Combipen 250/250 MG Capsule 10 is used to treat bacterial infections affecting the lungs, skin, urinary tract, and digestive system. It works by weakening bacterial cell walls and stopping bacterial growth. This capsule is also effective against bloodstream and reproductive tract infections. Completing the full course helps prevent recurrence.
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Combipen 250/250 MG Capsule 10
Pack of 10 Units
Old MRP ₹43
MRP ₹40.31
₹32.25
₹4.03/Units
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CompositionAbout Combipen 250/250 MG Capsule 10
Uses of Combipen 250/250 MG Capsule 10
Combipen 250/250 MG Capsule 10 is used to treat a wide range of bacterial infections affecting the ear, nose, throat, lungs, bones, and surgical wounds. It is also effective against infections like meningitis, gonorrhoea, and gastrointestinal infections. This antibiotic offers broad-spectrum bacterial coverage. Completing the full course ensures effective treatment.
Directions for Use of Combipen 250/250 MG Capsule 10
- Swallow the whole capsule with water.
- Do not crush, open, or chew the capsule.
- It is generally recommended to take the capsule on an empty stomach or as directed by the doctor.
- Remember to take the medicine at evenly spaced intervals, as directed by your doctor.
- Always consult your doctor for precise instructions tailored to your health condition.
Route of Administration
Combipen 250/250 MG Capsule 10 is taken orally.
Side Effects of Combipen 250/250 MG Capsule 10
Combipen 250/250 MG Capsule 10 may cause side effects such as nausea, vomiting, diarrhoea, rash, and itching. These effects are usually mild. If they persist, consult your healthcare provider.
Managing the Side Effects:
Most side effects are temporary, usually mild, and resolve upon ceasing the use of Combipen 250/250 MG Capsule 10. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Here are some useful guidelines for handling common side effects:
- Nausea and vomiting: Try taking Combipen 250/250 MG Capsule 10 with food to lessen these symptoms.
- Skin rash and itching: Applying a cool, damp cloth to the affected area can help relieve these symptoms. Avoid scratching the affected area, as it could worsen the rash.
How Combipen 250/250 MG Capsule 10 Works?
Combipen 250/250 MG Capsule 10 comprises of two active ingredients:
- Ampicillin (250 mg): This component belongs to a group of antibiotics known as beta-lactam antibiotics. It works by inhibiting the synthesis of bacterial cell walls. Ampicillin is active against both gram-positive and gram-negative bacteria.
- Cloxacillin (250 mg): Like ampicillin, cloxacillin is also a beta-lactam antibiotic. Its primary function is to fight against penicillinase-producing staphylococci (a type of bacteria). By doing so, it prevents these bacteria from building their cell walls, thereby stopping them from multiplying.
The combination of these two components provides broad-spectrum coverage against various bacterial infections.
Safety Measures & Warnings
Pregnancy
Combipen 250/250 MG Capsule 10 should be used during pregnancy only if clearly needed. It's a good idea to consult your doctor before taking this medicine if you are pregnant.
Breastfeeding
Ampicillin and cloxacillin, the active ingredients in Combipen 250/250 MG Capsule 10, are passed into human milk. Caution is advised when taking this medicine if you are breastfeeding.
Alcohol
Caution is advised if you are consuming alcohol alongside Combipen 250/250 MG Capsule 10. Please check with your doctor before consuming alcohol while on this medication.
Liver
Patients with known liver problems should exercise caution when starting Combipen 250/250 MG Capsule 10. This medicine might influence liver function, so it's best to discuss your liver health with your doctor before starting this medication.
Kidney
Caution is advised when using Combipen 250/250 MG Capsule 10 if you have kidney problems. Since the active ingredients in this medicine are primarily eliminated via the kidneys, patients with renal impairment may require dosage adjustments. Make sure to discuss any kidney health concerns with your doctor.
Using Machines & Driving
Combipen 250/250 MG Capsule 10 does not directly affect your ability to drive or operate machinery. However, if you experience side effects like dizziness, it's best to avoid such activities until you know how this medicine affects you.
Allergy
Combipen 250/250 MG Capsule 10 is contraindicated in patients who have had allergic reactions to penicillin or any other antibiotics in the past. If you have a history of allergies, inform your doctor about them before you start this medicine.
Children
Proceed with caution before giving this medicine to children under 18 years of age. Always consult a doctor before giving any medicine to a child.
Older Patients
Elderly patients could be more prone to the side effects of Combipen 250/250 MG Capsule 10. Hence, it is recommended that older patients use this medicine under medical supervision, particularly if they are over the age of 70, have age-related kidney or liver impairment, or are on any other medication.
Interactions of Combipen 250/250 MG Capsule 10
Drug-Drug Interactions
Combipen 250/250 MG Capsule 10 interacts with the following medicines:
- Antigout medication: Medicines like probenecid and allopurinol can lead to prolonged elevated levels of ampicillin in your blood. This may lead to a potential increase in side effects like skin rash.
- Oral contraceptives: Ampicillin present in Combipen 250/250 MG Capsule 10 may reduce the efficacy of oral contraceptives like ethinyl oestradiol and oestradiol.
- Bacteriostatic antibiotics: Medicines like chloramphenicol, erythromycin, and tetracycline may interfere with the bactericidal effect of ampicillin and cloxacillin, reducing the efficacy of Combipen 250/250 MG Capsule 10.
Drug-Food Interactions
- Iron-containing foods interfere with the absorption of antibiotics in Combipen 250/250 MG Capsule 10, making them less effective.
- Calcium-fortified food items like dairy products also reduce the absorption of the antibiotics in Combipen 250/250 MG Capsule 10.
Drug-Disease Interactions
Combipen 250/250 MG Capsule 10 interacts with the following diseases:
- Infectious mononucleosis: Ampicillin use in patients with infectious mononucleosis has been associated with the development of a rash.
- Kidney disease: Combipen 250/250 MG Capsule 10 should be used with caution in patients with kidney impairment, as they may require dose adjustments.
Dosage of Combipen 250/250 MG Capsule 10
Daily Dose
Your recommended dose of Combipen 250/250 MG Capsule 10 should be as your doctor prescribes. This will depend on the severity of your condition and how you respond to the medicine. Always stick to the prescribed dosage, and don't exceed it without consulting your doctor.
Over Dose
If you accidentally take more Combipen 250/250 MG Capsule 10 than recommended, you might experience side effects like nausea, vomiting, and diarrhoea. Inform your doctor promptly.
Missed Dose
If you forget to take a dose of Combipen 250/250 MG Capsule 10, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and keep to your regular dosing schedule. Never change your dosage without talking to your doctor.
Storage
- Keep your Combipen 250/250 MG Capsule 10 stored at room temperature in a cool, dry place.
- Protect the capsule from heat, light, and moisture.
- Always remember to keep this medicine out of reach of children.
- Ensure you use the medicine before the expiration date mentioned on the pack.
Diet & Lifestyle
- Drinking plenty of water can help flush out bacteria and support overall health.
- Maintaining regular meal times can help ensure you take your medicine at the right intervals.
Fact Box
| Available Dosage Types | Capsule |
| Habit Forming | No |
| Ailment | Respiratory Tract Infections, Genitourinary Tract Infections, Meningitis |
| Drug Category | Cell Wall Synthesis Inhibitor |
| Therapeutic Category | Antibiotic |
Frequently Asked Questions (FAQs)
What is Combipen 250/250 MG Capsule 10 used for?
Combipen 250/250 MG Capsule 10 is used to manage a variety of bacterial infections such as respiratory tract, gastrointestinal tract, and genitourinary tract infections. It is also effective in treating skin infections and preventing infections in surgical wounds.
How does Combipen 250/250 MG Capsule 10 work?
This medicine contains ampicillin and cloxacillin, which work together to prevent bacteria from synthesising the bacterial cell wall, resulting in the bacteria's death.
How should I take Combipen 250/250 MG Capsule 10?
You should take Combipen 250/250 MG Capsule 10 as advised by your doctor with water. It's important not to crush or open the capsule.
Can Combipen 250/250 MG Capsule 10 cause allergic reactions?
Yes, Combipen 250/250 MG Capsule 10 can cause allergic reactions in individuals with allergies to penicillin and other antibiotics. Always inform your doctor about all known allergies before taking any new medication.
Are there any precautions while taking Combipen 250/250 MG Capsule 10?
If you have kidney or liver problems or a history of allergic reactions to penicillin, it's advisable to consult a doctor before taking this medicine.
What are the possible side effects of Combipen 250/250 MG Capsule 10?
Common side effects include nausea, vomiting, diarrhoea, skin rash, and itching. If they persist or worsen, consult your doctor.
Can I take other medicines while using Combipen 250/250 MG Capsule 10?
Certain medicines like oral contraceptives and antigout medications can interact with Combipen 250/250 MG Capsule 10. It's a good practice to inform your doctor about all the medicines you are on.
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601 Akik Complex, Near Pakwan II, Bodakdev, S G Highway, Ahmedabad, Gujarat, India - 380054
Expiry on or after: April 2026
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References
- U.S. Food and Drug Administration. (2017, Oct). Ampicillin injection label. https://www.fda.gov/media/127633/download
- U.S. Food and Drug Administration. (2023, Nov 8). Ampicillin pac review 2023 - final. https://www.fda.gov/media/175001/download
- National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 6249, Ampicillin. https://pubchem.ncbi.nlm.nih.gov/compound/Ampicillin
- National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 6098, Cloxacillin. https://pubchem.ncbi.nlm.nih.gov/compound/Cloxacillin
- Bornside G. H. (1968). Synergistic antibacterial activity of ampicillin-cloxacillin mixtures against Proteus morganii. Applied microbiology, 16(10), 1507–1511. https://doi.org/10.1128/am.16.10.1507-1511.1968
- Sabath, L. D., Estey, V. J., & Finland, M. (1967). Independent measurement of ampicillin and cloxacillin in mixtures. Applied microbiology, 15(3), 468–470. https://doi.org/10.1128/am.15.3.468-470.1967
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We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.
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