.
For those with hormone-sensitive cancers, consider incorporating more plant-based foods rich in antioxidants to support your overall health during treatment.

Fact Box

Drug Category	Progestogen
Therapeutic Category	Anticancer medicine
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Breast cancer, endometrial cancer, AIDS-related weight loss

How long does it take for Megesta-160 Tablet to work?

It works at different speeds for different conditions. For appetite improvement, you may notice changes within weeks. For cancer-related benefits, it may take several weeks to months.

Can I suddenly stop taking Megesta-160 Tablet?

No. Never stop suddenly after long-term use. This can cause withdrawal symptoms and adrenal insufficiency (when your body doesn't make enough essential hormones). Your doctor should guide you.

Will I keep gaining weight after stopping Megesta-160 Tablet?

Weight gained while taking this medicine usually decreases after you stop. Healthy eating and regular exercise can help you manage your weight effectively afterwards.

Can Megesta-160 Tablet cure cancer?

No. It's not a cure, but it can slow the progression of certain hormone-sensitive cancers and improve symptoms. It works as a palliative treatment (reducing symptoms).

Is Megesta-160 Tablet safe for long-term use?

Long-term use requires regular check-ups and blood tests. Your doctor must monitor you closely to balance the benefits against possible risks.

What should I do if I experience breathing problems?

Contact your doctor immediately if you experience shortness of breath. It could indicate a serious side effect, such as a pulmonary embolism (blood clot in the lungs).

Does Megesta-160 Tablet affect blood sugar levels?

Yes. This medicine can raise blood glucose levels. If you have diabetes, your doctor may need to monitor your blood sugar more frequently during treatment.

Last Updated On 29 Apr. 2025 | 3:25PM (IST)

Certified Content

Written by

Ashmita Borgohain

Medical Content Writer & Editor | 12 years

MSc (Applied Genetics)

Reviewed by

Dr. Meenakshi Maruwada

Medical Content Writer & Strategist | 8 years

BDS, PGCAD, GMHE (IIM-B)

Check out Editorial Policy

Manufacturer details

Office No. 156, 1st Floor, Vardhman Grand Plaza Commercial complex, Rohini, Sec.-3, New Delhi-110085

Country of origin: INDIA

References

MedlinePlus. (n.d.). Megestrol oral: MedlinePlus drug information. Retrieved 1 April 2025, from https://medlineplus.gov/druginfo/meds/a682003.html
U.S. Food and Drug Administration. (2014). Megace ES (megestrol acetate) oral suspension, label and approval history [Label]. Retrieved 1 April 2025, from https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/021778s018lbl.pdf
Megestrol acetate. (2025, April 19). DrugBank Online | Database for Drug and Drug Target Info. https://go.drugbank.com/drugs/DB00351
Megestrol - StatPearls - NCBI bookshelf. (2023, June 26). National Center for Biotechnology Information. https://www.ncbi.nlm.nih.gov/books/NBK559205/

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We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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