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CompositionEpilex Chrono 300 Tablet contains Sodium Valproate and Valproic Acid in a specialized formulation used to manage various forms of epilepsy, including partial and generalized seizures. It stabilizes abnormal electrical activity in the brain to prevent seizure occurrence.
Beyond epilepsy, it is also effective for managing manic episodes in bipolar disorder and preventing migraine headaches. Discuss your treatment goals with your doctor to utilize this holistic approach to managing brain activity.
Epilex Chrono 300 Tablet is used for managing different types of epilepsy, including complex partial seizures in adults and children over 10 years old, controlling simple and complex absence seizures, managing manic episodes linked to bipolar disorder, and helping to prevent migraine headaches.
Take the tablet orally with a glass of water.
Do not break, crush or chew the tablet. It should be swallowed whole.
The medicine can be taken with or without food.
Make sure you take Epilex Chrono 300 Tablet exactly as your doctor has prescribed.
Avoid stopping the medicine abruptly. Always consult your doctor first.
Epilex Chrono 300 Tablet is taken orally.
Epilex Chrono 300 Tablet may cause tremor (involuntary muscle movements), somnolence (near-sleep or excessive sleep), sedation, dizziness, headache, confusion, memory impairment, nausea, vomiting, abdominal pain, diarrhea, and indigestion.
Here are some general guidelines for managing common side effects:
Abdominal pain: Try taking Epilex Chrono 300 Tablet with food.
Indigestion: Consider taking this medicine after meals to lessen this effect.
Epilex Chrono 300 Tablet consists of sodium valproate (300 mg), which works as follows:
Increases GABA levels: By raising the levels of an inhibitory neurotransmitter called GABA in the brain, it helps reduce abnormal electrical activity and calm overexcited neurons.
Blocks channels: It acts by blocking certain channels known as voltage-gated sodium channels and T-type calcium channels that are involved in the propagation of epileptic seizures.
Inhibits enzyme: It inhibits an enzyme called GABA transaminase which breaks down GABA. This action further ensures increased GABA levels in the brain.
These combined actions help stabilise abnormal electrical activity in the brain that causes epileptic seizures. In cases of bipolar disorder and migraines, the same mechanisms contribute towards mood stabilisation and prevention of migraines respectively.
If you are pregnant or planning to conceive, Epilex Chrono 300 Tablet should be used with caution. The medicine may cause major congenital malformations and neurodevelopmental disorders in the unborn child. Always discuss this with your doctor.
Epilex Chrono 300 Tablet is not recommended during breastfeeding as it is found in breast milk. It's best to consult your doctor about this because potential risks must be weighed against benefits.
While taking Epilex Chrono 300 Tablet, alcohol consumption should be avoided or limited. Alcohol might cause increased drowsiness or can affect the functioning of the medicine.
The use of Epilex Chrono 300 Tablet is contraindicated if you have active liver disease or significant hepatic dysfunction. If you have any liver-related issues, it's important to discuss them with your doctor before starting this medicine.
If you have any kidney problems, using Epilex Chrono 300 Tablet requires caution. Consult your doctor before taking this medicine if you have a history of kidney disease.
Epilex Chrono 300 Tablet may cause side effects like dizziness, sedation, or confusion which could affect your ability to operate machinery or drive. It's wise to avoid such activities till you know how the medicine affects you.
If you have known hypersensitivity to sodium valproate, valproic acid or any other ingredients of Epilex Chrono 300 Tablet, its use is contraindicated. Discuss any known allergies with your doctor before starting the medication.
Epilex Chrono 300 Tablet should be used with caution in children under 18 years of age due to a higher risk of hepatotoxicity. Always consult your doctor before giving this medicine to a child.
Older patients should use Epilex Chrono 300 Tablet under medical supervision as they may be more susceptible to its side effects. Caution is advised, particularly if patients are over 70 years of age and have other health conditions like liver and kidney issues. Your doctor will guide you based on your health status.
Other Anticonvulsants: Medicines like phenytoin, carbamazepine, and lamotrigine may interact with Epilex Chrono 300 Tablet. This interaction can decrease the levels of these medicines in your body, which may require a dose adjustment.
Benzodiazepines: Medicines like diazepam and lorazepam, also known as benzodiazepines, can interact with Epilex Chrono 300 Tablet. This combination could cause excessive sleepiness or sedation.
Carbapenem Antibiotics: Medicines like meropenem and imipenem, known as carbapenem antibiotics, can reduce the levels of Epilex Chrono 300 Tablet in your body.
Epilex Chrono 300 Tablet doesn't have any known interactions with food.
Urea Cycle Disorders: Patients who have known urea cycle disorders should avoid Epilex Chrono 300 Tablet. This medicine can increase the amount of ammonia in your blood, which could lead to confusion or loss of consciousness.
Mitochondrial Disorders: If you have a mitochondrial disorder caused by mutations in the POLG gene, Epilex Chrono 300 Tablet could exacerbate your symptoms.
The daily dose of Epilex Chrono 300 Tablet should be taken as directed by your doctor. The dosage could vary depending on factors such as the seriousness of your condition or how you respond to the medication. It is crucial to adhere to your prescribed dosage and not exceed it without consulting your doctor.
If you take more Epilex Chrono 300 Tablet than prescribed, you may feel excessively drowsy or experience a significant drop in body temperature. In such cases, contact your doctor for advice.
In case you miss a dose of Epilex Chrono 300 Tablet, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue with your regular dosage schedule. Do not increase your dosage without consulting your doctor.
Store Epilex Chrono 300 Tablet in a cool, dry place where the temperature stays below 30°C.
Keep it away from direct sunlight and moisture.
Always store this medicine out of sight and reach of children.
Ensure you use Epilex Chrono 300 Tablet before its expiry date.
If you're taking Epilex Chrono 300 Tablet for epilepsy, try to maintain a regular sleep pattern. Disrupted sleep can trigger seizures.
If you're using it to manage bipolar disorder, incorporating regular physical activity into your day can help manage mood swings.
| Dosage Forms Available | Tablet |
| Habit Forming | No |
| Ailment | Epilepsy, Bipolar Disorder, Migraines |
| Drug Category | Anticonvulsant |
| Therapeutic Category | Antiepileptic |
This medicine is primarily used to manage different types of epilepsy, manic episodes in bipolar disorder, and prevent migraines.
It works by increasing the levels of a neurotransmitter (chemical messenger) called GABA in the brain, which helps to reduce abnormal electrical activity and calms overexcited neurons.
You should take the tablet orally with water. It can be taken with or without food, but you must swallow it whole without chewing or crushing.
Common side effects may include dizziness, nausea, vomiting, increased appetite, weight gain, and hair loss. Consult your doctor if these persist or worsen.
Yes, it can interact with various medicines like aspirin, benzodiazepines (used for anxiety), other anticonvulsants, and more. Always inform your doctor about all medicines you're taking.
Use caution if you have liver disease history or bleeding disorders. It's not recommended for pregnant women and breastfeeding mothers without medical consultation.
In case of suspected overdose, immediately contact emergency medical services. Symptoms may include severe drowsiness, low blood pressure, breathing problems, and decreased body temperature.
Check out Editorial Policy
HIGHLIGHTS OF PRESCRIBING INFORMATION. (2016). [Prescribing information]. AbbVie Inc. https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/018081s065_018082s048lbl.pdf
DailyMed - VALPROIC ACID capsule. (n.d.). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=df742f4a-9440-538d-e053-2a95a90a1de6
Valproic acid: Uses, Interactions, Mechanism of Action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00313
Valproic acid: MedlinePlus drug information. (n.d.). https://medlineplus.gov/druginfo/meds/a682412.html
We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.
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