Sitaglyn M 50/1000 Tablet 10

Zydus Healthcare Ltd

Strip of 10 Units

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MRP ~~₹132~~

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Composition

Metformin (1000 Mg) + Sitagliptin (50 Mg)

Sitaglyn M 50/1000 Tablet 10 is used to manage blood sugar levels in adults with type 2 diabetes mellitus. It combines sitagliptin (a DPP-4 inhibitor) and metformin (a biguanide), which work together to improve insulin sensitivity and reduce glucose production in the liver, helping to control blood sugar levels.

In addition to controlling high blood sugar, this medicine helps prevent serious complications of diabetes, such as kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also reduce your risk of having a heart attack or stroke.

Remember to take this medicine as advised by your doctor. Always inform your doctor about any pre-existing conditions or ongoing medications before starting this medicine. If you notice any side effects while on this medication, promptly notify your doctor. It's important to continue taking the medication for the duration prescribed by your doctor to achieve optimal results.

Sitaglyn M 50/1000 Tablet 10 is used to manage Type 2 diabetes mellitus.

Swallow the tablet whole with a glass of water, ideally during your evening meal.
Do not crush, chew, or split the tablet.
Always take this medicine as part of a meal to help reduce potential gastrointestinal side effects.
Never exceed the recommended dose without consulting your doctor.
Remember not to stop taking this medicine without speaking to your doctor first.

Sitaglyn M 50/1000 Tablet 10 is taken orally.

You may experience the following common side effects when taking Sitaglyn M 50/1000 Tablet 10:

Diarrhoea
Headache
Nausea
Vomiting
Abdominal pain
Hypoglycemia: This means low blood sugar, which may make you feel dizzy or hungry.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which are resolved by discontinuing the use of Sitaglyn M 50/1000 Tablet 10. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some tips to manage two common side effects:

Diarrhoea: Try taking Sitaglyn M 50/1000 Tablet 10 with your meals to reduce this effect.
Hypoglycemia: If you experience low blood sugar levels after taking this medication, consider having a small snack before taking your dose.

Sitaglyn M 50/1000 Tablet 10 contains two active ingredients:

Sitagliptin (50 mg): Sitagliptin acts as an inhibitor of an enzyme called dipeptidyl peptidase-4 (DPP-4). Doing so increases the levels of certain proteins that help regulate insulin levels in the body after meals and reduces the amount of sugar produced by the liver.
Metformin (1000 mg): This compound works by reducing the amount of sugar your liver produces and absorbs from food. It also helps your body respond better to insulin, which is a substance that manages the amount of sugar in your bloodstream.

Pregnancy

Poorly managed diabetes during pregnancy can pose risks to both mother and baby. Therefore, it's important to consult your doctor about using Sitaglyn M 50/1000 Tablet 10 if you're pregnant or planning to conceive.

Breastfeeding

Although metformin is known to pass into breast milk, there's no information about sitagliptin's presence in human milk. If you are on this medicine, before you start breastfeeding, discuss with your doctor any potential impacts on your baby.

Alcohol

Drinking alcohol while taking this tablet may increase the risk of lactic acidosis. Caution is advised, and it’s best to discuss your alcohol consumption with your doctor.

Liver

If you have liver problems, exercise caution while using Sitaglyn M 50/1000 Tablet 10. Liver health issues may affect how this medicine works in your body, so consult your doctor before using it.

Kidney

Use of Sitaglyn M 50/1000 Tablet 10 is not recommended for people with severe kidney impairment. If you have a history of kidney problems, consult your doctor before starting this medicine.

Using Machines & Driving

There's no specific information suggesting that this medicine interferes with driving or operating machinery. However, always ensure you know how the medicine affects you before undertaking such tasks.

Allergy

Reports suggest some patients may experience allergic reactions while taking sitagliptin, one of the active ingredients in Sitaglyn M 50/1000 Tablet 10. If you've had allergies to ingredients of this medicine in the past, discuss these with your doctor before starting this medication.

Children

Safety and effectiveness of Sitaglyn M 50/1000 Tablet 10 in children under 18 years of age have not been established. It is essential to consult a doctor before giving this medicine to a child.

Older Patients

Older patients need to use this medicine under supervision, as they might be more susceptible to its effects. If you're above 70 years of age, discuss your overall health status with your doctor before starting Sitaglyn M 50/1000 Tablet 10.

Drug-Drug Interactions

Sitaglyn M 50/1000 Tablet 10 interacts with the following medicines:

Carbonic Anhydrase Inhibitors: Medicines like acetazolamide, topiramate, or methazolamide could potentially increase the risk of lactic acidosis when taken with this medicine.
Medicines Reducing Metformin Clearance: Medicines such as ranolazine, vandetanib, dolutegravir, or cimetidine may cause an increased accumulation of metformin in the body.

Drug-Food Interactions

Sitaglyn M 50/1000 Tablet 10 does not have any interactions with foods. the medicine should preferably taken with meals low in fat content.

Drug-Disease Interactions

Sitaglyn M 50/1000 Tablet 10 interacts with the following diseases:

Kidney dysfunction: The medicine could have adverse effects in individuals with kidney issues due to its potential to increase the risk of lactic acidosis.
Liver Disease: Patients with liver problems should use this medicine cautiously, as it may exacerbate their condition.
Heart Failure: Those suffering from heart failure should evaluate the risks and benefits before using this medication due to potential complications associated with DPP-4 inhibitors such as sitagliptin.
Pancreatitis: There have been reports of acute pancreatitis in some patients using sitagliptin. If you suspect pancreatitis, immediate discontinuation is recommended.

Daily Dose

The daily dose of Sitaglyn M 50/1000 Tablet 10 should be taken as suggested by your doctor. The dosage may vary depending on your specific health condition and how you respond to the medicine. Follow the prescribed dosage; don't change it without consulting your doctor.

Over Dose

In case you accidentally take an extra dose of Sitaglyn M 50/1000 Tablet 10, you might experience symptoms like diarrhoea, nausea, or stomach discomfort. If these symptoms persist or worsen, notify your doctor.

Missed Dose

If you forget to take your scheduled dose of Sitaglyn M 50/1000 Tablet 10, take it as soon as you remember. However, if it's nearly time for the next dose, skip the missed one and continue with your regular schedule. Avoid making any changes to your dosage without checking with your doctor.

Store Sitaglyn M 50/1000 Tablet 10 at room temperature, specifically between 20°C and 25°C.
Keep it away from moisture to maintain its effectiveness.
Always keep this medicine out of the reach of children.
Check the expiry date before use and avoid using it past that date.

Maintaining a balanced diet with a controlled intake of carbohydrates can help regulate your blood sugar levels. Consult your doctor for specific dietary advice tailored for you.
Regular exercises such as walking, cycling or swimming can also aid in better control of blood glucose levels. Make sure you engage in some form of physical activity daily, as suggested by your doctor.

Fact Box

Available Dosage Types	Tablet
Habit Forming	No
Ailment	Type 2 Diabetes Mellitus
Drug Category	DPP-4 Inhibitor, Biguanide
Therapeutic Category	Antidiabetic

What is Sitaglyn M 50/1000 Tablet 10?

It's a medicine containing metformin and sitagliptin, used alongside diet and exercise to manage blood sugar levels in adults with type 2 diabetes.

How does Sitaglyn M 50/1000 Tablet 10 work?

Metformin reduces blood sugar by decreasing glucose production and absorption and increasing its uptake. Sitagliptin regulates blood sugar by enhancing insulin release after meals.

Who should not take Sitaglyn M 50/1000 Tablet 10?

People with Type 1 Diabetes, diabetic ketoacidosis, and severe renal or hepatic impairment should avoid this medicine. Always consult your doctor first.

What are the possible side effects of Sitaglyn M 50/1000 Tablet 10?

Common side effects include upper respiratory tract infection, nasopharyngitis, diarrhoea, headache, nausea, vomiting, abdominal pain and low blood sugar. You should consult your doctor if they persist.

Can Sitaglyn M 50/1000 Tablet 10 be used during pregnancy?

Poorly managed diabetes during pregnancy can pose risks to both mother and baby. Consult your doctor before using this medication during pregnancy.

Is it safe to use Sitaglyn M 50/1000 Tablet 10 while breastfeeding?

Limited studies indicate metformin being present in breast milk while taking the medicine, but its effects on the baby are unknown. It's best to consult your doctor before use.

How should I store my Sitaglyn M 50/1000 Tablet 10?

Sitaglyn M 50/1000 Tablet 10 should be stored below 30°C. It should be kept away from excessive heat, humidity, and direct sunlight, and protected from moisture.

Last Updated On 13 May. 2025 | 11:20AM (IST)

Certified Content

Written by

Dr. Michelle Frank

Medical Content Writer | 9 years

Doctor of Medicine

Reviewed by

Dr. Divya Chauhan

Medical Content Writer & Reviewer | 7 years

BAMS, APG, PG

Check out Editorial Policy

Manufacturer details

Zydus Tower, Satellite Cross Roads, Sarkhej - Gandhinagar Highway, Ahmedabad Ahmedabad GJ 380015 IN

Country of origin: INDIA

Expiry on or after: October 2025

In case of any issues, contact us:

support@truemeds.in|08069808861

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

U.S. National Library of Medicine. (2022). Metformin hydrochloride and sitagliptin phosphate- Janumet tablet, film coated. DailyMed. Retrieved 1 April 2024, from https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=1200ea71-8a9e-4e49-bb77-7d9fe0d84ae7
U.S. National Library of Medicine. (2021). Sitagliptin. MedlinePlus. Retrieved 1 April 2024, from https://medlineplus.gov/druginfo/meds/a606023.html
U.S. Food and Drug Administration. (2007). Metformin hydrochloride and sitagliptin phosphate label. FDA. Retrieved 29 August 2024, from
https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/022044s042lbl.pdf
National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 4369359, Sitagliptin. Retrieved June 19, 2024 from https://pubchem.ncbi.nlm.nih.gov/compound/Sitagliptin.
National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 14219, Metformin Hydrochloride. Retrieved June 19, 2024 from https://pubchem.ncbi.nlm.nih.gov/compound/Metformin-Hydrochloride.

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We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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Intellihealth Solutions Private Limited

Office Unit no. 1, 2, 5, & 7, 6th floor Urmi Corporate Park Solaris, Saki Vihar Rd, Opp. L&T Flyover, New Mhada Colony, Budhia Jadhav Wadi, Mumbai, Maharashtra 400072.

CIN: U85320MH2019PTC320566

Telephone:09240250346

Grievance Officer

Name: Chandrasekhar Swaminathan

Email: grievance-officer@truemeds.in

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