Zyde Mf 80/500 Mg Tablet 10

Psychotropics India Ltd

Pack of 10 Units

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Old MRP ₹47.5

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₹35.62

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Prescription required for this medicine

Store Below 30° C

Composition

Gliclazide (80 Mg) + Metformin (500 Mg)

Zyde Mf 80/500 Mg Tablet 10 is used to manage type 2 diabetes mellitus in adults who require combination therapy when single-agent treatment is not sufficient. It is a combination of two diabetes-controlling agents that work together to lower blood sugar levels.

It contains gliclazide and metformin. Take it as prescribed, with meals to reduce stomach upset. Do not stop taking it without medical advice as your blood sugar may rise.

Keeping to a low-glycaemic diet, engaging in regular physical activity, maintaining a healthy weight and checking blood sugar regularly support effective diabetes management with this medicine.

Tell your doctor if you have liver disease, kidney disease, heart disease or pancreatic disease before starting. Report any signs of hypoglycaemia (shakiness, sweating, confusion), yellowing of the skin or eyes, severe stomach pain, or difficulty urinating.

Zyde Mf 80/500 Mg Tablet 10 is used to manage type 2 diabetes by lowering blood sugar levels and reducing the risk of diabetes-related complications when used alongside diet and exercise.

Uses of Zyde Mf 80/500 Mg Tablet 10 are:

• Blood Sugar Control: Helps regulate blood sugar levels in type 2 diabetes.

• Diabetes Management: Used in adults requiring combination therapy for better blood sugar control.

• Complication Prevention: Reduces the risk of heart disease, kidney damage and eye problems caused by high blood sugar.

Swallow the tablet whole with a glass of water.
Do not crush or chew the tablet.
Take the medicine in the dosage and frequency prescribed by your doctor.
Do not stop taking this medicine without discussing it with your doctor.

Zyde Mf 80/500 Mg Tablet 10 is taken orally.

Zyde Mf 80/500 Mg Tablet 10 may cause some side effects that are usually mild and go away as your body adjusts to the medicine.

A few common side effects of Zyde Mf 80/500 Mg Tablet 10:

• Digestive: Feeling sick (nausea), stomach pain and loose motions (diarrhoea). Taking the tablet with food can help reduce stomach upset.

• Neurological: Headache and dizziness.

• Vision: Blurred vision.

If side effects do not improve or become serious, speak to your doctor right away.

Management Of Side Effects:

Most side effects are temporary and generally harmless, which resolve upon discontinuing the medicine. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

You can also effectively manage common side effects like nausea, vomiting, diarrhoea, or stomach pain at home by taking the medicine with food.

Zyde Mf 80/500 Mg Tablet 10 works in the human body in the following ways:

Gliclazide (80 mg): Gliclazide belongs to the group of sulphonylureas. It helps control blood glucose levels by stimulating your pancreas to release more insulin.
Metformin hydrochloride (500 mg): Metformin hydrochloride is classified as a biguanide. Its primary function is to lower glucose production in the liver and reduce intestinal glucose absorption. Additionally, it enhances insulin sensitivity by promoting peripheral glucose uptake and utilisation. This activity, in turn, helps reduce high blood sugar levels.

Pregnancy

Zyde Mf 80/500 Mg Tablet 10 is contraindicated in pregnancy as it may cause harm to the foetus. Always consult your doctor before taking this medicine.

Breastfeeding

This medicine is contraindicated while breastfeeding as it may pass into breast milk and adversely affect the nursing infant. Always consult your doctor before starting this medicine.

Alcohol

Avoid alcohol consumption while on this medication as it could increase the risk of lactic acidosis (lactic acid built up in your body). Always consult your doctor regarding alcohol intake.

Liver

This medicine is contraindicated in patients with severe liver disorders as it could increase their risk of developing lactic acidosis. If you have liver issues, discuss them with your doctor before starting this medication.

Kidney

For those with severe kidney problems, especially severe renal impairment, Zyde Mf 80/500 Mg Tablet 10 is contraindicated. Always consult your doctor before taking this medicine.

Use In Driving And Operating Machinery

This medicine may cause dizziness or blurred vision in some individuals. If you feel dizzy or unwell, avoid doing activities such as driving or operating machinery until you feel better.

Allergy

Avoid taking this medicine if you are allergic to gliclazide, metformin hydrochloride, or any other ingredients in the tablet. Always discuss your allergies with your doctor.

Children

This medicine is not intended for use in children below 18 years. Always consult your doctor before giving any medicine to a child.

Older Patients

Elderly patients may have decreased hepatic or renal function, which puts them at a higher risk of developing lactic acidosis when taking Zyde Mf 80/500 Mg Tablet 10. Exercise caution and consult your doctor for guidance based on your health status.

Drug-Drug Interactions

Zyde Mf 80/500 Mg Tablet 10 may interact with the following medications:

Diuretics: Medicines like furosemide or hydrochlorothiazide may decrease the blood glucose-lowering effect of this tablet.
Corticosteroids: Medicines like prednisone can reduce the effectiveness of Zyde Mf 80/500 Mg Tablet 10 in managing blood sugar levels.
Angiotensin-converting enzyme (ACE) inhibitors: ACE inhibitors such as ramipril or lisinopril can enhance the medicine's blood sugar-lowering effect, causing extremely low blood sugar levels.
Other antidiabetic agents: Medicines like insulin or glimepiride may interact with this tablet, increasing the risk of low blood sugar.

Drug-Food Interactions

Zyde Mf 80/500 Mg Tablet 10 may interact with certain foods, such as:

High-fibre diet: A diet rich in fibre, like whole grains, legumes, and vegetables, may decrease the absorption and effectiveness of metformin hydrochloride.

Drug-Disease Interactions

Zyde Mf 80/500 Mg Tablet 10 may interact with the following diseases:

Type 1 diabetes: This medicine is contraindicated in patients with type 1 diabetes.
Diabetic ketoacidosis: Patients with diabetic ketoacidosis are also contraindicated from taking this medicine.
Liver or kidney disease: This medicine is contraindicated if you have severe liver or kidney problems, as it could increase your risk of developing lactic acidosis, a rare but serious condition.
Heart failure: People with heart conditions like congestive heart failure are also contraindicated from taking this medicine.

Daily Dose

Your doctor will determine the recommended daily dose of Zyde Mf 80/500 Mg Tablet 10, depending on individual factors such as the severity of your condition and your response to the medication.

Over Dose

If you accidentally take more than the prescribed dose, it can lead to common side effects such as nausea, diarrhoea, or headache. If you experience these symptoms, inform your doctor promptly.

Missed Dose

If you forget to take a dose of the medicine, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue with your regular schedule. Never double your dose to compensate for a missed one without consulting your doctor.

Keep Zyde Mf 80/500 Mg Tablet 10 in a dry place, protected from light and moisture.
Store it at room temperature, below 30°C.
Avoid storing the medicine in heat or direct sunlight, as this could affect its effectiveness.
Ensure this medicine is out of reach of children to prevent accidental consumption.
Always use the medicine before its expiry date.

Consider following a balanced diet low in sugar, which can help control blood glucose levels.
Regular physical activity can also aid in controlling your blood glucose levels. Try incorporating exercise into your daily routine, even if it's just a brisk walk. Always consult your doctor before starting any new exercise regimen.

Fact Box

Dosage Forms Available	Tablet
Habit Forming	No
Ailment	Type 2 Diabetes Mellitus
Drug Category	Sulphonylurea, Biguanide
Therapeutic Category	Antidiabetic

What is Zyde Mf 80/500 Mg Tablet 10 used for?

It's a medicine used to manage type 2 diabetes mellitus in adults, particularly when individual components of the medicine, gliclazide or metformin hydrochloride, cannot adequately control blood sugar levels.

How does Zyde Mf 80/500 Mg Tablet 10 work?

This medicine contains two active ingredients. Gliclazide stimulates the pancreas to secrete more insulin in your body, while metformin hydrochloride reduces glucose production in the liver and lowers intestinal glucose absorption. Together, they help reduce blood glucose levels.

Can I take Zyde Mf 80/500 Mg Tablet 10 if I'm pregnant or breastfeeding?

No, this medicine is contraindicated during pregnancy or breastfeeding as it may cause harm to the baby. Always consult your doctor for safer alternatives.

Can children take Zyde Mf 80/500 Mg Tablet 10?

No, Zyde Mf 80/500 Mg Tablet 10 is not usually recommended for children below 18 years. It is intended for the management of type 2 diabetes in adults. Always talk to a doctor before giving this medicine to a child.

Are there any side effects of Zyde Mf 80/500 Mg Tablet 10?

Yes, some people may experience side effects like diarrhoea, nausea, vomiting, and hypoglycaemia. If these symptoms persist, consult your doctor.

Can I drink alcohol while taking Zyde Mf 80/500 Mg Tablet 10?

No, it's best to avoid alcohol intake while on this medication, as it can increase the risk of lactic acidosis. Always consult your doctor regarding alcohol consumption.

What should I do if I overdose on Zyde Mf 80/500 Mg Tablet 10?

If you take too much Zyde Mf 80/500 Mg Tablet 10, seek medical help immediately. An overdose may cause low blood sugar symptoms such as dizziness, sweating, confusion, or blurred vision.

Last Updated On 05 Aug. 2026 | 1:54PM (IST)

Certified Content

Written by

Dr. Adhithya Mullath Ullas

Ayurveda Content Reviewer | 4 years

BAMS, MSc Diabetes

Reviewed by

Dr. Sachin Singh

Medical Team Lead & Reviewer | 7 years

MBBS

Check out Editorial Policy

Manufacturer details

Plot No. 17, Sector 20A, Faridabad-121001 Faridabad HR 121001 IN

Country of origin: INDIA

Expiry on or after: March 2027

In case of any issues, contact us:

support@truemeds.in|09240250346

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

GLUCOPHAGE (metformin hydrochloride tablets). (n.d.). accessdata.fda.gov. https://www.accessdata.fda.gov/drugsatfda_docs/label/2000/21202lbl.pdf
Website, N. (2024c, March 26). Gliclazide. nhs.uk. https://www.nhs.uk/medicines/gliclazide/
Gliclazide: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB01120
Campbell, D., Lavielle, R., & Nathan, C. (1991). The mode of action and clinical pharmacology of gliclazide: a review. Diabetes Research and Clinical Practice, 14, S21–S36. https://doi.org/10.1016/0168-8227(91)90005-x
Corcoran, C., & Jacobs, T. F. (2023b, August 17). Metformin. StatPearls - NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK518983/#
Metformin: MedlinePlus drug information. (n.d.). https://medlineplus.gov/druginfo/meds/a696005.html
METFORMIN-INDUCED LACTIC ACIDOSIS COMPLICATED BY ACUTE LIVER FAILURE. (2023, October). journal.chestnet.org. https://journal.chestnet.org/article/S0012-3692(23)02332-2/fulltext

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